{"product_id":"quantitative-molecular-pharmacology-and-informatics-in-drug-discovery-isbn-9780471988618","title":"Quantitative Molecular Pharmacology and Informatics in Drug Discovery","description":"Quantitative Molecular Pharmacology and Informatics in Drug Discovery Michael Lutz, Section Head, Cheminformatics Group and Terry Kenakin, Principal Research Scientist, Glaxo Wellcome Research and Development, Research Triangle Park, NC, USA Quantitative Molecular Pharmacology and Informatics in Drug Discovery combines pharmacology, genetics and statistics to provide a complete guide to the modern drug discovery process. The book discusses the pharmacology of drug testing and provides a detailed description of the statistical methods used to analyze the resulting data. Application of genetic and genomic tools for identification of biological targets is reviewed in the context of drug discovery projects. Covering both the theoretical principles upon which the techniques are based and the practicalities of drug discovery, this informative guide.\u003cbr\u003e * outlines in step-by-step detail the advantages and disadvantages of each technology and approach and links these to the type of chemical target being sought after in the drug discovery process; and,\u003cbr\u003e * provides excellent demonstrations of how to use powerful pharmacological and statistical tools to optimize high-throughput screening assays.\u003cbr\u003e Written by two internationally known and well-regarded experts, this book is an essential reference for research and development scientists working in the pharmaceutical and biotechnology industries. It will also be useful for postgraduates studying pharmacology and applied statistics.Der Informationsbedarf der pharmazeutischen Industrie ist ungewöhnlich komplex und kostspielig. Immer mehr Unternehmen nutzen die Informationstechnologie für Forschung und Versuchsprozesse, um Kosten zu senken, das Produkt schnell auf den Markt zu bringen und zu prognostizieren, ob sich das Produkt erfolgreich etabliert oder nicht. Diese Entwicklungen haben einen neuen Bereich hervorgebracht: Die Bioinformatik, eine Kombination aus Informationstechnologie, Informatik und Biochemie. Dieser Band vermittelt das nötige Hintergrundwissen zur quantitativen Molekularpharmakologie. Behandelt werden die jüngsten wissenschaftlichen und technischen Fortschritte, die neue Modelle für die pharmazeutische Forschung hervorgebracht haben. Ein unverzichtbarer Leitfaden für die Umsetzung dieser neuen Möglichkeiten. (10\/99)\u003cbr\u003e \u003cbr\u003e \u003cbr\u003e  Drug Discovery.\u003cbr\u003e \u003cbr\u003e Measurement of Drug Affinity.\u003cbr\u003e \u003cbr\u003e Efficacy.\u003cbr\u003e \u003cbr\u003e Pharmacological Assays Used in Screening for Therapeutic Ligands.\u003cbr\u003e \u003cbr\u003e Finding the Optimal Assay Format for the Chemical Target.\u003cbr\u003e \u003cbr\u003e Mathematical and Statistical Framework for Problems in Drug Discovery.\u003cbr\u003e \u003cbr\u003e Statistical Methods for Target Identification and Validation.\u003cbr\u003e \u003cbr\u003e Experimental Design.\u003cbr\u003e \u003cbr\u003e Analysis and Interpretation of Data.\u003cbr\u003e \u003cbr\u003e Index.  \"...a timely and important book...\" \"I recommend this book to pharmaceutical company statisticians...\"\u003cbr\u003e --Biometrics, September 2000  \u003cp\u003e\"...covers a tremendous amount of ground....I recommend this book to pharmaceutical statisticians...\"\u003cbr\u003e --Technometrics, 2000\u003c\/p\u003e  \u003cp\u003e\u003cstrong\u003eMichael Lutz\u003c\/strong\u003e is the author of \u003cem\u003eQuantitative Molecular Pharmacology and Informatics in Drug Discovery\u003c\/em\u003e, published by Wiley. \u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eTerry Kenakin\u003c\/strong\u003e is the author of \u003cem\u003eQuantitative Molecular Pharmacology and Informatics in Drug Discovery\u003c\/em\u003e, published by Wiley.   Quantitative Molecular Pharmacology and Informatics in Drug Discovery Michael Lutz, Section Head, Cheminformatics Group and Terry Kenakin, Principal Research Scientist, Glaxo Wellcome Research and Development, Research Triangle Park, NC, USA Quantitative Molecular Pharmacology and Informatics in Drug Discovery combines pharmacology, genetics and statistics to provide a complete guide to the modern drug discovery process. The book discusses the pharmacology of drug testing and provides a detailed description of the statistical methods used to analyze the resulting data. Application of genetic and genomic tools for identification of biological targets is reviewed in the context of drug discovery projects. Covering both the theoretical principles upon which the techniques are based and the practicalities of drug discovery, this informative guide.\u003cbr\u003e * outlines in step-by-step detail the advantages and disadvantages of each technology and approach and links these to the type of chemical target being sought after in the drug discovery process; and,\u003cbr\u003e * provides excellent demonstrations of how to use powerful pharmacological and statistical tools to optimize high-throughput screening assays.\u003cbr\u003e Written by two internationally known and well-regarded experts, this book is an essential reference for research and development scientists working in the pharmaceutical and biotechnology industries. It will also be useful for postgraduates studying pharmacology and applied statistics.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989896642789,"sku":"NP9780471988618","price":343.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780471988618.jpg?v=1761785831","url":"https:\/\/k12savings.com\/es\/products\/quantitative-molecular-pharmacology-and-informatics-in-drug-discovery-isbn-9780471988618","provider":"K12savings","version":"1.0","type":"link"}