{"product_id":"modern-tools-for-the-synthesis-of-complex-bioactive-molecules-isbn-9780470616185","title":"Modern Tools for the Synthesis of Complex Bioactive Molecules","description":"\u003cp\u003e\u003cb\u003eAll the latest tools needed to plan and perform the synthesis of complex bioactive molecules\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eFocusing on organic, organometallic, and bio-oriented processes, this book explores the impact and use of the latest synthetic tools for the synthesis of complex biologically active compounds. Readers will discover step by step how these synthetic tools have provided new, elegant solutions to many synthetic puzzles. Moreover, they will discover innovative methods that make it possible to control the exact connectivity of atoms within a molecule in order to set precise three-dimensional arrangements.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eModern Tools for the Synthesis of Complex Bioactive Molecules\u003c\/i\u003e features sixteen chapters, each one written by one or more leading experts in organic synthesis from around the world. It covers a broad range of topics that enable readers to take advantage of the latest methods for synthesizing complex molecules, including:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eModern catalysis, emphasizing key transformations such as C-H functionalizations, cross-couplings, gold-catalyzed reactions, metathesis-based syntheses, and asymmetric organocatalysis\u003c\/li\u003e \u003cli\u003eEco-compatible transformations, including rearrangements and domino reactions\u003c\/li\u003e \u003cli\u003eTools for the synthesis of carbohydrates and alkaloids\u003c\/li\u003e \u003cli\u003eNew techniques, including the use of fluorous tags and engineered biosynthesis\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThe last two chapters explore target- and diversity-oriented organic synthesis as well as the use of DNA-based asymmetric catalysis, which are all promising tools for the successful synthesis of complex bioactive molecules.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eModern Tools for the Synthesis of Complex Bioactive Molecules\u003c\/i\u003e is ideal for students and researchers who need to plan and perform the synthesis of complex molecules as efficiently as possible. The book's expert advice will help these readers quickly resolve a broad range of problems that can arise in organic syntheses.\u003c\/p\u003e  \u003cp\u003eFOREWORD vii\u003c\/p\u003e \u003cp\u003ePREFACE ix\u003c\/p\u003e \u003cp\u003eCONTRIBUTORS xi\u003c\/p\u003e \u003cp\u003eCHAPTER 1 C–H FUNCTIONALIZATION: A NEW STRATEGY FOR THE SYNTHESIS OF BIOLOGICALLY ACTIVE NATURAL PRODUCTS 1\u003cbr\u003e \u003ci\u003eSophie Rousseaux, Benoýˆt Lie´gault, and Keith Fagnou\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 2 THE NEGISHI CROSS-COUPLING IN THE SYNTHESIS OF NATURAL PRODUCTS AND BIOACTIVE MOLECULES 33\u003cbr\u003e \u003ci\u003eEvelina Colacino, Jean Martinez, and Fre´de´ric Lamaty\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 3 METAL-CATALYZED C–HETEROATOM CROSS-COUPLING REACTIONS 77\u003cbr\u003e \u003ci\u003eRenata Marcia de Figueiredo, Jean Marc Campagne, and Damien Prim\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 4 GOLDEN OPPORTUNITIES IN THE SYNTHESIS OF NATURAL PRODUCTS AND BIOLOGICALLY ACTIVE COMPOUNDS 111\u003cbr\u003e \u003ci\u003eFabien Gagosz\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 5 METATHESIS-BASED SYNTHESIS OF COMPLEX BIOACTIVES 155\u003cbr\u003e \u003ci\u003eJean-Alexandre Richard, Sin Yee Ng, and David Y.-K. Chen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 6 ENANTIOSELECTIVE ORGANOCATALYSIS: A POWERFUL TOOL FOR THE SYNTHESIS OF BIOACTIVE MOLECULES 189\u003cbr\u003e \u003ci\u003eMitsuru Shoji and Yujiro Hayashi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 7 ASYMMETRIC PHASE-TRANSFER CATALYSIS 213\u003cbr\u003e \u003ci\u003eSeiji Shirakawa, Shin A. Moteki, and Keiji Maruoka\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 8 REARRANGEMENTS IN NATURAL PRODUCT SYNTHESIS 243\u003cbr\u003e \u003ci\u003eJose´ Marco-Contelles and Elena Soriano\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 9 DOMINO REACTIONS IN THE ENANTIOSELECTIVE SYNTHESIS OF BIOACTIVE NATURAL PRODUCTS 271\u003cbr\u003e \u003ci\u003eLutz F. Tietze, Scott G. Stewart, and Alexander Du¨fert\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 10 FLUOROUS LINKER-FACILITATED SYNTHESIS OF BIOLOGICALLY INTERESTING MOLECULES 335\u003cbr\u003e \u003ci\u003eWei Zhang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 11 THE EVOLUTION OF IMMOBILIZED REAGENTS AND THEIR APPLICATION IN FLOW CHEMISTRY FOR THE SYNTHESIS OF NATURAL PRODUCTS AND PHARMACEUTICAL COMPOUNDS 359\u003cbr\u003e \u003ci\u003eRebecca M. Myers, Kimberley A. Roper, Ian R. Baxendale, and Steven V. Ley\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 12 SYNTHETIC APPROACHES TO BIOACTIVE CARBOHYDRATES 395\u003cbr\u003e \u003ci\u003eXavier Guinchard, Se´bastien Picard, and David Crich\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 13 AMMONIUM YLIDES AS BUILDING BLOCKS FOR ALKALOID SYNTHESIS 433\u003cbr\u003e \u003ci\u003eScott Bur and Albert Padwa\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 14 PRECURSOR-DIRECTED BIOSYNTHESIS OF POLYKETIDE AND NONRIBOSOMAL PEPTIDE NATURAL PRODUCTS 485\u003cbr\u003e \u003ci\u003eColin J. B. Harvey and Chaitan Khosla\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 15 TARGET-ORIENTED AND DIVERSITY-ORIENTED ORGANIC SYNTHESIS 513\u003cbr\u003e \u003ci\u003eRaphae¨l Rodriguez\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCHAPTER 16 DNA AS A TOOL FOR MOLECULAR DISCOVERY 539\u003cbr\u003e \u003ci\u003eMichael Smietana, Jean-Jacques Vasseur, Janine Cossy, and Stellios Arseniyadis\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eINDEX 557\u003c\/p\u003e  \u003cp\u003e\u003cb\u003eJANINE COSSY\u003c\/b\u003e graduated from the University of Reims working under the supervision of Prof. Jean-Pierre Pète. After a postdoctoral stay with Prof. Barry Trost (1980-1982) at the University of Wisconsin, she returned to Reims where she became Director of Research of the CNRS in 1990. The same year, she moved to Paris to become Professor of Organic Chemistry at the Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI ParisTech). She has published over 380 articles and filed thirteen patents in the field of synthetic organic chemistry and natural product synthesis. She is Associate Editor at \u003ci\u003eOrganic Letters\u003c\/i\u003e since 2005.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSTELLIOS ARSENIYADIS\u003c\/b\u003e was born in Greece in 1975. He studied chemistry at the Université Paris XI and received his PhD in 2002 from the Université Louis Pasteur (Strasbourg, France) working under the guidance of Dr. Charles Mioskowski. In 2001, he joined Rhodia ChiRex (Boston, USA) for an eighteen-month internship in collaboration with Prof. Stephen L. Buchwald (MIT, USA). He then spent a year as a postdoctoral fellow at Imperial College London (UK) working under the supervision of Prof. Alan C. Spivey, after which he joined Prof. K. C. Nicolaou's group at The Scripps Research Institute (La Jolla, USA) for an additional postdoc. In 2005, he was appointed by the CNRS as Chargé de Recherche in Prof. Janine Cossy's group. His research interests include the development of new synthetic tools and their application to the total synthesis of complex natural products.\u003c\/p\u003e  \u003cp\u003e\u003cb\u003eAll the latest tools needed to plan and perform the synthesis of complex bioactive molecules\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eFocusing on organic, organometallic, and bio-oriented processes, this book explores the impact and use of the latest synthetic tools for the synthesis of complex biologically active compounds. Readers will discover step by step how these synthetic tools have provided new, elegant solutions to many synthetic puzzles. Moreover, they will discover innovative methods that make it possible to control the exact connectivity of atoms within a molecule in order to set precise three-dimensional arrangements.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eModern Tools for the Synthesis of Complex Bioactive Molecules\u003c\/i\u003e features sixteen chapters, each one written by one or more leading experts in organic synthesis from around the world. It covers a broad range of topics that enable readers to take advantage of the latest methods for synthesizing complex molecules, including:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eModern catalysis, emphasizing key transformations such as C-H functionalizations, cross-couplings, gold-catalyzed reactions, metathesis-based syntheses, and asymmetric organocatalysis\u003c\/li\u003e \u003cli\u003eEco-compatible transformations, including rearrangements and domino reactions\u003c\/li\u003e \u003cli\u003eTools for the synthesis of carbohydrates and alkaloids\u003c\/li\u003e \u003cli\u003eNew techniques, including the use of fluorous tags and engineered biosynthesis\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThe last two chapters explore target- and diversity-oriented organic synthesis as well as the use of DNA-based asymmetric catalysis, which are all promising tools for the successful synthesis of complex bioactive molecules.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eModern Tools for the Synthesis of Complex Bioactive Molecules\u003c\/i\u003e is ideal for students and researchers who need to plan and perform the synthesis of complex molecules as efficiently as possible. The book's expert advice will help these readers quickly resolve a broad range of problems that can arise in organic syntheses.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989645017317,"sku":"NP9780470616185","price":184.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470616185.jpg?v=1761784938","url":"https:\/\/k12savings.com\/es\/products\/modern-tools-for-the-synthesis-of-complex-bioactive-molecules-isbn-9780470616185","provider":"K12savings","version":"1.0","type":"link"}