{"product_id":"the-molecular-basis-of-skeletogenesis-isbn-9780471494331","title":"The Molecular Basis of Skeletogenesis","description":"Brings together a cross-fertilization of ideas between human molecular genetics, develeopmental biology, tissue biology and the biochemistry of cell signalling pathways, in order to create new insights into the mechanisms of normal and abnormal skeletogenesis.Neue Einblicke in die Mechanismen der normalen und anormalen Skelettentwicklung verspricht dieser hochaktuelle neue Band der exzellenten Novartis-Reihe. Ansätze aus der Molekulargenetik des Menschen, Entwicklungsbiologie, Zell- und Gewebebiologie sowie der Biochemie der Signalweiterleitung verbinden sich hier zu einem breitgefächerten Bild. Auf dieser Basis wird die Äthiologie genetischer Erkrankungen, die das Skelett beeinflussen, besser verständlich. (07\/00) Introduction (B. Hall).\u003cbr\u003e Genetic Control of Skeletal Development (G. Karsentry).\u003cbr\u003e Early Steps in Limb Patterning and Chondrogenesis (S. Pizette \u0026amp; L. Niswander).\u003cbr\u003e General Discussion I.\u003cbr\u003e Developmental Mechanisms of Vertebrate Limb Evolution (M. Cohn).\u003cbr\u003e Regulation of Chondrocyte Growth and Differentiation by Fibroblast Growth Factor Receptor (D. Ornitz).\u003cbr\u003e Defects of Human Skeletogenesis--Models and Mechanisms (S. Mundlos).\u003cbr\u003e Genetic Control of the Cell Proliferation--Differentiation Balance in the Developing Skull Vault: Roles of Fibroblast Growth Factor Receptor Signalling Pathways (G. Morriss-Kay, et al.).\u003cbr\u003e \u003cbr\u003e Craniosynostosis and Related Limb Anomalies (A. Wilkie, et al.).\u003cbr\u003e \u003cbr\u003e The Parathyroid Hormone-Related Protein and Indian Hedgehog Feedback Loop in the Growth Plate (H. Kronenberg \u0026amp; U. Chung).\u003cbr\u003e Cartilage Matrix Resorption in Skeletogenesis (W. Wu, et al.).\u003cbr\u003e \u003cbr\u003e Retinoid signalling and skeletal development (T. Underhill, et al.).\u003cbr\u003e \u003cbr\u003e General Discussion II.\u003cbr\u003e Defects in Extracellular Matrix Structural Proteins in the Osteochondrodysplasias (D. Cohn).\u003cbr\u003e \u003cbr\u003e Genetic Control of Bone and Joint Formation (D. Kingsley).\u003cbr\u003e The Molecular Basis of Osteoclast Differentiation and Activation (T. Suda, et al.).\u003cbr\u003e \u003cbr\u003e Clinical Disorders of Bone Resorption (G. Russell, et al.).\u003cbr\u003e \u003cbr\u003e Final Discussion.\u003cbr\u003e Index of Contributors.\u003cbr\u003e Subject Index. \u003cp\u003e\u003cb\u003eGail Cardew\u003c\/b\u003e is the editor of \u003ci\u003eThe Molecular Basis of Skeletogenesis\u003c\/i\u003e, published by Wiley.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eJamie Goode\u003c\/b\u003e is a British author with a PhD in plant biology, and a wine columnist of \u003ci\u003eThe Sunday Express\u003c\/i\u003e. Goode also contributes to wine publications such as \u003ci\u003eHarpers\u003c\/i\u003e, \u003ci\u003eThe World of Fine Wine\u003c\/i\u003e, \u003ci\u003eDecanter\u003c\/i\u003e, \u003ci\u003eGrapesTALK\u003c\/i\u003e and \u003ci\u003eSommelier Journal\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003eThis book brings together a cross-fertilization of ideas between human molecular genetics, developmental biology, tissue biology and the biochemistry of cell signalling pathways, in order to create new insights into the mechanisms of normal and abnormal skeletogenesis. This broad perspective is essential in order to understand the aetiology of genetic diseases affecting skeletal development at all levels from genotype to phenotype, i.e. from mutation to syndrome.\u003c\/p\u003e \u003cp\u003eThe book encompasses normal and abnormal skeletogenesis process by process, beginning with the signalling pathways that control early patterning events, then the molecular control of osteoblast, chondrocyte and osteoclast differentiation, joint formation and finally osteoclast activity. Each step takes into consideration the results of mouse gene cloning and knockout studies, human molecular genetics, and new mouse studies stimulated by the human information. Such an integrated approach is essential if this new understanding is to be applied for future therapeutic strategies.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47990290055397,"sku":"NP9780471494331","price":211.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780471494331.jpg?v=1761787222","url":"https:\/\/k12savings.com\/es\/products\/the-molecular-basis-of-skeletogenesis-isbn-9780471494331","provider":"K12savings","version":"1.0","type":"link"}