Psychobiological Approaches for Anxiety Disorders

Psychobiological Approaches for Anxiety Disorders presents a comprehensive overview of the latest empirical evidence and research results on combining pharmacological agents and CBT techniques for the treatment of anxiety disorders.

• The first book to focus on the issue of enhancing CBT with pharmacological agents
• Features chapters from leading authors in the fields of psychiatry, pharmacology, clinical psychology, neuroscience, and emotion research
• Contributes significantly to the field by summarizing the contemporary research in combination treatments in anxiety disorders
• A valuable resource for clinicians in training, as well as experienced clinicians seeking to help patients with anxiety disorders

About the Contributors vii

About the Editor xi

Introduction 1
Stefan G. Hofmann

Chapter 1 The Biology and Efficacy of Combination Strategies for Anxiety Disorders 5
Keith A. Ganasen and Dan J. Stein

Chapter 2 Benzodiazepines 25
Bridget A. Hearon and Michael W. Otto

Chapter 3 Tricyclic Antidepressants and Monoamine Oxidase Inhibitors 41
Franklin R. Schneier

Chapter 4 Selective Serotonin Reuptake Inhibitors, Reversible Inhibitors of Monoamine Oxidase-A, and Buspirone 61
Borwin Bandelow, Markus Reitt, and Dirk Wedekind

Chapter 5 D-Cycloserine 75
Adam J. Guastella and Gail A. Alvares

Chapter 6 Yohimbine Hydrochloride 91
Samantha G. Farris, Michelle L. Davis, Lindsey B. DeBoer, Jasper A. J. Smits, and Mark B. Powers

Chapter 7 Cortisol 109
Leila Maria Soravia and Dominique J.-F. de Quervain

Chapter 8 Oxytocin 123
Markus Heinrichs, Frances S. Chen, and Gregor Domes

Chapter 9 Dietary Supplements 145
Lindsey B. DeBoer, Michelle L. Davis, Mark B. Powers, and Jasper A. J. Smits

Chapter 10 A Roadmap for the Research and Practice of Combination Strategies 181
Stefan G. Hofmann

Index 195

Stefan G. Hofmann is Professor of Psychology at Boston University and the Director of the Psychotherapy and Emotion Research Laboratory. The incoming President of the Association for Behavioral and Cognitive Therapies, he is widely published with more than 200 peer-reviewed journal articles and book chapters, and 10 books, including An Introduction to Modern CBT (2011, Wiley-Blackwell). Traditional anti-anxiety medications and cognitive behavioral therapy (CBT) are popular treatments for clients suffering from a wide range of anxiety disorders. However, there is a clear need for improved efficacy of these approaches, either when administered as mono-therapies or in combination. A promising contemporary approach to combination therapy is to enhance the mechanism of CBT utilizing pharmacological agents.

Psychobiological Approaches for Anxiety Disorders represents the first work to offer a comprehensive overview of the latest empirical evidence and research results on conventional and novel combination therapies for the treatment of anxiety disorders. Leading experts in neuroscience, psychiatry, psychopharmacology, emotion research, and psychotherapy address the evidence for and against combining pharmacological agents with CBT for the treatment of anxiety disorders, and outline the most promising future approaches. The result is an invaluable resource for clinicians and researchers alike.