{"product_id":"metal-complex-dna-interactions-isbn-9781405176293","title":"Metal Complex - DNA Interactions","description":"Metal ions and metal complexes have long been recognized as critically important components of nucleic acid chemistry, both in regulation of gene expression and as promising therapeutic agents. Understanding how metal complexes interact with DNA has become an active research area at the interface between chemistry, molecular biology and medicine.  \u003cp\u003e\u003ci\u003eMetal Complex - DNA Interactions\u003c\/i\u003e provides a comprehensive overview of this increasingly diverse field, presenting recent developments and the latest research with particular emphasis on metal-based drugs and metal ion toxicity. The text is divided into four parts:\u003c\/p\u003e \u003cul\u003e \u003cli\u003e \u003cdiv\u003e\n\u003ci\u003eBasic Structural and Kinetic Aspects:\u003c\/i\u003e includes chapters on sequence-selective metal binding to DNA and thermodynamic models. \u003c\/div\u003e \u003c\/li\u003e \u003cli\u003e \u003cdiv\u003e\n\u003ci\u003eMedical Applications:\u003c\/i\u003e focuses on anticancer platinum drugs, including discussions on DNA repair in antitumor effects of platinum drugs and photo-dynamic therapy.\u003c\/div\u003e \u003c\/li\u003e \u003cli\u003e \u003cdiv\u003e\n\u003ci\u003eDNA-Recognition - Nucleases and Sensor\u003c\/i\u003e: describes probes for DNA recognition, artificial restriction agents, metallo-DNAzymes for metal sensing applications and metal ion dependent catalysis in nucleic acid enzymes.\u003c\/div\u003e \u003c\/li\u003e \u003cli\u003e \u003cdiv\u003e\n\u003ci\u003eToxicological Aspects:\u003c\/i\u003e deals with structural studies of mercury–DNA interactions, chromium-induced DNA damage and repair, and the effect of arsenic and nickel on DNA integrity.\u003c\/div\u003e \u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThis book will be a valuable resource for academic researchers and professionals from a range of pharmaceutical and chemical industries, particularly those involved in the development of new and less toxic anticancer metallo-drugs, and in the field of environmental and toxicological chemistry.\u003c\/p\u003e  \u003cb\u003eA Basic Structural and Kinetic Aspects\u003c\/b\u003e  \u003cp\u003e1. Sequence-Selective Binding of Transition Metal Complexes to DNA\u003c\/p\u003e \u003cp\u003e2. Thermodynamic Models of Metal Ion -DNA.Interactions\u003c\/p\u003e \u003cp\u003e3. Metal Ion Coordination in G-quadruplexes\u003c\/p\u003e \u003cp\u003e4. Supramolecular Chemistry of Metal-Nucleobase Complexes\u003c\/p\u003e \u003cp\u003e\u003cb\u003eB Medical Applications\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5. Platinum Drugs, Nucleotides, and DNA: the Role of Interligand Interactions,\u003c\/p\u003e \u003cp\u003enucleotides and DNA\u003c\/p\u003e \u003cp\u003e6. Role of DNA Repair in Antitumor Effects of Platinum Drugs\u003c\/p\u003e \u003cp\u003e7. Telomeres and Telomerase: Potential Targets for Platinum Complexes\u003c\/p\u003e \u003cp\u003e8. Toward Photodynamic Therapy of Cancer with Platinum Group Metal Polyazine Complexes\u003c\/p\u003e \u003cp\u003e9. Platinated Oligonucleotides: Synthesis and Applications for the Control of Gene\u003c\/p\u003e \u003cp\u003eExpression\u003c\/p\u003e \u003cp\u003e10. New Titanium and Ruthenium Anticancer Drugs and their Interaction with DNA\u003c\/p\u003e \u003cp\u003e\u003cb\u003eC DNA-Recognition - Nucleases and Sensors\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e11. Groove-Binding Ruthenium(II) Complexes as Probes of DNA Recognition\u003c\/p\u003e \u003cp\u003e12. DNA Recognition and Binding by Peptide-Metal Complex conjugate\u003c\/p\u003e \u003cp\u003e13. Artificial Restriction Agents - Hydrolytic Agents for DNA Cleavage\u003c\/p\u003e \u003cp\u003e14. New Metallo-DNAzymes: Fundamental Studies of Metal-DNA Interactions and\u003c\/p\u003e \u003cp\u003eMetal Sensing Applications\u003c\/p\u003e \u003cp\u003e15. Two-metal Ion Dependent Catalysis in Nucleic Acid Enzymes\u003c\/p\u003e \u003cp\u003e\u003cb\u003eD Toxicological aspects\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e16. Mercury- DNA Interactions. Structural Studies on Mercury\u003csup\u003eII\u003c\/sup\u003e -Mediated T-T Base-Pair with NMR Spectroscopy\u003c\/p\u003e \u003cp\u003e17. Chromium-Induced DNA Damage and Repair\u003c\/p\u003e \u003cp\u003e18. Arsenic and nickel: Mechanisms Affecting DNA Integrity\u003c\/p\u003e  \"An impressive overview of the great diversity of current research.\" (\u003ci\u003eAngewandte Chemie International Edition\u003c\/i\u003e, February 2010)\u003cbr\u003e \u003cbr\u003e   \u003cp\u003e\"An essential part of the library for laboratories involved in bioinorganic and medicinal inorganic chemistry.\" (\u003ci\u003eChemistry World\u003c\/i\u003e, September 2009)\u003c\/p\u003e Nikolaos Hadjiliadis is Professor in the Dept of Chemistry at the University of Ioannina, Greece. Einar Sletten is Professor in the Dept of Chemistry at the University of Bergen, Norway.  The importance of metal-DNA interactions in living systems, and their potential applications especially in the treatment and diagnosis of diseases has stimulated considerable recent interest in this area. The most important application is the antitumour action of certain heavy metals, which work by binding to and distorting DNA, causing cell death. For example, Cisplatin (Cl2H6N2Pt ) is one of the most potent and widely used anticancer drugs in use today. \u003cbr\u003e \u003cp\u003e\u003cbr\u003e \u003c\/p\u003e \u003cp\u003eThis book provides an overview of metal-DNA interactions, the mechanism of their interaction, metal-based drugs and metal ion toxicity. It is essential reading for academic researchers in bioinorganic chemistry, biochemistry, biology, biotechnology and medicine, and pharmaceutical industries involved in developing metal-based drugs.\u003c\/p\u003e","brand":"Wiley-Blackwell","offers":[{"title":"Default Title","offer_id":47989611626725,"sku":"NP9781405176293","price":204.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781405176293.jpg?v=1761784805","url":"https:\/\/k12savings.com\/es\/products\/metal-complex-dna-interactions-isbn-9781405176293","provider":"K12savings","version":"1.0","type":"link"}