{"product_id":"topical-and-transdermal-drug-delivery-isbn-9780470450291","title":"Topical and Transdermal Drug Delivery","description":"\u003cb\u003ePractical drug development approaches presented by leading experts\u003c\/b\u003e  \u003cp\u003eDesigned to support the development of new, effective therapeutics, \u003ci\u003eTopical and Transdermal Drug Delivery: Principles and Practice\u003c\/i\u003e explains the principles underlying the field and then demonstrates how these principles are put into practice in the design and development of new drug products. Drawing together and reviewing the latest research findings, the book focuses on practical, tested, and proven approaches that are backed by industry case studies and the authors' firsthand experience. Moreover, the book emphasizes the mechanistic information that is essential for successful drug product development.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eTopical and Transdermal Drug Delivery: Principles and Practice\u003c\/i\u003e is divided into two parts:\u003c\/p\u003e \u003cul\u003e \u003cli\u003e \u003cp\u003e\u003cb\u003ePart One\u003c\/b\u003e, Current Science, Skin Permeation, and Enhancement Approaches, offers readers a fundamental understanding of the underlying science in the field. It describes the principles and techniques needed to successfully perform experimental approaches, covering such issues as skin permeation, enhancement, and assessment.\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003e\u003cb\u003ePart Two\u003c\/b\u003e, Topical and Transdermal Product Development, guides readers through the complete product development process from concept to approval, offering practical tips and cautions from experts in the field. This part also discusses regulations that are specific to the development of dermal drug products. The final chapter explores current and future trends, forecasting new development techniques and therapeutics.\u003c\/p\u003e \u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThroughout the book, the authors clearly set forth the basic science and experimental procedures, making it possible for researchers to design their own experimental approaches and accurately interpret their results.\u003c\/p\u003e \u003cp\u003eWith contributions from experienced drug researchers, this text is highly recommended for all researchers involved in topical and transdermal product development who need to know both the state of the science and the standards of practice.\u003c\/p\u003e  Preface ix  \u003cp\u003eAbout the Editors xi\u003c\/p\u003e \u003cp\u003eContributors xiii\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart One Current Science, Skin Permeation, and Enhancement Approaches\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1. Skin Structure, Function, and Permeation 3\u003cbr\u003e \u003ci\u003eHeather A.E. Benson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2. Passive Skin Permeation Enhancement 23\u003cbr\u003e \u003ci\u003eMajella E. Lane, Paulo Santos, Adam C. Watkinson, and Jonathan Hadgraft\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3. Electrical and Physical Methods of Skin Penetration Enhancement 43\u003cbr\u003e \u003ci\u003eJeffrey E. Grice, Tarl W. Prow, Mark A.F. Kendall, and Michael S. Roberts\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4. Clinical Applications of Transdermal Iontophoresis 67\u003cbr\u003e \u003ci\u003eDhaval R. Kalaria, Sachin Dubey, and Yogeshvar N. Kalia\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5. In Vitro Skin Permeation Methodology 85\u003cbr\u003e \u003ci\u003eBarrie Finnin, Kenneth A. Walters, and Thomas J. Franz\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6. Skin Permeation Assessment: Tape Stripping 109\u003cbr\u003e \u003ci\u003eSandra Wiedersberg and Sara Nicoli\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7. Skin Permeation Assessment: Microdialysis 131\u003cbr\u003e \u003ci\u003eRikke Holmgaard, Jesper B. Nielsen, and Eva Benfeldt\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8. Skin Permeation: Spectroscopic Methods 155\u003cbr\u003e \u003ci\u003eJonathan Hadgraft and Majella E. Lane\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9. Skin Permeation Assessment in Man: In Vitro–In Vivo Correlation 167\u003cbr\u003e \u003ci\u003ePaul A. Lehman, Sam G. Raney, and Thomas J. Franz\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10. Risk Assessment 183\u003cbr\u003e \u003ci\u003eJon R. Heylings\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart Two Topical and Transdermal Product Development\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e11. An Overview of Product Development from Concept to Approval 203\u003cbr\u003e \u003ci\u003eAdam C. Watkinson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12. Regulatory Aspects of Drug Development for Dermal Products 217\u003cbr\u003e \u003ci\u003eWilliam K. Sietsema\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13. Toxicological and Pre-clinical Considerations for Novel Excipients and New Chemical Entities 233\u003cbr\u003e \u003ci\u003eAndrew Makin and Jens Thing Mortensen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14. Topical Product Formulation Development 255\u003cbr\u003e \u003ci\u003eMarc B. Brown, Robert Turner, and Sian T. Lim\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15. Transdermal Product Formulation Development 287\u003cbr\u003e \u003ci\u003eKenneth J. Miller\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16. Sensitivity and Irritation Testing 309\u003cbr\u003e \u003ci\u003eBelum Viswanath Reddy, Geetanjali Sethi, and Howard I. Maibach\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17. New Product Development for Transdermal Drug Delivery: Understanding the Market Opportunity 345\u003cbr\u003e \u003ci\u003eHugh Alsop\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18. Transdermal and Topical Drug Delivery Today 357\u003cbr\u003e \u003ci\u003eAdam C. Watkinson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e19. Current and Future Trends: Skin Diseases and Treatment 367\u003cbr\u003e \u003ci\u003eSimon G. Danby, Gordon W. Duff, and Michael J. Cork\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 409\u003c\/p\u003e  \u003cb\u003eHeather A. E. Benson\u003c\/b\u003e, PhD, is an Associate Professor in the School of Pharmacy at Curtin University, Australia, where she leads the Skin Delivery Research Group. Internationally recognized for her research in skin biology and drug\/peptide delivery, Dr. Benson has published more than 100 peer-reviewed publications on the topic of drug delivery.  \u003cp\u003e\u003cb\u003eAdam C. Watkinson\u003c\/b\u003e, MBA, PhD, has worked in topical and transdermal drug delivery for twenty-three years and played key roles in the development of Axiron (transdermal testosterone) and Sancuso (transdermal granisetron) while at Acrux and ProStrakan, respectively. He has published extensively on his research, is the author of several patents, and holds an Honorary Chair at the School of Pharmacy at the University of London. He runs Storith Consulting, a firm offering advice in the areas of drug development and topical and transdermal drug delivery.\u003c\/p\u003e  \u003cb\u003ePractical drug development approaches presented by leading experts\u003c\/b\u003e  \u003cp\u003eDesigned to support the development of new, effective therapeutics, \u003ci\u003eTopical and Transdermal Drug Delivery: Principles and Practice\u003c\/i\u003e explains the principles underlying the field and then demonstrates how these principles are put into practice in the design and development of new drug products. Drawing together and reviewing the latest research findings, the book focuses on practical, tested, and proven approaches that are backed by industry case studies and the authors' firsthand experience. Moreover, the book emphasizes the mechanistic information that is essential for successful drug product development.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eTopical and Transdermal Drug Delivery: Principles and Practice\u003c\/i\u003e is divided into two parts:\u003c\/p\u003e \u003cul\u003e \u003cli\u003e \u003cp\u003e\u003cb\u003ePart One\u003c\/b\u003e, Current Science, Skin Permeation, and Enhancement Approaches, offers readers a fundamental understanding of the underlying science in the field. It describes the principles and techniques needed to successfully perform experimental approaches, covering such issues as skin permeation, enhancement, and assessment.\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003e\u003cb\u003ePart Two\u003c\/b\u003e, Topical and Transdermal Product Development, guides readers through the complete product development process from concept to approval, offering practical tips and cautions from experts in the field. This part also discusses regulations that are specific to the development of dermal drug products. The final chapter explores current and future trends, forecasting new development techniques and therapeutics.\u003c\/p\u003e \u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThroughout the book, the authors clearly set forth the basic science and experimental procedures, making it possible for researchers to design their own experimental approaches and accurately interpret their results.\u003c\/p\u003e \u003cp\u003eWith contributions from experienced drug researchers, this text is highly recommended for all researchers involved in topical and transdermal product development who need to know both the state of the science and the standards of practice.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47990395699429,"sku":"NP9780470450291","price":162.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470450291.jpg?v=1761787657","url":"https:\/\/k12savings.com\/es\/products\/topical-and-transdermal-drug-delivery-isbn-9780470450291","provider":"K12savings","version":"1.0","type":"link"}