{"product_id":"transition-metal-catalyzed-c-h-functionalization-of-heterocycles-2-volumes-isbn-9781119774136","title":"Transition-Metal-Catalyzed C-H Functionalization of Heterocycles, 2 Volumes","description":"\u003cb\u003eTransition-Metal-Catalyzed C-H Functionalization of Heterocycles\u003c\/b\u003e \u003cp\u003e\u003cb\u003eA comprehensive guide to recent advances in this field \u003c\/b\u003e \u003c\/p\u003e\u003cp\u003eConstituting the majority of all known compounds, heterocycles are structures that incorporate one or more heteroatoms within their core, thus exhibiting properties that are quite different from their all-carbon analogs. They are fundamental to all fields of chemistry and, therefore, their synthesis and modification has attracted a great deal of attention in the recent years. In this vein, transition-metal-catalyzed C-H bond functionalization forms a crucial tool for generating and analyzing heterocyclic compounds. \u003c\/p\u003e\u003cp\u003e\u003ci\u003eTransition-Metal-Catalyzed C-H Functionalization of Heterocycles, Two-Volume Set\u003c\/i\u003e, showcases diverse C-H functionalization methodologies and their incorporation into the latest research. The chapters serve as an essential tool depicting detailed site-selective functionalization of heterocyclic cores, along with a comprehensive discussion on their mechanistic approaches.  \u003c\/p\u003e\u003cp\u003eReaders of \u003ci\u003eTransition-Metal-Catalyzed C-H Functionalization of Heterocycles, Two-Volume-Set\u003c\/i\u003e will also find: \u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e A detailed introduction to C-H activation along with the mechanistic aspects of transition-metal-catalyzed C-H bond activation reactions\u003c\/li\u003e \u003cli\u003e Easy-to-use structures with each chapter dedicated to a type of heterocycle and its specific functionalization methodologies\u003c\/li\u003e \u003cli\u003eA leading team of international authors in C-H bond functionalization\u003c\/li\u003e\n\u003c\/ul\u003e \u003cp\u003e\u003ci\u003eTransition-Metal-Catalyzed C-H Functionalization of Heterocycles, Two-Volume-Set\u003c\/i\u003e is a valuable guide for students and researchers in organic synthesis and process development, in both academic and industrial contexts. \u003c\/p\u003e\u003cp\u003eContents\u003c\/p\u003e \u003cp\u003eList of Contributors xiii\u003c\/p\u003e \u003cp\u003e8 Functionalization of Pyridines, Quinolines, and Isoquinolines 357\u003c\/p\u003e \u003cp\u003eJun Zhou and Bing-Feng Shi\u003c\/p\u003e \u003cp\u003e8.1 Introduction 357\u003c\/p\u003e \u003cp\u003e8.2 C2-Selective Functionalization 358\u003c\/p\u003e \u003cp\u003e8.2.1 Alkylation 358\u003c\/p\u003e \u003cp\u003e8.2.2 Arylation 361\u003c\/p\u003e \u003cp\u003e8.2.2.1 Pyridine Derivatives as Substrates 361\u003c\/p\u003e \u003cp\u003e8.2.2.2 Pyridine N-oxides as Substrates 363\u003c\/p\u003e \u003cp\u003e8.2.2.3 N-iminopyridinium Ylides as Substrates 365\u003c\/p\u003e \u003cp\u003e8.2.3 Alkenylation 365\u003c\/p\u003e \u003cp\u003e8.2.4 Acylation, Amination, and Aminomethylation 367\u003c\/p\u003e \u003cp\u003e8.3 C3-Selective Functionalization 370\u003c\/p\u003e \u003cp\u003e8.3.1 Alkylation 370\u003c\/p\u003e \u003cp\u003e8.3.2 Arylation 371\u003c\/p\u003e \u003cp\u003e8.3.3 Alkenylation 374\u003c\/p\u003e \u003cp\u003e8.3.4 Borylation 377\u003c\/p\u003e \u003cp\u003e8.4 C4-Selective Functionalization 378\u003c\/p\u003e \u003cp\u003e8.4.1 Alkylation 378\u003c\/p\u003e \u003cp\u003e8.4.2 Arylation 380\u003c\/p\u003e \u003cp\u003e8.4.3 Alkenylation 381\u003c\/p\u003e \u003cp\u003e8.4.4 Borylation 382\u003c\/p\u003e \u003cp\u003e8.5 C8-Selective Functionalization 382\u003c\/p\u003e \u003cp\u003e8.6 Summary and Conclusions 387\u003c\/p\u003e \u003cp\u003e9 Transition Metal-Catalyzed C-H Bond Functionalization of Diazines and Their Benzo Derivatives 393\u003c\/p\u003e \u003cp\u003eChristian Bruneau and Rafael Gramage-Doria\u003c\/p\u003e \u003cp\u003e9.1 Introduction 393\u003c\/p\u003e \u003cp\u003e9.2 Carbon-carbon Bond Formation 394\u003c\/p\u003e \u003cp\u003e9.2.1 C-H Bond (Hetero)arylations 394\u003c\/p\u003e \u003cp\u003e9.2.2 C–H Bond Olefinations 406\u003c\/p\u003e \u003cp\u003e9.2.3 C–H Bond Alkylations 415\u003c\/p\u003e \u003cp\u003e9.2.4 C–H Bond Alkynylations 418\u003c\/p\u003e \u003cp\u003e9.2.5 C–H Bond Carboxylations 419\u003c\/p\u003e \u003cp\u003e9.3 Carbon-nitrogen Bond Formation 420\u003c\/p\u003e \u003cp\u003e9.4 Carbon-oxygen Bond Formation 424\u003c\/p\u003e \u003cp\u003e9.5 Carbon-sulfur Bond Formation 424\u003c\/p\u003e \u003cp\u003e9.6 Carbon-boron Bond Formation 425\u003c\/p\u003e \u003cp\u003e9.7 Carbon-silicon Bond Formation 425\u003c\/p\u003e \u003cp\u003e9.8 Carbon-halogen Bond Formation 427\u003c\/p\u003e \u003cp\u003e9.9 Conclusions 428\u003c\/p\u003e \u003cp\u003eAcknowledgments 429\u003c\/p\u003e \u003cp\u003e10 Functionalization of Chromenes and Their Derivatives 435\u003c\/p\u003e \u003cp\u003eLaura Cunningham, Sundaravel Vivek Kumar, and Patrick J. Guiry\u003c\/p\u003e \u003cp\u003e10.1 Introduction 435\u003c\/p\u003e \u003cp\u003e10.2 2 \u003ci\u003eH\u003c\/i\u003e-Chromenes 435\u003c\/p\u003e \u003cp\u003e10.3 2 \u003ci\u003eH\u003c\/i\u003e-Chromene-ones (Coumarins) 437\u003c\/p\u003e \u003cp\u003e10.3.1 C3-Selective Functionalization 437\u003c\/p\u003e \u003cp\u003e10.3.1.1 Alkenylation 437\u003c\/p\u003e \u003cp\u003e10.3.1.2 Arylation 438\u003c\/p\u003e \u003cp\u003e10.3.1.3 Other 441\u003c\/p\u003e \u003cp\u003e10.3.1.4 Annulation\/Cyclization 442\u003c\/p\u003e \u003cp\u003e10.3.2 C4–H Selective Functionalization 449\u003c\/p\u003e \u003cp\u003e10.3.3 C5-Selective Functionalization 456\u003c\/p\u003e \u003cp\u003e10.4 4 \u003ci\u003eH\u003c\/i\u003e-Chromene 459\u003c\/p\u003e \u003cp\u003e10.5 4 \u003ci\u003eH\u003c\/i\u003e-Chromenones (Chromones) 462\u003c\/p\u003e \u003cp\u003e10.5.1 C2-Selective C–H Activation 462\u003c\/p\u003e \u003cp\u003e10.5.2 C3-Selective C–H Activation 463\u003c\/p\u003e \u003cp\u003e10.5.3 C5-Selective C–H Activation 468\u003c\/p\u003e \u003cp\u003e10.5.3.1 Alkenylation 468\u003c\/p\u003e \u003cp\u003e10.5.3.2 Alkylation 471\u003c\/p\u003e \u003cp\u003e10.5.3.3 (Hetero)arylation 473\u003c\/p\u003e \u003cp\u003e10.5.3.4 Amination\/Amidation 474\u003c\/p\u003e \u003cp\u003e10.5.3.5 Others 477\u003c\/p\u003e \u003cp\u003e10.5.4 C6-Selective C–H Activation 478\u003c\/p\u003e \u003cp\u003e10.5.5 Conclusions 478\u003c\/p\u003e \u003cp\u003e11 Transition Metal-Catalyzed C–H Functionalization of Imidazo-fused Heterocycles 485\u003c\/p\u003e \u003cp\u003eRajeev Sakhuja and Anil Kumar\u003c\/p\u003e \u003cp\u003e11.1 Introduction 485\u003c\/p\u003e \u003cp\u003e11.2 C–C Bond Formation 486\u003c\/p\u003e \u003cp\u003e11.2.1 Alkylation 486\u003c\/p\u003e \u003cp\u003e11.2.1.1 Fluoro Alkylation 486\u003c\/p\u003e \u003cp\u003e11.2.1.2 Alkoxycarbonyl Alkylation 488\u003c\/p\u003e \u003cp\u003e11.2.1.3 Aryl\/heteroaryl Alkylation 489\u003c\/p\u003e \u003cp\u003e11.2.1.4 Amino Alkylation 493\u003c\/p\u003e \u003cp\u003e11.2.1.5 Sulfonyl\/Carbonyl\/Cyano Alkylation 496\u003c\/p\u003e \u003cp\u003e11.2.2 Alkenylation\/Alkynylation\/Allenylation 498\u003c\/p\u003e \u003cp\u003e11.2.3 Cyanation\/Carbonylation 503\u003c\/p\u003e \u003cp\u003e11.2.4 Arylation\/Heteroarylation 509\u003c\/p\u003e \u003cp\u003e11.3 C–S\/Se Bond Formation 525\u003c\/p\u003e \u003cp\u003e11.4 C–N Bond Formation 532\u003c\/p\u003e \u003cp\u003e11.5 C–P Bond Formation 533\u003c\/p\u003e \u003cp\u003e11.6 C–Si Bond Formation 535\u003c\/p\u003e \u003cp\u003e11.7 Conclusions 535\u003c\/p\u003e \u003cp\u003eAcknowledgments 536\u003c\/p\u003e \u003cp\u003e12 Dehydrogenative Annulation of Heterocycles: Synthesis of Fused Heterocycles 543\u003c\/p\u003e \u003cp\u003eNeha Jha and Manmohan Kapur\u003c\/p\u003e \u003cp\u003e12.1 Dehydrogenative Coupling: An Overview 543\u003c\/p\u003e \u003cp\u003e12.2 Importance of Heterocycles and Their Fused Congeners 545\u003c\/p\u003e \u003cp\u003e12.3 Metal-Catalyzed Dehydrogenative-coupling Reactions: Formation of C–Z Bonds 546\u003c\/p\u003e \u003cp\u003e12.3.1 C–C Bond Formation 546\u003c\/p\u003e \u003cp\u003e12.3.1.1 Synthesis of Large-sized Molecules: COTs 549\u003c\/p\u003e \u003cp\u003e12.3.2 Formation of C–N Bonds 550\u003c\/p\u003e \u003cp\u003e12.3.3 Formation of C–B Bonds 557\u003c\/p\u003e \u003cp\u003e12.4 Conclusions 562\u003c\/p\u003e \u003cp\u003e13 C–H Functionalization of Saturated Heterocycles Beyond the C2 Position 567\u003c\/p\u003e \u003cp\u003eAmalia-Sofia Piticari, Natalia Larionova, and James A. Bull\u003c\/p\u003e \u003cp\u003e13.1 Introduction 567\u003c\/p\u003e \u003cp\u003e13.2 Heterocycle Functionalization with a C2 Directing Group 567\u003c\/p\u003e \u003cp\u003e13.2.1 Carboxylic Acid-Linked C2 Directing Groups 567\u003c\/p\u003e \u003cp\u003e13.2.2 Applications of N-Heterocycle Functionalization with C2 Directing Groups 580\u003c\/p\u003e \u003cp\u003e13.3 Heterocycle Functionalization with C3 Directing Groups 586\u003c\/p\u003e \u003cp\u003e13.3.1 Carboxylic Acid-Linked C3 Directing Groups 586\u003c\/p\u003e \u003cp\u003e13.3.2 Amine-Linked C3 Directing Groups 590\u003c\/p\u003e \u003cp\u003e13.3.3 Alcohol-Linked C3 Directing Groups 592\u003c\/p\u003e \u003cp\u003e13.4 Heterocycle Functionalization with a C4 Directing Group 594\u003c\/p\u003e \u003cp\u003e13.5 Transannular Heterocycle Functionalization with N-linked Directing Groups 598\u003c\/p\u003e \u003cp\u003e13.6 Conclusions 603\u003c\/p\u003e \u003cp\u003e14 Asymmetric Functionalization of C–H Bonds in Heterocycles 609\u003c\/p\u003e \u003cp\u003eOlena Kuleshova and Laurean Ilies\u003c\/p\u003e \u003cp\u003e14.1 Introduction 609\u003c\/p\u003e \u003cp\u003e14.2 Enantioselective C–H Activation 609\u003c\/p\u003e \u003cp\u003e14.2.1 Activation of C(\u003ci\u003esp\u003c\/i\u003e\u003csup\u003e2\u003c\/sup\u003e)–H Bonds 609\u003c\/p\u003e \u003cp\u003e14.2.2 Activation of C(\u003ci\u003esp\u003c\/i\u003e\u003csup\u003e3\u003c\/sup\u003e)–H Bonds 611\u003c\/p\u003e \u003cp\u003e14.3 C–H Activation Followed by Enantioselective Functionalization 615\u003c\/p\u003e \u003cp\u003e14.3.1 Intramolecular Coupling 615\u003c\/p\u003e \u003cp\u003e14.3.1.1 Indoles and Pyrroles as Coupling Partners 615\u003c\/p\u003e \u003cp\u003e14.3.1.2 Imidazoles and Benzoimidazoles as Coupling Partners 618\u003c\/p\u003e \u003cp\u003e14.3.1.3 Pyridines and Pyridones as Coupling Partners 618\u003c\/p\u003e \u003cp\u003e14.3.2 Intermolecular Coupling 619\u003c\/p\u003e \u003cp\u003e14.3.2.1 Directing-Group-Free C–H Functionalization 619\u003c\/p\u003e \u003cp\u003e14.3.2.2 Functionalization Assisted by a Directing Group at the C3 Site 621\u003c\/p\u003e \u003cp\u003e14.3.2.3 Functionalization Assisted by a Directing Group at the N-1 Site 623\u003c\/p\u003e \u003cp\u003e14.3.3 Atropo-enantioselective Synthesis of Heterobiaryls 624\u003c\/p\u003e \u003cp\u003e14.4 Conclusions and Perspectives 627\u003c\/p\u003e \u003cp\u003e15 Transition Metal-Catalyzed C–H Functionalization of Nucleoside Bases 631\u003c\/p\u003e \u003cp\u003eYong Liang and Stanislaw F. Wnuk\u003c\/p\u003e \u003cp\u003e15.1 Introduction 631\u003c\/p\u003e \u003cp\u003e15.2 Direct Functionalization of the C5-H Bond in Uracil Nucleosides 632\u003c\/p\u003e \u003cp\u003e15.2.1 Cross-Dehydrogenative Alkenylation at the C5 Position 632\u003c\/p\u003e \u003cp\u003e15.2.2 Direct C–H Arylation at the C5 Position 634\u003c\/p\u003e \u003cp\u003e15.2.3 Direct C–H Alkylation at the C5 Position 635\u003c\/p\u003e \u003cp\u003e15.2.4 Miscellaneous Direct C–H Functionalizations 636\u003c\/p\u003e \u003cp\u003e15.3 Direct Functionalization of C6-H Bond in Uracil 637\u003c\/p\u003e \u003cp\u003e15.3.1 Stepwise C6-H Functionalization of Pyrimidine Nucleoside via Lithiation and Alkylation 637\u003c\/p\u003e \u003cp\u003e15.3.2 Direct C6-H Functionalization of the Uracil Base 637\u003c\/p\u003e \u003cp\u003e15.3.2.1 Functionalization with Aryl Halides 637\u003c\/p\u003e \u003cp\u003e15.3.2.2 Cross-Dehydrogenative Functionalization with Arenes 638\u003c\/p\u003e \u003cp\u003e15.3.2.3 Functionalization with Aryl Boronic Acid 639\u003c\/p\u003e \u003cp\u003e15.3.2.4 Intramolecular C6-H Functionalization of Uracil Derivatives 639\u003c\/p\u003e \u003cp\u003e15.4 Inverted C–H Functionalization of Uracil Nucleosides 640\u003c\/p\u003e \u003cp\u003e15.4.1 Inverted C5-H Functionalization of Uracil Nucleosides 640\u003c\/p\u003e \u003cp\u003e15.4.2 Inverted C6-H Functionalization of Uracil 641\u003c\/p\u003e \u003cp\u003e15.5 Direct C2-H Functionalization of Adenosine 641\u003c\/p\u003e \u003cp\u003e15.6 Direct C6-H Functionalization of Purine Nucleoside 642\u003c\/p\u003e \u003cp\u003e15.6.1 Direct C6-H Alkylation 642\u003c\/p\u003e \u003cp\u003e15.6.1.1 With Cycloalkanes 642\u003c\/p\u003e \u003cp\u003e15.6.1.2 With Boronic Acid 643\u003c\/p\u003e \u003cp\u003e15.6.1.3 With Alkyltrifluoroborate 643\u003c\/p\u003e \u003cp\u003e15.6.1.4 With Alkyl Carboxylic Acid 643\u003c\/p\u003e \u003cp\u003e15.6.1.5 With \u003ci\u003etert\u003c\/i\u003e-Alkyl Oxalate Salts 644\u003c\/p\u003e \u003cp\u003e15.6.2 Direct C6-H Arylation 644\u003c\/p\u003e \u003cp\u003e15.6.3 Other Direct C6-H Functionalization 645\u003c\/p\u003e \u003cp\u003e15.7 Direct Activation of C8-H Bond in Purine and Purine Nucleosides 645\u003c\/p\u003e \u003cp\u003e15.7.1 Cross-Coupling of Adenine Nucleosides with Aryl Halides 645\u003c\/p\u003e \u003cp\u003e15.7.2 Cross-Coupling of Inosine and Guanine Nucleosides with Aryl Halides 647\u003c\/p\u003e \u003cp\u003e15.7.3 Cross-Coupling of Adenine Nucleosides with Alkanes 648\u003c\/p\u003e \u003cp\u003e15.7.4 Miscellaneous Functionalization of Adenosine-related Substrates 649\u003c\/p\u003e \u003cp\u003e15.8 Conclusions 650\u003c\/p\u003e \u003cp\u003e16 C–H Activation for the Synthesis of C1-(hetero)aryl Glycosides 657\u003c\/p\u003e \u003cp\u003eMorgane de Robichon, Juba Ghouilem, Angélique Ferry, and Samir Messaoudi\u003c\/p\u003e \u003cp\u003e16.1 General Introduction 657\u003c\/p\u003e \u003cp\u003e16.2 Classical Methods to Prepare C-aryl Glycosides 657\u003c\/p\u003e \u003cp\u003e16.3 Directed C-H Activation Approach 658\u003c\/p\u003e \u003cp\u003e16.3.a Directed C\u003ci\u003esp\u003c\/i\u003e\u003csup\u003e2\u003c\/sup\u003e-C\u003ci\u003esp\u003c\/i\u003e\u003csup\u003e2\u003c\/sup\u003e Bond Formation 659\u003c\/p\u003e \u003cp\u003e16.3.a.1 Directing Group Attached to the Aryl Partner 659\u003c\/p\u003e \u003cp\u003e16.3.a.2 Directing Group Attached to the Sugar Nucleus 661\u003c\/p\u003e \u003cp\u003e16.3.b Directed C\u003ci\u003esp\u003c\/i\u003e\u003csup\u003e2\u003c\/sup\u003e-C\u003ci\u003esp\u003c\/i\u003e\u003csup\u003e3\u003c\/sup\u003e Bond Formation 662\u003c\/p\u003e \u003cp\u003e16.3.b.1 The Directing Group (DG) Attached to the Coupling Partner 662\u003c\/p\u003e \u003cp\u003e16.3.b.2 The Directing Group Attached to the Sugar Nucleus 675\u003c\/p\u003e \u003cp\u003e16.4 Conclusions and Perspectives 679\u003c\/p\u003e \u003cp\u003e17 Late-stage C–H Functionalization: Synthesis of Natural Products and Pharmaceuticals 683\u003c\/p\u003e \u003cp\u003eHarshita Shet and Anant R. Kapdi\u003c\/p\u003e \u003cp\u003e17.1 Introduction 683\u003c\/p\u003e \u003cp\u003e17.2 Synthesis of (±)-Ibogamine 684\u003c\/p\u003e \u003cp\u003e17.3 Synthesis of YD-3 and YC-1 (C–H Arylation of Indazoles) 685\u003c\/p\u003e \u003cp\u003e17.4 Synthesis of Complanadine A 685\u003c\/p\u003e \u003cp\u003e17.5 Synthesis of Diptoindonesin G (C–H Arylation of Benzofuran) 686\u003c\/p\u003e \u003cp\u003e17.6 Synthesis of Dragmacidin D (C–H Arylation of Indoles at the C3 Position) 687\u003c\/p\u003e \u003cp\u003e17.7 Synthesis of Celecoxib (C–H Arylation of Pyrazoles) 688\u003c\/p\u003e \u003cp\u003e17.8 Synthesis of Aspidospermidine 689\u003c\/p\u003e \u003cp\u003e17.9 Synthesis of Pipercyclobutanamide A 690\u003c\/p\u003e \u003cp\u003e17.10 Synthesis of Nigellidine Hydrobromide 691\u003c\/p\u003e \u003cp\u003e17.11 Synthesis of (+)-Linoxepin 691\u003c\/p\u003e \u003cp\u003e17.12 Synthesis of (±)-Rhazinal 692\u003c\/p\u003e \u003cp\u003e17.13 Synthesis of Podophyllotoxin (C–H Arylation) 693\u003c\/p\u003e \u003cp\u003e17.14 Synthesis of (±)-Rhazinilam 694\u003c\/p\u003e \u003cp\u003e17.15 Synthesis of Aeruginosins (sp\u003ci\u003e3\u003c\/i\u003e C–H Alkenylation and Arylation) 694\u003c\/p\u003e \u003cp\u003e17.16 Synthesis of Gamendazole 696\u003c\/p\u003e \u003cp\u003e17.17 Synthesis of Beclabuvir (BMS-791325) 697\u003c\/p\u003e \u003cp\u003e17.18 Conclusions 698\u003c\/p\u003e \u003cp\u003e18 Late-stage Functionalization of Pharmaceuticals, Agrochemicals, and Natural Products 703\u003c\/p\u003e \u003cp\u003eFrançois Richard, Elias Selmi-Higashi, and Stellios Arseniyadis\u003c\/p\u003e \u003cp\u003e18.1 C–H Methylation and Alkylation 704\u003c\/p\u003e \u003cp\u003e18.2 C–H Arylation and Olefination 705\u003c\/p\u003e \u003cp\u003e18.3 Formation of Other C−C Bonds 711\u003c\/p\u003e \u003cp\u003e18.4 C–H Hydroxylation 714\u003c\/p\u003e \u003cp\u003e18.5 C–H Amination 715\u003c\/p\u003e \u003cp\u003e18.6 C–H Trifluoromethylation 716\u003c\/p\u003e \u003cp\u003e18.7 C–H Difluoromethylation 716\u003c\/p\u003e \u003cp\u003e18.8 C–H Fluorination 718\u003c\/p\u003e \u003cp\u003e18.9 C–H Silylation 718\u003c\/p\u003e \u003cp\u003e18.10 C–H Phosphorylation 719\u003c\/p\u003e \u003cp\u003e18.11 C–H Deuteration and Tritiation 720\u003c\/p\u003e \u003cp\u003e18.12 Conclusions 723\u003c\/p\u003e \u003cp\u003eIndex 727\u003c\/p\u003e \u003cp\u003eBrief Contents\u003c\/p\u003e \u003cp\u003e\u003cb\u003eVolume 1:\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eList of Contributors xiii\u003c\/p\u003e \u003cp\u003ePreface xvii\u003c\/p\u003e \u003cp\u003e1 Historical Perspective and Mechanistic Aspects of C–H Bond Functionalization 1\u003c\/p\u003e \u003cp\u003eTariq M. Bhatti, Eileen Yasmin, Akshai Kumar, and Alan S. Goldman\u003c\/p\u003e \u003cp\u003e2 Recent Advances in C–H Functionalization of Five–Membered Heterocycles with Single Heteroatoms 61\u003c\/p\u003e \u003cp\u003eB. Prabagar and Zhuangzhi Shi\u003c\/p\u003e \u003cp\u003e3 Functionalization of Five-membered Heterocycles with Two Heteroatoms 109\u003c\/p\u003e \u003cp\u003eJung Min Joo\u003c\/p\u003e \u003cp\u003e4 Transition Metal-Catalyzed C–H Functionalization of Indole Benzenoid Ring 155\u003c\/p\u003e \u003cp\u003eVikash Kumar, Rajaram Maayuri, Lusina Mantry, and Parthasarathy Gandeepan\u003c\/p\u003e \u003cp\u003e5 Transition Metal-Catalyzed C2 and C3 Functionalization of Indoles 193\u003c\/p\u003e \u003cp\u003ePinki Sihag, Meledath Sudhakaran Keerthana, and Masilamani Jeganmohan\u003c\/p\u003e \u003cp\u003e6 C(sp2)–H Functionalization of Indolines at the C7-Position 251\u003c\/p\u003e \u003cp\u003eNeeraj Kumar Mishra and In Su Kim\u003c\/p\u003e \u003cp\u003e7 Transition Metal-Catalyzed C–H Functionalization of Benzofused Azoles with Two or More Heteroatoms 319\u003c\/p\u003e \u003cp\u003eTanumay Sarkar, Subhradeep Kar, Prabhat Kumar Maharana, Tariq. A. Shah, and Tharmalingam Punniyamurthy\u003c\/p\u003e \u003cp\u003eVolume 2:\u003c\/p\u003e \u003cp\u003eList of Contributors xiii\u003c\/p\u003e \u003cp\u003e8 Functionalization of Pyridines, Quinolines, and Isoquinolines 357\u003c\/p\u003e \u003cp\u003eJun Zhou and Bing-Feng Shi\u003c\/p\u003e \u003cp\u003e9 Transition Metal-Catalyzed C-H Bond Functionalization of Diazines and Their Benzo Derivatives 393\u003c\/p\u003e \u003cp\u003eChristian Bruneau and Rafael Gramage-Doria\u003c\/p\u003e \u003cp\u003e10 Functionalization of Chromenes and Their Derivatives 435\u003c\/p\u003e \u003cp\u003eLaura Cunningham, Sundaravel Vivek Kumar, and Patrick J. Guiry\u003c\/p\u003e \u003cp\u003e11 Transition Metal-Catalyzed C–H Functionalization of Imidazo-fused Heterocycles 485\u003c\/p\u003e \u003cp\u003eRajeev Sakhuja and Anil Kumar\u003c\/p\u003e \u003cp\u003e12 Dehydrogenative Annulation of Heterocycles: Synthesis of Fused Heterocycles 543\u003c\/p\u003e \u003cp\u003eNeha Jha and Manmohan Kapur\u003c\/p\u003e \u003cp\u003e13 C–H Functionalization of Saturated Heterocycles Beyond the C2 Position 567\u003c\/p\u003e \u003cp\u003eAmalia-Sofia Piticari, Natalia Larionova, and James A. Bull\u003c\/p\u003e \u003cp\u003e14 Asymmetric Functionalization of C–H Bonds in Heterocycles 609\u003c\/p\u003e \u003cp\u003eOlena Kuleshova and Laurean Ilies\u003c\/p\u003e \u003cp\u003e15 Transition Metal-Catalyzed C–H Functionalization of Nucleoside Bases 631\u003c\/p\u003e \u003cp\u003eYong Liang and Stanislaw F. Wnuk\u003c\/p\u003e \u003cp\u003e16 C–H Activation for the Synthesis of C1-(hetero)aryl Glycosides 657\u003c\/p\u003e \u003cp\u003eMorgane de Robichon, Juba Ghouilem, Angélique Ferry, and Samir Messaoudi\u003c\/p\u003e \u003cp\u003e17 Late-stage C–H Functionalization: Synthesis of Natural Products and Pharmaceuticals 683\u003c\/p\u003e \u003cp\u003eHarshita Shet and Anant R. Kapdi\u003c\/p\u003e \u003cp\u003e18 Late-stage Functionalization of Pharmaceuticals, Agrochemicals, and Natural Products 703\u003c\/p\u003e \u003cp\u003eFrançois Richard, Elias Selmi-Higashi, and Stellios Arseniyadis\u003c\/p\u003e \u003cp\u003eIndex 727\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e  \u003cp\u003e\u003cb\u003eTharmalingam Punniyamurthy, PhD\u003c\/b\u003e is Professor of Chemistry and Dean of Faculty Affairs at the Indian Institute of Technology Guwahati, India. \u003c\/p\u003e\u003cp\u003e\u003cb\u003eAnil Kumar, PhD\u003c\/b\u003e is Professor in the Department of Chemistry at the Birla Institute of Technology and Science, Pilani, India.   \u003c\/p\u003e\u003cp\u003e\u003cb\u003eA comprehensive guide to recent advances in this field \u003c\/b\u003e \u003c\/p\u003e\u003cp\u003eConstituting the majority of all known compounds, heterocycles are structures that incorporate one or more heteroatoms within their core, thus exhibiting properties that are quite different from their all-carbon analogs. They are fundamental to all fields of chemistry and, therefore, their synthesis and modification has attracted a great deal of attention in the recent years. In this vein, transition-metal-catalyzed C-H bond functionalization forms a crucial tool for generating and analyzing heterocyclic compounds. \u003c\/p\u003e\u003cp\u003e\u003ci\u003eTransition-Metal-Catalyzed C-H Functionalization of Heterocycles, Two-Volume Set\u003c\/i\u003e, showcases diverse C-H functionalization methodologies and their incorporation into the latest research. The chapters serve as an essential tool depicting detailed site-selective functionalization of heterocyclic cores, along with a comprehensive discussion on their mechanistic approaches.  \u003c\/p\u003e\u003cp\u003eReaders of \u003ci\u003eTransition-Metal-Catalyzed C-H Functionalization of Heterocycles, Two-Volume-Set\u003c\/i\u003e will also find: \u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e A detailed introduction to C-H activation along with the mechanistic aspects of transition-metal-catalyzed C-H bond activation reactions\u003c\/li\u003e \u003cli\u003e Easy-to-use structures with each chapter dedicated to a type of heterocycle and its specific functionalization methodologies\u003c\/li\u003e \u003cli\u003eA leading team of international authors in C-H bond functionalization\u003c\/li\u003e\n\u003c\/ul\u003e \u003cp\u003e\u003ci\u003eTransition-Metal-Catalyzed C-H Functionalization of Heterocycles, Two-Volume-Set\u003c\/i\u003e is a valuable guide for students and researchers in organic synthesis and process development, in both academic and industrial contexts.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47990407987429,"sku":"NP9781119774136","price":395.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781119774136.jpg?v=1761787707","url":"https:\/\/k12savings.com\/es\/products\/transition-metal-catalyzed-c-h-functionalization-of-heterocycles-2-volumes-isbn-9781119774136","provider":"K12savings","version":"1.0","type":"link"}