{"product_id":"upstream-industrial-biotechnology-2-volume-set-isbn-9781118131237","title":"Upstream Industrial Biotechnology, 2 Volume Set","description":"Biotechnology represents a major area of research focus, and many universities are developing academic programs in the field. This guide to biomanufacturing contains carefully selected articles from Wiley's \u003ci\u003eEncyclopedia of Industrial Biotechnology, Bioprocess, Bioseparation, and Cell Technology\u003c\/i\u003e as well as new articles (80 in all,) and features the same breadth and quality of coverage and clarity of presentation found in the original. For instructors, advanced students, and those involved in regulatory compliance, this two-volume desk reference offers an accessible and comprehensive resource. \u003cp\u003eVOLUME I: EXPRESSION SYSTEMS \u0026amp; PROCESS DEVELOPMENT\u003c\/p\u003e \u003cp\u003ePREFACE xi\u003c\/p\u003e \u003cp\u003eCONTRIBUTORS xiii\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART I INTRODUCTION 3\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART II INDUSTRIAL CELL GROWTH AND GENE EXPRESSION SYSTEMS 7\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Animal Cells, Suspension Culture 9\u003cbr\u003e\u003ci\u003eJohn R. Birch\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 Baculovirus Expression Systems 19\u003cbr\u003e\u003ci\u003eRobert D. Possee, Richard B. Hitchman, and Linda A. King\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 Baculovirus Kinetics, Insect Culture 33\u003cbr\u003e\u003ci\u003eLeslie Chan, Steve Reid, and Lars Keld Nielsen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 Cell Culture, Aseptic Techniques 49\u003cbr\u003e\u003ci\u003eJohn M. Davis and Kevin L. Shade\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 Cell Cycle in Bioprocesses 71\u003cbr\u003e\u003ci\u003eMariam Naciri and Mohamed Al-rubeai\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 Cell Growth and Protein Expression Kinetics 85\u003cbr\u003e\u003ci\u003eDhinakar S. Kompala\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 Cell Viability Measurement 97\u003cbr\u003e\u003ci\u003eNing Wei and Benjamin Sommer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 Contamination Detection in Animal Cell Culture 105\u003cbr\u003e\u003ci\u003eCarol Mclean and Colin Harbour\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 Culture Collections and Biological Resource Centers (BRCs) 131\u003cbr\u003e\u003ci\u003eDavid Smith\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 Culture Preservation 153\u003cbr\u003e\u003ci\u003eRobert L. Gherna\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 Expression and Secretion of Heterologous Proteins, Bacillus and Other Gram-Positive Bacteria 163\u003cbr\u003e\u003ci\u003eBoyke Bunk, Rebekka Biedendieck, Dieter Jahn, and Patricia S. Vary\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 Gene Expression in Human Cells 181\u003cbr\u003e\u003ci\u003eMarco A. Cacciuttolo, Gene Lee, John Chon, and John Lewis\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13 Gene expression in Pichia and other methylotroph yeast 195\u003cbr\u003e\u003ci\u003eKoti Sreekrishna\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14 Gene Expression in Recombinant Animal Cells and Transgenic Animals 213\u003cbr\u003e\u003ci\u003eRichard M. Twyman and Bruce Whitelaw\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15 Inoculum Expansion Methods, Animal Cell Lines 297\u003cbr\u003e\u003ci\u003eClaudia Kloth, Glenn Maclsaac, Haile Ghebremariam, and Alahari Arunakumari\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16 Insect Cell Culture 311\u003cbr\u003e\u003ci\u003eSomeet Narang, Erik M. Whiteley, Sunyia Hussain, and Michael J. Betenbaugh\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17 Kinetics of Microbial Growth 331\u003cbr\u003e\u003ci\u003eNicolai S. Panikov\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18 Microalgae, Mass Culture Methods 371\u003cbr\u003e\u003ci\u003eEmílio Molina Grima, Jose María Fernández Sevilla, and Francisco Gabriel Acién Fernández\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e19 Microbial Growth Measurement 399\u003cbr\u003e\u003ci\u003eArthur L. Koch\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e20 Microbial Media Composition 413\u003cbr\u003e\u003ci\u003eRosalie J. Cote\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e21 Microscopic Characterization of Cells 437\u003cbr\u003e\u003ci\u003eErwin Huebner\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e22 Mycoplasma Contamination of Cell Cultures 467\u003cbr\u003e\u003ci\u003eCord C. Uphoff and Hans G. Drexler\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e23 Protein Glycosylation: Analysis, Characterization, and Engineering 489\u003cbr\u003e\u003ci\u003eMikael R. Andersen, Jong Hyun Nam, and Susan T. Sharfstein\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e24 Secretion of Heterologous Proteins, Gram Positive Bacteria 543\u003cbr\u003e\u003ci\u003eEric Morello, Isabelle Poquet, Philippe Langella\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e25 Soluble Protein Expression in Bacteria 557\u003cbr\u003e\u003ci\u003eCatherine H. Schein\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART III MEDIA, CELL LINES AND PROCESS DEVELOPMENT 579\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e26 Animal Cell Culture Media 581\u003cbr\u003e\u003ci\u003eNatarajan Vijayasankaran, Jincai Li, Robert Shawley, Aaron Chen, Masaru Shiratori, Martin Gawlitzek, Feng Li, Robert Kiss, and Ashraf Amanullah\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e27 Animal Cell Culture, Effects of Osmolality and Temperature 599\u003cbr\u003e\u003ci\u003eJames C. Warren and Shyamsundar Subramanian\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e28 Animal Cell Stability 617\u003cbr\u003e\u003ci\u003eMartin S. Sinacore, Timothy S. Charlebois, Denis Drapeau, Mark Leonard, Scott Harrison, and S. Robert Adamson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e29 Animal Cell Types, Hybridomas 635\u003cbr\u003e\u003ci\u003eK. Heilmann and B. Micheel\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e30 Antibody Production, Human Recombinant 645\u003cbr\u003e\u003ci\u003eStefan Dübel\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e31 Antifoams and Pluronic Polyols, Cell Protection 663\u003cbr\u003e\u003ci\u003eDavid W. Murhammer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e32 Biominiaturization of Bioreactors 669\u003cbr\u003e\u003ci\u003eMichael A. Hanson and Govind Rao\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e33 Inoculum Preparation 699\u003cbr\u003e\u003ci\u003eCraig J.L. Gershater\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e34 Microcarrier Culture 711\u003cbr\u003e\u003ci\u003eSusan T. Sharfstein and Christian Kaisermayer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e35 Monoclonal Antibody Production, Cell Lines 733\u003cbr\u003e\u003ci\u003eJulia F. Markusen and David K. Robinson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e36 Plant Cell Culture, Laboratory Techniques 747\u003cbr\u003e\u003ci\u003eMark Richard Fowler\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e37 Scale-Up of Biotechnological Processes 759\u003cbr\u003e\u003ci\u003eMarko Zlokarnik\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eVOLUME II: EQUIPMENT, PROCESS DESIGN, SENSING, CONTROL, AND cGMP OPERATIONS\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003ePREFACE ix\u003c\/p\u003e \u003cp\u003eCONTRIBUTORS xi\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART IV BIOREACTOR DESIGN, ENGINEERING, PROCESS SENSING AND CONTROL 789\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e38 Aeration, Mixing, and Hydrodynamics in Animal Cell Bioreactors 791\u003cbr\u003e\u003ci\u003eRuben Godoy-Silva, Claudia Berdugo, and Jeffrey J. Chalmers\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e39 Biocatalytic Membrane Reactors 821\u003cbr\u003e\u003ci\u003eLidietta Giorno and Enrico Drioli\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e40 Bioreactor Scale-Down 847\u003cbr\u003e\u003ci\u003eLaura A. Palomares, Alvaro R. Lara, and Octavio T. Ramírez\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e41 Bioreactor Scale-Up 863\u003cbr\u003e\u003ci\u003eLaura A. Palomares and Octavio T. Ramírez\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e42 Bioreactors: Airlift Reactors 887\u003cbr\u003e\u003ci\u003eJ.C. Merchuk and F. Garcia Camacho\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e43 Bioreactors, Continuous Culture of Plant Cells 955\u003cbr\u003e\u003ci\u003eH.J.G. Ten Hoopen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e44 Bioreactors, Fluidized-Bed 963\u003cbr\u003e\u003ci\u003eWinfried Storhas\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e45 Bioreactors, Gas-Treatment 979\u003cbr\u003e\u003ci\u003eGraham Andrews and William Apel\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e46 Bioreactors, Perfusion 995\u003cbr\u003e\u003ci\u003eWei Wen Su\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e47 Bioreactors: Rotating Biological Contactors 1013\u003cbr\u003e\u003ci\u003eSusana Cortez, Pilar Teixeira, Rosário Oliveira, and Manuel Mota\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e48 Bioreactors, Stirred Tank for Culture of Plant Cells 1031\u003cbr\u003e\u003ci\u003ePauline M. Doran\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e49 Cell Immobilization, Engineering Aspects 1069\u003cbr\u003e\u003ci\u003eRonnie Willaert\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e50 Fermenter\/Bioreactor Design 1101\u003cbr\u003e\u003ci\u003eMarvin Charles and Jack Wilson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e51 Gas-Holdup in Bioreactors 1137\u003cbr\u003e\u003ci\u003eChristian Sieblist and Andreas Lübbert\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e52 Immobilization of Proteins and Enzymes, Mesoporous Supports 1147\u003cbr\u003e\u003ci\u003eMartin Hartmann and Dirk Jung\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e53 Immobilized Cells 1179\u003cbr\u003e\u003ci\u003eManojlovic Verica, Bugarski Branko, and Nedovic Viktor\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e54 Immobilized Enzymes 1201\u003cbr\u003e\u003ci\u003eJose M. Guisan, Lorena Betancor, and Gloria Fernandez-Lorente\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e55 Impeller Selection, Animal Cell Culture 1219\u003cbr\u003e\u003ci\u003eAlvin W. Nienow\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e56 Mammalian Cell Bioreactors 1233\u003cbr\u003e\u003ci\u003eWeichang Zhou, Gargi Seth, Maria J. Guardia, and Wei-Shou Hu\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e57 Mammalian Cell Culture Reactors, Scale-Up 1245\u003cbr\u003e\u003ci\u003eJ. Bryan Griffiths\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e58 Mass Transfer 1261\u003cbr\u003e\u003ci\u003eYusuf Chisti\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e59 Oxygen Transfer Rate Determination Methods 1303\u003cbr\u003e\u003ci\u003eFelix Garcia-Ochoa and Emilio Gomez\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e60 Photobioreactors 1327\u003cbr\u003e\u003ci\u003eMario R. Tredici, Graziella Chini Zittelli and Liliana Rodolfi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e61 Rheological Behavior of Fermentation Fluids 1347\u003cbr\u003e\u003ci\u003eColin R. Thomas and Grainne L. Riley\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e62 Rheology of Filamentous Microorganisms, Submerged Culture 1359\u003cbr\u003e\u003ci\u003eMaria Papagianni\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e63 Sampling and Sample Handling for Process Control 1377\u003cbr\u003e\u003ci\u003eBo Mattiasson and Martin Hedström\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e64 Solid State Fermentation, Kinetics 1387\u003cbr\u003e\u003ci\u003eDavid A. Mitchell, Deidre M. Stuart, and Robert D. Tanner\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e65 Solid Substrate Fermentation, Automation 1413\u003cbr\u003e\u003ci\u003eMario Fernández-fernández and J. Ricardo Pérez-correa\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e66 Stainless Steels 1427\u003cbr\u003e\u003ci\u003eC.P. Dillon\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e67 Static Mixing, Fermentation Processes 1435\u003cbr\u003e\u003ci\u003eRadu Z. Tudose and Maria Gavrilescu\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e68 Transfer Phenomena in Multiphase Systems 1451\u003cbr\u003e\u003ci\u003eRodica-Viorica Roman\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART V PROCESS ANALYTICAL TECHNOLOGIES (PAT) 1469\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e69 Bioprocess and Fermentation Monitoring 1471\u003cbr\u003e\u003ci\u003eMichael Pohlscheidt, Salim Charaniya, Marco Jenzsch, Christopher Bork, Tim L. Noetzel, and Andreas Luebbert\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e70 Flow Injection Analysis in Industrial Biotechnology 1493\u003cbr\u003e\u003ci\u003eElo Harald Hansen and Manuel Miró\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e71 Fluorescence Techniques for Bioprocess Monitoring 1511\u003cbr\u003e\u003ci\u003eFabienne Anton, Carsten Lindemann, Bernd Hitzmann, Kenneth F. Reardon, and Thomas Scheper\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e72 Off-Line Analysis in Animal Cell Culture 1523\u003cbr\u003e\u003ci\u003eHeino Büntemeyer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e73 Process Analytical Technology: Strategies for Biopharmaceuticals 1543\u003cbr\u003e\u003ci\u003eAnurag S. Rathore and Gautam Kapoor\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e74 Vent Gas Analysis 1567\u003cbr\u003e\u003ci\u003eDavid Pollard and Jens Christensen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART VI UPSTREAM cGMP OPERATIONS 1585\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e75 Antibody Manufacture, Disposable Systems 1587\u003cbr\u003e\u003ci\u003eRegine Eibl and Dieter Eibl\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e76 Bioreactor Operations 1595\u003cbr\u003e\u003ci\u003eDavid R. Gray\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e77 Bioreactors, Cell Culture, Commercial Production 1635\u003cbr\u003e\u003ci\u003eTan-Che Zhou, Wen-Wen Zhou, Weiwei Hu, and Jian-Jiang Zhong\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e78 Biotransformation, Process Optimization 1665\u003cbr\u003e\u003ci\u003eLutz Hilterhaus, Andreas Liese, and Udo Kragl\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e79 Foam Formation and Control in Bioreactors 1679\u003cbr\u003e\u003ci\u003eFrank Delvigne and Jean-Paul Lecomte\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e80 Pilot Plants, Design and Operation 1695\u003cbr\u003e\u003ci\u003eBeth H. Junker\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e81 Shear Sensitivity 1719\u003cbr\u003e\u003ci\u003eYusuf Chisti\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e82 Sterilization and Decontamination, Bioprocess Equipment 1763\u003cbr\u003e\u003ci\u003ePeter L. Roberts\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eINDEX 1781\u003c\/p\u003e  \u003cp\u003e\u003cstrong\u003eEditor-in-Chief, Dr. Michael C. Flickinger\u003c\/strong\u003e is the Associate Director for Academic Programs of the Golden LEAF Biomanufacturing Training and Education Center (BTEC) and a Professor of Microbiology and Chemical and Biomolecular Engineering at North Carolina State University, Raleigh.\u003cbr\u003eDr. Flickinger was Director of the University of Minnesota's Institute for Advanced Studies in Biological Process Technology, which was later renamed the Biotechnology Institute ), and a Professor of Biochemistry, Molecular Biology and Biophysics at the University of Minnesota, St. Paul. Prior to coming to Minnesota Dr. Flickinger was Director of the Fermentation Program at the National Cancer Institute in Frederick, Maryland.\u003cbr\u003eDr. Flickinger received his academic training at the University of Wisconsin, Madison.?(B.S.?(1973) in microbial biochemistry;? M.S. (1975) and Ph.D.?(1977) in pharmaceutical biochemistry.)? He did his postdoctoral work at the Laboratory for Renewable Resources Engineering? in the School of Chemical Engineering, Purdue University.\u003cbr\u003eHe is Editor-in-Chief of the \u003cem\u003eEncyclopedia of Industrial Biotechnology\u003c\/em\u003e (Wiley, 2010) and Co-Editor of the \u003cem\u003eEncyclopedia of Bioprocess Technology: Fermentation, Biocatalysis and Bioseparation\u003c\/em\u003e (Wiley, 1999).\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47990439379173,"sku":"NP9781118131237","price":605.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781118131237.jpg?v=1761787833","url":"https:\/\/k12savings.com\/es\/products\/upstream-industrial-biotechnology-2-volume-set-isbn-9781118131237","provider":"K12savings","version":"1.0","type":"link"}