{"product_id":"the-chemical-biology-of-nucleic-acids-isbn-9780470519745","title":"The Chemical Biology of Nucleic Acids","description":"With extensive coverage of synthesis techniques and applications, this text describes chemical biology techniques which have gained significant impetus during the last five years. It focuses on the methods for obtaining modified and native nucleic acids, and their biological applications. Topics covered include:  \u003cul\u003e \u003cli\u003e\u003ca id=\"_Toc223430553\" name=\"_Toc223430553\"\u003echemical synthesis of modified RNA\u003c\/a\u003e\u003c\/li\u003e \u003cli\u003eexpansion of the genetic alphabet in nucleic acids by creating new base pairs\u003c\/li\u003e \u003cli\u003echemical biology of DNA replication: probing DNA polymerase selectivity mechanisms with modified nucleotides\u003c\/li\u003e \u003cli\u003enucleic-acid-templated chemistry\u003c\/li\u003e \u003cli\u003echemical biology of peptide nucleic acids (PNA)\u003c\/li\u003e \u003cli\u003ethe interactions of small molecules with DNA and RNA\u003c\/li\u003e \u003cli\u003ethe architectural modules of folded RNAs\u003c\/li\u003e \u003cli\u003egenesis and biological applications of locked nucleic acid (LNA)\u003c\/li\u003e \u003cli\u003esmall non-coding RNA in bacteria\u003c\/li\u003e \u003cli\u003emicroRNA-guided gene silencing\u003c\/li\u003e \u003cli\u003enucleic acids based therapies\u003c\/li\u003e \u003cli\u003einnate immune recognition of nucleic acid\u003c\/li\u003e \u003cli\u003elight-responsive nucleic acids for the spatiotemporal control of biological processes\u003c\/li\u003e \u003cli\u003eDNA methylation\u003c\/li\u003e \u003cli\u003eframeworks for programming RNA devices\u003c\/li\u003e \u003cli\u003eRNA as a catalyst: The Diels-Alderase-Ribozyme\u003c\/li\u003e \u003cli\u003eevolving an understanding of RNA function by \u003ci\u003ein vitro\u003c\/i\u003e approaches\u003c\/li\u003e \u003cli\u003ethe chemical biology of aptamers: synthesis and applications\u003c\/li\u003e \u003cli\u003enucleic acids as detection tools\u003c\/li\u003e \u003cli\u003ebacterial riboswitch discovery and analysis\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eThe Chemical Biology of Nucleic Acids\u003c\/i\u003e is an essential compendium of the synthesis of nucleic acids and their biological applications for bioorganic chemists, chemical biologists, medicinal chemists, cell biologists, and molecular biologists.\u003c\/p\u003e \u003cp\u003eForeword vii\u003c\/p\u003e \u003cp\u003ePreface ix\u003c\/p\u003e \u003cp\u003eList of Contributors xi\u003c\/p\u003e \u003cp\u003e1 Chemical Synthesis of Modified RNA 1\u003cbr\u003e \u003ci\u003eClaudia Höbartner and Falk Wachowius\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 Expansion of the Genetic Alphabet in Nucleic Acids by Creating New Base Pairs 39\u003cbr\u003e \u003ci\u003eIchiro Hirao and Michiko Kimoto\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 Chemical Biology of DNA Replication: Probing DNA Polymerase Selectivity Mechanisms with Modified Nucleotides 63\u003cbr\u003e \u003ci\u003eAndreas Marx\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 Nucleic Acid-templated Chemistry 73\u003cbr\u003e \u003ci\u003eMichael Oberhuber\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 Chemical Biology of Peptide Nucleic Acids (PNAs) 103\u003cbr\u003e \u003ci\u003ePeter E. Nielsen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 The Interactions of Small Molecules with DNA and RNA 115\u003cbr\u003e \u003ci\u003eYun Xie, Victor K. Tam and Yitzhak Tor\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 The Architectural Motifs of Folded RNAs 141\u003cbr\u003e \u003ci\u003eValérie Fritsch and Eric Westhof\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 Genesis and Biological Applications of Locked Nucleic Acids (LNAs) 175\u003cbr\u003e \u003ci\u003eHarleen Kaur and Souvik Maiti\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 Small Non-coding RNA in Bacteria 199\u003cbr\u003e \u003ci\u003eSabine Brantl\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 MicroRNA-guided Gene Silencing 223\u003cbr\u003e \u003ci\u003eGunter Meister\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 Nucleic Acid-based Therapies 233\u003cbr\u003e \u003ci\u003eBritta Hoehn and John J. Rossi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 Innate Immune Recognition of Nucleic Acids 261\u003cbr\u003e \u003ci\u003eStefan Bauer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13 Light-responsive Nucleic Acids for the Spatiotemporal Control of Biological Processes 279\u003cbr\u003e \u003ci\u003eAlexander Heckel and Günter Mayer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14 DNA Methylation 307\u003cbr\u003e \u003ci\u003eAlbert Jeltsch and Renata Z. Jurkowska\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15 Frameworks for Programming RNA Devices 323\u003cbr\u003e \u003ci\u003eMaung Nyan Win, Joe C. Liang and Christina D. Smolke\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16 RNA as a Catalyst: The Diels–Alderase Ribozyme 339\u003cbr\u003e \u003ci\u003eAndres Jäschke\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17 Evolving an Understanding of RNA Function by In Vitro Approaches 355\u003cbr\u003e \u003ci\u003eQing Wang and Peter J. Unrau\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18 The Chemical Biology of Aptamers: Synthesis and Applications 377\u003cbr\u003e \u003ci\u003eGünter Mayer and Bernhard Wulffen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e19 Nucleic Acids as Detection Tools 401\u003cbr\u003e \u003ci\u003eJeffrey C.F. Lam, Sergio Aguirre and Yingfu li\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e20 Bacterial Riboswitch Discovery and Analysis 433\u003cbr\u003e \u003ci\u003eTyler D. Ames and Ronald R. Breaker\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 455\u003c\/p\u003e  \"This book will be a useful resource for post-graduates seeking to gain an overview of the subject as well as for specialists in specific areas of chemical biology.\" (ChemBioChem Book Reviews, 2010)\u003cbr\u003e \u003cbr\u003e   \u003cp\u003e\"Gunther Mayer and the contributors have assembled a valuable collection of well-written and timely articles. This book will be a useful resource for post-graduates seeking to gain an overview of the subject as well as for specialists in specific areas of chemical biology.\" (\u003ci\u003eChemMedChem\u003c\/i\u003e, November 2010)\u003c\/p\u003e \u003cp\u003e\u003cb\u003eGünter Mayer\u003c\/b\u003e, Assistant Professor, LIMES Prog. Unit Chemical Biology and Medicinal Chemistry, Kekulé-Institute for Organic Chemistry and Biochemistry, University of Bonn, Germany\u003cbr\u003eProfessor Mayer's research involves molecular diversity applied to elucidate the conformation, function and identity of biomolecules. He is a co-founder of NascaCell Technologies AG, a leading service provider of innovative biomolecules, where he headed the combinatorial biotechnology department. He has published papers in leading journals such as \u003ci\u003eNature, Angewandte Chemie\u003c\/i\u003e and \u003ci\u003eJournal of the American Chemical Society\u003c\/i\u003e.\u003c\/p\u003e  This book focuses on the methods for obtaining modified and native nucleic acids, and their biological applications.  \u003cp\u003eTopics covered include:\u003c\/p\u003e \u003cul\u003e \u003cli\u003echemical synthesis of modified RNA\u003c\/li\u003e \u003cli\u003eexpansion of the genetic alphabet in nucleic acids by creating new base pairs\u003c\/li\u003e \u003cli\u003echemical biology of DNA replication: probing DNA polymerase selectivity mechanisms with modified nucleotides\u003c\/li\u003e \u003cli\u003enucleic-acid-templated chemistry\u003c\/li\u003e \u003cli\u003echemical biology of peptide nucleic acids (PNA)\u003c\/li\u003e \u003cli\u003ethe interactions of small molecules with DNA and RNA\u003c\/li\u003e \u003cli\u003ethe architectural modules of folded RNAs\u003c\/li\u003e \u003cli\u003egenesis and biological applications of locked nucleic acid (LNA)\u003c\/li\u003e \u003cli\u003esmall non-coding RNA in bacteria\u003c\/li\u003e \u003cli\u003emicroRNA-guided gene silencing\u003c\/li\u003e \u003cli\u003enucleic acids based therapies\u003c\/li\u003e \u003cli\u003einnate immune recognition of nucleic acid\u003c\/li\u003e \u003cli\u003elight-responsive nucleic acids for the spatiotemporal control of biological processes\u003c\/li\u003e \u003cli\u003eDNA methylation\u003c\/li\u003e \u003cli\u003eframeworks for programming RNA devices\u003c\/li\u003e \u003cli\u003eRNA as a catalyst: The Diels-Alderase-Ribozyme\u003c\/li\u003e \u003cli\u003eevolving an understanding of RNA function by in vitro approaches\u003c\/li\u003e \u003cli\u003ethe chemical biology of aptamers: synthesis and applications\u003c\/li\u003e \u003cli\u003enucleic acids as detection tools\u003c\/li\u003e \u003cli\u003ebacterial riboswitch discovery and analysis\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eA comprehensive reference for bioorganic chemists, chemical biologists, medicinal chemists, cell biologists, and molecular biologists.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47990184804581,"sku":"NP9780470519745","price":215.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470519745.jpg?v=1761786828","url":"https:\/\/k12savings.com\/es\/products\/the-chemical-biology-of-nucleic-acids-isbn-9780470519745","provider":"K12savings","version":"1.0","type":"link"}