{"product_id":"nmr-in-pharmaceutical-science-isbn-9781118660256","title":"NMR in Pharmaceutical Science","description":"\u003cp\u003e\u003ci\u003eNMR in Pharmaceutical Sciences\u003c\/i\u003e is intended to be a comprehensive source of information for the many individuals that utilize MR in studies of relevance to the pharmaceutical sector. The book is intended to educate and inform those who develop and apply MR approaches within the wider pharmaceutical environment, emphasizing the toolbox that is available to spectroscopists and radiologists.\u003c\/p\u003e \u003cp\u003eThis book is structured on the key processes in drug discovery, development and manufacture, but underpinned by an understanding of fundamental NMR principles and the unique contribution that NMR (including MRI) can provide. After an introductory chapter, which constitutes an overview, the content is organised into five sections. The first section is on the basics of NMR theory and relevant experimental methods. The rest follow a sequence based on the chronology of drug discovery and development, firstly 'Idea to Lead' then 'Lead to Drug Candidate', followed by 'Clinical Development', and finally 'Drug Manufacture'.  The thirty one chapters cover a vast range of topics from analytical chemistry, including aspects involved in regulatory matters and in the prevention of fraud, to clinical imaging studies.\u003c\/p\u003e \u003cp\u003eWhilst this comprehensive volume will be essential reading for many scientists based in pharmaceutical and related industries, it should also be of considerable value to a much wider range of academic scientists whose research is related to the various aspects of pharmaceutical R\u0026amp;D; for them it will supply vital understanding of pharmaceutical industrial concerns and the basis of key decision making processes.\u003cbr\u003e\u003cbr\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAbout \u003ci\u003eeMagRes\u003c\/i\u003e Handbooks\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eeMagRes\u003c\/i\u003e (formerly the \u003ci\u003eEncyclopedia of Magnetic Resonance\u003c\/i\u003e) publishes a wide range of online articles on all aspects of magnetic resonance in physics, chemistry, biology and medicine. The existence of this large number of articles, written by experts in various fields, is enabling the publication of a series of \u003ci\u003eeMagRes\u003c\/i\u003e Handbooks on specific areas of NMR and MRI. The chapters of each of these handbooks will comprise a carefully chosen selection of \u003ci\u003eeMagRes\u003c\/i\u003e articles. In consultation with the \u003ci\u003eeMagRes\u003c\/i\u003e Editorial Board, the \u003ci\u003eeMagRes\u003c\/i\u003e handbooks are coherently planned in advance by specially-selected Editors, and new articles are written to give appropriate complete coverage. The handbooks are intended to be of value and interest to research students, postdoctoral fellows and other researchers learning about the scientific area in question and undertaking relevant experiments, whether in academia or industry.\u003c\/p\u003e \u003cp\u003eHave the content of this handbook and the complete content of \u003ci\u003eeMagRes\u003c\/i\u003e at your fingertips!\u003cbr\u003eVisit: \u003ca href=\"http:\/\/www.wileyonlinelibrary.com\/ref\/eMagRes\"\u003ewww.wileyonlinelibrary.com\/ref\/eMagRes\u003c\/a\u003e\u003c\/p\u003e \u003cp\u003eContributors xi\u003c\/p\u003e \u003cp\u003eSeries Preface xvii\u003c\/p\u003e \u003cp\u003ePreface xix\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart A: Introduction 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Drug Discovery and Development: The Role of NMR\u003cbr\u003e\u003ci\u003eJeremy R. Everett 3\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart B: NMR Theory \u0026amp; Experimental Methods 21\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2 Modern NMR Pulse Sequences in Pharmaceutical R\u0026amp;D\u003cbr\u003e\u003ci\u003eJohn A. Parkinson 23\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 Experimental NMR Methods for Pharmaceutical Research and Development\u003cbr\u003e\u003ci\u003eAnthony C. Dona 41\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 19F NMR Spectroscopy: Applications in Pharmaceutical Studies\u003cbr\u003e\u003ci\u003eJohn C. Lindon and Ian D. Wilson 53\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 Quantitative NMR Spectroscopy in Pharmaceutical R\u0026amp;D\u003cbr\u003e\u003ci\u003eUlrike Holzgrabe 63\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 High-throughput NMR in Pharmaceutical R\u0026amp;D\u003cbr\u003e\u003ci\u003eJohn C. Hollerton 79\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 Multivariate Data Analysis Methods for NMR-based Metabolic Phenotyping in Pharmaceutical and Clinical Research\u003cbr\u003e\u003ci\u003eKirill A. Veselkov, James S. McKenzie, and Jeremy K. Nicholson 89\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart C: Idea to Lead 103\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8 The Role of NMR in Target Identification and Validation for Pharmaceutical R\u0026amp;D\u003cbr\u003e\u003ci\u003eKrishna Saxena and Harald Schwalbe 105\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 High-resolution MAS NMR of Tissues and Cells\u003cbr\u003e\u003ci\u003eLeo L. Cheng 117\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 NMR Studies of Inborn Errors of Metabolism\u003cbr\u003e\u003ci\u003eSarantos Kostidis and Emmanuel Mikros 131\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 NMR-based Structure Confirmation of Hits and Leads in Pharmaceutical R\u0026amp;D\u003cbr\u003e\u003ci\u003ePhilip J. Sidebottom 147\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 Fragment-based Drug Design Using NMR Methods\u003cbr\u003e\u003ci\u003eLeonor Puchades-Carrasco and Antonio Pineda-Lucena 155\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13 Hit Discovery from Natural Products in Pharmaceutical R\u0026amp;D\u003cbr\u003e\u003ci\u003eOlivia Corcoran 173\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart D: Lead to Drug Candidate 183\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e14 NMR-based Structure Determination of Drug Leads and Candidates\u003cbr\u003e\u003ci\u003eTorren M. Peakman 185\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15 Mixture Analysis in Pharmaceutical R\u0026amp;D Using Hyphenated NMR Techniques\u003cbr\u003e\u003ci\u003eIan D. Wilson and John C. Lindon 197\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16 Conformation and Stereochemical Analysis of Drug Molecules\u003cbr\u003e\u003ci\u003eGary J. Sharman 207\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17 NMR Methods for the Assignment of Absolute Stereochemistry of Bioactive Compounds\u003cbr\u003e\u003ci\u003eJose M. Seco and Ricardo Riguera 221\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18 Applications of Preclinical MRI\/MRS in the Evaluation of Drug Efficacy and Safety\u003cbr\u003e\u003ci\u003eThomas M. Bocan, Lauren Keith, and David M. Thomasson 255\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e19 Practical Applications of NMR Spectroscopy in Preclinical Drug Metabolism Studies\u003cbr\u003e\u003ci\u003eRaman Sharma and Gregory S. Walker 267\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e20 Preclinical Drug Efficacy and Safety Using NMR Spectroscopy\u003cbr\u003e\u003ci\u003eMuireann Coen and Ian D. Wilson 281\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e21 Characterization of Pharmaceutical Compounds by Solid-state NMR\u003cbr\u003e\u003ci\u003eFrederick G. Vogt 297\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e22 Structure-based Drug Design Using NMR\u003cbr\u003e\u003ci\u003eMark Jeeves, Lee Quill, and Michael Overduin 317\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e23 Pharmaceutical Technology Studied by MRI\u003cbr\u003e\u003ci\u003eDavid G. Reid and Stephen J. Byard 331\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart E: Clinical Development 345\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e24 NMR-based Metabolic Phenotyping for Disease Diagnosis and Stratification\u003cbr\u003e\u003ci\u003eBeatriz Jiménez 347\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e25 NMR-based Pharmacometabonomics: A New Approach to Personalized Medicine\u003cbr\u003e\u003ci\u003eJeremy R. Everett 359\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e26 Clinical MRI Studies of Drug Efficacy and Safety\u003cbr\u003e\u003ci\u003eDavid G. Reid, Paul D. Hockings, and Nadeem Saeed 373\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e27 The Role of NMR in the Protection of Intellectual Property in Pharmaceutical R\u0026amp;D\u003cbr\u003e\u003ci\u003eFrederick G. Vogt 385\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart F: Drug Manufacture 395\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e28 Analysis of Counterfeit Medicines and Adulterated Dietary Supplements by NMR\u003cbr\u003e\u003ci\u003eMyriam Malet-Martino and Robert Martino 397\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e29 Pharmaceutical Industry: Regulatory Control and Impact on NMR Spectroscopy\u003cbr\u003e\u003ci\u003eAndrea Ruggiero and Sarah K. Branch 413\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e30 NMR Spectroscopy in the European and US Pharmacopeias\u003cbr\u003e\u003ci\u003eHelen Corns and Sarah K. Branch 425\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e31 NMR in Pharmaceutical Manufacturing\u003cbr\u003e\u003ci\u003eEdwin Kellenbach and Paulo Dani 441\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 453\u003c\/p\u003e \u003cp\u003e\u003cb\u003eJeremy R. Everett\u003c\/b\u003e, Ph.D., Department of Pharmaceutical, Chemical \u0026amp; Environmental Sciences, University of Greenwich, UK\u003c\/p\u003e \u003cp\u003e\u003cb\u003eJohn C. Lindon\u003c\/b\u003e, Ph.D., Imperial College London, UK\u003c\/p\u003e \u003cp\u003e\u003cb\u003eIan D. Wilson\u003c\/b\u003e, Ph.D., Imperial College London, UK\u003c\/p\u003e \u003cp\u003e\u003cb\u003eRobin Harris\u003c\/b\u003e, Ph.D., Department of Chemistry, University of Durham, UK\u003c\/p\u003e NMR in Pharmaceutical Sciences is intended to be a comprehensive source of information for the many individuals that utilize MR in studies of relevance to the pharmaceutical sector. The book is intended to educate and inform those who develop and apply MR approaches within the wider pharmaceutical environment, emphasizing the toolbox that is available to spectroscopists and radiologists. This book is structured on the key processes in drug discovery, development and manufacture, but underpinned by an understanding of fundamental NMR principles and the unique contribution that NMR (including MRI) can provide. After an introductory chapter, which constitutes an overview, the content is organised into five sections. The first section is on the basics of NMR theory and relevant experimental methods. The rest follow a sequence based on the chronology of drug discovery and development, firstly 'Idea to Lead' then 'Lead to Drug Candidate', followed by 'Clinical Development', and finally 'Drug Manufacture'. The thirty one chapters cover a vast range of topics from analytical chemistry, including aspects involved in regulatory matters and in the prevention of fraud, to clinical imaging studies. Whilst this comprehensive volume will be essential reading for many scientists based in pharmaceutical and related industries, it should also be of considerable value to a much wider range of academic scientists whose research is related to the various aspects of pharmaceutical R\u0026amp;D; for them it will supply vital understanding of pharmaceutical industrial concerns and the basis of key decision making processes.","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989692072165,"sku":"NP9781118660256","price":144.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781118660256.jpg?v=1761785123","url":"https:\/\/k12savings.com\/es\/products\/nmr-in-pharmaceutical-science-isbn-9781118660256","provider":"K12savings","version":"1.0","type":"link"}