{"product_id":"physics-of-nerve-cells-and-excitatory-membranes-isbn-9783527331802","title":"Physics of Nerve Cells and Excitatory Membranes","description":"\u003cp\u003e\u003cb\u003eUnique reference explaining how novel concepts in thermodynamics can explain the full range of nerve cell properties and functions\u003c\/b\u003e \u003c\/p\u003e\u003cp\u003e\u003ci\u003ePhysics of Nerves and Excitatory Membranes\u003c\/i\u003e lays out a novel concept for the function of excitatory membranes, nerve cells, and the brain that is based on thermodynamics, demonstrating that the propagation of a nerve pulse, its temporal length, the occurrence of ion channel-like events in nerve membranes, and the action of anesthetics are all rooted in thermodynamic couplings and may be described using the fluctuation-dissipation theorem that is fundamental for thermodynamics. This new view of excitatory membranes differs significantly from the traditional electrophysiological description of nerves that largely neglects the mechanical, thermal, and chemical properties of nerve cells and their membranes and thus struggles to explain important neuronal properties such as the action of general anesthetics. \u003c\/p\u003e\u003cp\u003e\u003ci\u003ePhysics of Nerves and Excitatory Membranes\u003c\/i\u003e is didactically written and includes information on: \u003c\/p\u003e\u003cul\u003e \u003cli\u003eThe structure and electrical properties of nerves, dimensions and mechanical properties of the nerve pulse, and optical changes during the action potential\u003c\/li\u003e \u003cli\u003eCable theory, voltage gating, the Hodgkin-Huxley model, and protein ion channels\u003c\/li\u003e \u003cli\u003eMembrane structure and melting, phase behavior, domains, and rafts, and the influence of voltage, drugs, proteins, pH, and ionic strength\u003c\/li\u003e \u003cli\u003eHeat capacity, sound propagation, relaxation timescales, and capacitance and capacitive susceptibility\u003c\/li\u003e \u003cli\u003eVoltage-gated and mechanosensitive lipid channels, temperature sensing, and selectivity of lipid channels\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003ePhysics of Nerves and Excitatory Membranes\u003c\/i\u003e is of prime interest for biophysicists studying biomembranes as well as for neurobiologists and clinical researchers studying anesthesia. Its accessible style makes it very well suited for teaching the subjects that it covers. Part I: INTRODUCTION\u003cbr\u003e I.1 Early Nerve Studies\u003cbr\u003e I.2 The early period of electrophysiology\u003cbr\u003e I.3 The Hodgkin-Huxley model and beyond\u003cbr\u003e I.4 Another line of thought\u003cbr\u003e I.5 Scope of this book\u003cbr\u003e Part II: THERMODYNAMICS\u003cbr\u003e II.1 Fundamental laws in thermodynamics\u003cbr\u003e II.2 Some statistical Thermodynamics\u003cbr\u003e II.3 Entropy\u003cbr\u003e II.4 The fluctuation relations\u003cbr\u003e Part III: PROPERTIES OF NERVES\u003cbr\u003e III.1 Structure of nerves\u003cbr\u003e III.2 Electrical properties of nerves\u003cbr\u003e III.3 The dimensions of the nerve pulse\u003cbr\u003e III.4 Mechanical properties of the nerve pulse\u003cbr\u003e III.5 Optical changes during the action potential\u003cbr\u003e III.6 Heat production and temperature changes during the nerve pulse\u003cbr\u003e III.7 Magnetic fields generated during the action potential\u003cbr\u003e III.8 Collisions of nerve pulses\u003cbr\u003e Part IV: BASIC PRINCIPLES OF ELECTROPHYSIOLOGY\u003cbr\u003e IV.1 Some historical considerations\u003cbr\u003e IV.2 Cable theory\u003cbr\u003e IV.3 Voltage Gating\u003cbr\u003e IV.4 The Hodgkin-Huxley model\u003cbr\u003e IV.5 Implications of the Hodgkin-Huxley model\u003cbr\u003e Part V: PROPERTIES OF ARTIFICIAL AND BIOLOGICAL MEMBRANES\u003cbr\u003e V.1 Membrane Structure\u003cbr\u003e V.2 Membrane Melting\u003cbr\u003e V.3 Phase behavior, domains and rafts\u003cbr\u003e V.4 Influence of hydrostatic pressure and lateral pressure\u003cbr\u003e V.5 Curvature\u003cbr\u003e V.6 Influence of pH and ionic strength\u003cbr\u003e V.7 Influence of Voltage\u003cbr\u003e V.8 Influence of Drugs and proteins\u003cbr\u003e Part VI: FLUCTUATIONS AND SUSCEPTIBILITIES\u003cbr\u003e VI.1 Entropy and fluctuations\u003cbr\u003e VI.2 Heat capacity\u003cbr\u003e VI.3 Relation between enthalpy, volume and area changes\u003cbr\u003e VI.4 Transitions and elastic constants\u003cbr\u003e VI.5 Sound propagation\u003cbr\u003e VI.6 Capacitance and capacitive susceptibility\u003cbr\u003e VI.7 Relaxation timescales\u003cbr\u003e Part VII: THE SOLITON THEORY\u003cbr\u003e VII.1 Hydrodynamics and sound propagation\u003cbr\u003e VII.2 Sound velocity in nerve membranes\u003cbr\u003e VII.3 The frequency dependence of the sound velocity\u003cbr\u003e VII.4 The nerve pulse as an electromechanical soliton\u003cbr\u003e VII.5 Nerve contraction and pulse trains\u003cbr\u003e VII.6 Excitation of solitons\u003cbr\u003e VII.7 Pulse collisions\u003cbr\u003e VII.8 Pulses on monolayers\u003cbr\u003e Part VIII: CHANNELS\u003cbr\u003e VIII.1 Protein ion channels\u003cbr\u003e VIII.2 The permeability of lipid membranes\u003cbr\u003e VIII.3 Voltage-gated lipid channels\u003cbr\u003e VIII.4 Mechanosensitive lipid channels\u003cbr\u003e VIII.5 Temperature sensing\u003cbr\u003e VIII.6 The influence of drugs on membrane permeability and lipid ion channels\u003cbr\u003e VIII.7 Channel lifetimes\u003cbr\u003e VIII.8 Selectivity of lipid channels\u003cbr\u003e VIII.9 Proteins as catalysts for lipid channel formation\u003cbr\u003e Part IX: MEDICAL CONSEQUENCES\u003cbr\u003e IX.1 Factors that influence excitation thresholds\u003cbr\u003e IX.2 Anesthesia\u003cbr\u003e IX.3 Adaptation\u003cbr\u003e IX.4 Nerve Stretching\u003cbr\u003e IX.5 Tremor and lithium\u003cbr\u003e IX.6 Ultrasound neurostimulation\u003cbr\u003e  \u003c\/p\u003e\u003cp\u003e\u003cb\u003eThomas Heimburg\u003c\/b\u003e is Professor for Biophysics at the Niels Bohr Institute of the University of Copenhagen (Denmark), where he is the head of the Membrane Biophysics Group. His research focuses on theoretical and experimental thermodynamics of biological systems, including biomembranes, artificial lipid membranes, and proteins. He is the author of the book \u003ci\u003eThermal Biophysics of Membranes\u003c\/i\u003e (Wiley-VCH, 2007) and an Editorial Board member of the journal \u003ci\u003eBiophysical Chemistry.\u003c\/i\u003e\u003c\/p\u003e","brand":"Wiley-Blackwell","offers":[{"title":"Default Title","offer_id":47989790474469,"sku":"NP9783527331802","price":130.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9783527331802.jpg?v=1761785478","url":"https:\/\/k12savings.com\/es\/products\/physics-of-nerve-cells-and-excitatory-membranes-isbn-9783527331802","provider":"K12savings","version":"1.0","type":"link"}