{"product_id":"molecular-hematology-isbn-9781394180455","title":"Molecular Hematology","description":"\u003cp\u003e\u003cb\u003eProvides a core knowledgebase for those with minimal exposure to hematologic molecular biology, fully revised and updated\u003c\/b\u003e \u003c\/p\u003e\u003cp\u003e\u003ci\u003eMolecular Hematology\u003c\/i\u003e brings together the most up-to-date and reliable information on the molecular basis of major hematologic diseases. Edited and authored by leading experts in the field, this volume demonstrates the clinical relevance of molecular biology in the diagnosis and treatment of blood disorders. Concise, accessible chapters address key topics in modern hematology, such as lymphoma genetics, molecular coagulation, thrombophilia, pharmacogenomics, platelet disorders, hemophilia, anemia, and multiple myeloma. Chapters introduce and summarize specific hematologic diseases, explore the pathogenesis of the disorder, highlight new and emerging molecular strategies, and more. \u003c\/p\u003e\u003cp\u003eNow in its fifth edition, \u003ci\u003eMolecular Hematology\u003c\/i\u003e is fully revised to incorporate contemporary hematology research and practice. Entirely new chapters cover topics such as CAR-T cell technology, COVID, cancer cell biology, gene therapy and gene editing in clinical practice, as well as the impact of molecular research on the diagnosis and treatment of various malignant hematologic diseases. This edition includes updated suggested readings and a wealth of new full-color charts, graphs, and illustrations throughout. \u003c\/p\u003e\u003cul\u003e \u003cli\u003eCovers the molecular biology of different blood diseases, their pathogeneses, and current molecular research and therapies\u003c\/li\u003e \u003cli\u003eIllustrates the impact of molecular research on hematologic investigations and therapeutics\u003c\/li\u003e \u003cli\u003eDiscusses how progress in basic science and therapeutics has improved the diagnosis and care of patients with various hematologic disorders\u003c\/li\u003e \u003cli\u003eSurveys recent developments in cancer-cell biology, with an emphasis on leukemia and lymphoma\u003c\/li\u003e \u003cli\u003eIncludes access to a companion Digital Edition providing search across the book, downloadable illustrations, and notation tools\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eMolecular Hematology\u003c\/i\u003e is a must-have resource for established and trainee clinicians, clinical scientists and researchers, medical students, and upper-level undergraduates in the fields of hematology, oncology, and molecular biology. \u003c\/p\u003e\u003cp\u003eList of contributors ix\u003c\/p\u003e \u003cp\u003eForeword xiii\u003c\/p\u003e \u003cp\u003ePreface xv\u003c\/p\u003e \u003cp\u003e1 Beginnings: the molecular pathology of hemoglobin 1\u003cbr\u003e \u003ci\u003eDouglas Higgs and Mohsin Badat\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 Stem cells 17\u003cbr\u003e \u003ci\u003eDavid T. Scadden\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 The genetics of acute myeloid leukemia 33\u003cbr\u003e \u003ci\u003eAmye M. Harrigan and Amy M. Trottier\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 Molecular diagnostics and risk assessment in myeloid malignancies 51\u003cbr\u003e \u003ci\u003eChristian Scharenberg and Torsten Haferlach\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 Molecular basis of acute lymphoblastic leukemia 67\u003cbr\u003e \u003ci\u003eShunsuke Kimura and Charles G. Mullighan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 Chronic myelogenous leukemia 83\u003cbr\u003e \u003ci\u003eHagop Kantarjian, Elias Jabbour and Susan O’Brien\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 Myeloproliferative neoplasms 99\u003cbr\u003e \u003ci\u003eJessica Spiers, Dina Mahdi, Christopher Saunders and Donal P. McLornan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 Lymphoma genetics 113\u003cbr\u003e \u003ci\u003eGiovanni Insuasti- Beltran, Chad M. McCall and Eric D. Hsi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 Molecular basis of chronic lymphocytic leukemia 127\u003cbr\u003e \u003ci\u003eBita Fakhri and Alexey Danilov\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 The molecular biology of multiple myeloma 137\u003cbr\u003e \u003ci\u003eUdit Yadav and Wilson I. Gonsalves\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 The molecular basis of bone marrow failure syndromes and red cell enzymopathies 145\u003cbr\u003e \u003ci\u003eDeena Iskander, Lucio Luzzatto and Anastasios Karadimitris\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 Anemia of chronic disease 169\u003cbr\u003e \u003ci\u003eTomas Ganz and Elizabeta Nemeth\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13 Molecular basis of iron metabolism 175\u003cbr\u003e \u003ci\u003eJodie L. Babitt and Tomas Ganz\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14 Perspectives in genomics and sickle cell disease therapeutics 187\u003cbr\u003e \u003ci\u003eAmbroise Wonkam\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15 Molecular coagulation and thrombophilia 201\u003cbr\u003e \u003ci\u003eBjörn Dahlbäck and Andreas Hillarp\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16 The molecular basis of hemophilia 217\u003cbr\u003e \u003ci\u003eKeith Gomez\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17 The molecular basis of von Willebrand disease 231\u003cbr\u003e \u003ci\u003eOmid Seidizadeh and Luciano Baronciani\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18 Platelet disorders 251\u003cbr\u003e \u003ci\u003eKenneth J. Clemetson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e19 The molecular basis of blood cell alloantigens 267\u003cbr\u003e \u003ci\u003eWinnie Chong, Louise Tilley and Colin Brown\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e20 Functions of blood group antigens 285\u003cbr\u003e \u003ci\u003eJonathan S. Stamler, Marilyn J. Telen and Carla Dinardo\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e21 Autoimmune hematological disorders 299\u003cbr\u003e \u003ci\u003eDrew Provan and John W. Semple\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e22 Molecular therapeutics in hematology: gene therapy 321\u003cbr\u003e \u003ci\u003eWilliam M. McKillop and Jeffrey A. Medin\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e23 Pharmacogenomics 343\u003cbr\u003e \u003ci\u003eLeo Kager and William E. Evans\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e24 Cancer stem cells 359\u003cbr\u003e \u003ci\u003eSara Ali and Dominique Bonnet\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e25 CAR- T cell therapy 369\u003cbr\u003e \u003ci\u003eJude Franklin, Prateek Pophali, Zachary Jackson, David Wald and David Avigan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e26 Molecular basis of transplantation 397\u003cbr\u003e \u003ci\u003ePramila Krishnamurthy, Victoria Potter and Francesco Dazzi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 413\u003c\/p\u003e  \u003cp\u003e\u003cb\u003eDREW PROVAN MD, FRCP, FRCPATH, \u003c\/b\u003eEmeritus Reader in Autoimmune Hematology, Centre for Immunology, Blizard Institute, Barts and The London School of Medicine \u0026amp; Dentistry, Queen Mary University of London, London, UK.  \u003c\/p\u003e\u003cp\u003e\u003cb\u003eHILLARD M. LAZARUS, MD, FACP, \u003c\/b\u003eProfessor of Hematology-Oncology, Full Professor of Medicine, The Department of Medicine, Division of Hematology-Oncology, Case Western Reserve University, Cleveland, Ohio 44106.    \u003c\/p\u003e\u003cp\u003e \u003cb\u003eProvides up-to-date and reliable information on the molecular basis of major hematologic diseases, authored and edited by leading experts in the field \u003c\/b\u003e \u003c\/p\u003e\u003cp\u003eMolecular techniques play a central role in the diagnosis and treatment of blood diseases. Molecular characterization of genes and proteins has improved our understanding of the pathogeneses of hematologic disorders and led to the development of exciting new drug therapies and recombinant proteins.  \u003c\/p\u003e\u003cp\u003e\u003ci\u003eMolecular Hematology \u003c\/i\u003eprovides a core knowledgebase on the molecular basis of major hematologic diseases. Perfect for those with limited exposure to hematologic molecular biology, this accessible volume demonstrates the clinical relevance of molecular biology in the diagnosis and treatment of blood disorders such as hemophilia, anemia, multiple myeloma, thrombophilia, platelet disorders, leukemia, and lymphoma.  \u003c\/p\u003e\u003cp\u003eNow in its fifth edition, \u003ci\u003eMolecular Hematology \u003c\/i\u003eis fully revised to incorporate current hematology research and practice. Entirely new chapters cover topics such as CAR-T cell technology, cancer cell biology, gene therapy and gene editing in clinical practice, and the impact of molecular research on the diagnosis and treatment of various malignant hematologic diseases. This edition includes updated suggested readings and a wealth of new full-color charts, graphs, and illustrations throughout.  \u003c\/p\u003e\u003cp\u003eIncluding access to a companion Digital Edition providing interactive search, downloadable illustrations, and notation tools, \u003ci\u003eMolecular Hematology, Fifth Edition\u003c\/i\u003e, is an invaluable resource for established and trainee clinicians, clinical scientists and researchers, medical students, and upper-level undergraduates in the fields of hematology, oncology, and molecular biology.\u003c\/p\u003e","brand":"Wiley-Blackwell","offers":[{"title":"Default Title","offer_id":47989647966437,"sku":"NP9781394180455","price":231.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781394180455.jpg?v=1761784949","url":"https:\/\/k12savings.com\/es\/products\/molecular-hematology-isbn-9781394180455","provider":"K12savings","version":"1.0","type":"link"}