{"product_id":"the-liver-isbn-9781119436829","title":"The Liver","description":"\u003cp\u003e\u003cb\u003eBridging the gap between basic scientific advances and the understanding of liver disease — the extensively revised new edition of the premier text in the field.\u003c\/b\u003e \u003c\/p\u003e \u003cp\u003eThe latest edition of\u003ci\u003e The Liver: Biology and Pathobiology\u003c\/i\u003e remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver’s growth, regeneration, metabolic functions, and more.\u003c\/p\u003e \u003cp\u003eNow in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters — including substantial original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology — provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology. Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and therapies. Edited by globally-recognized experts in the field, this authoritative volume:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eRelates molecular physiology to understanding disease pathology and treatment\u003c\/li\u003e \u003cli\u003eLinks the science and pathology of the liver to practical clinical applications\u003c\/li\u003e \u003cli\u003eFeatures 16 new “Horizons” chapters that explore new and emerging science and technology\u003c\/li\u003e \u003cli\u003eIncludes plentiful full-color illustrations and figures\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eThe Liver: Biology and Pathobiology, Sixth Edition\u003c\/i\u003e is an indispensable resource for practicing and trainee hepatologists, gastroenterologists, hepatobiliary and liver transplant surgeons, and researchers and scientists in areas including hepatology, cell and molecular biology, virology, and drug metabolism.\u003c\/p\u003eDie umfassend überarbeitete Neuauflage dieses Standardwerks erläutert die grundlegenden Fortschritte in der Forschung und vermittelt so alles Wissenswerte rund um Erkrankungen der Leber.\u003cbr\u003e \u003cbr\u003e Die neueste Auflage von The Liver: Biology and Pathobiology ist nach wie vor das Referenzwerk in der Hepatologie. Fortschritte in den Biowissenschaften und der Forschung werden in einen direkten Zusammenhang gestellt und erleichtern das Verständnis zu Struktur, Funktion und krankhafter Pathologie der Leber sowie möglicher Behandlungsoptionen.\u003cbr\u003e \u003cbr\u003e Die 6. Auflage wurde komplett überarbeitet und um die neuesten Erkenntnisse aus der Biologie und deren Einfluss auf Diagnose, Management und Vorbeugung von Lebererkrankungen erweitert. 70 neue Kapitel, darunter große Abhandlungen zu Leberkarzinomen und bahnbrechenden Fortschritten mit maßgeblichen Auswirkungen für die Hepatologie, liefern ein umfassendes und aktuelles Bild der Hepatologie von heute und morgen. Zu den Themen gehören: RNS-Struktur und -Funktion, Genombearbeitung, Genomanalyse von einzelnen Zellen und Molekülen, Molekularbiologie von Hepatitis, Arzneimittelwechselwirkungen, Medikamentendesign, Mechanismen und Therapien von Lebererkrankungen. Herausgeber sind international renommierte Experten.\u003cbr\u003e \u003cbr\u003e - Greift auf die molekulare Physiologie zurück, um die Pathologie und Behandlung von Lebererkrankungen verständlich zu erklären.\u003cbr\u003e - Stellt einen Zusammenhang zwischen Wissenschaft und Pathologie der Leber und klinischen Anwendungen her.\u003cbr\u003e - Enthält 16 neue Horizons-Kapitel, die neue und zukünftige Forschung und Technologie behandeln.\u003cbr\u003e - Mit unzähligen farbigen Illustrationen und Abbildungen.\u003cbr\u003e \u003cbr\u003e Die 6. Auflage von The Liver: Biology and Pathobiology ist ein Muss für Hepatologen, angehende Hepatologen, Gastroenterologen, hepatobiliäre Transplantationschirurgen, Forscher und Wissenschaftler aus den Bereichen Hepatologie, Zell- und Molekularbiologie, Virologie und Arzneimittelstoffwechsel.\u003cbr\u003e \u003cp\u003eList of Contributors x\u003c\/p\u003e \u003cp\u003ePreface xx\u003c\/p\u003e \u003cp\u003eAcknowledgments xxi\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart One: Introduction 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Organizational Principles of the Liver 3\u003cbr\u003e\u003ci\u003ePeter Nagy, Snorri S. Thorgeirsson, and Joe W. Grisham\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 Embryonic Development of the Liver 14\u003cbr\u003e\u003ci\u003eKenneth S. Zaret, Roque Bort, and Stephen A. Duncan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart Two: The Cells 23\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection A: Cell Biology of the Liver 25\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3 Cytoskeletal Motors: Structure and Function in Hepatocytes 27\u003cbr\u003e\u003ci\u003eMukesh Kumar, Arnab Gupta, and Roop Mallik\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 Hepatocyte Surface Polarity 36\u003cbr\u003e\u003ci\u003eAnne Müsch and Irwin M. Arias\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 Primary Cilia 50\u003cbr\u003e\u003ci\u003eCarolyn M. Ott\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 Endocytosis in Liver Function and Pathology 62\u003cbr\u003e\u003ci\u003eMicah B. Schott, Barbara Schroeder, and Mark A. McNiven\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 The Hepatocellular Secretory Pathway 75\u003cbr\u003e\u003ci\u003eCatherine L. Jackson and Mark A. McNiven\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 Mitochondrial Function, Dynamics, and Quality Control 86\u003cbr\u003e\u003ci\u003eMarc Liesa, Ilan Benador, Nathanael Miller, and Orian S. Shirihai\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 Nuclear Pore Complex 94\u003cbr\u003e\u003ci\u003eMichelle A. Veronin and Joseph S. Glavy\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 Protein Maturation and Processing at the Endoplasmic Reticulum 108\u003cbr\u003e\u003ci\u003eRamanujan S. Hegde\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 Protein Degradation and the Lysosomal System 122\u003cbr\u003e\u003ci\u003eSusmita Kaushik and Ana Maria Cuervo\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 Peroxisome Assembly, Degradation, and Disease 137\u003cbr\u003e\u003ci\u003eRong Hua and Peter K. Kim\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13 Organelle–Organelle Contacts: Origins and Functions 151\u003cbr\u003e\u003ci\u003eUri Manor\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14 Gap and Tight Junctions in Liver: Structure, Function, and Pathology 160\u003cbr\u003e\u003ci\u003eJohn W. Murray and David C. Spray\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15 Ribosome Biogenesis and its Role in Cell Growth and Proliferation in the Liver 174\u003cbr\u003e\u003ci\u003eKatherine I. Farley‐Barnes and Susan J. Baserga\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16 miRNAs and Hepatocellular Carcinoma 183\u003cbr\u003e\u003ci\u003eYusuke Yamamoto, Isaku Kohama, and Takahiro Ochiya\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17 Hepatocyte Apoptosis: Mechanisms and Relevance in Liver Diseases 195\u003cbr\u003e\u003ci\u003eHarmeet Malhi and Gregory J. Gores\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection B: The Hepatocyte 207\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e18 Copper Metabolism and the Liver 209\u003cbr\u003e\u003ci\u003eCynthia Abou Zeid, Ling Yi, and Stephen G. Kaler\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e19 The Central Role of the Liver in Iron Storage and Regulation of Systemic Iron Homeostasis 215\u003cbr\u003e\u003ci\u003eTracey A. Rouault, Victor R. Gordeuk, and Gregory J. Anderson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e20 Disorders of Bilirubin Metabolism 229\u003cbr\u003e\u003ci\u003eNamita Roy Chowdhury, Yanfeng Li, and Jayanta Roy Chowdhury\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e21 Hepatic Lipid Droplets in Liver Function and Disease 245\u003cbr\u003e\u003ci\u003eDouglas G. Mashek, Wenqi Cui, Linshan Shang, and Charles P. Najt\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e22 Lipoprotein Metabolism and Cholesterol Balance 255\u003cbr\u003e\u003ci\u003eMariana Acuña‐Aravena and David E. Cohen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection C: Transporters, Bile Acids, and Cholestasis 269\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e23 Bile Acid Metabolism in Health and Disease: An Update 271\u003cbr\u003e\u003ci\u003eTiangang Li and John Y.L. Chiang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e24 TGR5 (GPBAR1) in the Liver 286\u003cbr\u003e\u003ci\u003eVerena Keitel, Christoph G.W. Gertzen, Lina Spomer, Holger Gohlke, and Dieter Häussinger\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e25 Bile Acids as Signaling Molecules 299\u003cbr\u003e\u003ci\u003eThierry Claudel and Michael Trauner\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e26 Hepatic Adenosine Triphosphate‐Binding Cassette Transport Proteins and Their Role in Physiology 313\u003cbr\u003e\u003ci\u003ePeter L.M. Jansen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e27 Basolateral Plasma Membrane Organic Anion Transporters 327\u003cbr\u003e\u003ci\u003eM. Sawkat Anwer and Allan W. Wolkoff\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e28 Hepatic Nuclear Receptors 337\u003cbr\u003e\u003ci\u003eRaymond E. Soccio\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e29 Molecular Cholestasis 351\u003cbr\u003e\u003ci\u003ePaul Gissen and Richard J. Thompson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e30 Pathophysiologic Basis for Alternative Therapies for Cholestasis 364\u003cbr\u003e\u003ci\u003eClaudia D. Fuchs, Emina Halilbasic, and Michael Trauner\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e31 Adaptive Regulation of Hepatocyte Transporters in Cholestasis 378\u003cbr\u003e\u003ci\u003eJames L. Boyer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection D: Non‐Hepatocyte Cells 391\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e32 Cholangiocyte Biology and Pathobiology 393\u003cbr\u003e\u003ci\u003eMassimiliano Cadamuro, Romina Fiorotto, and Mario Strazzabosco\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e33 Polycystic Liver Diseases: Genetics, Mechanisms, and Therapies 408\u003cbr\u003e\u003ci\u003eTatyana Masyuk, Anatoliy Masyuk, and Nicholas LaRusso\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e34 The Liver Sinusoidal Endothelial Cell: Basic Biology and Pathobiology 422\u003cbr\u003e\u003ci\u003eKaren K. Sørensen and Bård Smedsrød\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e35 Fenestrations in the Liver Sinusoidal Endothelial Cell 435\u003cbr\u003e\u003ci\u003eVictoria C. Cogger, Nicholas J. Hunt, and David G. Le Couteur\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e36 Stellate Cells and Fibrosis 444\u003cbr\u003e\u003ci\u003eYoungmin A. Lee and Scott L. Friedman\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart Three: Functions of The Liver 455\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection A: Metabolic Functions 457\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e37 Non‐alcoholic Fatty Liver Disease and Insulin Resistance 459\u003cbr\u003e\u003ci\u003eMax C. Petersen, Varman T. Samuel, Kitt Falk Petersen, and Gerald I. Shulman\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e38 AMPK: Central Regulator of Glucose and Lipid Metabolism and Target of Type 2 Diabetes Therapeutics 472\u003cbr\u003e\u003ci\u003eDaniel Garcia, Maria M. Mihaylova, and Reuben J. Shaw\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e39 Insulin‐Mediated PI3K and AKT Signaling 485\u003cbr\u003e\u003ci\u003eHyokjoon Kwon and Jeffrey E. Pessin\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e40 Ca\u003csup\u003e2+\u003c\/sup\u003e Signaling in the Liver 496\u003cbr\u003e\u003ci\u003eMateus T. Guerra, M. Fatima Leite, and Michael H. Nathanson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e41 Clinical Genomics of NAFLD 509\u003cbr\u003e\u003ci\u003eFrank Lammert\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection B: Liver Growth and Regeneration 521\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e42 Stem Cell‐Fueled Maturational Lineages in Hepatic and Pancreatic Organogenesis 523\u003cbr\u003e\u003ci\u003eWencheng Zhang, Amanda Allen, Eliane Wauthier, Xianwen Yi, Homayoun Hani, Praveen\u003c\/i\u003e \u003ci\u003eSethupathy, David Gerber, Vincenzo Cardinale, Guido Carpino, Juan Dominguez‐Bendala, Giacomo\u003c\/i\u003e \u003ci\u003eLanzoni, Domenico Alvaro, Eugenio Gaudio, and Lola Reid\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e43 Developmental Morphogens and Adult Liver Repair 539\u003cbr\u003e\u003ci\u003eMariana Verdelho Machado and Anna Mae Diehl\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e44 Liver Repopulation by Cell Transplantation and the Role of Stem Cells in Liver Biology 550\u003cbr\u003e\u003ci\u003eDavid A. Shafritz and Markus Grompe\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e45 Liver Regeneration 566\u003cbr\u003e\u003ci\u003eGeorge K. Michalopoulos\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e46 β‐Catenin Signaling 585\u003cbr\u003e\u003ci\u003eSatdarshan P.S. Monga\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e47 Polyploidy in Liver Function, Mitochondrial Metabolism, and Cancer 603\u003cbr\u003e\u003ci\u003eEvan R. Delgado, Elizabeth C. Stahl, Nairita Roy, Patrick D. Wilkinson, and Andrew W. Duncan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart Four: Pathobiology of Liver Disease 615\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e48 Hepatic Encephalopathy 617\u003cbr\u003e\u003ci\u003eRoger F. Butterworth\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e49 The Kidney in Liver Disease 630\u003cbr\u003e\u003ci\u003eMoshe Levi, Shogo Takahashi, Xiaoxin X. Wang, and Marilyn E. Levi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e50 α1‐Antitrypsin Deficiency 645\u003cbr\u003e\u003ci\u003eDavid A. Rudnick and David H. Perlmutter\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e51 Pathophysiology of Portal Hypertension 659\u003cbr\u003e\u003ci\u003eYasuko Iwakiri and Roberto J. Groszmann\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e52 Non‐alcoholic Fatty Liver Disease: Mechanisms and Treatment 670\u003cbr\u003e\u003ci\u003eYaron Rotman and Devika Kapuria\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e53 Alcoholic Liver Disease 682\u003cbr\u003e\u003ci\u003eBin Gao, Xiaogang Xiang, Lorenzo Leggio, and George F. Koob\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e54 Drug‐Induced Liver Injury 701\u003cbr\u003e\u003ci\u003eLily Dara and Neil Kaplowitz\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e55 Oxidative Stress and Inflammation in the Liver 714\u003cbr\u003e\u003ci\u003eJohn J. Lemasters and Hartmut Jaeschke\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e56 The Role of Bile Acid‐Mediated Inflammation in Cholestatic Liver Injury 728\u003cbr\u003e\u003ci\u003eShi‐Ying Cai, Man Li, and James L. Boyer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e57 Toll‐like Receptors in Liver Disease 737\u003cbr\u003e\u003ci\u003eSo Yeon Kim and Ekihiro Seki\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart Five: Liver Cancer 747\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e58 Experimental Models of Liver Cancer: Genomic Assessment of Experimental Models 749\u003cbr\u003e\u003ci\u003eSun Young Yim, Jae‐Jun Shim, Bo Hwa Sohn, and Ju‐Seog Lee\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e59 Epidemiology of Hepatocellular Carcinoma 758\u003cbr\u003e\u003ci\u003eHashem B. El‐Serag\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e60 Mutations and Genomic Alterations in Liver Cancer 773\u003cbr\u003e\u003ci\u003eJessica Zucman‐Rossi and Jean‐Charles Nault\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e61 Treatment of Liver Cancer 782\u003cbr\u003e\u003ci\u003eTim F. Greten\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart Six: Hepatitis 793\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e62 Molecular Biology of Hepatitis Viruses 795\u003cbr\u003e\u003ci\u003eChristoph Seeger, William S. Mason, and Michael M.C. Lai\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e63 Immune Mechanisms of Viral Clearance and Disease Pathogenesis During Viral Hepatitis 821\u003cbr\u003e\u003ci\u003eCarlo Ferrari, Valeria Barili, Stefania Varchetta, and Mario U. Mondelli\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e64 Clinical Implications of the Molecular Biology of Hepatitis B Virus 851\u003cbr\u003e\u003ci\u003eTimothy M. Block, Ju‐Tao Guo, and W. Thomas London\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e65 Viral Escape Mechanisms in Hepatitis C and the Clinical Consequences of Persistent Infection 868\u003cbr\u003e\u003ci\u003eMarc G. Ghany, Christopher M. Walker, and Patrizia Farci\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e66 Tracking Hepatitis C Virus Interactions with the Hepatic Lipid Metabolism : A Hitchhiker’s Guide to Solve Remaining Translational Research Challenges in Hepatitis C 889\u003cbr\u003e\u003ci\u003eGabrielle Vieyres and Thomas Pietschmann\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e67 Nucleoside Antiviral Agents for HCV: What’s Left to Do? 906\u003cbr\u003e\u003ci\u003eFranck Amblard, Seema Mengshetti, Junxing Shi, Sijia Tao, Leda Bassit, and Raymond F. Schinazi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e68 Hepatitis E Virus: An Emerging Zoonotic Virus Causing Acute and Chronic Liver Disease 915\u003cbr\u003e\u003ci\u003eXiang‐Jin Meng\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e69 Biological Principles and Clinical Issues Underlying Liver Transplantation for Viral‐Induced End‐Stage Liver Disease in the Era of Highly Effective Direct‐Acting Antiviral Agents 926\u003cbr\u003e\u003ci\u003eMichael S. Kriss, James R. Burton, Jr., and Hugo R. Rosen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e70 Time for the Elimination of Hepatitis C Virus as a Global Health Threat 935\u003cbr\u003e\u003ci\u003eJohn W. Ward, Alan R. Hinman, and Harvey J. Alter\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart Seven: Horizons 953\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e71 Genome Editing by Targeted Nucleases and the CRISPR\/Cas Revolution 955\u003cbr\u003e\u003ci\u003eShawn M. Burgess\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e72 Imaging Cellular Proteins and Structures: Smaller, Brighter, and Faster 965\u003cbr\u003e\u003ci\u003eAubrey V. Weigel and Erik Lee Snapp\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e73 Liver‐Directed Gene Therapy 979\u003cbr\u003e\u003ci\u003ePatrik Asp, Chandan Guha, Namita Roy Chowdhury, and Jayanta Roy Chowdhury\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e74 Telomeres and Telomerase in Liver Generation and Cirrhosis 992\u003cbr\u003e\u003ci\u003eSonja C. Schätzlein and K. Lenhard Rudolph\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e75 Toxins and Biliary Atresia 1000\u003cbr\u003e\u003ci\u003eMichael Pack and Rebecca G. Wells\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e76 The Dual Role of ABC Transporters in Drug Metabolism and Resistance to Chemotherapy 1007\u003cbr\u003e\u003ci\u003eJean‐Pierre Gillet, Marielle Boonen, Michel Jadot, and Michael M. Gottesman\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e77 Stem Cell‐Derived Liver Cells: From Model System to Therapy 1015\u003cbr\u003e\u003ci\u003eHelmuth Gehart and Hans Clevers\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e78 Extracellular Vesicles and Exosomes: Biology and Pathobiology 1022\u003cbr\u003e\u003ci\u003eGyongyi Szabo and Fatemeh Momen‐Heravi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e79 Integrated Technologies for Liver Tissue Engineering 1028\u003cbr\u003e\u003ci\u003eTiffany N. Vo, Amanda X. Chen, Quinton B. Smith, Arnav Chhabra and Sangeeta N. Bhatia\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e80 Pluripotent Stem Cells and Reprogramming: Promise for Therapy 1036\u003cbr\u003e\u003ci\u003eJames A. Heslop and Stephen A. Duncan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e81 Chromatin Regulation and Transcription Factor Cooperation in Liver Cells 1043\u003cbr\u003e\u003ci\u003eIdo Goldstein\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e82 Drug Interactions in the Liver 1050\u003cbr\u003e\u003ci\u003eGuruprasad P. Aithal and Gerd A. Kullak‐Ublick\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e83 Metabolic Regulation of Hepatic Growth 1058\u003cbr\u003e\u003ci\u003eWolfram Goessling\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e84 The Gut Microbiome and Liver Disease 1062\u003cbr\u003e\u003ci\u003eLexing Yu, Jasmohan S. Bajaj, and Robert F. Schwabe\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e85 Lineage Tracing: Efficient Tools to Determine the Fate of Hepatic Cells in Health and Disease 1069\u003cbr\u003e\u003ci\u003eFrédéric Lemaigre\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e86 The Hepatocyte as a Household for Plasmodium Parasites 1075\u003cbr\u003e\u003ci\u003eVanessa Zuzarte‐Luis and Maria M. Mota\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 1081\u003c\/p\u003e  \u003cp\u003e\u003cb\u003eIRWIN M. ARIAS, MD,\u003c\/b\u003e National Institutes of Health, Bethesda, Maryland, USA. \u003c\/p\u003e\u003cp\u003e\u003cb\u003eHARVEY J. ALTER, MD,\u003c\/b\u003e National Institutes of Health, Bethesda, Maryland, USA. \u003c\/p\u003e\u003cp\u003e\u003cb\u003eJAMES L. BOYER, MD,\u003c\/b\u003e Yale University School of Medicine, New Haven, Connecticut, USA. \u003c\/p\u003e\u003cp\u003e\u003cb\u003eDAVID E. COHEN, MD,\u003c\/b\u003e Weill Cornell Medical College, New York, USA. \u003c\/p\u003e\u003cp\u003e\u003cb\u003eDAVID A. SHAFRITZ, MD,\u003c\/b\u003e Albert Einstein College of Medicine, New York, USA. \u003c\/p\u003e\u003cp\u003e\u003cb\u003eSNORRI S. THORGEIRSSON, MD,\u003c\/b\u003e National Institutes of Health, Bethesda, Maryland, USA. \u003c\/p\u003e\u003cp\u003e\u003cb\u003eALLAN W. WOLKOFF, MD,\u003c\/b\u003e Albert Einstein College of Medicine, New York, USA.   \u003c\/p\u003e\u003cp\u003e\u003cb\u003eBridging the gap between basic scientific advances and the understanding of liver disease—the extensively revised new edition of the premier text in the field\u003c\/b\u003e \u003c\/p\u003e\u003cp\u003eThe latest edition of\u003ci\u003e The Liver: Biology and Pathobiology\u003c\/i\u003e remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver's growth, regeneration, metabolic functions, and more. \u003c\/p\u003e\u003cp\u003eNow in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters — including substantial original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology — provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology. Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and therapies. Edited by globally-recognized experts in the field, this authoritative volume: \u003c\/p\u003e\u003cul\u003e \u003cli\u003eRelates molecular physiology to understanding disease pathology and treatment\u003c\/li\u003e \u003cli\u003eLinks the science and pathology of the liver to practical clinical applications\u003c\/li\u003e \u003cli\u003eFeatures 16 new \"Horizons\" chapters that explore new and emerging science and technology\u003c\/li\u003e \u003cli\u003eIncludes plentiful full-color illustrations and figures\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eThe Liver: Biology and Pathobiology, Sixth Edition\u003c\/i\u003e is an indispensable resource for practicing and trainee hepatologists, gastroenterologists, hepatobiliary and liver transplant surgeons, and researchers and scientists in areas including hepatology, cell and molecular biology, virology, and drug metabolism.\u003c\/p\u003e","brand":"Wiley-Blackwell","offers":[{"title":"Default Title","offer_id":47990281076965,"sku":"NP9781119436829","price":360.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781119436829.jpg?v=1761787185","url":"https:\/\/k12savings.com\/es\/products\/the-liver-isbn-9781119436829","provider":"K12savings","version":"1.0","type":"link"}