{"product_id":"science-of-the-placebo-isbn-9780727915948","title":"Science of the Placebo","description":"Based on a meeting in November 2000, this book brings together researchers from a wide range of disciplines to examine the biological, behavioral, social, cultural and ethical aspects related to the placebo effect. Perspectives on the necessity for including a placebo in randomized clinical trials will also be examined.\u003cbr\u003e This is the first attempt to examine the evidence-base of the placebo effect and will provide important information for clinicans.  Contributors. \u003cp\u003eForeword.\u003c\/p\u003e \u003cp\u003e1 An Overview.\u003c\/p\u003e \u003cp\u003eSection 1: Historical and Ethical Perspectives.\u003c\/p\u003e \u003cp\u003e2 “Seeing” the Placebo Effect: Historical Legacies and Present Opportunities.\u003c\/p\u003e \u003cp\u003e3 Ethical Issues in Use of Placebo in Medical Practice and Clinical Trials.\u003c\/p\u003e \u003cp\u003eSection 2: Elucidating Placebo Effects: Explanatory Mechanisms.\u003c\/p\u003e \u003cp\u003e4 Explanatory Mechanisms for Placebo Effects: Cultural Influences and the Meaning Response.\u003c\/p\u003e \u003cp\u003e5 Explanatory Mechanisms for Placebo Effects: Cognition, Personality and Social Learning.\u003c\/p\u003e \u003cp\u003e6 Explanatory Mechanisms for Placebo Effects: Pavlovian Conditioning.\u003c\/p\u003e \u003cp\u003e7 Regression to the Mean or Placebo Effect?.\u003c\/p\u003e \u003cp\u003eSection 3: Elucidating Placebo Effects: Intervening Psychophysiology.\u003c\/p\u003e \u003cp\u003e8 Neuriendocrine Meidators of Placebo Effects on Immunity.\u003c\/p\u003e \u003cp\u003e9 Endogenous Opioid and Non-Opioid Pathways as Mediators of Placebno Analgesia.\u003c\/p\u003e \u003cp\u003eSection 4: Use of Placebo Groups in Clinical Trials-Methodological and Ethical Issues.\u003c\/p\u003e \u003cp\u003e10 Placebo controlled Trials and Active Controlled Trials: Ethics and Inference.\u003c\/p\u003e \u003cp\u003e11 When is it Appropriate to Use a Placebo Arm in a Trial?.\u003c\/p\u003e \u003cp\u003e12 The Pros and Cons of Non-Inferiority (Equivalence) Trials.\u003c\/p\u003e \u003cp\u003e13 Use of Placebo in Large-Scale, Pragmatic Trials.\u003c\/p\u003e \u003cp\u003e14 Placebo Controls in Clinical Trials of New Therapies for Conditions for which there are Known Effective Treatments.\u003c\/p\u003e \u003cp\u003eSection 5: Priorities for Future Research.\u003c\/p\u003e \u003cp\u003e15 The Research and Ethical Agenda.\u003c\/p\u003e \u003cp\u003eSection 6: Conclusions and Future Directions.\u003c\/p\u003e \u003cp\u003e16 Conclusions and Future Directions.\u003c\/p\u003e \u003cp\u003eAppendix.\u003c\/p\u003e \u003cp\u003eIndex.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eHarry Guess\u003c\/b\u003e is the editor of \u003ci\u003eScience of the Placebo: Toward an Interdisciplinary Research Agenda\u003c\/i\u003e, published by Wiley.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eLinda Engel\u003c\/b\u003e is the editor of \u003ci\u003eScience of the Placebo: Toward an Interdisciplinary Research Agenda\u003c\/i\u003e, published by Wiley.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eArthur Kleinman\u003c\/b\u003e is the editor of \u003ci\u003eScience of the Placebo: Toward an Interdisciplinary Research Agenda\u003c\/i\u003e, published by Wiley.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eJohn Kusek\u003c\/b\u003e is the editor of \u003ci\u003eScience of the Placebo: Toward an Interdisciplinary Research Agenda\u003c\/i\u003e, published by Wiley.\u003c\/p\u003e  Do placebos work? For many conditions, you bet they do! Maybe in some people most of the time; maybe even in all people some of the time. Those are among the conclusions that experts drew from a comprehensive review of placebo effects that took place at the National Institutes of Health. The meeting, designed to bring basic biomedical and behavioral scientists together with clinicians and clinical trial experts, developed an expanded concept of the placebo, explored a variety of explanatory mechanisms of why placebos work when they work, and discussed the pros and cons of using placebos in clinical trials. The experts went on to develop a research agenda to further progress in the field. \u003cbr\u003e \u003cp\u003eThe result is a new look at placebos, one that calls for careful consideration of the complex ethical issues involved in exploiting placebo effects, but sees their potential as therapeutic allies in clinical practice.\u003cbr\u003e \u003c\/p\u003e \u003cp\u003eThe chapters serve as an essential practical and theoretical guide to practitioners, researchers, bioethicists, patients, and students who want a comprehensive review of the state of placebo science and placebo-controlled clinical trials. They include:\u003cbr\u003e \u003c\/p\u003e \u003cul\u003e \u003cli style=\"list-style: none\"\u003e\n\u003cbr\u003e \u003c\/li\u003e \u003cli\u003eThe historical context and ethical perspectives\u003c\/li\u003e \u003cli style=\"list-style: none\"\u003e\n\u003cbr\u003e \u003c\/li\u003e \u003cli\u003eExplanatory psychosocial and physiological mechanisms (for example, social and cultural meanings, classic conditioning, social learning, intervening psychophysiology)\u003c\/li\u003e \u003cli style=\"list-style: none\"\u003e\n\u003cbr\u003e \u003c\/li\u003e \u003cli\u003eThe need to distinguish placebo effects from biological and statistical artifacts\u003c\/li\u003e \u003cli style=\"list-style: none\"\u003e\n\u003cbr\u003e \u003c\/li\u003e \u003cli\u003eIssues concerning the use of placebo groups in clinical trials: ethics, methodological issues, pros, cons, and alternatives\u003c\/li\u003e \u003cli style=\"list-style: none\"\u003e\n\u003cbr\u003e \u003c\/li\u003e \u003cli\u003ePriorities for future research\u003c\/li\u003e \u003c\/ul\u003e \u003cbr\u003e \u003cp\u003e The publication of this book has important implications for clinical medicine, making it essential reading for clinical researchers, basic scientists and health care practitioners.\u003c\/p\u003e","brand":"BMJ Books","offers":[{"title":"Default Title","offer_id":47989994422501,"sku":"NP9780727915948","price":54.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780727915948.jpg?v=1761786144","url":"https:\/\/k12savings.com\/es\/products\/science-of-the-placebo-isbn-9780727915948","provider":"K12savings","version":"1.0","type":"link"}