{"product_id":"rethinking-cancer-isbn-9780262045216","title":"Rethinking Cancer","description":"\u003cb\u003eLeading scientists argue for a new paradigm for cancer research, proposing a complex systems view of cancer supported by empirical evidence.\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003eCurrent consensus in cancer research explains cancer as a disease caused by specific mutations in certain genes. After dramatic advances in genome sequencing, never before have we known so much about the individual cancer cell--and yet never before has it been so unclear what to do with this knowledge. In this volume, leading researchers argue for  a new theory framework for understanding and treating cancer. The contributors propose a complex systems view of cancer, presenting conceptual building blocks for a new research paradigm supported by empirical evidence.\u003cbr\u003e\u003cbr\u003eThe contributors first discuss the new research framework in terms of theoretical foundations and then take up the relevance of a systems approach, reviewing such topics as nonlinearity, recurrence after treatment, the cellular attractor concept, network theory, and non-coding DNA--the \"dark matter\" of our genome. They address the temporality of cancer progression, drawing on evolutionary theory and clinical experience. Finally, they cover the dominant role of the tissue microenvironment in cancer, analyzing topics including altered metabolic pathways, the disease-defining influence on metastasis, and the interconnectedness of different environmental niches across levels of organization.Series Foreword ix\u003cbr\u003ePreface xi\u003cbr\u003e1 Introduction and Overview 1\u003cbr\u003eI REDEFINING THE PROBLEM: THE THEORY DIMENSION OF CANCER 11 \u003cbr\u003e2 The Search for Progress and a New Theory Framework in Cancer Research 13\u003cbr\u003e3 Cancer as a System: Hard Lessons from Physics and a Way Forward 41\u003cbr\u003eII THE SYSTEMS DIMENSION OF CANCER 61 \u003cbr\u003e4 The Logic of Cancer Treatment: Why It Is So Hard to Cure Cancer; Treatment-Induced Progression, Hyper-Progression, and the Nietzsche Effect 63\u003cbr\u003e5 The Cell Attractor Concept as a Tool to Advance Our Understanding of Cancer 129\u003cbr\u003e6 Adaptation of Molecular Interaction Networks in Cancer Cells 141\u003cbr\u003e7 The Role of Genomic Dark Matter in Cancer: Using AI to Shine a Light on It; Why Cancer Genes Are Not the Whole Story 163\u003cbr\u003eIII THE TIME DIMENSION OF CANCER 185 \u003cbr\u003e8 Darwinism, Not Mutationalism, for New Cancer Therapies 187\u003cbr\u003e 9 Cancer as a Reversion to an Ancestral Phenotype 205\u003cbr\u003e10 Time and Timing in Oncology: What Therapy Scheduling Can Teach Us about Cancer Biology 227\u003cbr\u003eIV THE MICRO-\/ENVIRONMENT DIMENSION OF CANCER 245 \u003cbr\u003e11 Tissue Tension Modulates Metabolism and Chromatin Organization to Promote Malignancy 247\u003cbr\u003e12 Cancer Metabolism and Therapeutic Perspectives: Exploiting Acidic, Nutritional, and Oxidative Stresses 271\u003cbr\u003e13 Corrupted Vascular Tumor Niches Confer Aggressiveness and Chemoresistance to Neoplastic Cells 299\u003cbr\u003e14 Metastasis as a Tug of War between Cell Autonomy and Microenvironmental Control: Readdressing Unresolved Questions in Cancer Metastasis 323\u003cbr\u003e15 Niche Reconstruction to Revert or Transcend the Cancer State 353\u003cbr\u003eV WHAT NEXT? 391\u003cbr\u003eContributors 397 \u003cbr\u003eIndex 399Bernhard Strauss is Senior Research Associate at Cambridge University. Marta Bertolaso is Associate Professor of Philosophy of Science, Faculty of Engineering, University Campus Bio-Medico of Rome. Ingemar Ernberg leads the Ingemar Ernberg Group in the Department of Microbiology, Tumor, and Cell Biology at the Karolinska Institutet in Stockholm. Mina J. Bissell is Distinguished Scientist in the Biological Systems and Engineering Division at Lawrence Berkeley National Laboratory.","brand":"The MIT Press","offers":[{"title":"Default Title","offer_id":46301816783077,"sku":"NP9780262045216","price":60.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780262045216_0b68b427-f336-4a20-bdc3-b8d8411b4d88.jpg?v=1742925180","url":"https:\/\/k12savings.com\/es\/products\/rethinking-cancer-isbn-9780262045216","provider":"K12savings","version":"1.0","type":"link"}