{"product_id":"the-brain-in-motion-isbn-9780262048200","title":"The Brain in Motion","description":"\u003cb\u003eAn evolutionary perspective—from lampreys to humans—on how the forebrain coordinates movement while the networks in the brainstem and spinal cord handle the execution.\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003eAll living creatures interact with their environment: even the most basic have a set of innate motor circuits they rely on to feed, locomote, fight, and flee. In \u003ci\u003eThe Brain in Motion\u003c\/i\u003e, Sten Grillner describes the evolution of the motor repertoire of vertebrates, from protovertebrates to primates. With breadth and depth, Grillner explores how the brain uses the different microcircuits in the brainstem and spinal cord, coordinating them through commands from the forebrain. He also considers the normal function of the brain as a platform for understanding clinical conditions such as stroke, Parkinson´s and Huntington´s diseases, and spinal cord injury.\u003cbr\u003e\u003cbr\u003eGrillner also explains in \u003ci\u003eThe Brain in Motion\u003c\/i\u003e how the remarkable finding that the lamprey forebrain has all the components of the mammalian one has radically changed scientists’ views on the evolutionary origin of the vertebrate forebrain. We now know that the basic organization evolved 560 rather than 300 million years ago, as was previously thought. The forebrain, says Grillner, is like an orchestra conductor, while the microcircuits, with their reaching, grasping, posture, locomotion, and numerous other patterns of behavior, correspond to the members of the orchestra. The conductor determines when each will be called into action.\u003cbr\u003e\u003cbr\u003eProviding an elegantly integrated perspective, \u003ci\u003eThe Brain in Motion \u003c\/i\u003eis essential reading for anybody that works professionally with movement control and function and dysfunction, whether in basic research, clinically, or in the training of motor skills.Preface ix\u003cbr\u003e 1 THE VERTEBRATE MOTOR REPERTOIRE AND THE EVOLUTION\u003cbr\u003e OF THE BRAIN 1\u003cbr\u003e 1.1 Introduction 1\u003cbr\u003e 1.2 Vertebrate Motor Behavior from Lamprey to Humans: Overview in an\u003cbr\u003e Evolutionary Perspective 3\u003cbr\u003e 1.3 The Basic Building Blocks of Behavior: Motor Programs and Their\u003cbr\u003e Selection—Overview 21\u003cbr\u003e 1.4 The Blueprint of the Vertebrate Motor System Is 500 Million Years Old 27\u003cbr\u003e 2 EXECUTION OF MOVEMENT: A PALETTE OF CPGS AND MOTOR\u003cbr\u003e CENTERS FROM MIDBRAIN TO SPINAL CORD 39\u003cbr\u003e 2.1 Introduction 39\u003cbr\u003e 2.2 CPG Networks Producing Locomotor, Respiratory, and Chewing Movements\u003cbr\u003e and Related Behaviors 40\u003cbr\u003e 2.3 A Brainstem Center for Coordination of Reaching and Grasping Movements\u003cbr\u003e in the Lateral Reticular Medulla 66\u003cbr\u003e 2.4 The PAG Channels Commands from the Hypothalamus and Amygdala 71\u003cbr\u003e 2.5 Integration of Innate Motor Programs in Daily Life: Skilled Aspects of the\u003cbr\u003e Control of Motion 78\u003cbr\u003e 2.6 Conclusion 80con\u003cbr\u003e 3 THE VERTEBRATE SOLUTION FOR ACTION IN THE\u003cbr\u003e EGOCENTRIC SPACE: MULTISENSORY INTEGRATION IN\u003cbr\u003e THE TECTUM\/SUPERIOR COLLICULUS 81\u003cbr\u003e 3.1 Introduction 81\u003cbr\u003e 3.2 Multisensory Representation of the Surrounding Space in the Tectum\/SC 82\u003cbr\u003e 3.3 Tectum\/SC Control of Eye, Orienting, and Evasive Movements 89\u003cbr\u003e 3.4 Conclusion 96\u003cbr\u003e 4 THE ROLES OF THE BASAL GANGLIA: FOR INITIATION OF\u003cbr\u003e MOVEMENT AND MOTOR LEARNING 97\u003cbr\u003e 4.1 Overview: The Relation between the Cortex and the Basal Ganglia 97\u003cbr\u003e 4.2 Basal Ganglia: Organization 101\u003cbr\u003e 4.3 Synaptic Interaction within the Striatum 117\u003cbr\u003e 4.4 Integrated Function of the Basal Ganglia 127\u003cbr\u003e 4.5 Dysfunction of the Basal Ganglia: Parkinson’s and Huntington’s Diseases\u003cbr\u003e and Other Conditions 143\u003cbr\u003e 4.6 The Contribution of the Basal Ganglia to the Selection of Action and the\u003cbr\u003e Control of Movement Amplitude 153\u003cbr\u003e 4.7 The Organization of the Basal Ganglia Is Conserved from Lampreys\u003cbr\u003e to Primates 160\u003cbr\u003e 5 THE ROLE OF THE CORTEX IN THE CONTROL OF MOVEMENT 165\u003cbr\u003e 5.1 Introduction 165\u003cbr\u003e 5.2 Somatosensory and Visuomotor Coordination Critical in the Preparatory\u003cbr\u003e Phase and the Transition between Diferent Commands in a\u003cbr\u003e Motor Sequence 168\u003cbr\u003e 5.3 The Motor Areas in the Frontal Lobe of Primates and Other Vertebrates 175\u003cbr\u003e 5.4 Neocortical Organization at the Cellular Level and the Interaction between\u003cbr\u003e the Frontal Motor Areas, Striatum, and Downstream Motor Targets 189\u003cbr\u003e 5.5 Motor Capacity after Lesions to the Neocortex, Including the\u003cbr\u003e Motor Cortex 197\u003cbr\u003e 5.6 Cortical Control of Robotic Arms via the Brain-Machine Interface after\u003cbr\u003e Spinal Cord Injury 200\u003cbr\u003e 5.7 Concluding Remarks: The Neocortex and the Control of Movement 201\u003cbr\u003e 6 THE CEREBELLUM: CONTRIBUTES TO THE PERFECTION\u003cbr\u003e OF COORDINATION 203\u003cbr\u003e 6.1 Introduction 203\u003cbr\u003e 6.2 The Cerebellar Circuitry 203\u003cbr\u003e 6.3 Spinal Cord Interaction with the Cerebellum: Locomotion and\u003cbr\u003e Other Movements 210\u003cbr\u003e 6.4 The Cerebellum and the Vestibulo-Ocular and Optokinetic Reflexes:\u003cbr\u003e Calibration of Motor Action 215\u003cbr\u003e 6.5 Parallel Fiber Synapses onto Purkinje Cells: Active and Silent Synapses—\u003cbr\u003e Plasticity 218\u003cbr\u003e 6.6 The Cerebellum’s Role for Learning to Associate Two Related but\u003cbr\u003e Independent Processes: Conditioned Reflexes 219\u003cbr\u003e 6.7 Modeling and Simulation of the Cerebellar Circuitry 219\u003cbr\u003e 6.8 Concluding Remarks: The Overall Role of the Cerebellum 220\u003cbr\u003e 7 COMMENTS ON WHAT WE HAVE LEARNED AND\u003cbr\u003e THE CHALLENGES AHEAD 223\u003cbr\u003e 7.1 “To Move or Not to Move,” a Question Answered by the Basal Ganglia\u003cbr\u003e in Close Interaction with the Cortex 224\u003cbr\u003e 7.2 The Major Organizational Building Blocks of Motion 226\u003cbr\u003e 7.3 The Role of the Cerebellum: The Perfection of Coordination 226\u003cbr\u003e 7.4 Some Challenges Ahead 227\u003cbr\u003e References 231\u003cbr\u003e Index 261“Grillner’s \u003ci\u003eThe Brain in Motion\u003c\/i\u003e offers fundamental insights about motor control from a giant in the field who has a unique perspective on evolution and the power of modular design as observed in the brains of ‘simple’ vertebrates. The volume covers a remarkable range of the circuits and regions controlling movements, from spinal cord to cerebellum to basal ganglia to neocortex, conveyed with a clarity that opens up this domain to anyone interested in the brain and behavior. The chapter summaries give brilliantly condensed views and precious guides for the reader. A unique and valuable compendium that is a delight to read.”\u003cbr\u003e\u003cb\u003e—Ann M. Graybiel, Institute Professor, MIT\u003c\/b\u003e\u003cbr\u003e \u003cbr\u003e \u003cbr\u003e“This unique and very personal book is a must read. It conveys the author’s deep insight, makes the arch from historic background to latest research and crosses evolutionary boundaries.”\u003cbr\u003e\u003cb\u003e—Silvia Arber, Professor in Neuroscience, Biozentrum and FMI, University of Basel, Switzerland\u003c\/b\u003eSten Grillner is Distinguished Professor at the Karolinska Institute in Sweden and previous head of the Nobel Institute for Neurophysiology.","brand":"The MIT Press","offers":[{"title":"Default Title","offer_id":46304148717797,"sku":"NP9780262048200","price":60.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780262048200.jpg?v=1767738520","url":"https:\/\/k12savings.com\/es\/products\/the-brain-in-motion-isbn-9780262048200","provider":"K12savings","version":"1.0","type":"link"}