{"product_id":"textbook-of-von-willebrand-disease-isbn-9781119419488","title":"Textbook of Von Willebrand Disease","description":"\u003cp\u003e \u003cb\u003eComprehensive resource summarizing recent research on von Willebrand disease, showing clinicians how to optimize management of patients with this disorder\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eThe newly revised and updated second edition of \u003ci\u003e\u003cb\u003eTextbook of von Willebrand Disease: Basic and Clinical Aspects, 2\u003csup\u003end\u003c\/sup\u003e edition \u003c\/b\u003e\u003c\/i\u003edescribes the important and complex role of von Willebrand factor (VWF) in hemostasis and thrombosis, covering not only the current understanding of its molecular biology, but also the association between genetic variants of VWF and different von Willebrand disease (VWD) phenotypes. The text also reviews the important area of the obstetric and gynecological manifestations of VWD, as well as how to manage patients with VWD for surgery.  \u003c\/p\u003e\u003cp\u003eMany advances in agents are included in this updated edition, as well as the wide topics such as VWF in Angiogenesis, and VWF\/ADAMTS13 as risk factors of thrombosis. \u003c\/p\u003e\u003cp\u003eEdited by a team of experts in VWD and an international team of contributors, \u003ci\u003e\u003cb\u003eTextbook of von Willebrand Disease \u003c\/b\u003e\u003c\/i\u003ecovers sample topics such as:  \u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eVWF structure and function, biosynthesis and organization of VWF, modulation of VWF by ADAMTS13 and assessment of VWF clearance \u003c\/li\u003e\n\u003cli\u003eClinical, laboratory and molecular markers of different VWD types, from the mild forms of type 1 VWD and the moderate variants types 2A, 2B, 2M, 2N to the most severe type 3 VWD \u003c\/li\u003e\n\u003cli\u003ePediatric aspects of VWD and of women with VWD \u003c\/li\u003e\n\u003cli\u003eManagement of GI bleeds and appropriate therapies in surgery, and plasma-derived and recombinant VWF concentrates \u003c\/li\u003e\n\u003cli\u003eAcquired von Willebrand Syndrome, cardiovascular causes of AVWS, gastrointestinal bleeds in VWD and AVWS, and prophylaxis in von Willebrand disease \u003c\/li\u003e\n\u003c\/ul\u003e \u003cp\u003eProviding complete and accessible coverage of the subject, \u003ci\u003e\u003cb\u003eTextbook of von Willebrand Disease: Basic and Clinical Aspects, 2\u003csup\u003end\u003c\/sup\u003e edition \u003c\/b\u003e\u003c\/i\u003eis a valuable resource for hematologists in practice and in training, along with specialists in thrombosis, hemostasis, and bleeding\/clotting disorders. \u003c\/p\u003e\u003cp\u003eList of Contributors vii\u003c\/p\u003e \u003cp\u003eForeword xi\u003c\/p\u003e \u003cp\u003ePreface xiii\u003c\/p\u003e \u003cp\u003e1 Historical perspective on von Willebrand disease 1\u003cbr\u003e \u003ci\u003eErik E. Berntorp and Margareta Blombäck\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 Biosynthesis and organization of von Willebrand factor 7\u003cbr\u003e \u003ci\u003eSandra L. Haberichter\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 Von Willebrand factor structure and function 23\u003cbr\u003e \u003ci\u003eRobert R. Montgomery Veronica H. Flood and Sandra L. Haberichter\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 Regulation of von Willebrand factor expression 39\u003cbr\u003e \u003ci\u003eElham Ghorbanpour and David Lillicrap\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 Modulation of VWF by ADAMTS13 49\u003cbr\u003e \u003ci\u003eYaoxian Xu Anastasis Petri and James T.B. Crawley\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 Assessment of VWF clearance 63\u003cbr\u003e \u003ci\u003eOrla Rawley Laura L. Swystun and Jamie M. O’Sullivan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 Classification of VWD 73\u003cbr\u003e \u003ci\u003eJessica Garcia Sandra L. Haberichter and Veronica H. Flood\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 The epidemiology of von Willebrand disease 81\u003cbr\u003e \u003ci\u003eGiancarlo Castaman and Francesco Rodeghiero\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 Clinical aspects of von Willebrand disease: bleeding history 87\u003cbr\u003e \u003ci\u003ePaula D. James and Alberto Tosetto\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 Laboratory diagnosis of von Willebrand disease: the phenotype 95\u003cbr\u003e \u003ci\u003eEmmanuel J. Favaloro and Ulrich Budde\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 Molecular diagnosis of von Willebrand disease: the genotype 109\u003cbr\u003e \u003ci\u003ePamela Christopherson Robert R. Montgomery and Veronica H. Flood\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 Clinical laboratory and molecular markers of type 1 von Willebrand disease and low vonWillebrand factor 115\u003cbr\u003e \u003ci\u003eDavid Lillicrap\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13 Clinical and molecular markers of type 1C VWD 123\u003cbr\u003e \u003ci\u003eHeather Clift Veronica H. Flood and Sandra L. Haberichter\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14 Clinical and molecular markers of VWD2A 129\u003cbr\u003e \u003ci\u003eReinhard Schneppenheim and Giancarlo Castaman\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15 Clinical and molecular markers of VWD2B 137\u003cbr\u003e \u003ci\u003eGiancarlo Castaman and Augusto B. Federici\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16 Clinical and molecular markers of type 2M VWD 143\u003cbr\u003e \u003ci\u003eMaissaa Janbain Sandra L. Haberichter and Veronica H. Flood\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17 Clinical and molecular markers of VWD2N 149\u003cbr\u003e \u003ci\u003eJenny Goudemand and Mélanie Daniel\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18 Clinical laboratory and molecular markers of type 3 von Willebrand disease 159\u003cbr\u003e \u003ci\u003eLuciano Baronciani and Augusto B. Federici\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e19 Pediatric aspects of von Willebrand disease 177\u003cbr\u003e \u003ci\u003eRobert F. Sidonio Jr and Jorge Di Paola\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e20 Women with von Willebrand Disease 185\u003cbr\u003e \u003ci\u003eRezan Abdul Kadir\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e21 The use of desmopressin in von Willebrand disease 201\u003cbr\u003e \u003ci\u003eGiancarlo Castaman and Augusto B. Federici\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e22 Plasma-derived and recombinant VWF concentrates 215\u003cbr\u003e \u003ci\u003ePier Mannuccio Mannucci and Massimo Franchini\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e23 Pathophysiology epidemiology and management of acquired von Willebrand syndrome 221\u003cbr\u003e \u003ci\u003eUlrich Budde and Augusto B. Federici\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e24 Cardiovascular causes of AVWS 239\u003cbr\u003e \u003ci\u003eAntoine Rauch and Sophie Susen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e25 Von Willebrand factor regulation of angiogenesis and vascular integrity: implications forgastrointestinal angiodysplasia and beyond 247\u003cbr\u003e \u003ci\u003eAnna M. Randi and Giancarlo Castaman\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e26 Prophylaxis in von Willebrand disease 257\u003cbr\u003e \u003ci\u003eErik E. Berntorp and Augusto B. Federici\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e27 Risk of thrombosis and antithrombotic treatment in von Willebrand disease patients 265\u003cbr\u003e \u003ci\u003eFerdows Atiq and Frank W.G. Leebeek\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e28 Novel functions for VWF beyond hemostasis 271\u003cbr\u003e \u003ci\u003eFerdows Atiq and James S. O’Donnell\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 281\u003c\/p\u003e  \u003cp\u003e\u003cb\u003eProfessor Augusto B. Federici, \u003c\/b\u003eHematology and Transfusion Medicine, L. Sacco University Hospital and University of Milan, Milan, Italy. \u003c\/p\u003e\u003cp\u003e\u003cb\u003eProfessor Erik E. Berntorp, \u003c\/b\u003eDepartment of Translational Medicine, Malmö Centre for Thrombosis and Haemostasis, Lund University, Skåne University Hospital, Malmö, Sweden.  \u003c\/p\u003e\u003cp\u003e\u003cb\u003eProfessor David Lillicrap, \u003c\/b\u003eDepartment of Pathology and Molecular Medicine, Richardson Laboratory, Queen’s University, Kingston, ON, Canada. \u003c\/p\u003e\u003cp\u003e\u003cb\u003eProfessor Robert R. Montgomery, \u003c\/b\u003ePediatrics (Hematology) and Vice Chair, Versiti Blood Research Institute, Medical College of Wisconsin, Milwaukee, WI, USA.   \u003c\/p\u003e\u003cp\u003e \u003cb\u003eComprehensive resource summarizing recent research on von Willebrand disease, showing clinicians how to optimize management of patients with this disorder\u003c\/b\u003e \u003c\/p\u003e\u003cp\u003eThe newly revised and updated second edition of \u003ci\u003e\u003cb\u003eTextbook of von Willebrand Disease: Basic and Clinical Aspects, 2\u003csup\u003end\u003c\/sup\u003e edition \u003c\/b\u003e\u003c\/i\u003edescribes the important and complex role of von Willebrand factor (VWF) in hemostasis and thrombosis, covering not only the current understanding of its molecular biology, but also the association between genetic variants of VWF and different von Willebrand disease (VWD) phenotypes. The text also reviews the important area of the obstetric and gynecological manifestations of VWD, as well as how to manage patients with VWD for surgery.  \u003c\/p\u003e\u003cp\u003eMany advances in agents are included in this updated edition, as well as the wide topics such as VWF in Angiogenesis, and VWF\/ADAMTS13 as risk factors of thrombosis. \u003c\/p\u003e\u003cp\u003eEdited by a team of experts in VWD and an international team of contributors, \u003ci\u003e\u003cb\u003eTextbook of von Willebrand Disease \u003c\/b\u003e\u003c\/i\u003ecovers sample topics such as:  \u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eVWF structure and function, biosynthesis and organization of VWF, modulation of VWF by ADAMTS13 and assessment of VWF clearance \u003c\/li\u003e\n\u003cli\u003eClinical, laboratory and molecular markers of different VWD types, from the mild forms of type 1 VWD and the moderate variants types 2A, 2B, 2M, 2N to the most severe type 3 VWD \u003c\/li\u003e\n\u003cli\u003ePediatric aspects of VWD and of women with VWD \u003c\/li\u003e\n\u003cli\u003eManagement of GI bleeds and appropriate therapies in surgery, and plasma-derived and recombinant VWF concentrates \u003c\/li\u003e\n\u003cli\u003eAcquired von Willebrand Syndrome, cardiovascular causes of AVWS, gastrointestinal bleeds in VWD and AVWS, and prophylaxis in von Willebrand disease \u003c\/li\u003e\n\u003c\/ul\u003e \u003cp\u003eProviding complete and accessible coverage of the subject, \u003ci\u003e\u003cb\u003eTextbook of von Willebrand Disease: Basic and Clinical Aspects, 2\u003csup\u003end\u003c\/sup\u003e edition \u003c\/b\u003e\u003c\/i\u003eis a valuable resource for hematologists in practice and in training, along with specialists in thrombosis, hemostasis, and bleeding\/clotting disorders.\u003c\/p\u003e","brand":"Wiley-Blackwell","offers":[{"title":"Default Title","offer_id":47990147088613,"sku":"NP9781119419488","price":146.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781119419488.jpg?v=1761786683","url":"https:\/\/k12savings.com\/es\/products\/textbook-of-von-willebrand-disease-isbn-9781119419488","provider":"K12savings","version":"1.0","type":"link"}