{"product_id":"mitochondrial-biology-isbn-9780470066577","title":"Mitochondrial Biology","description":"With the recent renaissance in mitochondrial biology and increasing recognition of their role in many diseases, this book provides a timely summary of the current state-of-the-art in mitochondrial research. The book opens with the regulation of mitochondrial replication and biogenesis and reviews the mechanisms and functional consequences of mitochondrial fission and fusion. Further chapters address mitochondria and oxidative stress and their roles in cell signalling and cell death. The book includes extensive, fascinating discussion of the biochemistry of mitochondrial cell signalling (especially involving calcium) and of oxidative stress. The nature of the proteins engaged in these processes, many only recently discovered, is covered in detail.  \u003cp\u003eMitochondria have been strongly implicated in neurodegenerative diseases such as Parkinson’s, Huntington’s and amyotrophic lateral sclerosis. They are also affected in cancer, ageing and cardiovascular disease. The final section of the book reviews mitochondrial mutations and their consequences in ageing and other phenotypic manifestations. The authors discuss how mitochondrial proteins might constitute important therapeutic targets and describe initial attempts to develop compounds that can regulate their function.\u003c\/p\u003e  Symposium on New perspectives on mitochondrial biolog y, held at the Novartis Foundation, London, 28–30 November 2006.  \u003cp\u003eEditors: Derek J. Chadwick (Organizer) and Jamie Goode.\u003c\/p\u003e \u003cp\u003eThis symposium is based on a proposal by Michael Duchen.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eDavid G. Nicholls\u003c\/b\u003e Chair's introduction.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAlbert Neutzner, Richard J. Youle\u003c\/b\u003e and \u003cb\u003eMariusz Karbowski,\u003c\/b\u003e Outer mitochondrial membrane protein degradation by the proteasome.\u003cbr\u003e Discussion.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSarah E. Haigh, Gilad Twig, Anthony A. J. Molina, Jakob D. Wikstrom,\u003c\/b\u003e \u003cb\u003eMotti Deutsch\u003c\/b\u003e and \u003cb\u003eOrian S. Shirihai\u003c\/b\u003e PA-GFP: a window into the subcellular adventures of the individual mitochondrion.\u003cbr\u003e Discussion.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eLuca Scorrano,\u003c\/b\u003e Multiple functions of mitochondria-shaping proteins. Discussion.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eBruce M. Spiegelman,\u003c\/b\u003e Transcriptional control of mitochondrial energy metabolism through the PGC1 coactivators.\u003cbr\u003e Discussion.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eCharles Affourtit, Paul G. Crichton, Nadeene Parker\u003c\/b\u003e and \u003cb\u003eMartin D. Brand,\u003c\/b\u003e Novel uncoupling proteins.\u003cbr\u003e Discussion.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eCecilia Giulivi,\u003c\/b\u003e Mitochondria as generators and targets of nitric oxide. Discussion.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eGyörgy Hajnóczky, Masao Saotome, György Csordás, David Weaver\u003c\/b\u003e and \u003cb\u003eMuqing Yi,\u003c\/b\u003e Calcium signalling and mitochondrial motility.\u003cbr\u003e Discussion.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAnna Romagnoli, Paola Aguiari, Diego De Stefani, Sara Leo,\u003c\/b\u003e \u003cb\u003eSaverio Marchi, Alessandro Rimessi, Erika Zecchini, Paolo Pinton\u003c\/b\u003e and \u003cb\u003eRosario Rizzuto,\u003c\/b\u003e Endoplasmic reticulum\/mitochondria calcium cross-talk.\u003cbr\u003e Discussion.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eBrian O’Rourke, Sonia Cortassa, Fadi Akar\u003c\/b\u003e and \u003cb\u003eMiguel Aon,\u003c\/b\u003e Mitochondrial ion channels in cardiac function and dysfunction.\u003cbr\u003e Discussion.\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePaolo Bernardi\u003c\/b\u003e and \u003cb\u003eMichael Forte,\u003c\/b\u003e The mitochondrial permeability transition pore.\u003cbr\u003e Discussion.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eDominic James, Philippe A. Parone, Olivier Terradillos,\u003c\/b\u003e \u003cb\u003eSafa Lucken-Ardjomande, Sylvie Montessuit\u003c\/b\u003e and \u003cb\u003eJean-Claude Martinou,\u003c\/b\u003e Mechanisms of mitochondrial outer membrane permeabilization.\u003cbr\u003e Discussion.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eM. Flint Beal,\u003c\/b\u003e Mitochondria and neurodegeneration.\u003c\/p\u003e \u003cp\u003eDiscussion.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eMügen Terzioglu\u003c\/b\u003e and \u003cb\u003eNils-Göran Larsson,\u003c\/b\u003e Mitochondrial dysfunction in mammalian ageing.\u003cbr\u003e Discussion.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eEric A. Schon\u003c\/b\u003e and \u003cb\u003eSalvatore DiMauro.\u003c\/b\u003e Mitochondrial mutations: genotype to phenotype.\u003cbr\u003e Discussion.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eContributor Index.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSubject index.\u003c\/b\u003e\u003c\/p\u003e  \u003cb\u003eThe Novartis Foundation\u003c\/b\u003e is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.   \u003cp\u003eChairman: David G Nicholls, Buck Institute for Age Research, Novato, USA.\u003c\/p\u003e  The field of mitochondrial research has experienced a renaissance in recent years encompassing a complete re-evaluation of mitochondrial biochemistry and biology. It is now clear that mitochondria are not only involved in the business of ATP synthesis, but are also intimately involved in cell signalling and, particularly, in cell death.  \u003cp\u003eContaining contributions from many of the leading laboratories in mitochondrial biology worldwide, this book provides a timely summary of the current state-of-the-art research. It opens with coverage of the regulation of mitochondrial replication and biogenesis and a review of the mechanisms and functional consequences of mitochondrial fission and fusion.\u003c\/p\u003e \u003cp\u003eFurther chapters address the topic of mitochondria and oxidative stress and their roles in cell signalling and cell death: key steps in the progression of programmed cell death are initiated by mitochondrial signals and key steps in the progression of necrotic cell death start with mitochondrial dysfunction. The nature of the proteins engaged in these processes, many only recently discovered, is covered in detail.\u003c\/p\u003e \u003cp\u003eAs we learn more about these novel proteins and mechanisms – including the permeability transition pore and ion channels – we begin to see how they may play a role in cell physiology and pathology.  Mitochondria have been strongly implicated in neurodegenerative diseases such as Parkinson’s, Huntington’s and amyotrophic lateral sclerosis. They are also affected in cancer, ageing and cardiovascular disease. The final section of the book reviews mitochondrial mutations and their consequences in ageing and other phenotypic manifestations.  The authors discuss how mitochondrial proteins might constitute important therapeutic targets and describe initial attempts to develop compounds that can regulate their function.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eMitochondrial Biology: New Perspectives\u003c\/i\u003e includes extensive and lively discussions amongst the authors and will be of interest to cell and molecular biologists, biochemists, neuroscientists and neurologists working in this fascinating field.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989632434405,"sku":"NP9780470066577","price":211.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470066577.jpg?v=1761784888","url":"https:\/\/k12savings.com\/es\/products\/mitochondrial-biology-isbn-9780470066577","provider":"K12savings","version":"1.0","type":"link"}