{"product_id":"pharmacogenetics-and-individualized-therapy-isbn-9780470433546","title":"Pharmacogenetics and Individualized Therapy","description":"This resource provides thorough coverage of pharmacogenetics and its impact on pharmaceuticals, therapeutics, and clinical practice. It opens with the basics of pharmacogenetics, including drug disposition and pharmacodynamics. The following section moves into specific disease areas, including cardiovascular, psychiatry, cancer, asthma\/COPD, adverse drug reactions, transplantation, inflammatory bowel disease, and pain medication. Clinical practice and ethical issues make up the third section, with the fourth devoted to technologies like genotyping, genomics, and proteomics. In the fifth part, chapters discuss the impact of key regulatory issues on the pharmaceutical industry. \u003cp\u003ePreface vii\u003c\/p\u003e \u003cp\u003eContributors ix\u003c\/p\u003e \u003cp\u003e1. Pharmacogenetics: A Historical Perspective 1\u003cbr\u003e\u003ci\u003eAnn K. Daly\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart I Pharmacogenetics: Relationship to Pharmacokinetics and Pharmacodynamics\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2. Pharmacogenetics in Drug Metabolism: Role of Phase I Enzymes 15\u003cbr\u003e\u003ci\u003eVita Dol\u003c\/i\u003e\u003ci\u003ežan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3. Pharmacogenetics of Phase II Drug Metabolizing Enzymes 81\u003cbr\u003e\u003ci\u003eIngolf Cascorbi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4. Pharmacogenetics of Drug Transporters 101\u003cbr\u003e\u003ci\u003eHenriette E. Meyer zu Schwabedissen, Markus Grube, and Heyo K. Kroemer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5. Pharmacogenetics of Drug Targets 149\u003cbr\u003e\u003ci\u003eAnn K. Daly and Maria Arranz\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart II Pharmacogenetics: Therapeutic Areas\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6. Cardiovascular Pharmacogenetics 185\u003cbr\u003e\u003ci\u003eBas J. M. Peters, Anthonius de Boer, Tom Schalekamp, Olaf H. Klungel, and Anke-Hilse Maitland-van\u003c\/i\u003e \u003ci\u003eder Zee\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7. Pharmacogenetics in Psychiatry 215\u003cbr\u003e\u003ci\u003eEvangelia M. Tsapakis, Sarah Curran, Ruth I. Ohlsen, Nora S. Vyas, Katherine J. Aitchison, and Ann K.\u003c\/i\u003e \u003ci\u003eDaly\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8. Pharmacogenetics in Cancer 251\u003cbr\u003e\u003ci\u003eSharon Marsh\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9. Pharmacogenetics of Asthma and COPD 271\u003cbr\u003e\u003ci\u003eEllen S. Koster, Jan A. M. Raaijmakers, Anke-Hilse Maitland-van der Zee, and Gerard H. Koppelman\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10. Pharmacogenetics of Adverse Drug Reactions 295\u003cbr\u003e\u003ci\u003eAnn K. Daly, Martin Armstrong, and Munir Pirmohamed\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11. Pharmacogenomics of Inflammatory Bowel Diseases 323\u003cbr\u003e\u003ci\u003eAlexander Teml, Susanne Karner, Elke Schaeffeler, and Matthias Schwab\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12. Pharmacogenetics of Pain Medication 353\u003cbr\u003e\u003ci\u003eJ\u003c\/i\u003e\u003ci\u003eörn L\u003c\/i\u003e\u003ci\u003eötsch\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart III Pharmacogenetics: Implementation in Clinical Practice\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e13. Ethical and Social Issues in Pharmacogenomics Testing 377\u003cbr\u003e\u003ci\u003eSusanne Vijverberg, Toine Pieters, and Martina Cornel\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart IV Developments in Pharmacogenetic Research\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e14. High-Throughput Genotyping Technologies for Pharmacogenetics 403\u003cbr\u003e\u003ci\u003eBeatriz Sobrino and Angel Carracedo\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15. Developments in Analyses in Pharmacogenetic Datasets 415\u003cbr\u003e\u003ci\u003eAlison A. Motsinger-Reif\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart V Pharmacogenetics: Industry and Regulatory Affairs\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e16. Applications of Pharmacogenetics in Pharmaceutical Research and Development 439\u003cbr\u003e\u003ci\u003eDaniel K. Burns and Scott S. Sundseth\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17. Role of Pharmacogenetics in Registration Processes 461\u003cbr\u003e\u003ci\u003eMyong-Jin Kim, Issam Zineh, Shiew-Mei Huang, and Lawrence J. Lesko\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart VI Conclusions\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e18. Pharmacogenetics: Possibilities and Pitfalls 479\u003cbr\u003e\u003ci\u003eAnke-Hilse Maitland-van der Zee and Ann K. Daly\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 485\u003c\/p\u003e  \u003cp\u003e“This is a well-written book that I highly recommend to anyone interested in any aspect of personalized medicine.”  \u003ci\u003e(Doody’s,\u003c\/i\u003e \u003ci\u003e24 August 2012\u003c\/i\u003e\u003ci\u003e)\u003c\/i\u003e\u003c\/p\u003e  \u003cp\u003e\u003cb\u003eANKE-HILSE MAITLAND-VAN DER ZEE, P\u003csmall\u003eH\u003c\/small\u003eD,\u003c\/b\u003e is Associate Professor of Pharmacogenetics\/Pharmacogenomics at Utrecht University, the Netherlands. \u003c\/p\u003e\u003cp\u003e\u003cb\u003eANN K. DALY, P\u003csmall\u003eH\u003c\/small\u003eD,\u003c\/b\u003e is Professor of Pharmacogenetics at Newcastle University, UK.   \u003c\/p\u003e\u003cp\u003e\u003cb\u003eThe one-stop reference to pharmacogenetics and its impact on pharmaceuticals, therapeutics, and clinical practices\u003c\/b\u003e \u003c\/p\u003e\u003cp\u003e\u003ci\u003ePharmacogenetics and Individualized Therapy\u003c\/i\u003e offers thorough coverage of the study of the genetic determinants of drug response at the single gene level—and its impact on pharmaceuticals, therapeutics, and clinical practice. Providing an overview of the molecular basis of pharmacogenetics, the book helps readers understand the implications of genetic variability on pharmacokinetics and pharmacodynamics, as well as other aspects such as adverse drug reactions. Providing coverage of specific disease areas, including cardiovascular concerns, cancer and asthma\/COPD, transplantation, and pain medication, the book also looks at the clinical practices, along with the psychiatric and ethical issues that have come to dominate conversation about pharmacogenetics. \u003c\/p\u003e\u003cp\u003eThe technological applications of pharmacogenetics, including genotyping, drug disposition (metabolism and enzymes), and the impact of this research on the pharmaceutical industry and regulatory matters are all addressed in chapters by internationally recognized leaders from both academia and industry. \u003c\/p\u003e\u003cp\u003eIncluding chapters on specific therapeutic areas and clinical aspects, \u003ci\u003ePharmacogenetics and Individualized Therapy\u003c\/i\u003e helps readers, whether they're students or researchers, to understand the implications of genetic variability on pharmacokinetics and pharmacodynamics.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989773074661,"sku":"NP9780470433546","price":142.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470433546.jpg?v=1761785422","url":"https:\/\/k12savings.com\/es\/products\/pharmacogenetics-and-individualized-therapy-isbn-9780470433546","provider":"K12savings","version":"1.0","type":"link"}