Pharmacodynamics and Drug Development

Contains essential facts and concepts spanning many of the important drug classes. Features an authoritative section on general methodology and regulatory issues. The molecular biology and pharmacology of key receptor types are considered along with the detailed pharmacodynamics of a wide range of therapeutic drug groups. Partial table of contents:

OVERVIEW OF PHARMACODYNAMICS.

Basic Pharmacodynamic Concepts and Models (R. Wills).

Factors Influencing Variability in Kinetics and Dynamics (P. Narang& R. Li).

General Perspectives on the Role of Metabolite in Pharmacokineticsand Pharmacodynamics (R. Seifert).

Regulatory Perspective: The Role of Pharmacokinetics andPharmacodynamics (L. Lesko & R. Williams).

APPLICATION OF PHARMACODYNAMICS IN SELECTED THERAPEUTICDOMAINS.

Theoretical Models for Developing Anxiolytics (P. Nickell & T.Uhde).

Pharmacodynamics of Antipsychotic Drugs in Schizophrenia (J. Sramek& G. Simpson).

Antihypertensive Drugs (L. Prisant & A. Carr).

Pharmacodynamics of Antineoplastic Agents (G. Rosner & M.Ratain).

Virology and Antiviral Drug Development (M. Amantea, et al.).

FRONTIERS IN PHARMACODYNAMICS: INSIGHT FROM MOLECULARAPPROACHES.

Muscarinic Receptors: Pharmacological Subtypes, Structure, Functionand Regulation (L. Mei, et al.).

Serotonin Receptor Subtypes (D. Pritchett).

Index.

Neal R. Cutler is the editor of Pharmacodynamics and Drug Development: Perspectives in Clinical Pharmacology, published by Wiley. John J. Sramek is the editor of Pharmacodynamics and Drug Development: Perspectives in Clinical Pharmacology, published by Wiley. In recent years it has become clear that early information about pharmacodynamics leads to more efficient trial designs and improved clinical guidelines for the use of all drugs. Spanning many of the major drug classes, this book offers the essential facts and concepts and includes an authoritative section on general methodology and regulatory issues. The molecular biology and pharmacology of major receptor types are considered, as is the detailed pharmacodynamics of a wide range of therapeutic drug classes. The book will be of interest to researchers, clinical pharmacologists, physicians and regulators working in academia as well as the pharmaceutical industry worldwide.