{"product_id":"principles-of-genetics-isbn-9781119142287","title":"Principles of Genetics","description":"\u003cb\u003e\u003ci\u003ePrinciples of Genetics\u003c\/i\u003e\u003c\/b\u003e is one of the most popular texts in use for the introductory course. It opens a window on the rapidly advancing science of genetics by showing exactly how genetics is done. Throughout, the authors incorporate a human emphasis and highlight the role of geneticists to keep students interested and motivated. The seventh edition has been completely updated to reflect the latest developments in the field of genetics. Principles of Genetics continues to educate today’s students for tomorrows science by focusing on features that aid in content comprehension and application. This text is an unbound, three hole punched version. \u003cp\u003e\u003cb\u003eChapter 1 : The Science of Genetics 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eThe Personal Genome 1\u003c\/p\u003e \u003cp\u003ean Invitation 2\u003c\/p\u003e \u003cp\u003eThree Great Milestones in Genetics 2\u003c\/p\u003e \u003cp\u003eMendel: Genes And The Rules Of Inheritance 2\u003c\/p\u003e \u003cp\u003eWatson And Crick: The Structure Of DNA 3\u003c\/p\u003e \u003cp\u003eThe Human Genome Project: Sequencing DNA And Cataloging Genes 4\u003c\/p\u003e \u003cp\u003eDNA as the Genetic Material 6\u003c\/p\u003e \u003cp\u003eDNA Replication: Propagating Genetic Information 6\u003c\/p\u003e \u003cp\u003eGene Expression: Using Genetic Information 7\u003c\/p\u003e \u003cp\u003eMutation: Changing Genetic Information 9\u003c\/p\u003e \u003cp\u003eGenetics and Evolution 10\u003c\/p\u003e \u003cp\u003eLevels of Genetic analysis 11\u003c\/p\u003e \u003cp\u003eClassical Genetics 11\u003c\/p\u003e \u003cp\u003eMolecular Genetics 11\u003c\/p\u003e \u003cp\u003ePopulation Genetics 12\u003c\/p\u003e \u003cp\u003eGenetics in the World: applications of Genetics to human Endeavors 12\u003c\/p\u003e \u003cp\u003eGenetics In Agriculture 12\u003c\/p\u003e \u003cp\u003eGenetics In Medicine 14\u003c\/p\u003e \u003cp\u003eGenetics In Society 15\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 2 : Cellular Reproduction 18\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eDolly 18\u003c\/p\u003e \u003cp\u003eCells and Chromosomes 19\u003c\/p\u003e \u003cp\u003eThe Cellular Environment 19\u003c\/p\u003e \u003cp\u003eProkaryotic And Eukaryotic Cells 20\u003c\/p\u003e \u003cp\u003eChromosomes: Where Genes Are Located 20\u003c\/p\u003e \u003cp\u003eCell Division 23\u003c\/p\u003e \u003cp\u003eMitosis 24\u003c\/p\u003e \u003cp\u003eMeiosis 27\u003c\/p\u003e \u003cp\u003eMeiosis: An Overview 27\u003c\/p\u003e \u003cp\u003eMeiosis I 27\u003c\/p\u003e \u003cp\u003eSolve It : how Much DNA in human Meiotic Cells 27\u003c\/p\u003e \u003cp\u003eMeiosis II And The Outcomes Of Meiosis 31\u003c\/p\u003e \u003cp\u003eSolve It : How Many Chromosome Combinations in Sperm 31\u003c\/p\u003e \u003cp\u003eLife Cycles of Some Model Genetic Organisms 32\u003c\/p\u003e \u003cp\u003eSaccharomyces Cerevisiae, Baker’s Yeast 32\u003c\/p\u003e \u003cp\u003eArabidopsis Thaliana, A Flowering Plant 33\u003c\/p\u003e \u003cp\u003eMus Musculus, The Mouse 34\u003c\/p\u003e \u003cp\u003eProblem-Solving Skills Counting\u003c\/p\u003e \u003cp\u003eChromosomes and Chromatids 36\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 3 : Mendelism: The Basic Principles of Inheritance 40\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eThe Birth of Genetics: A Scientific Revolution 40\u003c\/p\u003e \u003cp\u003eMendel’s Study of heredity 41\u003c\/p\u003e \u003cp\u003eMendel’s Experimental Organism, The Garden Pea 41\u003c\/p\u003e \u003cp\u003eMonohybrid Crosses: The Principles of Dominance And Segregation 42\u003c\/p\u003e \u003cp\u003eDihybrid Crosses: The Principle of Independent Assortment 44\u003c\/p\u003e \u003cp\u003eApplications of Mendel’s principles 46\u003c\/p\u003e \u003cp\u003eThe Punnett Square Method 46\u003c\/p\u003e \u003cp\u003eThe Forked-Line Method 46\u003c\/p\u003e \u003cp\u003eThe Probability Method 47\u003c\/p\u003e \u003cp\u003eSolve It : Using probabilities in a Genetic problem 48\u003c\/p\u003e \u003cp\u003eTesting Genetic hypotheses 48\u003c\/p\u003e \u003cp\u003eTwo Examples: Data From Mendel And Devries 49\u003c\/p\u003e \u003cp\u003eThe Chi-Square Test 49\u003c\/p\u003e \u003cp\u003eSolve It : Using the Chi-Square test 52\u003c\/p\u003e \u003cp\u003eMendelian principles in human Genetics 52\u003c\/p\u003e \u003cp\u003ePedigrees 53\u003c\/p\u003e \u003cp\u003eMendelian Segregation In Human Families 54\u003c\/p\u003e \u003cp\u003eGenetic Counseling 54\u003c\/p\u003e \u003cp\u003eProblem-Solving Skills Making Predictions From Pedigrees 56\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 4 : Extensions of Mendelism 62\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eGenetics Grows beyond Mendel’s Monastery Garden 62\u003c\/p\u003e \u003cp\u003eAllelic Variation and Gene Function 63\u003c\/p\u003e \u003cp\u003eIncomplete Dominance and Codominance 63\u003c\/p\u003e \u003cp\u003eMultiple Alleles 64\u003c\/p\u003e \u003cp\u003eAllelic Series 65\u003c\/p\u003e \u003cp\u003eTesting Gene Mutations for Allelism 65\u003c\/p\u003e \u003cp\u003eSolve It:The Test for Allelism 66\u003c\/p\u003e \u003cp\u003eVariation among the Effects of Mutations 66\u003c\/p\u003e \u003cp\u003eGenes Function to Produce Polypeptides 67\u003c\/p\u003e \u003cp\u003eWhy Are Some Mutations Dominant and Others Recessive? 68\u003c\/p\u003e \u003cp\u003eGene Action: From Genotype to Phenotype 69\u003c\/p\u003e \u003cp\u003eInfluence of the Environment 69\u003c\/p\u003e \u003cp\u003eEnvironmental Effects on the Expression of Human Genes 70\u003c\/p\u003e \u003cp\u003ePenetrance and Expressivity 70\u003c\/p\u003e \u003cp\u003eGene Interactions 71\u003c\/p\u003e \u003cp\u003eEpistasis 71\u003c\/p\u003e \u003cp\u003eEpistasis and Genetic Pathways 72\u003c\/p\u003e \u003cp\u003ePleiotropy 74\u003c\/p\u003e \u003cp\u003eProblem-Solving Skills Going from Pathways to Phenotypic Ratios 75\u003c\/p\u003e \u003cp\u003eInbreeding: Another Look at Pedigrees 76\u003c\/p\u003e \u003cp\u003eThe Effects of Inbreeding 76\u003c\/p\u003e \u003cp\u003eGenetic Analysis of Inbreeding 77\u003c\/p\u003e \u003cp\u003eUses Of The Inbreeding Coefficient 80\u003c\/p\u003e \u003cp\u003eSolve It : Compound Inbreeding 80\u003c\/p\u003e \u003cp\u003eMeasuring Genetic Relationships 81\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 5 : The Chromosomal Basis of Mendelism 88\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eSex, Chromosomes, and Genes 88\u003c\/p\u003e \u003cp\u003eChromosomes 89\u003c\/p\u003e \u003cp\u003eChromosome Number 89\u003c\/p\u003e \u003cp\u003eSex Chromosomes 89\u003c\/p\u003e \u003cp\u003eThe Chromosome Theory of Heredity 91\u003c\/p\u003e \u003cp\u003eExperimental Evidence Linking the Inheritance of Genes to Chromosomes 91\u003c\/p\u003e \u003cp\u003eNondisjunction as Proof of the Chromosome Theory 92\u003c\/p\u003e \u003cp\u003eThe Chromosomal Basis of Mendel’s Principles of Segregation and Independent Assortment 94\u003c\/p\u003e \u003cp\u003eSolve It : Sex Chromosome Nondisjunction 94\u003c\/p\u003e \u003cp\u003eProblem-Solving Skills Tracking X-Linked and Autosomal Inheritance 96\u003c\/p\u003e \u003cp\u003eSex-Linked Genes in Humans 97\u003c\/p\u003e \u003cp\u003eHemophilia, an X-Linked Blood-Clotting Disorder 97\u003c\/p\u003e \u003cp\u003eColor Blindness, an X-Linked Vision Disorder 97\u003c\/p\u003e \u003cp\u003eGenes on the Human Y Chromosome 99\u003c\/p\u003e \u003cp\u003eGenes on Both the X and Y Chromosomes 99\u003c\/p\u003e \u003cp\u003eSOLVE IT Calculating the Risk for Hemophilia 99\u003c\/p\u003e \u003cp\u003eSex Chromosomes and Sex Determination 99\u003c\/p\u003e \u003cp\u003eSex Determination in Humans 100\u003c\/p\u003e \u003cp\u003eSex Determination in Drosophila 101\u003c\/p\u003e \u003cp\u003eSex Determination in Other Animals 101\u003c\/p\u003e \u003cp\u003eDosage Compensation of X-Linked Genes 103\u003c\/p\u003e \u003cp\u003eHyperactivation of X-linked Genes in Male Drosophila 103\u003c\/p\u003e \u003cp\u003eInactivation of X-linked Genes in Female Mammals 103\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 6 : Variation in Chromosome Number and Structure 109\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eChromosomes, Agriculture, and Civilization 109\u003c\/p\u003e \u003cp\u003eCytological Techniques 110\u003c\/p\u003e \u003cp\u003eAnalysis of Mitotic Chromosomes 110\u003c\/p\u003e \u003cp\u003eThe Human Karyotype 112\u003c\/p\u003e \u003cp\u003eCytogenetic Variation: An Overview 113\u003c\/p\u003e \u003cp\u003ePolyploidy 114\u003c\/p\u003e \u003cp\u003eSterile Polyploids 114\u003c\/p\u003e \u003cp\u003eFertile Polyploids 115\u003c\/p\u003e \u003cp\u003eTissue-Specific Polyploidy and Polyteny 116\u003c\/p\u003e \u003cp\u003eSolve It : Chromosome Pairing in Polyploids 116\u003c\/p\u003e \u003cp\u003eAneuploidy 118\u003c\/p\u003e \u003cp\u003eTrisomy in Humans 119\u003c\/p\u003e \u003cp\u003eMonosomy 120\u003c\/p\u003e \u003cp\u003eProblem-Solving Skills : Tracing Sex Chromosome Nondisjunction 122\u003c\/p\u003e \u003cp\u003eDeletions and Duplications of Chromosome Segments 122\u003c\/p\u003e \u003cp\u003eRearrangements of Chromosome Structure 124\u003c\/p\u003e \u003cp\u003eInversions 124\u003c\/p\u003e \u003cp\u003eTranslocations 125\u003c\/p\u003e \u003cp\u003eCompound Chromosomes and Robertsonian Translocations 126\u003c\/p\u003e \u003cp\u003eSolve It : Pollen Abortion in Translocation Heterozygotes 127\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 7 : Linkage, Crossing Over, and Chromosome Mapping in Eukaryotes 133\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eThe World’s First Chromosome Map 133\u003c\/p\u003e \u003cp\u003eLinkage, Recombination, and Crossing Over 134\u003c\/p\u003e \u003cp\u003eEarly Evidence for Linkage and Recombination 134\u003c\/p\u003e \u003cp\u003eCrossing Over as the Physical Basis of Recombination 136\u003c\/p\u003e \u003cp\u003eEvidence That Crossing Over Causes Recombination 137\u003c\/p\u003e \u003cp\u003eChiasmata and the Time of Crossing Over 138\u003c\/p\u003e \u003cp\u003eChromosome Mapping 139\u003c\/p\u003e \u003cp\u003eCrossing Over as a Measure of Genetic Distance 139\u003c\/p\u003e \u003cp\u003eRecombination Mapping with a Two-Point Testcross 140\u003c\/p\u003e \u003cp\u003eRecombination Mapping with a Three-Point Testcross 140\u003c\/p\u003e \u003cp\u003eSolve It : Mapping Two Genes with Testcross Data 141\u003c\/p\u003e \u003cp\u003eProblem-Solving Skills Using a Genetic Map to Predict the Outcome of a Cross 144\u003c\/p\u003e \u003cp\u003eRecombination Frequency and Genetic Map Distance 144\u003c\/p\u003e \u003cp\u003eCytogenetic Mapping 146\u003c\/p\u003e \u003cp\u003eLocalizing Genes Using Deletions and Duplications 146\u003c\/p\u003e \u003cp\u003eGenetic Distance and Physical Distance 147\u003c\/p\u003e \u003cp\u003eSolve It : Cytological Mapping of a Drosophila Gene 148\u003c\/p\u003e \u003cp\u003eLinkage Analysis in Humans 148\u003c\/p\u003e \u003cp\u003eAn Example: Linkage Between Blood Groups\u003c\/p\u003e \u003cp\u003eAnd The Nail-Patella Syndrome 149\u003c\/p\u003e \u003cp\u003eDetecting Linkage With Molecular Markers 150\u003c\/p\u003e \u003cp\u003eRecombination and Evolution 151\u003c\/p\u003e \u003cp\u003eEvolutionary Significance of Recombination 151\u003c\/p\u003e \u003cp\u003eSuppression of Recombination by Inversions 152\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 8 : The Genetics of Bacteria and Their Viruses 161\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eMulti - Drug-Resistant Bacteria: A Ticking Timebomb? 161\u003c\/p\u003e \u003cp\u003eViruses and Bacteria in Genetics 162\u003c\/p\u003e \u003cp\u003eThe Genetics of Viruses 163\u003c\/p\u003e \u003cp\u003eBacteriophage T4 163\u003c\/p\u003e \u003cp\u003eBacteriophage Lambda 164\u003c\/p\u003e \u003cp\u003eThe Genetics of Bacteria 167\u003c\/p\u003e \u003cp\u003eMutant Genes in Bacteria 168\u003c\/p\u003e \u003cp\u003eUnidirectional Gene Transfer in Bacteria 169\u003c\/p\u003e \u003cp\u003eMechanisms of Genetic Exchange in Bacteria 170\u003c\/p\u003e \u003cp\u003eTransformation 171\u003c\/p\u003e \u003cp\u003eMechanism Of Transformation 172\u003c\/p\u003e \u003cp\u003eConjugation 173\u003c\/p\u003e \u003cp\u003eUsing Conjugation To Map E. Coli Genes 175\u003c\/p\u003e \u003cp\u003ePlasmids and Episomes 177\u003c\/p\u003e \u003cp\u003eProblem-Solving Skills Mapping Genes Using Conjugation Data 178\u003c\/p\u003e \u003cp\u003eF Factors and Sexduction 179\u003c\/p\u003e \u003cp\u003eTransduction 180\u003c\/p\u003e \u003cp\u003eSolve It : How Can You Map Closely Linked Genes  Using Partial Diploids? 181\u003c\/p\u003e \u003cp\u003eEvolutionary Significance Of Genetic Exchange In Bacteria 183\u003c\/p\u003e \u003cp\u003eSolve It : How Do Bacterial Genomes Evolve? 183\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 9 : DNA and the Molecular Structure of Chromosomes 189\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eDiscovery of Nuclein 189\u003c\/p\u003e \u003cp\u003eProof That Genetic Information Is Stored in DNA and RNA 190\u003c\/p\u003e \u003cp\u003eProof That DNA Mediates Transformation 190\u003c\/p\u003e \u003cp\u003eProof That DNA Carries the Genetic Information in Bacteriophage T2 191\u003c\/p\u003e \u003cp\u003eProof That RNA Stores the Genetic Information in Some Viruses 193\u003c\/p\u003e \u003cp\u003eThe Structures of DNA and Rna 194\u003c\/p\u003e \u003cp\u003eNature of the Chemical Subunits in DNA and RNA 194\u003c\/p\u003e \u003cp\u003eDNA Structure: The Double Helix 195\u003c\/p\u003e \u003cp\u003eProblem-Solving Skills Calculating base Content in DNA 199\u003c\/p\u003e \u003cp\u003eDNA Structure: Alternate Forms of the Double Helix 199\u003c\/p\u003e \u003cp\u003eSolve It : What Are Some Important Features of Double-Stranded DNA? 200\u003c\/p\u003e \u003cp\u003eDNA Structure: Negative Supercoils In Vivo 200\u003c\/p\u003e \u003cp\u003eChromosome Structure in Viruses and Prokaryotes 201\u003c\/p\u003e \u003cp\u003eChromosome Structure in Eukaryotes 203\u003c\/p\u003e \u003cp\u003eChemical Composition of Eukaryotic Chromosomes 203\u003c\/p\u003e \u003cp\u003eOne Large DNA Molecule per Chromosome 204\u003c\/p\u003e \u003cp\u003eNucleosomes 205\u003c\/p\u003e \u003cp\u003ePackaging Of Chromatin In Eukaryotic Chromosomes 207\u003c\/p\u003e \u003cp\u003eSolve It : How Many Nucleosomes in One Human X Chromosome? 207\u003c\/p\u003e \u003cp\u003eSpecial Features of Eukaryotic Chromosomes 208\u003c\/p\u003e \u003cp\u003eComplexity Of DNA In Chromosomes: Unique And Repetitive Sequences 209\u003c\/p\u003e \u003cp\u003eCentromeres 211\u003c\/p\u003e \u003cp\u003eTelomeres 211\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 10 : Replication of DNA and Chromosomes 217\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eMonozygotic Twins: Are They Identical? 217\u003c\/p\u003e \u003cp\u003eBasic Features of DNA Replication In Vivo 218\u003c\/p\u003e \u003cp\u003eSemiconservative Replication Of DNA Molecules 218\u003c\/p\u003e \u003cp\u003eSemi conservative replication of eukaryotic chromosomes 220\u003c\/p\u003e \u003cp\u003eOrigins of Replication 221\u003c\/p\u003e \u003cp\u003eSolve It : Semiconservative Replication of DNA 221\u003c\/p\u003e \u003cp\u003eProblem-Solving Skills Predicting Patterns of 3 H Labeling in Chromosomes 223\u003c\/p\u003e \u003cp\u003eReplication Forks 224\u003c\/p\u003e \u003cp\u003eBidirectional Replication 225\u003c\/p\u003e \u003cp\u003eDNA Replication in Prokaryotes 228\u003c\/p\u003e \u003cp\u003eContinuous Synthesis of One Strand; Discontinuous Synthesis of the Other Strand 228\u003c\/p\u003e \u003cp\u003eCovalent Closure of Nicks in DNA by DNA Ligase 229\u003c\/p\u003e \u003cp\u003eInitiation of DNA Replication 230\u003c\/p\u003e \u003cp\u003eInitiation of DNA Chains with RNA Primers 230\u003c\/p\u003e \u003cp\u003eUnwinding DNA with Helicases, DNA-Binding Proteins, and Topoisomerases 232\u003c\/p\u003e \u003cp\u003eMultiple DNA Polymerases 235\u003c\/p\u003e \u003cp\u003eProofreading 237\u003c\/p\u003e \u003cp\u003eThe Primosome and the Replisome 238\u003c\/p\u003e \u003cp\u003eRolling-Circle Replication 240\u003c\/p\u003e \u003cp\u003eUnique Aspects of Eukaryotic Chromosome Replication 241\u003c\/p\u003e \u003cp\u003eThe Cell Cycle 241\u003c\/p\u003e \u003cp\u003eMultiple Replicons per Chromosome 241\u003c\/p\u003e \u003cp\u003eTwo or More DNA Polymerases at a Single Replication Fork 242\u003c\/p\u003e \u003cp\u003eSolve It : Understanding Replication of the Human X Chromosome 243\u003c\/p\u003e \u003cp\u003eDuplication of Nucleosomes at Replication Forks 243\u003c\/p\u003e \u003cp\u003eTelomerase: Replication of Chromosome Termini 244\u003c\/p\u003e \u003cp\u003eTelomere Length and Aging in Humans 245\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 11 : Transcription and RNA Processing 252\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eStorage and Transmission of Information with Simple Codes 252\u003c\/p\u003e \u003cp\u003eTransfer of Genetic Information: The Central Dogma 253\u003c\/p\u003e \u003cp\u003eTranscription and Translation 253\u003c\/p\u003e \u003cp\u003eFive Types of RNA Molecules 254\u003c\/p\u003e \u003cp\u003eThe Process of Gene Expression 255\u003c\/p\u003e \u003cp\u003eAn mRNA Intermediary 255\u003c\/p\u003e \u003cp\u003eGeneral Features of RNA Synthesis 257\u003c\/p\u003e \u003cp\u003eProblem-Solving Skills Distinguishing RNAs Transcribed from Viral and Host DNAs 258\u003c\/p\u003e \u003cp\u003eTranscription in Prokaryotes 259\u003c\/p\u003e \u003cp\u003eRNA Polymerases: Complex Enzymes 259\u003c\/p\u003e \u003cp\u003eInitiation of RNA Chains 260\u003c\/p\u003e \u003cp\u003eElongation of RNA Chains 260\u003c\/p\u003e \u003cp\u003eTermination of RNA Chains 261\u003c\/p\u003e \u003cp\u003eConcurrent Transcription, Translation, and mRNA Degradation 262\u003c\/p\u003e \u003cp\u003eTranscription and RNA Processing in Eukaryotes 263\u003c\/p\u003e \u003cp\u003eFive RNA Polymerases\/Five Sets of Genes 263\u003c\/p\u003e \u003cp\u003eInitiation of RNA Chains 265\u003c\/p\u003e \u003cp\u003eSolve It : Initiation of Transcription by RNA Polymerase II in Eukaryotes 265\u003c\/p\u003e \u003cp\u003eRNA Chain Elongation and the Addition of 5 Methyl Guanosine Caps 266\u003c\/p\u003e \u003cp\u003eTermination by Chain Cleavage and the Addition of 3 Poly(A) Tails 267\u003c\/p\u003e \u003cp\u003eSolve It : Formation of the 3 -Terminus of an RNA Polymerase II Transcript 268\u003c\/p\u003e \u003cp\u003eRNA Editing: Altering the Information Content of mRNA Molecules 268\u003c\/p\u003e \u003cp\u003eInterrupted Genes in Eukaryotes: Exons and Introns 269\u003c\/p\u003e \u003cp\u003eEvidence For Introns 270\u003c\/p\u003e \u003cp\u003eSome Very Large Eukaryotic Genes 271\u003c\/p\u003e \u003cp\u003eIntrons: Biological Significance? 271\u003c\/p\u003e \u003cp\u003eRemoval of Intron Sequences by RNA Splicing 272\u003c\/p\u003e \u003cp\u003eSequence Signals For RNA Splicing 272\u003c\/p\u003e \u003cp\u003etRNA Precursor Splicing: Unique Nuclease and Ligase Activities 273\u003c\/p\u003e \u003cp\u003eAutocatalytic Splicing 273\u003c\/p\u003e \u003cp\u003ePre-mRNA Splicing: snRNAs, snRNPs, and the spliceosome 274\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 12 : Translation and the Genetic Code 280\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eSickle - Cell Anemia : Devastating Effects of a Single Amino Acid Change 280\u003c\/p\u003e \u003cp\u003eProtein Structure 281\u003c\/p\u003e \u003cp\u003ePolypeptides: Twenty Different Amino Acid Subunits 281\u003c\/p\u003e \u003cp\u003eProteins: Complex Three-Dimensional Structures 281\u003c\/p\u003e \u003cp\u003eGenes Encode Polypeptides 284\u003c\/p\u003e \u003cp\u003eBeadle and Tatum: One Gene–One Enzyme 284\u003c\/p\u003e \u003cp\u003eCrick and Colleagues: Each Amino Acid In A Polypeptide Is Specified By Three Nucleotides 286\u003c\/p\u003e \u003cp\u003eThe Components of Polypeptide Synthesis 289\u003c\/p\u003e \u003cp\u003eOverview Of Gene Expression 289\u003c\/p\u003e \u003cp\u003eRibosomes 290\u003c\/p\u003e \u003cp\u003eTransfer RNAs 292\u003c\/p\u003e \u003cp\u003eThe Process of Polypeptide Synthesis 294\u003c\/p\u003e \u003cp\u003ePolypeptide Chain Initiation 294\u003c\/p\u003e \u003cp\u003ePolypeptide Chain Elongation 298\u003c\/p\u003e \u003cp\u003ePolypeptide Chain Termination 300\u003c\/p\u003e \u003cp\u003eSolve It : Control of Translation in Eukaryotes 300\u003c\/p\u003e \u003cp\u003eThe Genetic Code 302\u003c\/p\u003e \u003cp\u003eProperties of the Genetic Code 302\u003c\/p\u003e \u003cp\u003eDeciphering the Code 302\u003c\/p\u003e \u003cp\u003eInitiation and Termination Codons 303\u003c\/p\u003e \u003cp\u003eA Degenerate and Ordered Code 303\u003c\/p\u003e \u003cp\u003eA Nearly Universal Code 305\u003c\/p\u003e \u003cp\u003eProblem-Solving Skills Predicting Amino Acid Substitutions Induced by Mutagens 305\u003c\/p\u003e \u003cp\u003eCodon-tRNA Interactions 306\u003c\/p\u003e \u003cp\u003eRecognition of Codons by tRNAs: The Wobble Hypothesis 306\u003c\/p\u003e \u003cp\u003eSuppressor Mutations That Produce tRNAs with Altered Codon Recognition 307\u003c\/p\u003e \u003cp\u003eSolve It : Effects of Base-Pair Substitutions in the Coding Region of the HBB Gene 308\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 13 : Mutation, DNA Repair, and Recombination 313\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eXeroderma Pigmentosum : Defective Repair of Damaged DNA in Humans 313\u003c\/p\u003e \u003cp\u003eMutation 314\u003c\/p\u003e \u003cp\u003eSomatic and Germinal Mutations 314\u003c\/p\u003e \u003cp\u003eSpontaneous and Induced Mutations 314\u003c\/p\u003e \u003cp\u003eForward And Reverse Mutations 315\u003c\/p\u003e \u003cp\u003eUsually Deleterious and Recessive 315\u003c\/p\u003e \u003cp\u003eThe Molecular Basis of Mutation 317\u003c\/p\u003e \u003cp\u003eSingle Base-Pair Changes And Frameshift Mutations 317\u003c\/p\u003e \u003cp\u003eSolve It : Nucleotide-Pair Substitutions in the Human HBB Gene 318\u003c\/p\u003e \u003cp\u003eTransposon Insertion Mutations 318\u003c\/p\u003e \u003cp\u003eMutations Caused By Expanding Trinucleotide Repeats 319\u003c\/p\u003e \u003cp\u003eMutagenesis 320\u003c\/p\u003e \u003cp\u003eMuller’s Demonstration That Mutations Can Be\u003c\/p\u003e \u003cp\u003eInduced With X-Rays 320\u003c\/p\u003e \u003cp\u003eInducing Mutations With Radiation 321\u003c\/p\u003e \u003cp\u003eInducing Mutations With Chemicals 323\u003c\/p\u003e \u003cp\u003eScreening Chemicals For Mutagenicity: The Ames Test 326\u003c\/p\u003e \u003cp\u003eProblem-Solving Skills Predicting Amino Acid\u003c\/p\u003e \u003cp\u003eChanges Induced by Chemical Mutagens 327\u003c\/p\u003e \u003cp\u003eAssigning Mutations to Genes by the\u003c\/p\u003e \u003cp\u003eComplementation Test 329\u003c\/p\u003e \u003cp\u003eLewis’s Test For Allelism 329\u003c\/p\u003e \u003cp\u003eApplying The Complementation Test: An Example 331\u003c\/p\u003e \u003cp\u003eSolve It : How Can You Assign Mutations to Genes? 331\u003c\/p\u003e \u003cp\u003eDNA Repair Mechanisms 333\u003c\/p\u003e \u003cp\u003eLight-Dependent Repair 333\u003c\/p\u003e \u003cp\u003eExcision Repair 333\u003c\/p\u003e \u003cp\u003eOther DNA Repair Mechanisms 334\u003c\/p\u003e \u003cp\u003eInherited Human Diseases With Defects\u003c\/p\u003e \u003cp\u003eIn DNA Repair 336\u003c\/p\u003e \u003cp\u003eDNA Recombination Mechanisms 338\u003c\/p\u003e \u003cp\u003eRecombination: Cleavage and Rejoining of DNA Molecules 338\u003c\/p\u003e \u003cp\u003eGene Conversion: DNA Repair Synthesis Associated with Recombination 341\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 14 : The Techniques of Molecular Genetics 350\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eTreatment of Pituitary Dwarfism with Human Growth Hormone 350\u003c\/p\u003e \u003cp\u003eBasic Techniques Used to Identify, Amplify, and Clone Genes 351\u003c\/p\u003e \u003cp\u003eDNA Cloning: An Overview 351\u003c\/p\u003e \u003cp\u003eRestriction Endonucleases 351\u003c\/p\u003e \u003cp\u003eSolve It : How Many NotI Restriction Fragments in Chimpanzee DNA? 354\u003c\/p\u003e \u003cp\u003eProducing Recombinant DNA Molecules In Vitro 354\u003c\/p\u003e \u003cp\u003eAmplification of Recombinant DNA Molecules in Cloning Vectors 354\u003c\/p\u003e \u003cp\u003eCloning Large Genes and Segments of Genomes in BACs, PACs, and YACs 357\u003c\/p\u003e \u003cp\u003eAmplification of DNA Sequences by the Polymerase Chain Reaction (PCR) 358\u003c\/p\u003e \u003cp\u003eConstruction and Screening of DNA Libraries 360\u003c\/p\u003e \u003cp\u003eConstruction of Genomic Libraries 360\u003c\/p\u003e \u003cp\u003eConstruction of cDNA Libraries 361\u003c\/p\u003e \u003cp\u003eScreening DNA Libraries for Genes of Interest 361\u003c\/p\u003e \u003cp\u003eSolve It How Can You Clone a Specific NotI Restriction Fragment from the Orangutan Genome? 363\u003c\/p\u003e \u003cp\u003eThe Molecular Analysis of DNA, RNA, and Protein 364\u003c\/p\u003e \u003cp\u003eAnalysis of DNAs by Southern Blot Hybridizations 364\u003c\/p\u003e \u003cp\u003eAnalysis of RNAs by Northern Blot Hybridizations 365\u003c\/p\u003e \u003cp\u003eAnalysis of RNAs by Reverse Transcriptase-PCR (RT-PCR) 366\u003c\/p\u003e \u003cp\u003eAnalysis of Proteins by Western Blot Techniques 368\u003c\/p\u003e \u003cp\u003eThe Molecular Analysis of Genes and Chromosomes 368\u003c\/p\u003e \u003cp\u003ePhysical Maps of DNA Molecules Based on Restriction Enzyme Cleavage Sites 369\u003c\/p\u003e \u003cp\u003eNucleotide Sequences of Genes and Chromosomes 370\u003c\/p\u003e \u003cp\u003eProblem-Solving Skills Determining the Nucleotide Sequences of Genetic Elements 373\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 15 : Genomics 379\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eGenomes from Denisova Cave 379\u003c\/p\u003e \u003cp\u003eGenomics: An Overview 380\u003c\/p\u003e \u003cp\u003eThe Scope Of Genomics 380\u003c\/p\u003e \u003cp\u003eGenomics Databases 380\u003c\/p\u003e \u003cp\u003eProblem-Solving Skills Using Bioinformatics to Investigate DNA Sequences 382\u003c\/p\u003e \u003cp\u003eCorrelated Genetic, Cytological, and Physical Maps of Chromosomes 382\u003c\/p\u003e \u003cp\u003eGenetic, Cytological, and Physical Maps 383\u003c\/p\u003e \u003cp\u003eHigh-Density Genetic Maps of Molecular Markers 384\u003c\/p\u003e \u003cp\u003eContig Maps And Clone Banks 385\u003c\/p\u003e \u003cp\u003eMap-Based Cloning Of Genes 387\u003c\/p\u003e \u003cp\u003eThe Human Genome Project 387\u003c\/p\u003e \u003cp\u003eMapping The Human Genome 388\u003c\/p\u003e \u003cp\u003eSequencing The Human Genome 388\u003c\/p\u003e \u003cp\u003eGeneral Features Of The Human Genome 390\u003c\/p\u003e \u003cp\u003eRepeated Sequences In The Human Genome 390\u003c\/p\u003e \u003cp\u003eGenes In The Human Genome 391\u003c\/p\u003e \u003cp\u003eSolve It : What Can You Learn about DNA Sequences Using Bioinformatics? 392\u003c\/p\u003e \u003cp\u003eSingle-Nucleotide Polymorphisms And The Human Hapmap Project 395\u003c\/p\u003e \u003cp\u003eRNA and Protein Assays of Genome Functions 397\u003c\/p\u003e \u003cp\u003eMicroarrays And Gene Chips 397\u003c\/p\u003e \u003cp\u003eThe Green Fluorescent Protein As A Reporter Of Protein Presence 400\u003c\/p\u003e \u003cp\u003eGenome Diversity and Evolution 401\u003c\/p\u003e \u003cp\u003eProkaryotic Genomes 401\u003c\/p\u003e \u003cp\u003eA Living Bacterium With A Chemically Synthesized Genome 403\u003c\/p\u003e \u003cp\u003eThe Genomes Of Mitochondria And Chloroplasts 404\u003c\/p\u003e \u003cp\u003eEukaryotic Genomes 407\u003c\/p\u003e \u003cp\u003eComparative Genomics: A Way To Study Evolution 408\u003c\/p\u003e \u003cp\u003ePaleogenomics 409\u003c\/p\u003e \u003cp\u003eSolve It What Do We Know about the Mitochondrial Genome of the Extinct Woolly Mammoth? 411\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 16 : Applications of Molecular Genetics 417\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eGene Therapy Improves Sight in Child with Congenital Blindness 417\u003c\/p\u003e \u003cp\u003eUse of Recombinant DNA Technology to Identify Human Genes and Diagnose Genetic Diseases 418\u003c\/p\u003e \u003cp\u003eHuntington’s Disease 418\u003c\/p\u003e \u003cp\u003eProblem-Solving Skills Testing for Mutant Alleles that Cause Fragile X Mental Retardation 421\u003c\/p\u003e \u003cp\u003eCystic Fibrosis 421\u003c\/p\u003e \u003cp\u003eMolecular Diagnosis of Human Diseases 424\u003c\/p\u003e \u003cp\u003eHuman Gene Therapy 426\u003c\/p\u003e \u003cp\u003eDifferent Types Of Gene Therapy 426\u003c\/p\u003e \u003cp\u003eGene Therapy Vectors 427\u003c\/p\u003e \u003cp\u003eCriteria For Approving Gene Therapy 427\u003c\/p\u003e \u003cp\u003eGene Therapy For Autosomal Immunodeficiency Disease 428\u003c\/p\u003e \u003cp\u003eGene Therapy For X-Linked Immunodeficiency Disease 428\u003c\/p\u003e \u003cp\u003eSuccessful Gene Therapy And Future Prospects 430\u003c\/p\u003e \u003cp\u003eDNA Profiling 431\u003c\/p\u003e \u003cp\u003eDNA Profiling 431\u003c\/p\u003e \u003cp\u003ePaternity Tests 435\u003c\/p\u003e \u003cp\u003eForensic Applications 435\u003c\/p\u003e \u003cp\u003eSolve It : How Can DNA Profiles Be Used to Establish Identity? 435\u003c\/p\u003e \u003cp\u003eProduction of Eukaryotic Proteins in Bacteria 437\u003c\/p\u003e \u003cp\u003eHuman Growth Hormone 437\u003c\/p\u003e \u003cp\u003eProteins with Industrial Applications 438\u003c\/p\u003e \u003cp\u003eTransgenic Animals and Plants 439\u003c\/p\u003e \u003cp\u003eTransgenic Animals: Microinjection of DNA into Fertilized Eggs and Transfection of Embryonic Stem Cells 439\u003c\/p\u003e \u003cp\u003eTransgenic Plants: The Ti Plasmid of Agrobacterium tumefaciens 440\u003c\/p\u003e \u003cp\u003eReverse Genetics: Dissecting Biological Processes by Inhibiting Gene Expression 442\u003c\/p\u003e \u003cp\u003eKnockout Mutations in the Mouse 443\u003c\/p\u003e \u003cp\u003eT-DNA and Transposon Insertions 445\u003c\/p\u003e \u003cp\u003eRNA Interference 446\u003c\/p\u003e \u003cp\u003eSolve It : How Might RNA Interference Be Used to Treat Burkitt’s Lymphoma? 448\u003c\/p\u003e \u003cp\u003eGenome Engineering 448\u003c\/p\u003e \u003cp\u003eThe Crispr\/Cas9 System For Cleaving DNA Molecules 448\u003c\/p\u003e \u003cp\u003eTargeted Mutagenesis With The Crispr\/Cas9 System 450\u003c\/p\u003e \u003cp\u003eDeleting, Replacing, And Editing Genes With The Crispr\/ Cas9 System 452\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 17 : Regulation of Gene Expression in Prokaryotes 459\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eD’Hérelle’s Dream 459\u003c\/p\u003e \u003cp\u003eStrategies for Regulating Genes in Prokaryotes 460\u003c\/p\u003e \u003cp\u003eConstitutive, Inducible, and Repressible Gene Expression 461\u003c\/p\u003e \u003cp\u003ePositive and Negative Control of Gene Expression 462\u003c\/p\u003e \u003cp\u003eOperons: Coordinately Regulated Units of Gene Expression 464\u003c\/p\u003e \u003cp\u003eThe Lactose Operon in E. coli: Induction and Catabolite Repression 466\u003c\/p\u003e \u003cp\u003eSolve It : Constitutive Mutations in the E. coli lac Operon 468\u003c\/p\u003e \u003cp\u003eInduction 468\u003c\/p\u003e \u003cp\u003eCatabolite Repression 469          \u003c\/p\u003e \u003cp\u003eProblem-Solving Skills Testing Your Understanding of the lac Operon 471\u003c\/p\u003e \u003cp\u003eProtein–DNA Interactions That Control Transcription of the lac Operon 472\u003c\/p\u003e \u003cp\u003eThe Tryptophan Operon in E. coli: Repression and Attenuation 474\u003c\/p\u003e \u003cp\u003eRepression 474\u003c\/p\u003e \u003cp\u003eAttenuation 475\u003c\/p\u003e \u003cp\u003eSolve It : Regulation of the Histidine Operon of Salmonella typhimurium 477\u003c\/p\u003e \u003cp\u003ePosttranscriptional Regulation of Gene\u003c\/p\u003e \u003cp\u003eExpression in Prokaryotes 479\u003c\/p\u003e \u003cp\u003eTranslational Control of Gene Expression 479\u003c\/p\u003e \u003cp\u003ePosttranslational Regulatory Mechanisms 479\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 18 : Regulation of Gene Expression in Eukaryotes 484\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eAfrican Trypanosomes : A Ward robe of Molecular DisguIses 484\u003c\/p\u003e \u003cp\u003eWays of Regulating Eukaryotic Gene Expression: An Overview 485\u003c\/p\u003e \u003cp\u003eDimensions of Eukaryotic Gene Regulation 485\u003c\/p\u003e \u003cp\u003eControlled Transcription of DNA 485\u003c\/p\u003e \u003cp\u003eAlternate Splicing of RNA 486\u003c\/p\u003e \u003cp\u003eCytoplasmic Control of Messenger RNA Stability 486\u003c\/p\u003e \u003cp\u003eSolve It : Counting mRNAs 487\u003c\/p\u003e \u003cp\u003eInduction of Transcriptional Activity by Environmental and Biological Factors 487\u003c\/p\u003e \u003cp\u003eTemperature: The Heat-Shock Genes 488\u003c\/p\u003e \u003cp\u003eSignal Molecules: Genes That Respond to Hormones 488\u003c\/p\u003e \u003cp\u003eMolecular Control of Transcription in Eukaryotes 490\u003c\/p\u003e \u003cp\u003eDNA Sequences Involved in the Control of Transcription 490\u003c\/p\u003e \u003cp\u003eProteins Involved in the Control of Transcription: Transcription Factors 491\u003c\/p\u003e \u003cp\u003eProblem-Solving Skills Defining the Sequences Required for a Gene’s Expression 492\u003c\/p\u003e \u003cp\u003ePosttranscriptional Regulation of Gene Expression by RNA Interference 494\u003c\/p\u003e \u003cp\u003eRNAi Pathways 494\u003c\/p\u003e \u003cp\u003eSources of Short Interfering RNAs and MicroRNAs 496\u003c\/p\u003e \u003cp\u003eSolve It Using RnAi in Cell Research 497\u003c\/p\u003e \u003cp\u003eGene Expression and Chromatin\u003c\/p\u003e \u003cp\u003eOrganization 497\u003c\/p\u003e \u003cp\u003eEuchromatin and Heterochromatin 498\u003c\/p\u003e \u003cp\u003eMolecular Organization of Transcriptionally Active DNA 498\u003c\/p\u003e \u003cp\u003eChromatin Remodeling 499\u003c\/p\u003e \u003cp\u003eDNA Methylation 500\u003c\/p\u003e \u003cp\u003eImprinting 502\u003c\/p\u003e \u003cp\u003eActivation and Inactivation of Whole Chromosomes 503\u003c\/p\u003e \u003cp\u003eInactivation of X Chromosomes in Mammals 504\u003c\/p\u003e \u003cp\u003eHyperactivation of X Chromosomes in Drosophila 505\u003c\/p\u003e \u003cp\u003eHypoactivation of X Chromosomes in Caenorhabditis 506\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 19 : Inheritance of Complex Traits 511\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eCardiovascular Disease: A Combination of Genetic and Environmental Factors 511\u003c\/p\u003e \u003cp\u003eComplex Traits 512\u003c\/p\u003e \u003cp\u003eQuantifying Complex Traits 512\u003c\/p\u003e \u003cp\u003eGenetic and Environmental Factors Influence Quantitative Traits 512\u003c\/p\u003e \u003cp\u003eMultiple Genes Influence Quantitative Traits 512\u003c\/p\u003e \u003cp\u003eThreshold Traits 514\u003c\/p\u003e \u003cp\u003eStatistics of Quantitative Genetics 515\u003c\/p\u003e \u003cp\u003eFrequency Distributions 515\u003c\/p\u003e \u003cp\u003eThe Mean and the Modal Class 516\u003c\/p\u003e \u003cp\u003eThe Variance and the Standard Deviation 516\u003c\/p\u003e \u003cp\u003eStatistical Analysis of Quantitative Traits 517\u003c\/p\u003e \u003cp\u003eThe Multiple Factor Hypothesis 518\u003c\/p\u003e \u003cp\u003ePartitioning the Phenotypic Variance 518\u003c\/p\u003e \u003cp\u003eBroad-Sense Heritability 519\u003c\/p\u003e \u003cp\u003eSolve It Estimating Genetic and Environmental Variance Components 519\u003c\/p\u003e \u003cp\u003eNarrow-Sense Heritability 520\u003c\/p\u003e \u003cp\u003ePredicting Phenotypes 521\u003c\/p\u003e \u003cp\u003eSolve It Using the Narrow-Sense Heritability 522\u003c\/p\u003e \u003cp\u003eArtificial Selection 522\u003c\/p\u003e \u003cp\u003eMolecular Analysis of Complex Traits 523\u003c\/p\u003e \u003cp\u003eQuantitative Trait Loci 523\u003c\/p\u003e \u003cp\u003eGenome-Wide Association Studies Of Human Diseases 526\u003c\/p\u003e \u003cp\u003eProblem-Solving Skills Detecting Dominance at a QTL 527\u003c\/p\u003e \u003cp\u003eCorrelations between Relatives 531\u003c\/p\u003e \u003cp\u003eCorrelating Quantitative Phenotypes between Relatives 531\u003c\/p\u003e \u003cp\u003eInterpreting Correlations between Relatives 533\u003c\/p\u003e \u003cp\u003eQuantitative Genetics of Human\u003c\/p\u003e \u003cp\u003eBehavioral Traits 535\u003c\/p\u003e \u003cp\u003eIntelligence 535\u003c\/p\u003e \u003cp\u003ePersonality 536\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 20 : Population Genetics 541\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eA Remote Colony 541\u003c\/p\u003e \u003cp\u003eThe Theory of Allele Frequencies 542\u003c\/p\u003e \u003cp\u003eEstimating Allele Frequencies 542\u003c\/p\u003e \u003cp\u003eRelating Genotype Frequencies to Allele Frequencies: The Hardy–Weinberg Principle 543\u003c\/p\u003e \u003cp\u003eApplications of the Hardy–Weinberg Principle 543\u003c\/p\u003e \u003cp\u003eExceptions to the Hardy–Weinberg Principle 545\u003c\/p\u003e \u003cp\u003eSolve It : The Effects of Inbreeding on Hardy– Weinberg Frequencies 546\u003c\/p\u003e \u003cp\u003eUsing Allele Frequencies in Genetic Counseling 547\u003c\/p\u003e \u003cp\u003eNatural Selection 548\u003c\/p\u003e \u003cp\u003eThe Concept of Fitness 548\u003c\/p\u003e \u003cp\u003eNatural Selection at the Level of the Gene 549\u003c\/p\u003e \u003cp\u003eSolve It : Selection against a Harmful Recessive Allele 550\u003c\/p\u003e \u003cp\u003eRandom Genetic Drift 552\u003c\/p\u003e \u003cp\u003eRandom Changes in Allele Frequencies 552\u003c\/p\u003e \u003cp\u003eThe Effects of Population Size 553\u003c\/p\u003e \u003cp\u003eProblem-Solving Skills Applying Genetic Drift to Pitcairn Island 554\u003c\/p\u003e \u003cp\u003ePopulations in Genetic Equilibrium 554\u003c\/p\u003e \u003cp\u003eBalancing Selection 555\u003c\/p\u003e \u003cp\u003eMutation–Selection Balance 556\u003c\/p\u003e \u003cp\u003eMutation–Drift Balance 557\u003c\/p\u003e \u003cp\u003eAnswers to Odd-Numbered Questions and Problems 563\u003c\/p\u003e \u003cp\u003eGlossary 584\u003c\/p\u003e \u003cp\u003eIndex 607\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 21 (Online) : Transposable Genetic Elements WC-1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eMaize: A Staple Crop with a Cultural Heritage WC-1\u003c\/p\u003e \u003cp\u003eTransposable Elements: An Overview WC-2\u003c\/p\u003e \u003cp\u003eTransposable Elements in Bacteria WC-3\u003c\/p\u003e \u003cp\u003eIs Elements WC-3\u003c\/p\u003e \u003cp\u003eComposite Transposons WC-5\u003c\/p\u003e \u003cp\u003eThe Tn3 Element WC-5\u003c\/p\u003e \u003cp\u003eSolve It: Accumulating Drug-Resistance Genes WC-5\u003c\/p\u003e \u003cp\u003eCut-and-Paste Transposons in Eukaryotes WC-7\u003c\/p\u003e \u003cp\u003eAc and Ds Elements in Maize WC-7\u003c\/p\u003e \u003cp\u003eP Elements and Hybrid Dysgenesis in Drosophila WC-9\u003c\/p\u003e \u003cp\u003eProblem-Solving Skills Analyzing\u003c\/p\u003e \u003cp\u003eTransposon Activity in Maize W C - 10\u003c\/p\u003e \u003cp\u003eRetroviruses and Retrotransposons WC-11\u003c\/p\u003e \u003cp\u003eRetroviruses WC-12\u003c\/p\u003e \u003cp\u003eRetroviruslike Elements WC-14\u003c\/p\u003e \u003cp\u003eRetroposons WC-16\u003c\/p\u003e \u003cp\u003eTransposable Elements in Humans WC-17\u003c\/p\u003e \u003cp\u003eThe Genetic and Evolutionary Significance of Transposable Elements WC-20\u003c\/p\u003e \u003cp\u003eTransposons as Mutagens WC-20\u003c\/p\u003e \u003cp\u003eGenetic Transformation with Transposons WC-20\u003c\/p\u003e \u003cp\u003eSolve It Transposon-Mediated Chromosome Rearrangements W C - 22\u003c\/p\u003e \u003cp\u003eTransposons and Genome Organization WC-22\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 22 (Online) : The Genetic Control of Animal Development WC-28\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eStem-Cell Therapy WC-28\u003c\/p\u003e \u003cp\u003eA Genetic Perspective on Development WC-29\u003c\/p\u003e \u003cp\u003eMaternal Gene Activity in Development WC-31\u003c\/p\u003e \u003cp\u003eMaternal-Effect Genes WC-31\u003c\/p\u003e \u003cp\u003eDetermination of the Dorsal-Ventral and Anterior-Posterior Axes WC-32\u003c\/p\u003e \u003cp\u003eSolve It:  A Maternal-Effect Mutation in the cinnamon Gene W C - 32\u003c\/p\u003e \u003cp\u003eZygotic Gene Activity in Development WC-35\u003c\/p\u003e \u003cp\u003eBody Segmentation WC-35\u003c\/p\u003e \u003cp\u003eOrgan Formation WC-37\u003c\/p\u003e \u003cp\u003eSpecification of Cell Types WC-39\u003c\/p\u003e \u003cp\u003eSolve It Cave Blindness W C - 39\u003c\/p\u003e \u003cp\u003eProblem-Solving Skills The Effects of Mutations during Eye Development W C - 41\u003c\/p\u003e \u003cp\u003eGenetic Analysis of Development in Vertebrates WC-41\u003c\/p\u003e \u003cp\u003eVertebrate Homologues of Invertebrate Genes WC-41\u003c\/p\u003e \u003cp\u003eThe Mouse: Random Insertion Mutations and Gene-specific Knockout Mutations WC-42\u003c\/p\u003e \u003cp\u003eStudies with Mammalian Stem Cells WC-43\u003c\/p\u003e \u003cp\u003eReproductive Cloning WC-44\u003c\/p\u003e \u003cp\u003eGenetic Changes in the Differentiation of Vertebrate Immune Cells WC-45\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 23 (Online) :The Genetic Basis of Cancer WC-51\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eA Molecular Family Connection WC-51\u003c\/p\u003e \u003cp\u003eCancer: A Genetic Disease WC-52\u003c\/p\u003e \u003cp\u003eThe Many Forms of Cancer WC-52\u003c\/p\u003e \u003cp\u003eCancer and the Cell Cycle WC-53\u003c\/p\u003e \u003cp\u003eCancer and Programmed Cell Death WC-54\u003c\/p\u003e \u003cp\u003eA Genetic Basis for Cancer WC-54\u003c\/p\u003e \u003cp\u003eOncogenes WC-55\u003c\/p\u003e \u003cp\u003eTumor-Inducing Retroviruses and Viral Oncogenes WC-55\u003c\/p\u003e \u003cp\u003eCellular Homologues of Viral Oncogenes: The Proto-Oncogenes WC-56\u003c\/p\u003e \u003cp\u003eSolve It : The v-erbB and v-fms Viral Oncogenes WC-56\u003c\/p\u003e \u003cp\u003eMutant Cellular Oncogenes and Cancer WC-57\u003c\/p\u003e \u003cp\u003eChromosome Rearrangements and Cancer WC-59\u003c\/p\u003e \u003cp\u003eTumor Suppressor Genes WC-60\u003c\/p\u003e \u003cp\u003eInherited Cancers and Knudson’s Two-Hit Hypothesis WC-60\u003c\/p\u003e \u003cp\u003eCellular Roles of Tumor Suppressor Proteins WC-63\u003c\/p\u003e \u003cp\u003epRB WC-63\u003c\/p\u003e \u003cp\u003eProblem-Solving Skills Estimating Mutation Rates in Retinoblastoma W C - 63\u003c\/p\u003e \u003cp\u003ep53 WC-65\u003c\/p\u003e \u003cp\u003eSolve It Downstream of p53 WC-65\u003c\/p\u003e \u003cp\u003epAPC WC-67\u003c\/p\u003e \u003cp\u003ephMSH2 WC-68\u003c\/p\u003e \u003cp\u003epBRCA1 and pBRCA2 WC-69\u003c\/p\u003e \u003cp\u003eGenetic Pathways to Cancer WC-70\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 24 (Online) : Evolutionary Genetics WC-76\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eD’ou venons nous ? Que sommes nous ? Ou allons nous? WC-76\u003c\/p\u003e \u003cp\u003eThe Emergence of Evolutionary Theory WC-77\u003c\/p\u003e \u003cp\u003eDarwin’s Theory of Evolution WC-77\u003c\/p\u003e \u003cp\u003eEvolutionary Genetics WC-78\u003c\/p\u003e \u003cp\u003eGenetic Variation in Natural Populations WC-79\u003c\/p\u003e \u003cp\u003eVariation in Phenotypes WC-79\u003c\/p\u003e \u003cp\u003eVariation in Chromosome Structure WC-80\u003c\/p\u003e \u003cp\u003eVariation in Protein Structure WC-81\u003c\/p\u003e \u003cp\u003eVariation in Nucleotide Sequences WC-81\u003c\/p\u003e \u003cp\u003eMolecular Evolution WC-82\u003c\/p\u003e \u003cp\u003eMolecules as “Documents of Evolutionary History” WC-83\u003c\/p\u003e \u003cp\u003eMolecular Phylogenies WC-84\u003c\/p\u003e \u003cp\u003eRates of Molecular Evolution WC-84\u003c\/p\u003e \u003cp\u003eProblem-Solving Skills Using Mitochondrial DNA to Establish a Phylogeny W C - 85\u003c\/p\u003e \u003cp\u003eThe Molecular Clock WC-87\u003c\/p\u003e \u003cp\u003eVariation in the Evolution of Protein Sequences WC-87\u003c\/p\u003e \u003cp\u003eSolve It Calculating Divergence Times W C - 87\u003c\/p\u003e \u003cp\u003eVariation in the Evolution of DNA Sequences WC-88\u003c\/p\u003e \u003cp\u003eThe Neutral Theory of Molecular Evolution WC-89\u003c\/p\u003e \u003cp\u003eMolecular Evolution and Phenotypic Evolution WC-90\u003c\/p\u003e \u003cp\u003eSolve It Evolution by Mutation and Genetic Drift WC-90\u003c\/p\u003e \u003cp\u003eSpeciation WC-92\u003c\/p\u003e \u003cp\u003eWhat Is a Species? WC-92\u003c\/p\u003e \u003cp\u003eModes of Speciation WC-94\u003c\/p\u003e \u003cp\u003eHuman Evolution WC-96\u003c\/p\u003e \u003cp\u003eHumans and the Great Apes WC-96\u003c\/p\u003e \u003cp\u003eHuman Evolution in the Fossil Record WC-96\u003c\/p\u003e \u003cp\u003eDNA Sequence Variation and Human Origins WC-97\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAppendices (Online)\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eAppendix A: The Rules of Probability WA-1\u003c\/p\u003e \u003cp\u003eAppendix B: Binomial Probabilities WA-3\u003c\/p\u003e \u003cp\u003eAppendix C: Evolutionary Rates WA-5\u003c\/p\u003e  \u003cp\u003eD. Peter Snustad and Michael J. Simmons are the authors of Principles of Genetics, Binder Ready Version, 7th Edition, published by Wiley.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989852078309,"sku":"NP9781119142287","price":83.5,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781119142287.jpg?v=1761785676","url":"https:\/\/k12savings.com\/es\/products\/principles-of-genetics-isbn-9781119142287","provider":"K12savings","version":"1.0","type":"link"}