{"product_id":"methods-and-applications-of-statistics-in-clinical-trials-volume-1-isbn-9781118304730","title":"Methods and Applications of Statistics in Clinical Trials, Volume 1","description":"\u003cp\u003e\u003cb\u003e\u003ci\u003eA complete guide to the key statistical concepts essential for the design and construction of clinical trials\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eAs the newest major resource in the field of medical research, \u003ci\u003eMethods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs \u003c\/i\u003epresents a timely and authoritative reviewof the central statistical concepts used to build clinical trials that obtain the best results. The referenceunveils modern approaches vital to understanding, creating, and evaluating data obtained throughoutthe various stages of clinical trial design and analysis.\u003c\/p\u003e \u003cp\u003eAccessible and comprehensive, the first volume in a two-part set includes newly-written articles as well as established literature from the \u003ci\u003eWiley Encyclopedia of Clinical Trials. \u003c\/i\u003eIllustrating a variety of statistical concepts and principles such as longitudinal data, missing data, covariates, biased-coin randomization, repeated measurements, and simple randomization, the book also provides in-depth coverage of the various trial designs found within phase I-IV trials. \u003ci\u003eMethods and Applications of\u003c\/i\u003e \u003ci\u003eStatistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs \u003c\/i\u003ealso features:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eDetailed chapters on the type of trial designs, such as adaptive, crossover, group-randomized, multicenter, non-inferiority, non-randomized, open-labeled, preference, prevention, and superiority trials\u003c\/li\u003e \u003cli\u003eOver 100 contributions from leading academics, researchers, and practitioners\u003c\/li\u003e \u003cli\u003eAn exploration of ongoing, cutting-edge clinical trials on early cancer and heart disease, mother-to-child human immunodeficiency virus transmission trials, and the AIDS Clinical Trials Group\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eMethods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs \u003c\/i\u003eis an excellent reference for researchers, practitioners, and students in the fields of clinicaltrials, pharmaceutics, biostatistics, medical research design, biology, biomedicine, epidemiology,and public health.\u003c\/p\u003e \u003cp\u003eContributors xxiii\u003c\/p\u003e \u003cp\u003ePreface xxix\u003c\/p\u003e \u003cp\u003e1 Absolute Risk Reduction 1\u003c\/p\u003e \u003cp\u003e2 Accelerated Approval 14\u003c\/p\u003e \u003cp\u003e3 AIDS Clinical Trials Group (ACTG) 27\u003c\/p\u003e \u003cp\u003e4 Algorithm-Based Designs 40 \u003c\/p\u003e \u003cp\u003e5 Alpha-Spending Function 53 \u003c\/p\u003e \u003cp\u003e6 Application of New Designs in Phase I Trials 65 \u003c\/p\u003e \u003cp\u003e7 ASCOT Trial 74\u003c\/p\u003e \u003cp\u003e8 Benefit\/Risk Assessment in Prevention Trials 80 \u003c\/p\u003e \u003cp\u003e9 Biased Coin Randomization 90 \u003c\/p\u003e \u003cp\u003e10 Biological Assay, Overview 106 \u003c\/p\u003e \u003cp\u003e11 Block Randomization 125 \u003c\/p\u003e \u003cp\u003e12 Censored Data 139\u003c\/p\u003e \u003cp\u003e13 Clinical Data Coordination 146 \u003c\/p\u003e \u003cp\u003e14 Clinical Data Management 164 \u003c\/p\u003e \u003cp\u003e15 Clinical Significance 170\u003c\/p\u003e \u003cp\u003e16 Clinical Trial Misconduct 191\u003c\/p\u003e \u003cp\u003e17 Clinical Trials, Early Cancer and Heart Disease 205 \u003c\/p\u003e \u003cp\u003e18 Cluster Randomization 216 \u003c\/p\u003e \u003cp\u003e19 Coherence in Phase I Clinical Trials 230\u003c\/p\u003e \u003cp\u003e20 Compliance and Survival Analysis 240 \u003c\/p\u003e \u003cp\u003e21 Composite Endpoints in Clinical Trials 246\u003c\/p\u003e \u003cp\u003e22 Confounding 252 \u003c\/p\u003e \u003cp\u003e23 Control Groups 263\u003c\/p\u003e \u003cp\u003e24 Coronary Drug Project 273\u003c\/p\u003e \u003cp\u003e25 Covariates 285\u003c\/p\u003e \u003cp\u003e26 Crossover Design 300\u003c\/p\u003e \u003cp\u003e27 Crossover Trials 310\u003c\/p\u003e \u003cp\u003e28 Diagnostic Studies 320\u003c\/p\u003e \u003cp\u003e29 DNA Bank 340\u003c\/p\u003e \u003cp\u003e30 Up-and-Down and Escalation Designs 353\u003c\/p\u003e \u003cp\u003e31 Dose Ranging Crossover Designs 362\u003c\/p\u003e \u003cp\u003e32 Flexible Designs 383 \u003c\/p\u003e \u003cp\u003e33 Gene Therapy 399\u003c\/p\u003e \u003cp\u003e34 Global Assessment Variables 423\u003c\/p\u003e \u003cp\u003e35 Good Clinical Practice (GCP) 438\u003c\/p\u003e \u003cp\u003e36 Group-Randomized Trials 448\u003c\/p\u003e \u003cp\u003e37 Group Sequential Designs 467\u003c\/p\u003e \u003cp\u003e38 Hazard Ratio 483\u003c\/p\u003e \u003cp\u003e39 Large Simple Trials 500\u003c\/p\u003e \u003cp\u003e40 Longitudinal Data 510\u003c\/p\u003e \u003cp\u003e41 Maximum Duration and Information Trials 515\u003c\/p\u003e \u003cp\u003e42 Missing Data 522\u003c\/p\u003e \u003cp\u003e43 Mother to Child Human Immunodeficiency Virus Transmission Trials 536\u003c\/p\u003e \u003cp\u003e44 Multiple Testing in Clinical Trials 550\u003c\/p\u003e \u003cp\u003e45 Multicenter Trials 558\u003c\/p\u003e \u003cp\u003e46 Multiple Endpoints 570\u003c\/p\u003e \u003cp\u003e47 Multiple Risk Factor Intervention Trial 577\u003c\/p\u003e \u003cp\u003e48 N-of-1 Randomized Trials 587\u003c\/p\u003e \u003cp\u003e49 Noninferiority Trial 598\u003c\/p\u003e \u003cp\u003e50 Nonrandomized Trials 609 \u003c\/p\u003e \u003cp\u003e51 Open-Labeled Trials 619\u003c\/p\u003e \u003cp\u003e52 Optimizing Schedule of Administration in Phase I Clinical Trials 625\u003c\/p\u003e \u003cp\u003e53 Partially Balanced Designs 635\u003c\/p\u003e \u003cp\u003e54 Phase I\/II Clinical Trials 658\u003c\/p\u003e \u003cp\u003e55 Phase II\/III Trials 667\u003c\/p\u003e \u003cp\u003e56 Phase I Trials 682\u003c\/p\u003e \u003cp\u003e57 Phase II Trials 692\u003c\/p\u003e \u003cp\u003e58 Phase III Trials 700\u003c\/p\u003e \u003cp\u003e59 Phase IV Trials 711\u003c\/p\u003e \u003cp\u003e60 Phase I Trials in Oncology 719\u003c\/p\u003e \u003cp\u003e61 Placebos 725\u003c\/p\u003e \u003cp\u003e62 Planning a Group-Randomized Trial 736\u003c\/p\u003e \u003cp\u003e63 Postmenopausal Estrogen\/Progestin Interventions Trial (PEPI) 744\u003c\/p\u003e \u003cp\u003e64 Preference Trials 759\u003c\/p\u003e \u003cp\u003e65 Prevention Trials 770\u003c\/p\u003e \u003cp\u003e66 Primary Efficacy Endpoint 779\u003c\/p\u003e \u003cp\u003e67 Prognostic Variables in Clinical Trials 789\u003c\/p\u003e \u003cp\u003e68 Randomization Procedures 799\u003c\/p\u003e \u003cp\u003e69 Randomization Schedule 813 \u003c\/p\u003e \u003cp\u003e70 Repeated Measurements 827\u003c\/p\u003e \u003cp\u003e71 Simple Randomization 841\u003c\/p\u003e \u003cp\u003e72 Subgroups 850\u003c\/p\u003e \u003cp\u003e73 Superiority Trials 867\u003c\/p\u003e \u003cp\u003e74 Surrogate Endpoints 878\u003c\/p\u003e \u003cp\u003e75 TNT Trial 887\u003c\/p\u003e \u003cp\u003e76 UGDP Trial 894\u003c\/p\u003e \u003cp\u003e77 Women's Health Initiative Hormone Therapy Trials 918\u003c\/p\u003e \u003cp\u003e78 Women's Health Initiative Dietary Modification Trial 931\u003c\/p\u003e \u003cp\u003eIndex 945\u003c\/p\u003e \u003cp\u003e“Methods and Applications of Statistics in Clinical Trials is a comprehensive, in-depth and up-to-date guide to statistics in clinical research.  Most readers will have more than an introductory understanding of statistics.”  (\u003ci\u003eJournal of Clinical Research Best Practices\u003c\/i\u003e, 5 May 2015)\u003c\/p\u003e \u003cp\u003e“This book provides an excellent description of the methods and applications of statistics to design clinical trials and to understand and evaluate data at different stages of clinical trials. It is strongly recommended for researchers, practitioners, and students.”  (\u003ci\u003eDoody’s\u003c\/i\u003e, 13 February 2015)\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e  \u003cp\u003e\u003cb\u003eN. BALAKRISHNAN, PhD,\u003c\/b\u003e is Professor in the Department of Mathematics and Statistics at McMaster University, Canada. He is the author of over twenty books and is the coeditor of \u003ci\u003eEncyclopedia of Statistical Sciences, Second Edition,\u003c\/i\u003e also published by Wiley.\u003c\/p\u003e  \u003cp\u003e\u003cb\u003e\u003ci\u003eA complete guide to the key statistical concepts essential for the design and construction of clinical trials\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eAs the newest major resource in the field of medical research, \u003ci\u003eMethods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs\u003c\/i\u003e presents a timely and authoritative review of the central statistical concepts used to build clinical trials that obtain the best results. The reference unveils modern approaches vital to understanding, creating, and evaluating data obtained throughout the various stages of clinical trial design and analysis.\u003c\/p\u003e \u003cp\u003eAccessible and comprehensive, the first volume in a two-part set includes newly written articles as well as established literature from the \u003ci\u003eWiley Encyclopedia of Clinical Trials\u003c\/i\u003e. Illustrating a variety of statistical concepts and principles such as longitudinal data, missing data, covariates, biased-coin randomization, repeated measurements, and simple randomization, the book also provides in-depth coverage of the various trial designs found within phase I–IV trials. \u003ci\u003eMethods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs\u003c\/i\u003e also features:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eDetailed chapters on the type of trial designs, such as adaptive, crossover, group-randomized, multicenter, non-inferiority, non-randomized, open-labeled, preference, prevention, and superiority trials\u003c\/li\u003e \u003cli\u003eOver 100 contributions from leading academics, researchers, and practitioners\u003c\/li\u003e \u003cli\u003eAn exploration of ongoing, cutting-edge clinical trials on early cancer and heart disease, mother-to-child human immunodeficiency virus transmission trials, and the AIDS Clinical Trials Group\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eMethods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs\u003c\/i\u003e is an excellent reference for researchers, practitioners, and students in the fields of clinical trials, pharmaceutics, biostatistics, medical research design, biology, biomedicine, epidemiology, and public health.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989614969061,"sku":"NP9781118304730","price":231.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781118304730.jpg?v=1761784818","url":"https:\/\/k12savings.com\/es\/products\/methods-and-applications-of-statistics-in-clinical-trials-volume-1-isbn-9781118304730","provider":"K12savings","version":"1.0","type":"link"}