{"product_id":"translational-research-and-discovery-in-gastroenterology-isbn-9781118492871","title":"Translational Research and Discovery in Gastroenterology","description":"\u003cp\u003e\u003ci\u003eTranslational Gastroenterology: Organogenesis to Disease\u003c\/i\u003e bridges the gap between basic and clinical research by providing information on GI (gastrointestinal) organ development discovered through scientific inquiry, alongside clinical observations of acquired and congenital abnormalities. Paired chapters, written from basic science and clinical viewpoints, review the major biological pathways and molecules at work in organ ontogeny and disease. In addition to a comprehensive survey of GI organ development and pathologies, the book also highlights model organisms and new areas of research, with chapters devoted to recent advances in the field of GI stem cell biology, and the potential for tissue engineering of GI organs.\u003c\/p\u003e \u003cp\u003eThe topics covered provide a unique window onto current activity in the field of gastroenterology, fostering enhanced knowledge for developmental biologists as well as for clinical practitioners.\u003c\/p\u003e \u003cp\u003eNotable features include the following:\u003c\/p\u003e \u003cp\u003e• Basic science chapters review the molecular and cellular pathways of GI organ development alongside clinical chapters examining organ-based diseases, closing the gap between the bench and the clinic.\u003c\/p\u003e \u003cp\u003e• Derivative organs – esophagus, stomach, pylorus, small intestine, colon, liver, and pancreas –as well as tissues such as serosa and enteric nervous system that are common to multiple GI organs.\u003c\/p\u003e \u003cp\u003e• Chapters detailing the use of model organisms – Drosophila, sea urchin, zebrafish, C. elegans, Xenopus – for basic discovery studies are included.\u003c\/p\u003e \u003cp\u003e• Chapters on GI stem cells and the potential for tissue engineering of the GI organs provide a view to the future of research and therapy in these organs.\u003c\/p\u003e \u003cp\u003eList of Contributors ix\u003c\/p\u003e \u003cp\u003eForeword xiii\u003c\/p\u003e \u003cp\u003ePreface xv\u003c\/p\u003e \u003cp\u003e1 Endoderm Development: From Progenitors to Organ Buds 1\u003cbr\u003e\u003ci\u003eDavid A.F. Loebel, Keren Kaufman-Francis, Yoji Kojima, Henry C.Y. Chung, and Patrick P.L. Tam\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 Genetic and Cellular Mechanisms Regulating Esophageal Development 15\u003cbr\u003e\u003ci\u003eWei-Yao Ku and Jianwen Que\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 Congenital and Acquired Diseases of the Esophagus 27\u003cbr\u003e\u003ci\u003eIljana Gaffar, Yousef El-Gohary, and George Gittes\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 Basic Science of Stomach Development 43\u003cbr\u003e\u003ci\u003eTae-Hee Kim and Ramesh A. Shivdasani\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 Congenital and Acquired Diseases of the Stomach 57\u003cbr\u003e\u003ci\u003eRamon U. Jin and Jason C. Mills\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 The Pylorus: Development and Disease 73\u003cbr\u003e\u003ci\u003eAjay Prakash, Aaron M. Udager, and Deborah L. Gumucio\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 Basic Science of Small Intestinal Development 85\u003cbr\u003e\u003ci\u003eCayla A. Thompson and Michele A. Battle\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 Clinical Small Intestine 99\u003cbr\u003e\u003ci\u003eMichael A. Helmrath and Kavita Deonarine\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 Basic Science of Colon Development 113\u003cbr\u003e\u003ci\u003eMattheus C.B. Wielenga and Gijs R. van den Brink\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 Congenital and Acquired Diseases of the Colon 125\u003cbr\u003e\u003ci\u003eJennifer J. Freeman and Daniel H. Teitelbaum\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 Intestinal Serosa 139\u003cbr\u003e\u003ci\u003eNichelle I. Winters and David M. Bader\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 Basic Science of Liver Development 151\u003cbr\u003e\u003ci\u003eAnn DeLaForest and Stephen A. Duncan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13 Congenital and Acquired Diseases of the Liver 165\u003cbr\u003e\u003ci\u003eZahida Khan, Edgar N. Tafaleng, Kyle A. Soltys, and Ira J. Fox\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14 Developmental Biology of the Pancreas 179\u003cbr\u003e\u003ci\u003eL. Charles Murtaugh\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15 Congenital Disorders of the Pancreas 193\u003cbr\u003e\u003ci\u003eMark Lowe\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16 Enteric Nervous System Development 209\u003cbr\u003e\u003ci\u003eE. Michelle Southard-Smith and Melissa A. Musser\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17 Congenital and Acquired Disorders of the Enteric Nervous System 225\u003cbr\u003e\u003ci\u003eRobert O. Heuckeroth\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18 Gut Development in the Sea Urchin 241\u003cbr\u003e\u003ci\u003eMegan L. Martik and David R. McClay\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e19 Intestinal Stem Cell Specification in the Drosophila Midgut 253\u003cbr\u003e\u003ci\u003eNeus Rafel and Benjamin Ohlstein\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e20 The Caenorhabditis elegans Intestine 263\u003cbr\u003e\u003ci\u003eJames D. McGhee, Tobias Wiesenfahrt, and Aidan E. Dineen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e21 Xenopus as a Model for GI Development 275\u003cbr\u003e\u003ci\u003eZheng Zhang and Aaron M. Zorn\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e22 Zebrafish Models of GI Development and Disease 289\u003cbr\u003e\u003ci\u003eAshley Alvers and Michel Bagnat\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e23 Gastrointestinal Stem Cells 303\u003cbr\u003e\u003ci\u003eElise S. Demitrack and Linda C. Samuelson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e24 Translating Embryonic Development into Models of Human Gastrointestinal Development and Disease 317\u003cbr\u003e\u003ci\u003eStacy R. Finkbeiner and Jason R. Spence\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 327\u003c\/p\u003e  \u003cp\u003e\u003cb\u003eDeborah L. Gumucio, PhD\u003c\/b\u003e, is the James Douglas Engel Professor and Interim Chair of the Department of Cell and Developmental Biology at the University of Michigan Medical School and Project Director of the University of Michigan’s BioArtography Program.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eLinda C. Samuelson, PhD\u003c\/b\u003e, is the John A. Williams Collegiate Professor of Gastrointestinal Physiology and Professor in the Departments of Molecular and Integrative Physiology and Internal Medicine at the University of Michigan Medical School and serves as Associate Director for the Center for Organogenesis at the University of Michigan.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eJason R. Spence, PhD\u003c\/b\u003e, is Assistant Professor of Internal Medicine and Assistant Professor of Cell and Developmental Biology at the University of Michigan Medical School.\u003c\/p\u003e  \u003cp\u003e\u003ci\u003eTranslational Gastroenterology: Organogenesis to Disease\u003c\/i\u003e bridges the gap between basic and clinical research by providing information on GI (gastrointestinal) organ development discovered through scientific inquiry, alongside clinical observations of acquired and congenital abnormalities. Paired chapters, written from basic science and clinical viewpoints, review the major biological pathways and molecules at work in organ ontogeny and disease. In addition to a comprehensive survey of GI organ development and pathologies, the book also highlights model organisms and new areas of research, with chapters devoted to recent advances in the field of GI stem cell biology, and the potential for tissue engineering of GI organs.\u003c\/p\u003e \u003cp\u003eThe topics covered provide a unique window onto current activity in the field of gastroenterology, fostering enhanced knowledge for developmental biologists as well as for clinical practitioners.\u003c\/p\u003e \u003cp\u003eNotable features include the following:\u003c\/p\u003e \u003cp\u003e• Basic science chapters review the molecular and cellular pathways of GI organ development alongside clinical chapters examining organ-based diseases, closing the gap between the bench and the clinic.\u003c\/p\u003e \u003cp\u003e• Derivative organs – esophagus, stomach, pylorus, small intestine, colon, liver, and pancreas –as well as tissues such as serosa and enteric nervous system that are common to multiple GI organs.\u003c\/p\u003e \u003cp\u003e• Chapters detailing the use of model organisms – Drosophila, sea urchin, zebrafish, C. elegans, Xenopus – for basic discovery studies are included.\u003c\/p\u003e \u003cp\u003e• Chapters on GI stem cells and the potential for tissue engineering of the GI organs provide a view to the future of research and therapy in these organs.\u003c\/p\u003e","brand":"Wiley-Blackwell","offers":[{"title":"Default Title","offer_id":47990408642789,"sku":"NP9781118492871","price":173.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781118492871.jpg?v=1761787710","url":"https:\/\/k12savings.com\/es\/products\/translational-research-and-discovery-in-gastroenterology-isbn-9781118492871","provider":"K12savings","version":"1.0","type":"link"}