{"product_id":"ribosome-inactivating-proteins-isbn-9781118125656","title":"Ribosome-inactivating Proteins","description":"This important reference provides up-to-date information on all aspects of ribosome-inactivating proteins (RIPs). Including a list of all known RIPs, their distribution in nature, structure, genetics and chemical and immunological properties, this reference covers mechanisms of action, including the enzymatic activity on various polynucleotide substrates; the interaction with, and entry into cells; the toxicity to animals, including the pathology of poisoning; and the immunomodulatory and allergenic activity. The book further emphasizes the use of immunotoxins and other conjugates in clinical trials for the therapy of cancer and intractable pain.  \u003cp\u003e\u003ci\u003eContributors vii\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003ePreface xi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1 Introduction and History 1\u003cbr\u003e \u003ci\u003eFiorenzo Stirpe\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 Occurrence and Taxonomical Distribution of Ribosome-inactivating Proteins Belonging to the Ricin\/Shiga Toxin Superfamily 11\u003cbr\u003e \u003ci\u003eChenjing Shang, Willy J. Peumans, and Els J. M. Van Damme\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 Ribosome-inactivating Proteins from Phytolaccaceae 28\u003cbr\u003e \u003ci\u003eAugusto Parente, Angela Chambery, Antimo Di Maro, Rosita Russo, and Valeria Severino\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 Ribosome-inactivating Proteins in Caryophyllaceae, Cucurbitaceae, and Euphorbiaceae 44\u003cbr\u003e \u003ci\u003eTzi Bun Ng and Jack Ho Wong\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 Non-toxic Type 2 Ribosome-inactivating Proteins 67\u003cbr\u003e \u003ci\u003ePilar Jiménez, Manuel José Gayoso, and Tomás Girbés\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 The Intracellular Journey of Type 2 Ribosome-inactivating Proteins 83\u003cbr\u003e \u003ci\u003eRobert A. Spooner and J. Michael Lord\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 Shiga Toxins: The Ribosome-inactivating Proteins from Pathogenic Bacteria 97\u003cbr\u003e \u003ci\u003eMaurizio Brigotti\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 The Structure and Action of Ribosome-inactivating Proteins 111\u003cbr\u003e \u003ci\u003eJon D. Robertus and Arthur F. Monzingo\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 Updated Model of the Molecular Evolution of RIP Genes 134\u003cbr\u003e \u003ci\u003eWilly J Peumans, Chenjing Shang, and Els J. M. Van Damme\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 Enzymology of the Ribosome-inactivating Proteins 151\u003cbr\u003e \u003ci\u003eYaeta Endo\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 A Long Journey to the Cytosol: What do We Know about Entry of Type 1 RIPs Inside a Mammalian Cell? 161\u003cbr\u003e \u003ci\u003eRodolfo Ippoliti and Maria Serena Fabbrini\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 Ribosome-inactivating Proteins: Pathology from Cells to Organs 178\u003cbr\u003e \u003ci\u003eGareth D. Griffiths\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13 Antiviral and Antifungal Properties of RIPs 198\u003cbr\u003e \u003ci\u003eGabriela Krivdova, Kira C. M. Neller, Bijal A. Parikh, and Katalin A. Hudak\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14 Insecticidal and Antifungal Activities of Ribosome-inactivating Proteins 212\u003cbr\u003e \u003ci\u003eLúcia Rosane Bertholdo Vargas and Célia Regina Carlini\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15 Immunology of RIPs and their Immunotoxins 223\u003cbr\u003e \u003ci\u003eGiulio Fracasso and Marco Colombatti\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16 Ribosome-inactivating Proteins in Cancer Treatment 244\u003cbr\u003e \u003ci\u003eDouglas A. Lappi and Fiorenzo Stirpe\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17 Nervous System Research with RIP Conjugates: From Determination of Function to Therapy 253\u003cbr\u003e \u003ci\u003eDouglas A. Lappi, Jack Feldman, Dale Sengelaub, and Jill McGaughy\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18 Embryotoxic and Abortifacient Activities of Ribosome-inactivating Proteins 270\u003cbr\u003e \u003ci\u003eWood Yee Chan, Jack Ho Wong, and Tzi Bun Ng\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e19 The Potential for Misuse of Ribosome-inactivating Proteins 281\u003cbr\u003e \u003ci\u003eGareth D. Griffiths\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eIndex 287\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eColor plates appear between pages 116 and 117\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eFiorenzo Stirpe\u003c\/b\u003e is Professor Emeritus at the Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Italy.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eDouglas A. Lappi\u003c\/b\u003e is the President and Chief Scientific Officer of Advanced Targeting Systems, USA.\u003c\/p\u003e \u003cp\u003eRibosome-inactivating proteins (RIPs) do as their name suggests: they inactivate the ribosomes crucial to protein synthesis at the cellular level, ultimately killing cells. While some are extremely toxic, ricin being the consummate example, most RIPs are not and have been found useful in a number of medical and research applications such as in cancer and neurological research.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eRibosome-Inactivating Proteins: Ricin and Related Proteins\u003c\/i\u003e provides up-to-date information on all aspects of this broad-ranging family of proteins. The text includes comprehensive coverage of RIPs, providing detail on their distribution in nature, chemical structure, genetics, and chemical and immunological properties. The book also describes mechanistic aspects, including the enzymatic activity on various polynucleotide substrates; the interaction with and entry into cells; the toxicity to animals, pathology of poisoning; and the immunomodulatory and allergenic activity.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eRibosome-Inactivating Proteins\u003c\/i\u003e: \u003ci\u003eRicin and Related Proteins\u003c\/i\u003e covers biological activities with potential applications in research in biology, medicine, and applied sciences; antiviral and insecticidal properties; and the conjugates of RIPs as immunotoxins and with other carriers capable of directing them toward specific target cells. Emphasis is given to the use of immunotoxins and other conjugates in clinical trials for the therapy of cancer and intractable pain. Finally, the possible uses of toxic RIPs for criminal uses and as biological weapons for warfare and terrorist attacks are summarized.\u003cbr\u003e\u003cbr\u003e\u003c\/p\u003e \u003cul\u003e \u003cli\u003eCovers the use of RIPs in human therapies, such as targeted tumor treatment and pain management.\u003c\/li\u003e \u003cli\u003eChapters on RIP activities as they relate to applications in research, agriculture, and medicine.\u003c\/li\u003e \u003cli\u003eIncludes chapters on RIP antiviral properties, insecticidal properties, and use in neuroscience research.\u003c\/li\u003e \u003cli\u003eDescribes the unique characteristics of RIPs in various plant families.\u003c\/li\u003e \u003cli\u003eConcluding section with a timely discussion of RIPs as bioweapons.\u003c\/li\u003e \u003c\/ul\u003e","brand":"Wiley-Blackwell","offers":[{"title":"Default Title","offer_id":47989964079333,"sku":"NP9781118125656","price":162.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781118125656.jpg?v=1761786051","url":"https:\/\/k12savings.com\/es\/products\/ribosome-inactivating-proteins-isbn-9781118125656","provider":"K12savings","version":"1.0","type":"link"}