{"product_id":"the-genetics-of-neurodevelopmental-disorders-isbn-9781118524886","title":"The Genetics of Neurodevelopmental Disorders","description":"\u003cp\u003eNeurodevelopmental disorders arise from disturbances to various processes of brain development, which can manifest in diverse ways. They encompass many rare genetic syndromes as well as common, heritable conditions such as intellectual disability, autism, ADHD, schizophrenia and many types of epilepsy. \u003ci\u003eThe Genetics of Neurodevelopmental Disorders\u003c\/i\u003e examines recent revolutionary advances in our understanding of the genetics of these disorders, exploring both basic discoveries and the translation of new findings into the clinical setting.\u003c\/p\u003e \u003cp\u003eThe book begins by examining the genetic architecture and etiology of neurodevelopmental disorders. It describes the striking recent progress in identifying pathogenic mutations, which are grouped here based on the neurodevelopmental processes impacted. Subsequent chapters consider the use of cellular and animal models to elucidate the cascading consequences of such mutations, from molecular and cellular levels to emergent effects on neural circuits, brain systems and subsequent psychological development. The text concludes by examining the important clinical implications of the recent advances in the field, from recognition of the genetic causes in individual patients to development of new treatments and interventions.\u003c\/p\u003e \u003cp\u003eA timely synthesis, \u003ci\u003eThe Genetics of Neurodevelopmental Disorders\u003c\/i\u003e is a unique and essential resource for neuroscientists, geneticists, neurologists and psychiatrists and an accessible and up-to-date overview for medical and science students.\u003c\/p\u003e \u003cp\u003eList of Contributors vii\u003c\/p\u003e \u003cp\u003eForeword\u003cbr\u003e\u003ci\u003eKevin J. Mitchell\u003c\/i\u003e ix\u003c\/p\u003e \u003cp\u003e1 The Genetic Architecture of Neurodevelopmental Disorders 1\u003cbr\u003e\u003ci\u003eKevin J. Mitchell\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 Overlapping Etiology of Neurodevelopmental Disorders 29\u003cbr\u003e\u003ci\u003eEric Kelleher and Aiden Corvin\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 The Mutational Spectrum of Neurodevelopmental Disorders 49\u003cbr\u003e\u003ci\u003eNancy D. Merner, Patrick A. Dion, and Guy A. Rouleau\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 The Role of Genetic Interactions in Neurodevelopmental Disorders 69\u003cbr\u003e\u003ci\u003eJason H. Moore and Kevin J. Mitchell\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 Developmental Instability, Mutation Load, and Neurodevelopmental Disorders 81\u003cbr\u003e\u003ci\u003eRonald A. Yeo and Steven W. Gangestad\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 Environmental Factors and Gene–Environment Interactions 111\u003cbr\u003e\u003ci\u003eJohn McGrath\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 The Genetics of Brain Malformations 129\u003cbr\u003e\u003ci\u003eM. Chiara Manzini and Christopher A. Walsh\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 Disorders of Axon Guidance 155\u003cbr\u003e\u003ci\u003eHeike Blockus and Alain Chédotal\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 Synaptic Disorders 195\u003cbr\u003e\u003ci\u003eCatalina Betancur and Kevin J. Mitchell\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 Human Stem Cell Models of Neurodevelopmental Disorders 239\u003cbr\u003e\u003ci\u003ePeter Kirwan and Frederick J. Livesey\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 Animal Models for Neurodevelopmental Disorders 261\u003cbr\u003e\u003ci\u003eHala Harony-Nicolas and Joseph D. Buxbaum\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 Cascading Genetic and Environmental Effects on Development: Implications for Intervention 275\u003cbr\u003e\u003ci\u003eEsha Massand and Annette Karmiloff-Smith\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13 Human Genetics and Clinical Aspects of Neurodevelopmental Disorders 289\u003cbr\u003e\u003ci\u003eGholson J. Lyon and Jason O'Rawe\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14 Progress Toward Therapies and Interventions for Neurodevelopmental Disorders 319\u003cbr\u003e\u003ci\u003eAyokunmi Ajetunmobi and Daniela Tropea\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eSubject Index 345\u003c\/p\u003e \u003cp\u003eGene Index 353\u003c\/p\u003e \u003cb\u003eKevin J. Mitchell\u003c\/b\u003e is an Associate Professor at the Smurfit Institute of Genetics and Institute of Neuroscience at Trinity College Dublin","brand":"Wiley-Blackwell","offers":[{"title":"Default Title","offer_id":47990239690981,"sku":"NP9781118524886","price":160.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781118524886.jpg?v=1761787024","url":"https:\/\/k12savings.com\/es\/products\/the-genetics-of-neurodevelopmental-disorders-isbn-9781118524886","provider":"K12savings","version":"1.0","type":"link"}