{"product_id":"the-enteric-nervous-system-isbn-9781405133760","title":"The Enteric Nervous System","description":"\u003cb\u003eCovers all aspects of the structure, function, neurochemistry, transmitter identification and development of the enteric nervous system\u003c\/b\u003e \u003cbr\u003e \u003cp\u003eThis book brings together extensive knowledge of the structure and cell physiology of the enteric nervous system and provides an up-to-date synthesis of the roles of the enteric nervous system in the control of motility, secretion and blood supply in the gastrointestinal tract.\u003cbr\u003e \u003c\/p\u003e \u003cp\u003e\u003cbr\u003e \u003c\/p\u003e \u003cp\u003eIt includes sections on the enteric nervous system in disease, genetic abnormalities that affect enteric nervous system function, and targets for therapy in the enteric nervous system. It also includes many newly created explanatory diagrams and illustrations of the organization of enteric nerve circuits.\u003cbr\u003e \u003c\/p\u003e \u003cp\u003e\u003cbr\u003e \u003c\/p\u003e \u003cp\u003eThis new book is ideal for gastroenterologists (including trainees\/fellows), clinical physiologists and educators. It is invaluable for the many scientists in academia, research institutes and industry who have been drawn to work on the gastrointestinal innervation because of its intrinsic interest, its economic importance and its involvement in unsolved health problems. It also provides a valuable resource for undergraduate and graduate teaching.\u003c\/p\u003e  \u003cb\u003eChapter 1: Structure of the enteric nervous system.\u003c\/b\u003e \u003cp\u003eThe enteric plexuses.\u003c\/p\u003e \u003cp\u003eInterconnections between the plexuses.\u003c\/p\u003e \u003cp\u003eExtent of the ganglionated plexuses.\u003c\/p\u003e \u003cp\u003eIntramural extensions of extrinsic nerves.\u003c\/p\u003e \u003cp\u003eElectron microscope studies.\u003c\/p\u003e \u003cp\u003eEnteric glia.\u003c\/p\u003e \u003cp\u003eThe structural similarities and functional differences between regions may have an evolutionary basis.\u003c\/p\u003e \u003cp\u003eDevelopment of the enteric nervous system.\u003c\/p\u003e \u003cp\u003eMaturation of enteric neurons and development of function.\u003c\/p\u003e \u003cp\u003eChanges in enteric neurons with aging.\u003c\/p\u003e \u003cp\u003eSummary and conclusions.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 2: Constituent neurons of the enteric nervous system\u003c\/b\u003e.\u003c\/p\u003e \u003cp\u003eShapes of enteric neurons.\u003c\/p\u003e \u003cp\u003eCell physiological classifications of enteric neurons.\u003c\/p\u003e \u003cp\u003eFunctionally defined enteric neurons.\u003c\/p\u003e \u003cp\u003eNeurons in human intestine with equivalence to those investigated in laboratory animals.\u003c\/p\u003e \u003cp\u003eSummary and conclusions.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 3: Reflex circuitry of the enteric nervous system\u003c\/b\u003e.\u003c\/p\u003e \u003cp\u003eEvolution of ideas about enteric circuitry.\u003c\/p\u003e \u003cp\u003eMotility controlling circuits of the small and large intestine.\u003c\/p\u003e \u003cp\u003eIntrinsic secretomotor and vasomotor circuits.\u003c\/p\u003e \u003cp\u003eAssemblies of neurons.\u003c\/p\u003e \u003cp\u003eCircuits in the esophagus and stomach.\u003c\/p\u003e \u003cp\u003eCo-ordination of motility, secretomotor and vasomotor reflexes.\u003c\/p\u003e \u003cp\u003eCircuits connecting the intestine, biliary system and pancreas.\u003c\/p\u003e \u003cp\u003eSympathetic innervation of the gastrointestinal tract.\u003c\/p\u003e \u003cp\u003eSummary and conclusions.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 4: Pharmacology of transmission and sites of drug action in the enteric nervous system\u003c\/b\u003e.\u003c\/p\u003e \u003cp\u003eChemical coding and multiple transmitters.\u003c\/p\u003e \u003cp\u003eTransmitters of motor neurons that innervate the smooth muscle of the gut.\u003c\/p\u003e \u003cp\u003eTransmitters at neuro-neuronal synapses.\u003c\/p\u003e \u003cp\u003eSites within the reflex circuitry where specific pharmacologies of transmission can be deduced to occur.\u003c\/p\u003e \u003cp\u003eTransmission from entero-endocrine cells to IPANs.\u003c\/p\u003e \u003cp\u003eRoles of interstitial cells of Cajal in neuromuscular transmission.\u003c\/p\u003e \u003cp\u003eTransmitters of secretomotor and vasodilator neurons.\u003c\/p\u003e \u003cp\u003eSynapses in secretomotor and vasodilator pathways.\u003c\/p\u003e \u003cp\u003eTransmitters of motor neurons innervating gastrin cells.\u003c\/p\u003e \u003cp\u003eSummary and conclusions.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 5: Neural control of motility.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eRhythmic activity of gastrointestinal muscle.\u003c\/p\u003e \u003cp\u003eStructure and properties of interstitial cells of Cajal.\u003c\/p\u003e \u003cp\u003eRelationship between slow wave activity and neural control.\u003c\/p\u003e \u003cp\u003eGastric motility.\u003c\/p\u003e \u003cp\u003ePatterns of small intestine motility and their intrinsic neural control.\u003c\/p\u003e \u003cp\u003eMotility of the colon.\u003c\/p\u003e \u003cp\u003eNeural control of the esophagus.\u003c\/p\u003e \u003cp\u003eGall-bladder motility.\u003c\/p\u003e \u003cp\u003eSphincters.\u003c\/p\u003e \u003cp\u003eMuscle of the mucosa.\u003c\/p\u003e \u003cp\u003eMechanism of sympathetic inhibition of motility in non-sphincter regions.\u003c\/p\u003e \u003cp\u003eSympathetic innervation of the sphincters.\u003c\/p\u003e \u003cp\u003ePhysiological effects of noradrenergic neurons on motility in undisturbed animals.\u003c\/p\u003e \u003cp\u003eReflex activities of sympathetic neurons that affect motility.\u003c\/p\u003e \u003cp\u003eSummary and conclusions.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 6: Enteric neurons and the physiological control of fluid secretion and vasodilation\u003c\/b\u003e.\u003c\/p\u003e \u003cp\u003eWater and electrolyte secretion in the small and large intestines.\u003c\/p\u003e \u003cp\u003eReflex control of water and electrolyte secretion.\u003c\/p\u003e \u003cp\u003eSecretion of gastric acid.\u003c\/p\u003e \u003cp\u003ePepsinogen secretion.\u003c\/p\u003e \u003cp\u003eGastric secretion of bicarbonate.\u003c\/p\u003e \u003cp\u003eSecretion into the gall bladder.\u003c\/p\u003e \u003cp\u003ePancreatic exocrine secretion.\u003c\/p\u003e \u003cp\u003eSummary and conclusions.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 7: Disorders of motility and secretion and therapeutic targets in the enteric nervous system.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eTherapeutic endpoints for motility disorders.\u003c\/p\u003e \u003cp\u003eTherapies for secretory diarrheas.\u003c\/p\u003e \u003cp\u003eEnteric neuropathies involving neuronal loss or phenotypic changes.\u003c\/p\u003e \u003cp\u003eMitochondriopathies with intestinal manifestations.\u003c\/p\u003e \u003cp\u003eIrritable bowel syndrome and plasticity of enteric neurons.\u003c\/p\u003e \u003cp\u003eSummary and conclusions.\u003c\/p\u003e \u003cp\u003eEpilogue: the future of enteric neurobiology.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003eIndex.\u003c\/p\u003e  \"As someone who has contributed extensively to our current understanding, John Furness provides an insightful and personal account that integrates a vast array of literature into a nicely illustrated and very readable book that will be of interest to anyone working in the field.\" \u003cp\u003eProfessor David Grundy, \u003ci\u003eEuropean Journal of Gastroenterology \u0026amp; Hepatology\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\"Each chapter is very well written, focused on the specific topic and easily understandable. Also, the text has been widely integrated by more than sixty high-quality schemes, illustrations and drawings... Furthermore, the entire book has been well supported by classic publications and updated literature making all together more than 12000 references in all.\"\u003cbr\u003e \u003c\/p\u003e \u003cp\u003eDr Roberto De Giorgio, \u003ci\u003eDigestive and Liver Diseases\u003c\/i\u003e\u003c\/p\u003e  John Furness is an expert on the enteric nervous system and its functions and has published over 300 relevant papers. In addition to his academic roles, he is a consultant in the GI drug development programs of GlaxoSmithKline, Novartis and Pfizer and has contracts with GSK and Pfizer for target identification and lead compound testing.\u003cbr\u003e \u003cp\u003e\u003cu\u003eRelevant honours include:\u003c\/u\u003e\u003cbr\u003e Distinguished Achievement Award, Australian Neuroscience Society, 2003\u003cbr\u003e Davenport Medal, American Physiological Society, 1997\u003cbr\u003e Grossman Lecturer, Cambridge, 1995 (The field of the Grossman Foundation is gastroenterology)\u003cbr\u003e Australian Physiological and Pharmacological Society Lecture and Medal, 1995\u003cbr\u003e Distinguished Research Prize, Gastroenterological Society of Australia, 1994\u003cbr\u003e Janssen Research Award, 1993 (The field of the award is gastroenterology)\u003cbr\u003e Fellow, Australian Academy of Science, Elected 1989\u003c\/p\u003e  \u003cb\u003eCovers all aspects of the structure, function, neurochemistry, transmitter identification and development of the enteric nervous system\u003c\/b\u003e \u003cbr\u003e \u003cp\u003eThe enteric nervous system is of special interest because it is the only substantial grouping of neurons outside the central nervous system that form circuits capable of autonomous reflex activity. In humans it contains around 500 million neurons that fall into about 20 functional classes. Because of its size, complexity, and certain structural similarities, it has been likened to a second brain.\u003cbr\u003e \u003c\/p\u003e \u003cp\u003e\u003cbr\u003e \u003c\/p\u003e \u003cp\u003eThis book brings together extensive knowledge of the structure and cell physiology of the enteric nervous system and provides an up-to-date synthesis of the roles of the enteric nervous system in the control of motility, secretion and blood supply in the gastrointestinal tract.\u003cbr\u003e \u003c\/p\u003e \u003cp\u003e\u003cbr\u003e \u003c\/p\u003e \u003cp\u003eIt includes sections on the enteric nervous system in disease, genetic abnormalities that affect enteric nervous system function, and targets for therapy in the enteric nervous system. It also includes many newly created explanatory diagrams and illustrations of the organization of enteric nerve circuits.\u003cbr\u003e \u003c\/p\u003e \u003cp\u003e\u003cbr\u003e \u003c\/p\u003e \u003cp\u003eThis new book is ideal for gastroenterologists (including trainees\/fellows), clinical physiologists and educators. It will be invaluable for the many scientists in academia, research institutes and industry who have been drawn to work on the gastrointestinal innervation because of its intrinsic interest, its economic importance and its involvement in unsolved health problems. It provides a valuable resource for undergraduate and graduate teaching.\u003c\/p\u003e","brand":"Wiley-Blackwell","offers":[{"title":"Default Title","offer_id":47990219014373,"sku":"NP9781405133760","price":197.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781405133760.jpg?v=1761786952","url":"https:\/\/k12savings.com\/es\/products\/the-enteric-nervous-system-isbn-9781405133760","provider":"K12savings","version":"1.0","type":"link"}