{"product_id":"the-gnrh-neuron-and-its-control-isbn-9781119233244","title":"The GnRH Neuron and its Control","description":"\u003cp\u003e\u003ci\u003eThe GnRH Neuron and its Control\u003c\/i\u003e examines the developmental biology of GnRH neurons including their birth in the nasal placode of the early embryo, perinatal programming, and sexual differentiation, in addition to the hypothalamic mechanisms that control GnRH neurons in adulthood to generate pulsatile and surge modes of GnRH secretion throughout the major life stages including aging. The morphology, electrophysiology, signal transduction pathways, transcriptional regulators, and genomics underlying function of the adult GnRH neuron is discussed in detail, as is the neuroendocrinology and cell biology governing the generation of both modes of GnRH release.\u003c\/p\u003e \u003cp\u003eThe book also reviews the neurobiological mechanisms and circuitry responsible for the modulation of the activity of GnRH neurons by season, stress, nutrition, and metabolism, and covers the current and potential therapeutic approaches to regulating GnRH secretion and action. Filled with newly identified research and classical fundamental knowledge to GnRH biology, it will provide students, researchers, and practitioners with an in-depth understanding of reproductive neuroendocrinology.\u003c\/p\u003e \u003cp\u003eThis is the fifth volume in the Masterclass in Neuroendocrinology Series, a co- publication between Wiley and the INF (International Neuroendocrine Federation) that aims to illustrate highest standards and encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology.\u003c\/p\u003e \u003cp\u003eList of Contributors vii\u003c\/p\u003e \u003cp\u003eSeries Preface xi\u003c\/p\u003e \u003cp\u003ePreface xiii\u003c\/p\u003e \u003cp\u003eAbout the Companion Website xv\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart I Historical Introduction to the GnRH Neuron\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 The Framework Upon Which Current Research on the GnRH Neuron and its Control is Built 3\u003cb\u003e\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eTony M. Plant and Allan E. Herbison\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart II GnRH Neuron Development\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2 Prenatal Development of GnRH Neurons 15\u003cbr\u003e \u003ci\u003eYufei Shan and Susan Wray\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 Fetal\/perinatal Programming Causing Sexual Dimorphism of the Kisspeptin–GnRH NeuronalNetwork 43\u003cbr\u003e \u003ci\u003eHiroko Tsukamura, Kei‐ichiro Maeda and Yoshihisa Uenoyama\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 Postnatal Development of GnRH Neuronal Function 61\u003cbr\u003e \u003ci\u003eEi Terasawa\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart III GnRH Neuron Biology\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5 Regulation of GnRH Gene Expression 95\u003cbr\u003e \u003ci\u003eHanne M. Hoffmann and Pamela L. Mellon\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 Morphology of the Adult GnRH Neuron 121\u003cbr\u003e \u003ci\u003eRebecca E. Campbell\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 The Anatomy of the GnRH Neuron Network in the Human 149\u003cbr\u003e \u003ci\u003eKatalin Skrapits and Erik Hrabovszky\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 Electrophysiology of Rodent GnRH Neurons 177\u003cbr\u003e \u003ci\u003eRichard Piet and Allan E. Herbison\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 Anatomy and Physiology of GnRH Neurons and Their Control of Pituitary Function in Fish 203\u003cbr\u003e \u003ci\u003eYoshitaka Oka\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart IV Regulation of GnRH Neuron Function\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e10 Unveiling the Importance of Glia and Vascular Endothelial Cells in the Control of GnRH NeuronalFunction 227\u003cbr\u003e \u003ci\u003eVincent Prevot and Ariane Sharif\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 Genetic Strategies Examining Kisspeptin Regulation of GnRH Neurons 259\u003cbr\u003e \u003ci\u003eMichael Candlish, Philipp Wartenberg and Ulrich Boehm\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 KNDy Hypothesis for Generation of GnRH Pulses: Evidence from Sheep and Goats 289\u003cbr\u003e \u003ci\u003eRobert L. Goodman, Satoshi Okhura, Hiroaki Okamura,  Lique M. Coolen and Michael N. Lehman\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13 Generation of the GnRH Surge and LH Surge by the Positive Feedback Effect of Estrogen 325\u003cbr\u003e \u003ci\u003eIain Clarke\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14 Influence of Stress on the GnRH Neuronal Network 357\u003cbr\u003e \u003ci\u003ePasha Grachev and Kevin T. O’Byrne\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15 Metabolic Regulation of GnRH Neurons 383\u003cbr\u003e \u003ci\u003eMaggie C. Evans and Greg M. Anderson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16 Seasonal Control of the GnRH Neuronal Network as a Means of Uncovering Novel CentralMechanisms Governing Mammalian Reproduction 411\u003cbr\u003e \u003ci\u003eSébastien Milesi, Paul Klosen and Valerie Simonneaux\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart V GnRH in the Clinic\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e17 Human Genetics of GnRH Neuron Function 445\u003cbr\u003e \u003ci\u003eA. Kemal Topaloglu and L. Damla Kotan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18 Modulators of GnRH Secretion and Therapeutic Applications 469\u003cbr\u003e \u003ci\u003eClaire L. Newton, Ross C. Anderson and Robert P. Millar\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 499\u003c\/p\u003e   \u003cp\u003e \u003cb\u003eEditors:\u003c\/b\u003e\u003cbr\u003e \u003cb\u003eAllan E. Herbison,\u003c\/b\u003e \u003ci\u003eUniversity of Otago, New Zealand.\u003c\/i\u003e  \t \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTony M. Plant,\u003c\/b\u003e \u003ci\u003eUniversity of Pittsburgh, USA.\u003c\/i\u003e     \u003c\/p\u003e\u003cp\u003e \u003ci\u003eThe GnRH Neuron and its Control\u003c\/i\u003e examines the developmental biology of GnRH neurons including their birth in the nasal placode of the early embryo, perinatal programming,  and sexual differentiation, in addition to the hypothalamic mechanisms that control GnRH neurons in adulthood to generate pulsatile and surge modes of GnRH secretion throughout the major life stages including aging. The morphology, electrophysiology, signal transduction pathways, transcriptional regulators, and genomics underlying function of the adult GnRH neuron is discussed in detail, as is the neuroendocrinology and cell biology governing the generation of both modes of GnRH release.   \u003c\/p\u003e\u003cp\u003e The book also reviews the neurobiological mechanisms and circuitry responsible for the modulation of the activity of GnRH neurons by season, stress, nutrition, and metabolism,  and covers the current and potential therapeutic approaches to regulating GnRH secretion and action. Filled with newly identified research and classical fundamental knowledge to GnRH biology, it will provide students, researchers, and practitioners with an in-depth understanding of reproductive neuroendocrinology.   \u003c\/p\u003e\u003cp\u003e This is the sixth volume in the Masterclass in Neuroendocrinology Series, a co-publication between Wiley and the INF (International Neuroendocrine Federation) that aims to illustrate highest standards and encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field  of neuroendocrinology.\u003c\/p\u003e","brand":"Wiley-Blackwell","offers":[{"title":"Default Title","offer_id":47990242017509,"sku":"NP9781119233244","price":179.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781119233244.jpg?v=1761787032","url":"https:\/\/k12savings.com\/es\/products\/the-gnrh-neuron-and-its-control-isbn-9781119233244","provider":"K12savings","version":"1.0","type":"link"}