{"product_id":"metals-in-cells-isbn-9781119953234","title":"Metals in Cells","description":"\u003cp\u003eOver the last three decades a lot of research on the role of metals in biochemistry and medicine has been done. As a result many structures of biomolecules with metals have been characterized and medicinal chemistry studied the effects of metal containing drugs.\u003c\/p\u003e \u003cp\u003eThis new book (from the EIBC Book Series) covers recent advances made by top researchers in the field of metals in cells [the “metallome”] and include:  regulated metal ion uptake and trafficking, sensing of metals within cells and across tissues, and identification of the vast cellular factors designed to orchestrate assembly of metal cofactor sites while minimizing toxic side reactions of metals. In addition, it features aspects of metals in disease, including the role of metals in neuro-degeneration, liver disease, and inflammation, as a way to highlight the detrimental effects of mishandling of metal trafficking and response to \"foreign\" metals. With the breadth of our recently acquired understanding of metals in cells, a book that features key aspects of cellular handling of inorganic elements is both timely and important. At this point in our understanding, it is worthwhile to step back and take an expansive view of how far our understanding has come, while also highlighting how much we still do not know.\u003c\/p\u003e \u003cp\u003eThe content from this book will publish online, as part of \u003ci\u003eEIBC\u003c\/i\u003e in December 2013, find out more about the \u003ci\u003eEncyclopedia of Inorganic and Bioinorganic Chemistry\u003c\/i\u003e, the essential online resource for researchers and students working in all areas of \u003ca href=\"http:\/\/onlinelibrary.wiley.com\/book\/10.1002\/9781119951438\"\u003einorganic and bioinorganic chemistry\u003c\/a\u003e.\u003c\/p\u003e  \u003cp\u003eContributors xi\u003c\/p\u003e \u003cp\u003eSeries Preface xix\u003c\/p\u003e \u003cp\u003eVolume Preface xxi\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART 1: INTRODUCTION 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eMechanisms Controlling the Cellular Metal Economy 3\u003cbr\u003e \u003ci\u003eBenjamin A. Gilston and Thomas V. O’Halloran\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART 2: PROBING METALS AND CROSS TALK IN THE METALLOME 15\u003c\/b\u003e\u003cbr\u003e \u003cbr\u003e The Metallome 17\u003cbr\u003e \u003ci\u003eVadim N. Gladyshev and Yan Zhang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCyanobacterial Models that Address Cross-Talk in Metal Homeostasis 39\u003cbr\u003e \u003ci\u003eCarl J. Patterson, Rafael Pernil, Andrew W. Foster and Nigel J. Robinson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eSparing and Salvaging Metals in Chloroplasts 51\u003cbr\u003e \u003ci\u003eCrysten E. Blaby-Haas and Sabeeha S. Merchant\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eFluorescent Probes for Monovalent Copper 65\u003cbr\u003e \u003ci\u003eM. Thomas Morgan, Pritha Bagchi and Christoph J. Fahrni\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eFluorescent Zinc Sensors 85\u003cbr\u003e \u003ci\u003eAmy E. Palmer, Jose G. Miranda and Kyle P. Carter\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eX-Ray Fluorescence Microscopy 99\u003cbr\u003e \u003ci\u003eJames E. Penner-Hahn\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART 3: MOVING METALS IN CELLS 111\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eIron and Heme Transport and Trafficking 113\u003cbr\u003e \u003ci\u003eYvette Y. Yien and Barry H. Paw\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIron in Plants 131\u003cbr\u003e \u003ci\u003eJessica B. Weng and Mary Lou Guerinot\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eTransport of Nickel and Cobalt in Prokaryotes 145\u003cbr\u003e \u003ci\u003eThomas Eitinger\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eTransport Mechanism and Cellular Functions of Bacterial Cu(I)-ATPases 155\u003cbr\u003e \u003ci\u003eJose M. Arguello, Teresita Padilla-Benavides and Jessica M. Collins\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCopper Transport in Fungi 163\u003cbr\u003e \u003ci\u003eSimon Labbe, Jude Beaudoin and Raphael Ioannoni\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eStructural Biology of Copper Transport 175\u003cbr\u003e \u003ci\u003eAdrian G. Flores, Christopher R. Pope and Vinzenz M. Unger\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eZinc Transporters and Trafficking in Yeast 183\u003cbr\u003e \u003ci\u003eYi-Hsuan Wu and David J. Eide\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCadmium Transport in Eukaryotes 195\u003cbr\u003e \u003ci\u003eNathan Smith, Wenzhong Wei and Jaekwon Lee\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART 4: METALS IN REGULATION 207\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eMetal Specificity of Metallosensors 209\u003cbr\u003e \u003ci\u003eKhadine A. Higgins and David P. Giedroc\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eMetal Homeostasis and Oxidative Stress in Bacillus subtilis 225\u003cbr\u003e \u003ci\u003eZhen Ma and John D. Helmann\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eRegulation of Manganese and Iron Homeostasis in the Rhizobia and Related α-Proteobacteria 237\u003cbr\u003e \u003ci\u003eMark R. O’Brian\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eThe Iron Starvation Response in Saccharomyces cerevisiae 249\u003cbr\u003e \u003ci\u003eCaroline C. Philpott and Pamela M. Smith\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eHepcidin Regulation of Iron Homeostasis 265\u003cbr\u003e \u003ci\u003eClara Camaschella and Laura Silvestri\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eNikR: Mechanism and Function in Nickel Homeostasis 277\u003cbr\u003e \u003ci\u003eMichael D. Jones, Andrew M. Sydor and Deborah B. Zamble\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eRegulation of Copper Homeostasis in Plants 289\u003cbr\u003e \u003ci\u003eMarinus Pilon and Wiebke Tapken\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eRegulation of Zinc Transport 301\u003cbr\u003e \u003ci\u003eTaiho Kambe\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eSelenoproteins—Regulation 311\u003cbr\u003e \u003ci\u003eLucia A. Seale and Marla J. Berry\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART 5: METALS IN CELLULAR DAMAGE AND DISEASE 321\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eMetals in Bacterial Pathogenicity and Immunity 323\u003cbr\u003e \u003ci\u003eJennifer S. Cavet\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eManganese in Neurodegeneration 335\u003cbr\u003e \u003ci\u003eDaiana Silva Avila, Robson Luiz Puntel, Felix Antunes Soares, Joao Batista Teixeira da Rocha and Michael Aschner\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIron Sequestration in Immunity 349\u003cbr\u003e \u003ci\u003eColin Correnti and Roland K. Strong\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eMolecular Basis of Hemochromatosis 361\u003cbr\u003e \u003ci\u003ePaul J. Schmidt\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCopper in Brain and Neurodegeneration 373\u003cbr\u003e \u003ci\u003eJeffrey R. Liddell, Ashley I. Bush and Anthony R. White\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCopper Transporting ATPases in Mammalian Cells 395\u003cbr\u003e \u003ci\u003eNan Yang and Svetlana Lutsenko\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCopper in Immune Cells 409\u003cbr\u003e \u003ci\u003eKarrera Y. Djoko, Maud E.S. Achard and Alastair G. McEwan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eSelenoenzymes and Selenium Trafficking: An Emerging Target for Therapeutics 421\u003cbr\u003e \u003ci\u003eWilliam Self and Sarah Rosario\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eResistance Pathways for Metalloids and Toxic Metals 429\u003cbr\u003e \u003ci\u003eZijuan Liu, Christopher Rensing and Barry P. Rosen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART 6: COFACTOR ASSEMBLY 443\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eFe–S Cluster Biogenesis in Archaea and Bacteria 445\u003cbr\u003e \u003ci\u003eHarsimranjit K. Chahal, Jeff M. Boyd and F. Wayne Outten\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eMitochondrial Iron Metabolism and the Synthesis of Iron–Sulfur Clusters 473\u003cbr\u003e \u003ci\u003eAndrew Dancis and Paul A. Lindahl\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e[FeFe]-Hydrogenase Cofactor Assembly 491\u003cbr\u003e \u003ci\u003eEric M. Shepard, Amanda S. Byer, Eric S. Boyd, Kevin D. Swanson, John W. Peters and Joan B. Broderick\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e[NiFe]-Hydrogenase Cofactor Assembly 507\u003cbr\u003e \u003ci\u003eBasem Soboh and R. Gary Sawers\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCopper in Mitochondria 517\u003cbr\u003e \u003ci\u003eKatherine E. Vest and Paul A. Cobine\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eMo Cofactor Biosynthesis and Crosstalk with FeS 529\u003cbr\u003e \u003ci\u003eFlorian Bittner and Ralf R. Mendel\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eNitrogenase Cofactor Assembly 543\u003cbr\u003e \u003ci\u003eJared A. Wiig, Chi Chung Lee, Markus W. Ribbe and Yilin Hu\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 555\u003c\/p\u003e \u003cp\u003e\u003cb\u003eProf. Robert A. Scott\u003c\/b\u003e (Editor-in-Chief \u003ci\u003eEncyclopedia of Inorganic and Bioinorganic Chemistry\u003c\/i\u003e)\u003cbr\u003eDistinguished Research Professor, University of Georgia, USA.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eProf. Valeria Culotta, Biochemistry and Molecular Biology Department, Joint Departmental Affiliations Environmental Health Sciences\u003c\/b\u003e\u003cbr\u003eResearch in the Culotta lab focuses on the role of metal ions and oxygen radicals in biology and disease. Metal ions such as copper, iron and manganese are not only trace nutrients but can be quite toxic. One mechanism of toxicity is through generation of reactive oxygen species (ROS) that have been implicated in numerous human disorders from neurodegeneration to cancer to aging. Through molecular genetic approaches and high through-put genetic screens in yeast, we have identified a number genes and pathways that are involved in transition metal and reactive oxygen metabolism. Virtually all are well conserved throughout eukaryotes including humans. Our laboratory uses a combination of yeast, \u003ci\u003eC. elegans\u003c\/i\u003e and cell culture systems at the crossroads of bioinorganic chemistry, cell biology and molecular genetics.\u003c\/p\u003e \u003cp\u003eThe last half-century has seen an explosive growth in our understanding of the role of inorganic elements in biology, focusing first on biochemical function of proteins with tightly bound metals. As a result, many structures and functions of biomolecules with metals have been characterized. In parallel, the understanding of inorganic elements in medicinal chemistry and the development of metal-containing drugs has developed.\u003c\/p\u003e \u003cp\u003eThis research led inevitably to an interest in how Nature incorporates inorganic elements into metalloproteins and how cells “manage” their “inorganic portfolio,” acquiring the right amount of each element in the right location without making mistakes, while avoiding toxicity. More recent research efforts have focused on this understanding of inorganic cell biology. Significant advances have been prompted by a combination of new methods to probe intracellular metal locations and the dynamics of metal movement in cells, high-resolution detection of metal-biomolecule interactions, and the revolution of genomic, proteomic, metabolic, and even “metallomic” approaches to the study of inorganic physiology. Environmental metals and metalloids, including iron, copper, zinc, cobalt, manganese, molybdenum, and selenium, are all accumulated by cells and organisms in the micro- to millimolar range. Yet despite this abundant sea of diverse metals, only the correct metal cofactor is matched with a partner metalloprotein – mistakes in metal ion biology rarely occur. At the same time, free metal ions can be detrimental to cellular components and processes, so systems have evolved to carefully control trace element concentrations and locations (homeostasis).\u003c\/p\u003e \u003cp\u003eThis book covers recent advances made by top researchers in the field of metals in cells [the “metallome”] and includes: regulated metal ion uptake and trafficking, sensing of metals within cells and across tissues, and identification of the vast cellular factors designed to orchestrate assembly of metal cofactor sites while minimizing toxic side reactions of metals. In addition, it features aspects of metals in disease, including the role of metals in neurodegeneration, liver disease, and\u003cbr\u003einflammation, as a way to highlight the detrimental effects of mishandling of metal trafficking and response to “foreign” metals. This book is an important addition to the bioinorganic literature and relates new discoveries in systems biology and toxicology to new results in bioinorganic chemistry.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAbout EIBC Books\u003c\/b\u003e\u003cbr\u003eThe Encyclopedia of Inorganic and Bioinorganic Chemistry (EIBC) was created as an online reference in 2012 by merging the Encyclopedia of Inorganic Chemistry and the Handbook of Metalloproteins. The resulting combination proves to be the defining reference work in the field of inorganic and bioinorganic chemistry, and a lot of chemistry libraries around the world have access to the online version. Many readers, however, prefer to have more concise thematic volumes in print, targeted to their specific area of interest. This feedback from EIBC readers has encouraged the Editors to plan a series of EIBC Books [formerly called EIC Books], focusing on topics of current interest. EIBC Books will appear on a regular basis, will be edited by the EIBC Editors and specialist Guest Editors, and will feature articles from leading scholars in their fields. EIBC Books aim to provide both the starting research student and the confirmed research worker with a critical distillation of the leading concepts in inorganic and bioinorganic chemistry, and provide a structured entry into the fields covered.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989613068517,"sku":"NP9781119953234","price":236.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781119953234.jpg?v=1761784809","url":"https:\/\/k12savings.com\/es\/products\/metals-in-cells-isbn-9781119953234","provider":"K12savings","version":"1.0","type":"link"}