{"product_id":"neurostereology-isbn-9781118444214","title":"Neurostereology","description":"\u003cp\u003eStereological methods provide researchers with unparalleled quantitative data from tissue samples and allow for well-evidenced research advances in a broad range of scientific fields. Presenting a concise introduction to the methodology and application of stereological research in neuroscience, \u003ci\u003eNeurostereology \u003c\/i\u003eprovides a fuller understanding of the use of these methods in research and a means for replicating successful scientific approaches. Providing sound footing for future research, \u003ci\u003eNeurostereology\u003c\/i\u003e is a useful tool for basic and clinical researchers and advanced students looking to integrate these methods into their research.\u003c\/p\u003e  \u003cp\u003e\u003cb\u003eContributors ix\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePreface xiii\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Stereological Estimation of Brain Volume and Surface Area from MR Images 3\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eNiyazi Acer and Mehmet Turgut\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eBackground 3\u003c\/p\u003e \u003cp\u003eThe Cavalieri Principle 3\u003c\/p\u003e \u003cp\u003eVolume Estimation Using Spatial Grid of Points 7\u003c\/p\u003e \u003cp\u003eSurface Area Estimation 8\u003c\/p\u003e \u003cp\u003eIsotropic Cavalieri Design 14\u003c\/p\u003e \u003cp\u003eSections Analyzed with Independent Grid Design 14\u003c\/p\u003e \u003cp\u003eSurface Area Using the Invariator 16\u003c\/p\u003e \u003cp\u003eVolume and Surface Area Estimation Using Segmentation Method 17\u003c\/p\u003e \u003cp\u003eDiscussion 18\u003c\/p\u003e \u003cp\u003eReferences 19\u003c\/p\u003e \u003cp\u003eWebliography 21\u003c\/p\u003e \u003cp\u003eAppendix A: R Commands for Point Counting Method 21\u003c\/p\u003e \u003cp\u003eAppendix B: R Commands for Vertical Section to Estimate Surface Area 23\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Cell Proliferation in the Brains of Adult Rats Exposed to Traumatic Brain Injury 27\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eSandra A. Acosta, Naoki Tajiri, Paula C. Bickford, and Cesar V. Borlongan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eBackground 27\u003c\/p\u003e \u003cp\u003eMaterials and Methods 28\u003c\/p\u003e \u003cp\u003eResults 29\u003c\/p\u003e \u003cp\u003eDiscussion 33\u003c\/p\u003e \u003cp\u003eAcknowledgments 37\u003c\/p\u003e \u003cp\u003eReferences 37\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Age Effects in Substantia Nigra of Asian Indians 39\u003c\/b\u003e\u003cbr\u003e \u003ci\u003ePhalguni Anand Alladi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eBackground 39\u003c\/p\u003e \u003cp\u003eMaterials and Methods 40\u003c\/p\u003e \u003cp\u003eDiscussion 43\u003c\/p\u003e \u003cp\u003eAcknowledgments 48\u003c\/p\u003e \u003cp\u003eReferences 49\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Design-Based Stereology in the Brain Bank Setting 53\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eMark W. Burke\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eBackground 53\u003c\/p\u003e \u003cp\u003eSpecimen Preparation 53\u003c\/p\u003e \u003cp\u003eA Practical Application of Design-Based Stereology 57\u003c\/p\u003e \u003cp\u003eResults 59\u003c\/p\u003e \u003cp\u003eConclusion 60\u003c\/p\u003e \u003cp\u003eReferences 61\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Practical Stereology for Preclinical Neurotoxicology 63\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eMark T. Butt\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eBackground 63\u003c\/p\u003e \u003cp\u003eSpecimen Quality 64\u003c\/p\u003e \u003cp\u003ePractical Stereology 70\u003c\/p\u003e \u003cp\u003eSoftware Validation\/Verifi cation 70\u003c\/p\u003e \u003cp\u003eReferences 72\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 An Overabundance of Prefrontal Cortex Neurons Underlies Early Brain Overgrowth in Autism 73\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eEric Courchesne, Peter R. Mouton, Michael E. Calhoun, Clelia Ahrens-Barbeau, Melodie J. Hallet, Cynthia Carter Barnes, Karen Pierce, and Katarina Semendeferi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eBackground 73\u003c\/p\u003e \u003cp\u003eMethods 74\u003c\/p\u003e \u003cp\u003eResults 78\u003c\/p\u003e \u003cp\u003eDiscussion 80\u003c\/p\u003e \u003cp\u003eAcknowledgments 81\u003c\/p\u003e \u003cp\u003eReferences 82\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Order in Chaos: Stereological Studies of Nervous Tissue 85\u003c\/b\u003e\u003cbr\u003e \u003ci\u003ePeter Dockery\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eBackground 85\u003c\/p\u003e \u003cp\u003eThe Stereological Approach 85\u003c\/p\u003e \u003cp\u003eAxonal Number and Composition in the Murine Optic Nerve 91\u003c\/p\u003e \u003cp\u003eAxonal and Fiber Size Distributions 92\u003c\/p\u003e \u003cp\u003eThe Myelin Sheath 93\u003c\/p\u003e \u003cp\u003eConclusion 94\u003c\/p\u003e \u003cp\u003eReferences 95\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Comparative Stereology Studies of Brains from Marine Mammals 99\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eNina Eriksen and Bente Pakkenberg\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eBackground 99\u003c\/p\u003e \u003cp\u003eDescription of Different Marine Mammalian Brains 99\u003c\/p\u003e \u003cp\u003eParts of the Brain 102\u003c\/p\u003e \u003cp\u003eReferences 109\u003c\/p\u003e \u003cp\u003eAppendix: Cited Stereological Approaches 110\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Quantitative Assessment of Hippocampus Architecture Using the Optical Disector 113\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eShozo Jinno\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eBackground 113\u003c\/p\u003e \u003cp\u003eThe Hippocampus 114\u003c\/p\u003e \u003cp\u003eConclusion 123\u003c\/p\u003e \u003cp\u003eReferences 123\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 The Possible Applications (and Pitfalls!) of Stereological Analysis in Postmortem Brain Research 129\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eAhmad A. Khundakar and Alan J. Thomas\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eBackground 129\u003c\/p\u003e \u003cp\u003eThe Legacy of Two-Dimensional (2D) Analysis 129\u003c\/p\u003e \u003cp\u003eDensity: A Necessary Evil 130\u003c\/p\u003e \u003cp\u003e“Come on, Feel the Noise”: Recognizing Confounding Factors 130\u003c\/p\u003e \u003cp\u003e“I Am Not a Number”: The Importance of Sound Patient Clinical History 131\u003c\/p\u003e \u003cp\u003eLessons Learned from Stereology: Toward a More Unifi ed Approach to Brain Banking and Postmortem Tissue Research (and Beyond!) 132\u003c\/p\u003e \u003cp\u003eObtain the Full Reference Volume or “Make Do and Mend” 133\u003c\/p\u003e \u003cp\u003eTurn Down the “Noise” 134\u003c\/p\u003e \u003cp\u003e“Check the Information, Expand the Knowledge” 135\u003c\/p\u003e \u003cp\u003eShow Your Work! 135\u003c\/p\u003e \u003cp\u003eConclusion 136\u003c\/p\u003e \u003cp\u003eAcknowledgments 136\u003c\/p\u003e \u003cp\u003eReferences 136\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Visualization of Blood Vessels in Two-Dimensional and Three-Dimensional Environments for Vascular Stereology in the Brain 139\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eZerina Lokmic\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eBackground 139\u003c\/p\u003e \u003cp\u003eVascular Stereology of Tissue Sections 139\u003c\/p\u003e \u003cp\u003eVisualization of Brain Blood Vessels 142\u003c\/p\u003e \u003cp\u003eConclusion 149\u003c\/p\u003e \u003cp\u003eAcknowledgment 149\u003c\/p\u003e \u003cp\u003eReferences 149\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Blood Flow Analysis in Epilepsy Using a Novel Stereological Approach 153\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eRocio Leal-Campanario, Luis Alarcon-Martinez, Susana Martinez-Conde, Michael Calhoun, and Stephen Macknik\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eBackground 153\u003c\/p\u003e \u003cp\u003eMaterials and Methods 155\u003c\/p\u003e \u003cp\u003eResults 166\u003c\/p\u003e \u003cp\u003eDiscussion 172\u003c\/p\u003e \u003cp\u003eReferences 173\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 AD-Type Neuron Loss in Transgenic Mouse Models 177\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eKebreten F. Manaye and Peter R. Mouton\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eBackground 177\u003c\/p\u003e \u003cp\u003eMaterials and Methods 179\u003c\/p\u003e \u003cp\u003eResults 182\u003c\/p\u003e \u003cp\u003eDiscussion 185\u003c\/p\u003e \u003cp\u003eAcknowledgments 187\u003c\/p\u003e \u003cp\u003eReferences 188\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Quantification in Populations of Nonuniformly Distributed Cells in the Human Cerebral Cortex 191\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eWilliam L. Maxwell\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eBackground 191\u003c\/p\u003e \u003cp\u003eMaterials and Methods 191\u003c\/p\u003e \u003cp\u003eResults 196\u003c\/p\u003e \u003cp\u003eDiscussion 205\u003c\/p\u003e \u003cp\u003eReferences 208\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 The Effects of High-Fat Diet on the Mouse Hypothalamus: A Stereological Study 211\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eMohammad Reza Namavar, Samira Raminfard, Zahra Vojdani Jahromi, and Hassan Azari\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eBackground 211\u003c\/p\u003e \u003cp\u003eMaterials and Methods 212\u003c\/p\u003e \u003cp\u003eResults 213\u003c\/p\u003e \u003cp\u003eDiscussion 215\u003c\/p\u003e \u003cp\u003eAcknowledgments 217\u003c\/p\u003e \u003cp\u003eReferences 218\u003c\/p\u003e \u003cp\u003e\u003cb\u003e16 2D and 3D Morphometric Analyses Comparing Three Rodent Models 221\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eJiHyuk Park and S. Omar Ahmad\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eBackground 221\u003c\/p\u003e \u003cp\u003eMaterials and Methods 221\u003c\/p\u003e \u003cp\u003eResults 226\u003c\/p\u003e \u003cp\u003eDiscussion 230\u003c\/p\u003e \u003cp\u003eReferences 235\u003c\/p\u003e \u003cp\u003e\u003cb\u003e17 A Stereologic Perspective on Autism Neuropathology 237\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eNeha Uppal and Patrick R. Hof\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eBackground 237\u003c\/p\u003e \u003cp\u003eCortical Areas 237\u003c\/p\u003e \u003cp\u003eHippocampus 248\u003c\/p\u003e \u003cp\u003eNoncortical Areas 249\u003c\/p\u003e \u003cp\u003eConclusions 253\u003c\/p\u003e \u003cp\u003eReferences 254\u003c\/p\u003e \u003cp\u003eIndex 257\u003c\/p\u003e  \u003cp\u003e\u003cstrong\u003ePeter R. Mouton\u003c\/strong\u003e is Professor of Stereology in the Department of Pathology and Cell Biology, Byrd Alzheimer's Center and Research Institute, University of South Florida. Dr. Mouton has written two early books on the broader use of stereology in biomedical research, \u003cem\u003eA Concise Guide to Unbiased Stereology\u003c\/em\u003e (JHUP 2010) and \u003cem\u003ePrinciples and Practices of Unbiased Stereology\u003c\/em\u003e (JHUP 2002). Dr. Mouton also serves as the Director of the Stereology Research Center, Inc and provides training and workshops in stereological research modalities.   \u003c\/p\u003e\u003cp\u003eStereological methods provide researchers with unique quantitative perspectives on anatomical structure that have proven particularly useful in the study of neural tissue. \u003ci\u003eNeurostereology: Unbiased Stereology of Neural Systems\u003c\/i\u003e is a timely synthesis that brings together state-of-the-art stereology theory and practices with cutting-edge research by leading neuroscientists using these approaches. \u003ci\u003eNeurostereology: Unbiased Stereology of Neural Systems\u003c\/i\u003e explores unbiased strategies to quantify stereology parameters in nervous tissue from humans and experimental animals.\u003c\/p\u003e \u003cp\u003eChapters explore a variety of study designs and resolutions, from in vivo neuroimaging (MRI, CT) to individual nerve fibers. Focusing on the most important uses of stereology, this book will be a powerful resource for the international community of neuroscience researchers in academic institutions, government agencies, and the pharmaceutical industry.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eKEY FEATURES\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e• Brings together the theory and application of this important research methodology\u003c\/p\u003e \u003cp\u003e• Explores the use of neurostereology across a range of tissue types and neural structures\u003c\/p\u003e \u003cp\u003e• Highlights principles and practices shared by all neurostereology research\u003c\/p\u003e \u003cp\u003e• Global synthesis of this increasingly important tool for neuroscience research.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eEDITOR\u003c\/b\u003e\u003cbr\u003e Peter R. Mouton, Director of the Stereology Resource Center, is Professor of Stereology in the Department of Pathology and Cell Biology and at the Byrd Alzheimer’s Center and Research Institute, University of South Florida School of Medicine, Tampa, Florida. Dr. Mouton is the author of two previous stereology books published by The Johns Hopkins University Press: Principles and Practices of Unbiased Stereology: An Introduction for Bioscientists; and Unbiased Stereology: A Concise Guide.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eRELATED TITLES\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eTranslational Neuroscience: A Guide to a Successful Program\u003c\/i\u003e\u003cbr\u003e Edgar Garcia-Rill\u003cbr\u003e ISBN: 978-0-470-96071-4\u003c\/p\u003e \u003cp\u003e\u003ci\u003eThe Cerebellum: Learning Movement, Language, and Social Skills\u003c\/i\u003e\u003cbr\u003e Dianne Broussard\u003cbr\u003e ISBN: 978-1-118-12563-2\u003c\/p\u003e","brand":"Wiley-Blackwell","offers":[{"title":"Default Title","offer_id":47989685092581,"sku":"NP9781118444214","price":154.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781118444214.jpg?v=1761785097","url":"https:\/\/k12savings.com\/es\/products\/neurostereology-isbn-9781118444214","provider":"K12savings","version":"1.0","type":"link"}