{"product_id":"oral-bioavailability-isbn-9780470260999","title":"Oral Bioavailability","description":"\u003cp\u003eUnderstand and assess the design, delivery, and efficacy of orally administered drugs\u003c\/p\u003e \u003cp\u003eA practical guide to understanding oral bioavailability, one of the major hurdles in drug development and delivery, Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications is designed to help chemists, biologists, life science researchers, pharmaceutical scientists, pharmacologists, clinicians, and graduate and students become familiar with the fundamentals and practices of the science of oral bioavailability.\u003c\/p\u003e \u003cp\u003eThe difference in rate and extent between a drug taken orally and the actual amount of a drug reaching the circulatory system, oral bioavailability is an essential parameter for determining the efficacy and adverse effects of new and developing medications, as well as finding an optimal dosing regimen.\u003c\/p\u003e \u003cp\u003eThis book provides a much-needed one-stop resource to help readers better understand and appreciate the many facets and complex problems of oral bioavailability, including the basic barriers to oral bioavailability, the methods used to determine relevant parameters, and the challenges of drug delivery.\u003c\/p\u003e \u003cp\u003eIn addition, this comprehensive book discusses biological and physicochemical methods for improving bioavailability, integrates physicochemistry with physiology and molecular biology, and includes several state-of-the-art technologies and approaches—Caco-2 cell culture model, MDCK, and other related cell culture models—which are used to study the science of oral bioavailability.\u003c\/p\u003e  \u003cb\u003eForeword.\u003c\/b\u003e  \u003cp\u003e\u003cb\u003ePreface.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eContributors.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eChapter 1. Barriers to Oral Bioavailability-An Overview (\u003ci\u003eMing Hu and Xiaoling Li\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eChapter 2. Physicochemical Characterization of Pharmaceutical Solids (\u003ci\u003eSmita Debnath\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eChapter 3. Solubility of Pharmaceutical Solids (\u003ci\u003eLauren Wiser, Xiaoling Gao, Bhaskara Jasti, and Xiaoling Li\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eChapter 4. \u003ci\u003eIn Vitro\u003c\/i\u003e Dissolution of Pharmaceutical Solids (\u003ci\u003eJosephine L. P. Soh and Paul W. S. Heng\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eChapter 5. Biological and Physiological Features of the Gastrointestinal Tract Relevant to Oral Drug Absorption (\u003ci\u003ePaul C. Ho\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eChapter 6. Absorption of Drugs via Passive Diffusion and Carrier-Mediated Pathways (\u003ci\u003eMiki Susanto Park and Jae H. Chang\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eChapter 7. \u003ci\u003eIn vitro-In vivo\u003c\/i\u003e Correlation of Pharmaceutical Dosage Forms (\u003ci\u003eDeliang Zhou and Yihong Qiu\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eChapter 8. Drug Metabolism in Gastroinestinal Tract (\u003ci\u003eRashim Singh and Ming Hu\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eChapter 9. Efflux of Drugs via Transporters: The “Anti-absorption” Pathways (\u003ci\u003eJae H. Chang, James A. Uchizono and Miki Susanto Park\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eChapter 10. Liver Drug Metabolism (\u003ci\u003eLeslie M. Tompkins, and Hongbing Wang\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eChapter 11. Protein Binding of Drugs (\u003ci\u003eAntonia Kotsiou and Christine Tesseromatis\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eChapter 12. Urinary Excretion of Drugs and Drug Reabsorption (\u003ci\u003ePankaj Gupta, Bo Feng and Jack Cook\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eChapter 13. Pharmacokinetic Behaviors of Orally Administered Drugs (\u003ci\u003eJaime A. Yáñez, Dion R. Brocks, M. Laird Forrest, and Neal M. Davies\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eChapter 14. Effects of Food on Drug Absorption (\u003ci\u003eVenugopal P. Marasanapalle, Xiaoling Li, and Bhaskara R. Jasti\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eChapter 15. Drug-Drug Interactions and Drug-Dietary Chemical Interactions (\u003ci\u003eGe Lin, Zhong Zuo, Na Li, and Li Zhang\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eChapter 16. Anatomical and Physiological Factors Affecting Oral Drug Bioavailability in Rates, Dogs, and Humans (\u003ci\u003eAyman El-Kattan, Susan Hurst, Joanne Brodfuehrer, Cho-Ming Loi\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eChapter 17. Amino Acid Drug Transporters (\u003ci\u003eZhong Qiu Liu, and Ming Hu\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eChapter 18. Drug Transporters and Their Role in Absorption and Disposition of Peptides and Peptide Based Pharmaceuticals \u003ci\u003e(David J. Lindley, Stephen M. Carl, Dea Herrera-Ruiz, Li F. Pan, Lori B. Ward, Jonathan M. E. Goole, Olafur S. Gudmundsson, and Gregory T. Knipp\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eChapter 19. Organic Anion and Cation Drug Transporters (\u003ci\u003eTakashi Sekine and Hiroshi Kusuhara\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eChapter 20. Gastroretentive Drug Delivery Systems (\u003ci\u003eJohn R. Cardinal and Avinash Nangia\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eChapter 21. Lipid Based and self-emulsifying Oral Drug Delivery Systems (\u003ci\u003eSravan Penchala, Anh-Nhan Pham, Ying Huang and Jeffrey Wang\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eChapter 22. Prodrug Strategies to Enhance Oral Drug Absorption (\u003ci\u003eSai H.S. Boddu, Deep Kwatra, and Ashim K. Mitra\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eChapter 23. Oral Delivery of Protein\/Peptide Therapeutics (\u003ci\u003ePuchun Liu and Steven Dinh\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eChapter 24. ABC Transporters in Intestinal and Liver Efflux (\u003ci\u003eMarilyn E. Morris and Yash A. Gandhi\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eChapter 25. Interplay between Efflux Transporter and Metabolic Enzymes (\u003ci\u003eStephen Wang\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eChapter 26. Regulatory Considerations in Metabolism- and Transporter-Based Drug Interactions (\u003ci\u003eYuanchao (Derek) Zhang, Lei Zhang, John M. Strong, Shiew-Mei Huang\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eChapter 27. Caco-2 Cell Culture Model for Oral Drug Absorption (\u003ci\u003eKaustubh Kulkarni and Ming Hu\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eChapter 28. MDCK Cells and Other Cell Culture Models of Oral Drug Absorption (\u003ci\u003eDeep Kwatra, Sai H. S. Boddu, Ashim K. Mitra\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eChapter 29. Intestinal Perfusion Methods for Oral Drug Absorption (\u003ci\u003eWei Zhu and Eun-Jung (Zenobia) Jeong\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eChapter 30. Liver Perfusion and Primary Hepatocytes for Studying Drug Metabolism and Metabolite Excretion (\u003ci\u003eCindy Q. Xia, Chuang Lu, and Suresh K. Balani\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eChapter 31. In vivo Methods for Oral Bioavailability Studies (\u003ci\u003eAna Ruiz-Garcia and Marival Bermejo\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eChapter 32. Determination of Regulation of Drug Metabolizing Enzymes and Transporters (\u003ci\u003eBin Zhang and Wen Xie\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eChapter 33. Computational and Pharmacoinformatic Approaches to Oral Bioavailability Prediction (\u003ci\u003eMiguel Ángel Cabrera-Pérez, and Isabel González-Álvarez\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e\u003cb\u003eIndex.\u003c\/b\u003e \u003c\/p\u003e \"This book comprehensively covers the topics and issues of oral bioavailability and applications in drug development. The book helps readers master the basic terminology of the field, understand the basic barriers to oral bioavailability, be acquainted with the methods used to determine relevant parameters, and comprehend the challenge associated with oral drug delivery.\" (Fort Mill Times, 18 October 2011) \u003cbr\u003e\u003cbr\u003e  \u003cp\u003e\u003c\/p\u003eMing Hu, PhD, is Professor of Pharmaceutics at the College of Pharmacy, University of Houston. Dr. Hu is on the editorial boards of Molecular Pharmaceutics and the Journal of Alternative and Complementary Medicine. \u003cp\u003eXiaoling Li, PhD, is Professor of Pharmaceutics and Associate Dean of Graduate Education and Research at the Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific. He is a Fellow of the American Association of Pharmaceutical Scientists.\u003c\/p\u003e   \u003cp\u003eUnderstand and assess the design, delivery, and efficacy of orally administered drugs\u003c\/p\u003e \u003cp\u003eA practical guide to understanding oral bioavailability, one of the major hurdles in drug development and delivery, Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications is designed to help chemists, biologists, life science researchers, pharmaceutical scientists, pharmacologists, clinicians, and graduate and students become familiar with the fundamentals and practices of the science of oral bioavailability.\u003c\/p\u003e \u003cp\u003eThe difference in rate and extent between a drug taken orally and the actual amount of a drug reaching the circulatory system, oral bioavailability is an essential parameter for determining the efficacy and adverse effects of new and developing medications, as well as finding an optimal dosing regimen.\u003c\/p\u003e \u003cp\u003eThis book provides a much-needed one-stop resource to help readers better understand and appreciate the many facets and complex problems of oral bioavailability, including the basic barriers to oral bioavailability, the methods used to determine relevant parameters, and the challenges of drug delivery.\u003c\/p\u003e \u003cp\u003eIn addition, this comprehensive book discusses biological and physicochemical methods for improving bioavailability, integrates physicochemistry with physiology and molecular biology, and includes several state-of-the-art technologies and approaches—Caco-2 cell culture model, MDCK, and other related cell culture models—which are used to study the science of oral bioavailability.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989724643557,"sku":"NP9780470260999","price":191.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470260999.jpg?v=1761785256","url":"https:\/\/k12savings.com\/es\/products\/oral-bioavailability-isbn-9780470260999","provider":"K12savings","version":"1.0","type":"link"}