{"product_id":"methods-and-applications-of-statistics-in-clinical-trials-volume-2-isbn-9781118304761","title":"Methods and Applications of Statistics in Clinical Trials, Volume 2","description":"\u003cp\u003e\u003ci\u003eMethods and Applications of Statistics in Clinical Trials, Volume 2: Planning, Analysis, and Inferential Methods\u003c\/i\u003e includes updates of established literature from the Wiley Encyclopedia of Clinical Trials as well as original material based on the latest developments in clinical trials. Prepared by a leading expert, the second volume includes numerous contributions from current prominent experts in the field of medical research. In addition, the volume features:\u003c\/p\u003e \u003cp\u003e• Multiple new articles exploring emerging topics, such as evaluation methods with threshold, empirical likelihood methods, nonparametric ROC analysis, over- and under-dispersed models, and multi-armed bandit problems\u003c\/p\u003e \u003cp\u003e• Up-to-date research on the Cox proportional hazard model, frailty models, trial reports, intrarater reliability, conditional power, and the kappa index\u003c\/p\u003e \u003cp\u003e• Key qualitative issues including cost-effectiveness analysis, publication bias, and regulatory issues, which are crucial to the planning and data management of clinical trials\u003c\/p\u003e Contributors xix \u003cp\u003ePreface xxiii\u003c\/p\u003e \u003cp\u003e1 Analysis of Over- and Underdispersed Data 1\u003c\/p\u003e \u003cp\u003e2 Analysis of Variance (ANOVA) 10\u003c\/p\u003e \u003cp\u003e3 Assessment of Health-Related Quality of Life 26\u003c\/p\u003e \u003cp\u003e4 Bandit Processes and Response-Adaptive Clinical Trials: The Art of Exploration Versus Exploitation 40\u003c\/p\u003e \u003cp\u003e5 Bayesian Dose-Finding Designs in Healthy Volunteers 51\u003c\/p\u003e \u003cp\u003e6 Bootstrap 62\u003c\/p\u003e \u003cp\u003e7 Conditional Power in Clinical Trial Monitoring 102\u003c\/p\u003e \u003cp\u003e8 Cost-Effectiveness Analysis 111\u003c\/p\u003e \u003cp\u003e9 Cox-Type Proportional Hazards Models 126\u003c\/p\u003e \u003cp\u003e10 Empirical Likelihood Methods in Clinical Experiments 146\u003c\/p\u003e \u003cp\u003e11 Frailty Models 166\u003c\/p\u003e \u003cp\u003e12 Futility Analysis 174\u003c\/p\u003e \u003cp\u003e13 Imaging Science in Medicine I: Overview 187\u003c\/p\u003e \u003cp\u003e14 Imaging Science in Medicine, II: Basics of X-Ray Imaging 213\u003c\/p\u003e \u003cp\u003e15 Imaging Science in Medicine, III: Digital (21st Century) X-Ray Imaging 264\u003c\/p\u003e \u003cp\u003e16 Intention-to-Treat Analysis 313\u003c\/p\u003e \u003cp\u003e17 Interim Analyses 323\u003c\/p\u003e \u003cp\u003e18 Interrater Reliability 334\u003c\/p\u003e \u003cp\u003e19 Intrarater Reliability 340\u003c\/p\u003e \u003cp\u003e20 Kaplan-Meier Plot 357\u003c\/p\u003e \u003cp\u003e21 Logistic Regression 365\u003c\/p\u003e \u003cp\u003e22 Metadata 380\u003c\/p\u003e \u003cp\u003e23 Microarray 392\u003c\/p\u003e \u003cp\u003e24 Multi-Armed Bandits, Gittins Index, and Its Calculation 416\u003c\/p\u003e \u003cp\u003e25 Multiple Comparisons 436\u003c\/p\u003e \u003cp\u003e26 Multiple Evaluators 446\u003c\/p\u003e \u003cp\u003e27 Noncompartmental Analysis 457\u003c\/p\u003e \u003cp\u003e28 Nonparametric ROC Analysis for Diagnostic Trials 483\u003c\/p\u003e \u003cp\u003e29 Optimal Biological Dose for Molecularly Targeted Therapies 496\u003c\/p\u003e \u003cp\u003e30 Over- and Underdispersion Models 506\u003c\/p\u003e \u003cp\u003e31 Permutation Tests in Clinical Trials 527\u003c\/p\u003e \u003cp\u003e32 Pharmacoepidemiology, Overview 536\u003c\/p\u003e \u003cp\u003e33 Population Pharmacokinetic and Pharmacodynamic Methods 551\u003c\/p\u003e \u003cp\u003e34 Proportions: Inferences and Comparisons 570\u003c\/p\u003e \u003cp\u003e35 Publication Bias 595\u003c\/p\u003e \u003cp\u003e36 Quality of Life 608\u003c\/p\u003e \u003cp\u003e37 Relative Risk Modeing 622\u003c\/p\u003e \u003cp\u003e38 Sample Size Considerations for Morbidity\/Mortality Trials 633\u003c\/p\u003e \u003cp\u003e39 Sample Size for Comparing Means 642\u003c\/p\u003e \u003cp\u003e40 Sample Size for Comparing Proportions 653\u003c\/p\u003e \u003cp\u003e41 Sample Size for Comparing Time-to-Event Data 664\u003c\/p\u003e \u003cp\u003e42 Sample Size for Comparing Variabilities 672\u003c\/p\u003e \u003cp\u003e43 Screening, Models of 689\u003c\/p\u003e \u003cp\u003e44 Screening Trials 721\u003c\/p\u003e \u003cp\u003e45 Secondary Efficacy End Points 731\u003c\/p\u003e \u003cp\u003e46 Sensitivity, Specificity, and Receiver Operator Characteristic (ROC) Methods 740\u003c\/p\u003e \u003cp\u003e47 Software for Genetics\/Genomics 752\u003c\/p\u003e \u003cp\u003e48 Stability Study Designs 778\u003c\/p\u003e \u003cp\u003e49 Subgroup Analysis 793\u003c\/p\u003e \u003cp\u003e50 Survival Analysis, Overview 802\u003c\/p\u003e \u003cp\u003e51 The FDA and Regulatory Issues 815\u003c\/p\u003e \u003cp\u003e52 The Kappa Index 836\u003c\/p\u003e \u003cp\u003e53 Treatment Interruption 846\u003c\/p\u003e \u003cp\u003e54 Trial Reports: Improving Reporting, Minimizing Bias, and Producing Better Evidence-Based Practice 860\u003c\/p\u003e \u003cp\u003e55 U.S. Department of Veterans Affairs Cooperative Studies Program 876\u003c\/p\u003e \u003cp\u003e56 Women's Health Initiative: Statistical Aspects and Selected Early Results 901\u003c\/p\u003e \u003cp\u003e57 World Health Organization (WHO): Global Health Situation 914\u003c\/p\u003e \u003cp\u003eIndex 925\u003c\/p\u003e \u003cp\u003e“This book provides a good overview on most relevant topics for clinical trials.”  (\u003ci\u003eBiometrical Journal\u003c\/i\u003e, 1 October 2015)\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e  \u003cp\u003e\u003cb\u003eN. BALAKRISHNAN, P\u003csmall\u003eH\u003c\/small\u003eD,\u003c\/b\u003e is Professor in the Department of Mathematics and Statistics at McMaster University, Canada. He is the author of over twenty books and is the coeditor of \u003ci\u003eEncyclopedia of Statistical Sciences, Second Edition\u003c\/i\u003e, also published by Wiley.\u003c\/p\u003e  \u003cp\u003e\u003cb\u003e\u003ci\u003eAn essential guide to planning the next steps in clinical trial design, management, and data analysis\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eThe second volume in a comprehensive two-part set, \u003ci\u003eMethods and Applications of Statistics in Clinical Trials, Volume 2: Planning, Analysis, and Inferential Methods\u003c\/i\u003e provides the next steps of planning, analyzing, and managing clinical data. After \u003ci\u003eMethods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs\u003c\/i\u003e establishes the key principles behind clinical trials, the second volume concentrates on methods of planning, designing, data analysis, and statistical inference in clinical trials.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eMethods and Applications of Statistics in Clinical Trials, Volume 2: Planning, Analysis, and Inferential Methods\u003c\/i\u003e includes updates of established literature from the \u003ci\u003eWiley Encyclopedia of Clinical Trials\u003c\/i\u003e as well as original material based on the latest developments in clinical trials. Prepared by a leading expert, the second volume includes numerous contributions from current prominent experts in the field of medical research. In addition, the volume features:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eMultiple new articles exploring emerging topics, such as evaluation methods with threshold, empirical likelihood methods, nonparametric ROC analysis, over- and under-dispersed models, and multi-armed bandit problems\u003c\/li\u003e \u003cli\u003eUp-to-date research on the Cox proportional hazard model, frailty models, trial reports, intrarater reliability, conditional power, and the kappa index\u003c\/li\u003e \u003cli\u003eKey qualitative issues including cost-effectiveness analysis, publication bias, and regulatory issues, which are crucial to the planning and data management of clinical trials\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eMethods and Applications of Statistics in Clinical Trials, Volume 2: Planning, Analysis, and Inferential Methods\u003c\/i\u003e is an excellent reference for researchers, practitioners, and students in the fields of clinical trials, pharmaceutics, biostatistics, medical research design, biology, biomedicine, epidemiology, and public health.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989615001829,"sku":"NP9781118304761","price":225.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781118304761.jpg?v=1761784819","url":"https:\/\/k12savings.com\/es\/products\/methods-and-applications-of-statistics-in-clinical-trials-volume-2-isbn-9781118304761","provider":"K12savings","version":"1.0","type":"link"}