{"product_id":"molecular-basis-of-oxidative-stress-isbn-9781119790266","title":"Molecular Basis of Oxidative Stress","description":"\u003cp\u003e\u003cb\u003eIn-depth resource on mechanisms of oxidative stress and damage and the role of free radicals in disease, diagnosis, and therapeutics\u003c\/b\u003e \u003c\/p\u003e\u003cp\u003e\u003ci\u003eMolecular Basis of Oxidative Stress\u003c\/i\u003e is a comprehensive resource on the molecular and chemical bases of oxidative stress, providing insight on various diseases caused by oxidative stress (cancer, cardiovascular, neurodegenerative) and the role of reactive oxygen species (ROS) in disease pathogenesis along with in-depth knowledge about the mechanisms of oxidative stress and damage, free radical chemistry, and the role of free radicals in disease, diagnosis, and therapeutics. \u003c\/p\u003e\u003cp\u003eThoroughly updated and expanded to reflect advances in the years since its original publication, the Second Edition includes new chapters covering topics like oxidative stress mechanisms, biomarkers, and therapeutic strategies in the management and treatment of diseases. The disease section features 10 new emerging diseases, including kidney and eye diseases and COPD. \u003c\/p\u003e\u003cp\u003eThis Second Edition also covers developments in the field in the last several years, such as an increase in mortality rate from air pollution and obstructive pulmonary diseases in which exogenous oxidants are initiators. \u003c\/p\u003e\u003cp\u003eWritten by a team of highly qualified academics, \u003ci\u003eMolecular Basis of Oxidative Stress\u003c\/i\u003e discusses sample topics including: \u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eClassification, physico-chemical properties, sources, and detection of reactive species and etiology of COPD from cigarette smoke and pollution\u003c\/li\u003e \u003cli\u003eOxidative, reductive and indirect non-redox modifications of key biomolecular systems such as lipids, proteins, and DNA by reactive species\u003c\/li\u003e \u003cli\u003eGene expression of antioxidant defense enzymes, mitochondrial dysfunction and aberrant activation of NOX and cell signaling\u003c\/li\u003e \u003cli\u003eBiomarkers of oxidative stress in neurodegenerative diseases and emerging fields inbiomarker discovery such as cysteinylated albumin and nitroalkene fatty acids\u003c\/li\u003e\n\u003c\/ul\u003e \u003cp\u003eImparting strong foundational knowledge of redox chemistry, chemistry of oxidative damage and mechanisms of oxidative stress, and oxidative stress-mediated disease pathogenesis, \u003ci\u003eMolecular Basis of Oxidative Stress \u003c\/i\u003eis an essential reference for both novice and advanced toxicologists, biochemists, and pharmacologists, along with clinical and medical scientists in various fields such as oncology, cardiovascular, andneuroscience. \u003c\/p\u003e\u003cp\u003eList of Contributors xxi\u003c\/p\u003e \u003cp\u003ePreface to Second Edition xxix\u003c\/p\u003e \u003cp\u003ePreface First Edition xxxi\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Chemistry of Reactive Species 1\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eFrederick A. Villamena\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.1 Redox Chemistry 1\u003c\/p\u003e \u003cp\u003e1.2 Classification of Reactive Species 2\u003c\/p\u003e \u003cp\u003e1.3 Reactive Oxygen Species 4\u003c\/p\u003e \u003cp\u003e1.4 Reactive Nitrogen Species 15\u003c\/p\u003e \u003cp\u003e1.5 Reactive Sulfur and Chlorine Species 18\u003c\/p\u003e \u003cp\u003e1.6 Reactivity 23\u003c\/p\u003e \u003cp\u003e1.7 Origins of Reactive Species 27\u003c\/p\u003e \u003cp\u003e1.8 Methods of Detection 32\u003c\/p\u003e \u003cp\u003eReferences 39\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Lipid Peroxidation and Nitration 49\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eSean S. Davies and Lilu Guo\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eOverview 49\u003c\/p\u003e \u003cp\u003e2.1 Peroxidation of PUFAs 49\u003c\/p\u003e \u003cp\u003e2.2 Cyclic Endoperoxides and Their Products 52\u003c\/p\u003e \u003cp\u003e2.3 Fragmented Products of Lipid Peroxidation 58\u003c\/p\u003e \u003cp\u003e2.4 Epoxy Fatty Acids 62\u003c\/p\u003e \u003cp\u003e2.5 Lipid Nitrosylation 62\u003c\/p\u003e \u003cp\u003eSummary 65\u003c\/p\u003e \u003cp\u003eReferences 65\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Protein Posttranslational Modification 71\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eJames L. Hougland Joseph Darling and Susan Flynn\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eOverview 71\u003c\/p\u003e \u003cp\u003e3.1 Oxidative Stress-Related PTMs: Oxidation Reactions 71\u003c\/p\u003e \u003cp\u003e3.2 Amino Acid Modification by Oxidation-Produced Electrophiles 80\u003c\/p\u003e \u003cp\u003e3.3 Detection of Oxidative-Stress Related PTMs 81\u003c\/p\u003e \u003cp\u003e3.4 Role of PTMs in Cellular Redox Signaling 84\u003c\/p\u003e \u003cp\u003eSummary 85\u003c\/p\u003e \u003cp\u003eReferences 85\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 DNA Oxidation 93\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eDessalegn B. Nemera Amy R. Jones and Edward J. Merino\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eOverview 93\u003c\/p\u003e \u003cp\u003e4.1 The Context of Cellular DNA Oxidation 93\u003c\/p\u003e \u003cp\u003e4.2 Oxidation of Oligonucleotides 94\u003c\/p\u003e \u003cp\u003e4.3 Examination of Specific Oxidative Lesions 96\u003c\/p\u003e \u003cp\u003eFuture Outlook of DNA Oxidative Lesions 103\u003c\/p\u003e \u003cp\u003eReferences 103\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Cellular Antioxidants and Phase 2 Proteins 113\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eYunbo li\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.1 Definitions 113\u003c\/p\u003e \u003cp\u003e5.2 Roles in Oxidative Stress 113\u003c\/p\u003e \u003cp\u003e5.3 Molecular Regulation 117\u003c\/p\u003e \u003cp\u003e5.4 Induction in Chemoprevention 119\u003c\/p\u003e \u003cp\u003e5.5 Inactivation 119\u003c\/p\u003e \u003cp\u003eReferences 121\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Mitochondrial Dysfunction 129\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eYeong-Renn Chen and Chwen-Lin Chen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.1 Mitochondria and Submitochondrial Particles 129\u003c\/p\u003e \u003cp\u003e6.2 Energy Transduction 131\u003c\/p\u003e \u003cp\u003e6.3 Mitochondrial Stress 132\u003c\/p\u003e \u003cp\u003e6.4 Superoxide Anion Radical Generation as Mediated by ΔPH Δψ ETC and Disease Pathogenesis 133\u003c\/p\u003e \u003cp\u003eReferences 143\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 NADPH Oxidases: Structure and Function 147\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eMark T. Quinn\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eOverview 147\u003c\/p\u003e \u003cp\u003e7.1 Introduction 147\u003c\/p\u003e \u003cp\u003e7.2 Phagocyte NADPH Oxidase Structure 147\u003c\/p\u003e \u003cp\u003e7.3 Phagocyte ROS Production 152\u003c\/p\u003e \u003cp\u003e7.4 Phagocyte NADPH Oxidase Function 155\u003c\/p\u003e \u003cp\u003e7.5 Nonphagocyte NADPH Oxidase Structure 156\u003c\/p\u003e \u003cp\u003e7.6 Nonphagocyte ROS Production 161\u003c\/p\u003e \u003cp\u003e7.7 Functions of Nonphagocyte NADPH Oxidases 162\u003c\/p\u003e \u003cp\u003eSummary 169\u003c\/p\u003e \u003cp\u003eAcknowledgments 169\u003c\/p\u003e \u003cp\u003eReferences 170\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Cell Signaling and Transcription 189\u003cbr\u003e \u003cbr\u003e \u003c\/b\u003e\u003ci\u003eImran Rehmani Fange Liu and Aimin Liu\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eOverview 189\u003c\/p\u003e \u003cp\u003e8.1 Common Mechanisms of Redox Signaling 189\u003c\/p\u003e \u003cp\u003e8.2 Redox and Oxygen-Sensitive Transcription Factors in Prokaryotes 191\u003c\/p\u003e \u003cp\u003e8.3 Redox Signaling in Metazoans 195\u003c\/p\u003e \u003cp\u003e8.4 Oxygen Sensing in Metazoans 200\u003c\/p\u003e \u003cp\u003e8.5 Medical Significance of Redox and Oxygen-Sensing Pathways 204\u003c\/p\u003e \u003cp\u003eConcluding Remarks 205\u003c\/p\u003e \u003cp\u003eReferences 205\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Oxidative Stress and Redox Signaling in Carcinogenesis 213\u003cbr\u003e \u003cbr\u003e \u003c\/b\u003e\u003ci\u003eRodrigo Franco Aracely Garcia-Garcia Thomas B. Kryston Alexandros G. Georgakilas Mihalis I. Panayiotidis and Aglaia Pappa\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eOverview 213\u003c\/p\u003e \u003cp\u003e9.1 Redox Environment and Cancer 213\u003c\/p\u003e \u003cp\u003e9.2 Oxidative Modifications to Biomolecules and Carcinogenesis 217\u003c\/p\u003e \u003cp\u003e9.3 Measurement of Oxidative DNA Damage in Human Cancer 223\u003c\/p\u003e \u003cp\u003e9.4 Epigenetic Involvement in Oxidative Stress-Induced Carcinogenesis 223\u003c\/p\u003e \u003cp\u003e9.5 Deregulation of Cell Death Pathways by Oxidative Stress in Cancer Progression 226\u003c\/p\u003e \u003cp\u003eConclusions and Perspective 230\u003c\/p\u003e \u003cp\u003eAcknowledgments 231\u003c\/p\u003e \u003cp\u003eReferences 231\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Neurodegeneration from Drugs and Aging-Derived Free Radicals 247\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eAnnmarie Ramkissoon Aaron M. Shapiro Margaret M. Loniewska and Peter G. Wells\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eOverview 247\u003c\/p\u003e \u003cp\u003e10.1 ROS Formation 247\u003c\/p\u003e \u003cp\u003e10.2 Protection against ROS 273\u003c\/p\u003e \u003cp\u003e10.3 Nrf2 Regulation of Protective Responses 279\u003c\/p\u003e \u003cp\u003eSummary and Conclusions 291\u003c\/p\u003e \u003cp\u003eAcknowledgments 291\u003c\/p\u003e \u003cp\u003eReferences 291\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Cardiac Ischemia and Reperfusion 321\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eMurugesan Velayutham and Jay L. Zweier\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eOverview 321\u003c\/p\u003e \u003cp\u003e11.1 Oxygen in the Heart 321\u003c\/p\u003e \u003cp\u003e11.2 Sources of ROS during Ischemia and Reperfusion 322\u003c\/p\u003e \u003cp\u003e11.3 Modulation of Substrates Metabolites and Cofactors during I-R 326\u003c\/p\u003e \u003cp\u003e11.4 ROS-Mediated Cellular Communication during I-R 328\u003c\/p\u003e \u003cp\u003e11.5 ROS and Cell Death during Ischemia and Reperfusion 329\u003c\/p\u003e \u003cp\u003e11.6 Potential Therapeutic Strategies 330\u003c\/p\u003e \u003cp\u003eSummary and Conclusion 331\u003c\/p\u003e \u003cp\u003eReferences 331\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Atherosclerosis: Oxidation Hypothesis 339\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eChandrakala Aluganti Narasimhulu Dmitry Litvinov Xueting Jiang Zhaohui Yang and Sampath Parthasarathy\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eOverview 339\u003c\/p\u003e \u003cp\u003e12.1 Lipid Peroxidation 339\u003c\/p\u003e \u003cp\u003e12.2 Oxidation Hypothesis of Atherosclerosis 340\u003c\/p\u003e \u003cp\u003e12.3 Animal Models of Atherosclerosis 341\u003c\/p\u003e \u003cp\u003e12.4 Aldehyde Generation from Peroxidized Lipids 343\u003c\/p\u003e \u003cp\u003eSummary 344\u003c\/p\u003e \u003cp\u003eAcknowledgments 345\u003c\/p\u003e \u003cp\u003eReferences 345\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Cystic Fibrosis 355\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eNeal S. Gould and Brian J. Day\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eOverview 355\u003c\/p\u003e \u003cp\u003e13.1 Lung Disease Characteristics in CF 355\u003c\/p\u003e \u003cp\u003e13.2 Role of CFTR in the Lung 358\u003c\/p\u003e \u003cp\u003e13.3 Oxidative Stress in the CFTR-Deficient Lung 358\u003c\/p\u003e \u003cp\u003e13.4 Antioxidant Therapies for CF 361\u003c\/p\u003e \u003cp\u003eSummary 363\u003c\/p\u003e \u003cp\u003eReferences 363\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Cigarette Smoking and Air Pollution 369\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eAndrew J. Ghio and Urmila Kodavanti\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14.1 Exposure to Cigarette Smoke 369\u003c\/p\u003e \u003cp\u003e14.2 Air Pollution Particles 371\u003c\/p\u003e \u003cp\u003e14.3 Ozone 374\u003c\/p\u003e \u003cp\u003e14.4 Nitrogen and Sulfur Oxides 374\u003c\/p\u003e \u003cp\u003e14.5 Interaction between PM and Oxidant Gases 375\u003c\/p\u003e \u003cp\u003e14.6 Oxidative Stress and Mechanistic Pathways of Disease After Exposure to Air Pollutants 375\u003c\/p\u003e \u003cp\u003eReferences 375\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 Oxidative Stress in Chronic Obstructive Pulmonary Disease 381\u003cbr\u003e \u003c\/b\u003e\u003ci\u003ePeter J. Barnes\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15.1 Introduction 381\u003c\/p\u003e \u003cp\u003e15.2 Increased Oxidative Stress in COPD 382\u003c\/p\u003e \u003cp\u003e15.3 Effects of Oxidative Stress in COPD 384\u003c\/p\u003e \u003cp\u003e15.4 Strategies for Reducing Oxidative Stress 386\u003c\/p\u003e \u003cp\u003e15.5 Conclusions 389\u003c\/p\u003e \u003cp\u003eReferences 389\u003c\/p\u003e \u003cp\u003e\u003cb\u003e16 Oxidative Stress in the Eye 395\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eAnnie K. Ryan Wade W. Rich Peter A. Jansen Megan M. Allyn Katelyn E. Swindle-Reilly and Matthew A. Reilly\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16.1 Introduction 395\u003c\/p\u003e \u003cp\u003e16.2 The Cornea 396\u003c\/p\u003e \u003cp\u003e16.3 The Lens 400\u003c\/p\u003e \u003cp\u003e16.4 The Vitreous Humor 403\u003c\/p\u003e \u003cp\u003e16.5 The Retina and Optic Nerve 404\u003c\/p\u003e \u003cp\u003e16.6 Therapeutic Approaches to ROS Elevation in the Eye 407\u003c\/p\u003e \u003cp\u003e16.7 Conclusion 408\u003c\/p\u003e \u003cp\u003eReferences 408\u003c\/p\u003e \u003cp\u003e\u003cb\u003e17 The Role of Oxidative Stress in Chronic Kidney Disease (CKD) 417\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eAra Aboolian Jordan Younes Alejandra Romero Jay C. Jha Karin Jandeleit-Dahm and Jaroslawna Meister\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17.1 Introduction 417\u003c\/p\u003e \u003cp\u003e17.2 Sources of Oxidative Stress in CKD 419\u003c\/p\u003e \u003cp\u003e17.3 Mechanisms by Which Oxidative Stress Contributes to CKD 421\u003c\/p\u003e \u003cp\u003e17.4 Interplay Between Oxidative Stress and Senescence in CKD 423\u003c\/p\u003e \u003cp\u003e17.5 Treatment Options for CKD 423\u003c\/p\u003e \u003cp\u003eReferences 429\u003c\/p\u003e \u003cp\u003e\u003cb\u003e18 Biomarkers of Oxidative Stress in Neurodegenerative Diseases 437\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eRukhsana Sultana Giovanna Cenini and D. Allan Butterfield\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eOverview 437\u003c\/p\u003e \u003cp\u003e18.1 Introduction 437\u003c\/p\u003e \u003cp\u003e18.2 Biomarkers of Protein Oxidation\/Nitration 439\u003c\/p\u003e \u003cp\u003e18.3 Biomarkers of Lipid Peroxidation 441\u003c\/p\u003e \u003cp\u003e18.4 Biomarkers of Carbohydrate Oxidation 444\u003c\/p\u003e \u003cp\u003e18.5 Biomarkers of Nucleic Acid Oxidation 445\u003c\/p\u003e \u003cp\u003eAcknowledgments 446\u003c\/p\u003e \u003cp\u003eReferences 446\u003c\/p\u003e \u003cp\u003e\u003cb\u003e19 Cysteinylated Albumin as Oxidative Stress Biomarker and Therapeutic Target 455\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eAlessandra Altomare Giulio Vistoli Cristina Banfi and Giancarlo Aldini\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e19.1 Introduction 455\u003c\/p\u003e \u003cp\u003e19.2 Cellular and Extracellular Thiols Distribution 455\u003c\/p\u003e \u003cp\u003e19.3 HSA and CYS34 456\u003c\/p\u003e \u003cp\u003e19.4 CYS34 Reactivity and Reactions 458\u003c\/p\u003e \u003cp\u003e19.5 CYS34 Oxidized Forms in Physio-Pathological Conditions 460\u003c\/p\u003e \u003cp\u003e19.6 Endogenous Regulation of Intracellular and Extracellular Thiol-Redox Homeostasis 462\u003c\/p\u003e \u003cp\u003e19.7 Molecular and Therapeutic Strategies for Reversing Mercaptalbumin from the Oxidized Forms 462\u003c\/p\u003e \u003cp\u003e19.8 Conclusion 464\u003c\/p\u003e \u003cp\u003eReferences 465\u003c\/p\u003e \u003cp\u003e\u003cb\u003e20 Nitroalkene Fatty Acids: Formation Metabolism Reactivity and Signaling 469\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eMartina Steglich Martín Sosa Francisco J. Schopfer and Lucía Turell\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e20.1 Introduction 469\u003c\/p\u003e \u003cp\u003e20.2 Diet and Fatty Acids 469\u003c\/p\u003e \u003cp\u003e20.3 Nitroalkene Fatty Acids in Vivo Formation 470\u003c\/p\u003e \u003cp\u003e20.4 Metabolism and Distribution 471\u003c\/p\u003e \u003cp\u003e20.5 Reactivity of Nitroalkene Fatty Acids 472\u003c\/p\u003e \u003cp\u003e20.6 Nitroalkylation as A Protein Post-Translational Modification 473\u003c\/p\u003e \u003cp\u003e20.7 Nitrooleic Acid and Disease 475\u003c\/p\u003e \u003cp\u003e20.8 Concluding Remarks 477\u003c\/p\u003e \u003cp\u003eAbbreviations 477\u003c\/p\u003e \u003cp\u003eReferences 478\u003c\/p\u003e \u003cp\u003e\u003cb\u003e21 Synthetic Antioxidants 483\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eGrégory Durand\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eOverview 483\u003c\/p\u003e \u003cp\u003e21.1 Endogenous Enzymatic System of Defense 483\u003c\/p\u003e \u003cp\u003e21.2 Metal-Based Synthetic Antioxidants 484\u003c\/p\u003e \u003cp\u003e21.3 Nonmetal-Based Antioxidants 488\u003c\/p\u003e \u003cp\u003e21.4 Nitrones 495\u003c\/p\u003e \u003cp\u003eReferences 504\u003c\/p\u003e \u003cp\u003eIndex 513\u003c\/p\u003e  \u003cp\u003e\u003cb\u003eFrederick A. Villamena,\u003c\/b\u003e  PhD, is an Associate Professor of Biological Chemistry and Pharmacology at The Ohio State University, College of Medicine. \u003c\/p\u003e\u003cp\u003e\u003cb\u003eHenry Jay Forman,\u003c\/b\u003e PhD,  is both Distinguished Professor Emeritus of Biochemistry at the University of California, Merced and Research Professor Emeritus of Gerontology at the University of Southern California Leonard Davis School of Gerontology.    \u003c\/p\u003e\u003cp\u003e\u003cb\u003eIn-depth resource on mechanisms of oxidative stress and damage and the role of free radicals in disease, diagnosis, and therapeutics\u003c\/b\u003e \u003c\/p\u003e\u003cp\u003e\u003ci\u003eMolecular Basis of Oxidative Stress\u003c\/i\u003e is a comprehensive resource on the molecular and chemical bases of oxidative stress, providing insight on various diseases caused by oxidative stress (cancer, cardiovascular, neurodegenerative) and the role of reactive oxygen species (ROS) in disease pathogenesis along with in-depth knowledge about the mechanisms of oxidative stress and damage, free radical chemistry, and the role of free radicals in disease, diagnosis, and therapeutics. \u003c\/p\u003e\u003cp\u003eThoroughly updated and expanded to reflect advances in the years since its original publication, the Second Edition includes new chapters covering topics like oxidative stress mechanisms, biomarkers, and therapeutic strategies in the management and treatment of diseases. The disease section features 10 new emerging diseases, including kidney and eye diseases and COPD. \u003c\/p\u003e\u003cp\u003eThis Second Edition also covers developments in the field in the last several years, such as an increase in mortality rate from air pollution and obstructive pulmonary diseases in which exogenous oxidants are initiators. \u003c\/p\u003e\u003cp\u003eWritten by a team of highly qualified academics, \u003ci\u003eMolecular Basis of Oxidative Stress\u003c\/i\u003e discusses sample topics including: \u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eClassification, physico-chemical properties, sources, and detection of reactive species and etiology of COPD from cigarette smoke and pollution\u003c\/li\u003e \u003cli\u003eOxidative, reductive and indirect non-redox modifications of key biomolecular systems such as lipids, proteins, and DNA by reactive species\u003c\/li\u003e \u003cli\u003eGene expression of antioxidant defense enzymes, mitochondrial dysfunction and aberrant activation of NOX and cell signaling\u003c\/li\u003e \u003cli\u003eBiomarkers of oxidative stress in neurodegenerative diseases and emerging fields inbiomarker discovery such as cysteinylated albumin and nitroalkene fatty acids\u003c\/li\u003e\n\u003c\/ul\u003e \u003cp\u003eImparting strong foundational knowledge of redox chemistry, chemistry of oxidative damage and mechanisms of oxidative stress, and oxidative stress-mediated disease pathogenesis, \u003ci\u003eMolecular Basis of Oxidative Stress \u003c\/i\u003eis an essential reference for both novice and advanced toxicologists, biochemists, and pharmacologists, along with clinical and medical scientists in various fields such as oncology, cardiovascular, andneuroscience.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989647016165,"sku":"NP9781119790266","price":249.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781119790266.jpg?v=1761784945","url":"https:\/\/k12savings.com\/es\/products\/molecular-basis-of-oxidative-stress-isbn-9781119790266","provider":"K12savings","version":"1.0","type":"link"}