{"product_id":"searching-for-molecular-solutions-isbn-9780470146828","title":"Searching for Molecular Solutions","description":"\u003cp\u003e\u003cb\u003eA comprehensive look at empirical approaches to molecular discovery, their relationships with rational design, and the future of both\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eEmpirical methods of discovery, along with serendipitous and rational design approaches, have played an important role in human history. \u003ci\u003eSearching for Molecular Solutions\u003c\/i\u003e compares empirical discovery strategies for biologically useful molecules with serendipitous discovery and rational design, while also considering the strengths and limitations of empirical pathways to molecular discovery.\u003c\/p\u003e \u003cp\u003eLogically arranged, this text examines the different modes of molecular discovery, empha-sizing the historical and ongoing importance of empirical strategies. Along with a broad overview of the subject matter, \u003ci\u003eSearching for Molecular Solutions\u003c\/i\u003e explores:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eThe differing modes of molecular discovery\u003c\/li\u003e \u003cli\u003eBiological precedents for evolutionary approaches\u003c\/li\u003e \u003cli\u003eDirected evolutionary methods and related areas\u003c\/li\u003e \u003cli\u003eEnzyme evolution and design\u003c\/li\u003e \u003cli\u003eFunctional nucleic acid discovery\u003c\/li\u003e \u003cli\u003eAntibodies and other recognition molecules\u003c\/li\u003e \u003cli\u003eGeneral aspects of molecular recognition\u003c\/li\u003e \u003cli\u003eSmall molecule discovery approaches\u003c\/li\u003e \u003cli\u003eRational molecular design\u003c\/li\u003e \u003cli\u003eThe interplay between empirical and rational strategies and their ongoing roles in the future of molecular discovery\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eSearching for Molecular Solutions\u003c\/i\u003e covers several major areas of modern research, development, and practical applications of molecular sciences. This text offers empirical-rational principles of broad relevance to scientists, professionals, and students interested in general aspects of molecular discovery, as well as the thought processes behind experimental approaches.\u003c\/p\u003e \u003cp\u003eAcknowledgments xi\u003c\/p\u003e \u003cp\u003eIntroduction xiii\u003c\/p\u003e \u003cp\u003e1 If It Works, It Works: Pragmatic Molecular Discovery 1\u003c\/p\u003e \u003cp\u003e2 Empirical Miracles: Nature's Precedents for Empirical Solutions 22\u003c\/p\u003e \u003cp\u003e3 Evolution's Gift: Natural Somatic Diversification and Molecular Design 61\u003c\/p\u003e \u003cp\u003e4 Evolution While You Wait 103\u003c\/p\u003e \u003cp\u003e5 The Blind Protein Maker 145\u003c\/p\u003e \u003cp\u003e6 The Blind Shaper of Nucleic Acids 187\u003c\/p\u003e \u003cp\u003e7 Evolving and Creating Recognition Molecules 234\u003c\/p\u003e \u003cp\u003e8 Molecules Small and Large 275\u003c\/p\u003e \u003cp\u003e9 An Empirical--Rational Loop Forwards 315\u003c\/p\u003e \u003cp\u003e10 Exploring the Limits 343\u003c\/p\u003e \u003cp\u003eGlossary 365\u003c\/p\u003e \u003cp\u003eBibliography 374\u003c\/p\u003e \u003cp\u003eReferences in Figure Legends 440\u003c\/p\u003e \u003cp\u003eIndex 443\u003c\/p\u003e  \"This is a valuable resource that compares empirical discovery and rational design, while also considering the strengths and limitations of empirical pathways to molecular discovery. Scientists, professionals, and students interested in general aspects of molecular discovery will find this book extremely useful.\" (Doody's, 19 August 2011)  \u003cp\u003e \u003c\/p\u003e \u003cb\u003eIan S. Dunn, PhD,\u003c\/b\u003e is the Director of Research at Cytocure, LLC, in Beverly, Massachusetts. In keeping with the scope of this book, he has a diverse background in immunology, cell and molecular biology, and biotechnology. His current research focuses on antigen gene regulation in melanoma cells. \u003cp\u003e\u003cb\u003eA comprehensive look at empirical approaches to molecular discovery, their relationships with rational design, and the future of both\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eEmpirical methods of discovery, along with serendipitous and rational design approaches, have played an important role in human history. \u003ci\u003eSearching for Molecular Solutions\u003c\/i\u003e compares empirical discovery strategies for biologically useful molecules with serendipitous discovery and rational design, while also considering the strengths and limitations of empirical pathways to molecular discovery.\u003c\/p\u003e \u003cp\u003eLogically arranged, this text examines the different modes of molecular discovery, empha-sizing the historical and ongoing importance of empirical strategies. Along with a broad overview of the subject matter, \u003ci\u003eSearching for Molecular Solutions\u003c\/i\u003e explores:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eThe differing modes of molecular discovery\u003c\/li\u003e \u003cli\u003eBiological precedents for evolutionary approaches\u003c\/li\u003e \u003cli\u003eDirected evolutionary methods and related areas\u003c\/li\u003e \u003cli\u003eEnzyme evolution and design\u003c\/li\u003e \u003cli\u003eFunctional nucleic acid discovery\u003c\/li\u003e \u003cli\u003eAntibodies and other recognition molecules\u003c\/li\u003e \u003cli\u003eGeneral aspects of molecular recognition\u003c\/li\u003e \u003cli\u003eSmall molecule discovery approaches\u003c\/li\u003e \u003cli\u003eRational molecular design\u003c\/li\u003e \u003cli\u003eThe interplay between empirical and rational strategies and their ongoing roles in the future of molecular discovery\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eSearching for Molecular Solutions\u003c\/i\u003e covers several major areas of modern research, development, and practical applications of molecular sciences. This text offers empirical-rational principles of broad relevance to scientists, professionals, and students interested in general aspects of molecular discovery, as well as the thought processes behind experimental approaches.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eNote:\u003c\/b\u003e CD-ROM\/DVD and other supplementary materials are not included as part of eBook file.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989996388581,"sku":"NP9780470146828","price":166.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470146828.jpg?v=1761786151","url":"https:\/\/k12savings.com\/es\/products\/searching-for-molecular-solutions-isbn-9780470146828","provider":"K12savings","version":"1.0","type":"link"}