{"product_id":"tumor-microenvironment-isbn-9780470749968","title":"Tumor Microenvironment","description":"The microenvironment in which a tumor originates plays a critical role in its initiation and progression. \u003ci\u003eTumor Microenvironment\u003c\/i\u003e reviews the importance of tumor microenvironment in cancer management. Particular emphasis is placed on discussing how the unique characteristics of the tumor microenvironment not only impact disease progression and response to conventional anticancer therapies, but have also led to the identification of potential new therapeutic targets and treatment possibilities for cancer patients. \u003ci\u003eTumor Microenvironment\u003c\/i\u003e also reviews the fundamental basis of target development, preclinical assessment, and the current clinical status of these therapies.  \u003cb\u003ePreface.\u003c\/b\u003e  \u003cp\u003e\u003cb\u003eList of Contributors.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 The Microenvironment in Cancer\u003c\/b\u003e (\u003ci\u003eNicole N. Parker and Dietmar W. Siemann\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e1.1 Introduction.\u003c\/p\u003e \u003cp\u003e1.2 A highly selective process is required to obtain the cancer phenotype.\u003c\/p\u003e \u003cp\u003e1.3 The cancer phenotype.\u003c\/p\u003e \u003cp\u003e1.4 The extracellular matrix.\u003c\/p\u003e \u003cp\u003e1.5 Motility, invasion, and metastatic ability.\u003c\/p\u003e \u003cp\u003e1.6 Impact of the tumor microenvironment on the control of cancer.\u003c\/p\u003e \u003cp\u003e1.7 Targeting the tumor microenvironment.\u003c\/p\u003e \u003cp\u003e1.8 Summary.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Establishing the Tumor Microenvironment\u003c\/b\u003e (\u003ci\u003eAllison S. Betof and Mark W. Dewhirst\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e2.1 Introduction.\u003c\/p\u003e \u003cp\u003e2.2 From cancerous cells to a tumor.\u003c\/p\u003e \u003cp\u003e2.3 A tumor is more than cancer cells and fibroblasts.\u003c\/p\u003e \u003cp\u003e2.4 Communication between the tumor cells and stroma.\u003c\/p\u003e \u003cp\u003e2.5 Hypoxia and angiogenesis.\u003c\/p\u003e \u003cp\u003e2.6 Conclusion.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Contributions of the Extracellular Matrix to Tumorigenesis\u003c\/b\u003e (\u003ci\u003eMarie Schluterman Burdine and Rolf A. Brekken\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e3.2 Manipulation of the ECM during tumor development.\u003c\/p\u003e \u003cp\u003e3.3 Matricellular proteins and their complex effects on tumor development.\u003c\/p\u003e \u003cp\u003e3.4 Conclusion.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Matrix Metalloproteinases and Their Inhibitors – Friend or Foe\u003c\/b\u003e (\u003ci\u003eMumtaz V. Rojiani, Marzenna Wiranowska and Amyn M. Rojiani\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e4.1 Introduction.\u003c\/p\u003e \u003cp\u003e4.2 Matrix metalloproteinases.\u003c\/p\u003e \u003cp\u003e4.3 Tissue inhibitors of matrix metalloproteinases.\u003c\/p\u003e \u003cp\u003e4.4 Concluding comments.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Role of Tumor-Associated Macrophages (TAM) in Cancer Related Inflammation\u003c\/b\u003e (\u003ci\u003eAntonio Sica and Chiara Porta\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e5.1 Introduction.\u003c\/p\u003e \u003cp\u003e5.2 Functional plasticity of macrophages.\u003c\/p\u003e \u003cp\u003e5.3 Macrophages as key orchestrators of cancer-related inflammation.\u003c\/p\u003e \u003cp\u003e5.4 Recruitment and differentiation of TAM.\u003c\/p\u003e \u003cp\u003e5.5 Protumoral functions of TAM.\u003c\/p\u003e \u003cp\u003e5.6 Molecular determinants of TAM functions.\u003c\/p\u003e \u003cp\u003e5.7 Therapeutic targeting of TAM.\u003c\/p\u003e \u003cp\u003e5.8 Conclusions.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Bone Marrow Stroma and the Leukemic Microenvironment\u003c\/b\u003e (\u003ci\u003eWilliam B. Slayton and Zhongbo Hu\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e6.1 Introduction.\u003c\/p\u003e \u003cp\u003e6.2 Components and function of the normal bone marrow microenvironment.\u003c\/p\u003e \u003cp\u003e6.3 Leukemia and its microenvironment.\u003c\/p\u003e \u003cp\u003e6.4 Summary.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Microenvironment Factors Influencing Skeletal Metastases\u003c\/b\u003e (\u003ci\u003eAlessandro Fatatis, Julia A. D'Ambrosio, Whitney L. Jamieson, Danielle L. Jernigan and Mike R. Russell\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e7.1 Introduction.\u003c\/p\u003e \u003cp\u003e7.2 The bone microenvironment as a target for cancer cell dissemination.\u003c\/p\u003e \u003cp\u003e7.3 Roles of the bone microenvironment in promoting the arrest of circulating cancer cells at the skeleton.\u003c\/p\u003e \u003cp\u003e7.4 Concluding remarks.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Premetastatic Niches\u003c\/b\u003e (\u003ci\u003eKevin L. Bennewith, Janine T. Erler and Amato J. Giaccia\u003c\/i\u003e).\u003cbr\u003e \u003c\/p\u003e \u003cp\u003e8.1 Introduction.\u003c\/p\u003e \u003cp\u003e8.2 ‘Seeds’ influencing the 'Soil'.\u003c\/p\u003e \u003cp\u003e8.3 Cellular components of premetastatic niches.\u003c\/p\u003e \u003cp\u003e8.4 ECM components of premetastatic niches.\u003c\/p\u003e \u003cp\u003e8.5 Premetastatic niche formation precedes metastatic growth.\u003c\/p\u003e \u003cp\u003e8.6 Therapeutic targeting of the premetastatic niche.\u003c\/p\u003e \u003cp\u003e8.7 Evidence for premetastatic niches in the clinic.\u003c\/p\u003e \u003cp\u003e8.8 Concluding remarks.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Hypoxia, Anerobic Metabolism, and Interstitial Hypertension\u003c\/b\u003e (\u003ci\u003eMichael F. Milosevic\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e9.1 Introduction.\u003c\/p\u003e \u003cp\u003e9.2 Pathophysiology of the tumor microenvironment.\u003c\/p\u003e \u003cp\u003e9.3 Evaluating the tumor microenvironment.\u003c\/p\u003e \u003cp\u003e9.4 Biologic and therapeutic implications.\u003c\/p\u003e \u003cp\u003e9.5 Clinical implications.\u003c\/p\u003e \u003cp\u003e9.6 Summary.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Hypoxia and the DNA Damage Response\u003c\/b\u003e (\u003ci\u003eIsabel M. Pires, Rachel Poole and Ester M. Hammond\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e10.1 Introduction.\u003c\/p\u003e \u003cp\u003e10.2 The DNA damage response.\u003c\/p\u003e \u003cp\u003e10.3 Hypoxia regulation of DNA repair.\u003c\/p\u003e \u003cp\u003e10.4 Context synthetic lethality: exploiting hypoxic deregulation of DNA repair.\u003c\/p\u003e \u003cp\u003e10.5 Conclusions.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Non-Invasive Imaging of the Tumor Microenvironment\u003c\/b\u003e (\u003ci\u003eBenedicte F. Jordan and Bernard Gallez\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e11.1 Introduction.\u003c\/p\u003e \u003cp\u003e11.2 Imaging tumor vasculature, perfusion, and angiogenesis.\u003c\/p\u003e \u003cp\u003e11.3 Imaging tumor hypoxia: chronic and acute.\u003c\/p\u003e \u003cp\u003e11.4 Imaging tumor oxygen consumption.\u003c\/p\u003e \u003cp\u003e11.5 EPR oximetry.\u003c\/p\u003e \u003cp\u003e11.6 Imaging tumor interstitial fluid pressure (IFP).\u003c\/p\u003e \u003cp\u003e11.7 Imaging tumor pH.\u003c\/p\u003e \u003cp\u003e11.8 Imaging tumor redox status.\u003c\/p\u003e \u003cp\u003e11.9 Imaging tumor response.\u003c\/p\u003e \u003cp\u003e11.10 Optimizing therapeutic intervention using molecular imaging.\u003c\/p\u003e \u003cp\u003e11.11 Conclusions.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Hypoxia-Inducible Factor 1 (HIF1) Mediated Adaptive Responses in the Solid Tumor\u003c\/b\u003e (\u003ci\u003eTereza Goliasova and Nicholas C. Denko\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e12.1 Introduction.\u003c\/p\u003e \u003cp\u003e12.2 Molecular consequences of tumor hypoxia.\u003c\/p\u003e \u003cp\u003e12.3 Hypoxia inducible factor 1.\u003c\/p\u003e \u003cp\u003e12.4 HIF-1 subunits and domain structure.\u003c\/p\u003e \u003cp\u003e12.5 Regulation of HIF-1α protein stability and activity by post-translational modifications.\u003c\/p\u003e \u003cp\u003e12.6 HIF isoforms.\u003c\/p\u003e \u003cp\u003e12.7 Oxygen-independent HIF signaling.\u003c\/p\u003e \u003cp\u003e12.8 HIF target genes.\u003c\/p\u003e \u003cp\u003e12.9 Hypoxia and oxygen delivery.\u003c\/p\u003e \u003cp\u003e12.10 Hypoxia and glucose metabolism.\u003c\/p\u003e \u003cp\u003e12.11 Hypoxia and acidosis.\u003c\/p\u003e \u003cp\u003e12.12 Hypoxia and metastasis.\u003c\/p\u003e \u003cp\u003e12.13 Therapeutic implications.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Regulation of the Unfolded Protein Response in Cancer\u003c\/b\u003e (\u003ci\u003eJing Zhang and Albert C. Koong\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e13.1 Introduction.\u003c\/p\u003e \u003cp\u003e13.2 The UPR signaling cascade.\u003c\/p\u003e \u003cp\u003e13.3 Hypoxia activates UPR.\u003c\/p\u003e \u003cp\u003e13.4 UPR and expression of UPR-targeted genes in cancer.\u003c\/p\u003e \u003cp\u003e13.5 Concluding remarks.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Influence of Hypoxia on Metastatic Spread\u003c\/b\u003e (\u003ci\u003eRichard P. Hill and Naz Chaudary\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e14.1 Introduction.\u003c\/p\u003e \u003cp\u003e14.2 The metastatic process.\u003c\/p\u003e \u003cp\u003e14.3 The tumor microenvironment and metastasis.\u003c\/p\u003e \u003cp\u003e14.4 Summary.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 Drug Penetration and Therapeutic Resistance\u003c\/b\u003e (\u003ci\u003eAndrew I. Minchinton and Alastair H. Kyle\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e15.1 Introduction.\u003c\/p\u003e \u003cp\u003e15.2 Tumor microenvironment.\u003c\/p\u003e \u003cp\u003e15.3 Drug penetration.\u003c\/p\u003e \u003cp\u003e15.4 \u003ci\u003eIn vitro\u003c\/i\u003e tumor models.\u003c\/p\u003e \u003cp\u003e15.5 Conclusions.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e16 Impact on Radiotherapy\u003c\/b\u003e (\u003ci\u003eMichael R. Horsman, Jens Overgaard and Dietmar W. Siemann\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e16.1 Introduction.\u003c\/p\u003e \u003cp\u003e16.2 The tumour vasculature and microenvironment.\u003c\/p\u003e \u003cp\u003e16.3 Influence of tumor hypoxia on radiation therapy.\u003c\/p\u003e \u003cp\u003e16.4 Reducing hypoxia by increasing oxygen delivery.\u003c\/p\u003e \u003cp\u003e16.5 Radiosensitizing hypoxic cells.\u003c\/p\u003e \u003cp\u003e16.6 Killing the resistant cell population.\u003c\/p\u003e \u003cp\u003e16.7 Vascular targeting approaches.\u003c\/p\u003e \u003cp\u003e16.8 Conclusions and future perspectives.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e17 HIF-1 Inhibitors for Cancer Therapy\u003c\/b\u003e (\u003ci\u003eAnnamaria Rapisarda and Giovanni Melillo\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e17.1 Introduction.\u003c\/p\u003e \u003cp\u003e17.2 Small molecule inhibitors of HIF-1.\u003c\/p\u003e \u003cp\u003e17.3 Exploiting HIF-1 inhibitors in combination strategies.\u003c\/p\u003e \u003cp\u003e17.4 Conclusions.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e18 Vascular-Targeted Molecular Therapy\u003c\/b\u003e (\u003ci\u003eGraeme J. Dougherty and Shona T. Dougherty\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e18.1 Introduction.\u003c\/p\u003e \u003cp\u003e18.2 Approaches to targeting tumor vasculature \u003ci\u003ein vivo\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e18.3 Alternative targeting strategies.\u003c\/p\u003e \u003cp\u003e18.4 Concluding remarks.\u003c\/p\u003e \u003cp\u003eAcknowledgements.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eIndex.\u003c\/b\u003e\u003c\/p\u003e \"Overall, it would be useful to basic scientists interested in understanding the role of stroma, in particular the role of hypoxia, in cancer progression.\" (Doody's, 16 September 2011)  \u003cp\u003e \"Tumor Microenvironment is informative and current. This field of study is already evolving beyond the microenvironment into the host systemic environment and the role of endocrine factors in tumor progression. If a second edition of the book is published, it will most certainly encompass these newly emerging concepts.\" (Elsevier, 2011)\u003c\/p\u003e  \u003cstrong\u003eDietmar W. Siemann\u003c\/strong\u003e is the editor of Tumor Microenvironment, published by Wiley.","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47990417948901,"sku":"NP9780470749968","price":190.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470749968.jpg?v=1761787745","url":"https:\/\/k12savings.com\/es\/products\/tumor-microenvironment-isbn-9780470749968","provider":"K12savings","version":"1.0","type":"link"}