{"product_id":"metabolomics-by-in-vivo-nmr-isbn-9780470847190","title":"Metabolomics by In Vivo NMR","description":"\u003ci\u003eMetabolism By In Vivo NMR\u003c\/i\u003e reviews and extends the experimental and theoretical reports concerning in vivo NMR, a pioneering approach that offers versatile new ways of studying metabolic pathways. Perfectly timed to coincide with recent findings that demonstrate the novelty and strength of this approach, the book covers recent applications in biochemistry, medicine, and psychology; in vivo NMR techniques; MCA; glucose metabolism focusing on glycogen; the value of muscle glycogen measurements in exercise; and much more.  \u003cul\u003e \u003cli\u003eThis book is unique in linking in vivo \u003csup\u003e13\u003c\/sup\u003eC NMR measurements of neuronal activity and energetics with applications to functional imaging and certain disease states\u003c\/li\u003e \u003cli\u003eProvides a fundamental neurochemical explanation of brain activity applicable to functional imaging, theories of neuronal activity and disease states, e.g. epilepsy, psychiatric diseases and developmental disorders\u003c\/li\u003e \u003cli\u003eNovel and potentially controversial\u003c\/li\u003e \u003cli\u003eWill inspire future research directions.\u003c\/li\u003e \u003c\/ul\u003e  \u003cp\u003eContributors xi\u003c\/p\u003e \u003cp\u003eForeword xiii\u003cbr\u003e \u003ci\u003eSir George K. Radda, Medical Research Council, UK\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection A: Background\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Introduction 1\u003cbr\u003e \u003ci\u003eRobert G. Shulman\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 In Vivo NMR Spectroscopy – Techniques; Direct Detection; MRS; Kinetics and Labels; Fluxes; Concentrations 7\u003cbr\u003e \u003ci\u003eRobin de Graaf\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 Metabolic Control Analysis for the NMR Spectroscopist 31\u003cbr\u003e \u003ci\u003eDavid A. Fell\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection B: \u003csup\u003e13\u003c\/sup\u003eC and \u003csup\u003e31\u003c\/sup\u003eP NMR Studies of the Regulation of Glucose Metabolism\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4 MRS Studies of the Role of the Muscle Glycogen Synthesis Pathway in the Pathophysiology of Type 2 Diabetes 45\u003cbr\u003e \u003ci\u003eGerald I. Shulman and Douglas L. Rothman\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 Phosphorylation of Allosteric Enzymes can serve Homeostasis rather than Control Flux: the Example of Glycogen Synthase 59\u003cbr\u003e \u003ci\u003eJames R.A. Schafer, David A. Fell, Douglas Rothman and Robert G. Shulman\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 Regulation of Glycogen Metabolism in Muscle during Exercise 73\u003cbr\u003e \u003ci\u003eThomas B. Price\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 \u003csup\u003e13\u003c\/sup\u003eC NMR Studies of Heart Glycogen Metabolism 87\u003cbr\u003e \u003ci\u003eMaren R. Laughlin, Douglas L. Rothman and Robert G. Shulman\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 Bioenergetics Implication of Metabolic Fluctuation during Muscle Contraction 103\u003cbr\u003e \u003ci\u003eThomas Jue\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 Lactate, Glycogen and Fatigue 125\u003cbr\u003e \u003ci\u003eRobert G. Shulman and Douglas L. Rothman\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 Futile Cycling in Yeast: How to Control Gluttony in the Midst of Plenty 137\u003cbr\u003e \u003ci\u003eJan den Hollander and Robert G. Shulman\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 Trehalose Energetics in Yeast Spores 149\u003cbr\u003e \u003ci\u003eRobert G. Shulman and Jan den Hollander\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 Metabolic Networks in the Liver by \u003csup\u003e2\u003c\/sup\u003eH and \u003csup\u003e13\u003c\/sup\u003eC NMR 159\u003cbr\u003e \u003ci\u003eA. Dean Sherry and Craig R. Malloy\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13 Summarized Reflections on Metabolism 175\u003cbr\u003e \u003ci\u003eRobert G. Shulman and James R. A. Schafer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 185\u003c\/p\u003e Editors: \u003cb\u003eRobert G. Shulman\u003c\/b\u003e and \u003cb\u003eDouglas L. Rothman\u003c\/b\u003e, Yale University School of Medicine, New Haven, Connecticut, USA  \u003ci\u003eIn vivo\u003c\/i\u003e NMR of metabolites has built upon classical metabolic pathways to revolutionize our understanding of metabolism. In this book \u003ci\u003ein vivo\u003c\/i\u003e studies of metabolic fluxes in human muscle, heart and liver have utilized Metabolic Control Analysis (MCA) to relate metabolism to higher-level physiological functions. These novel approaches have located the genetic defect of Type II diabetes in recruitment of the muscle glucose transporter during glycogen synthesis, and have evaluated effects of diet and exercise upon this crucial step.  \u003cp\u003eFlux control in muscle serves to guide interpretations of glucose consumption in the heart, and in yeast suddenly faced with more glucose than they need to oxidize. NMR studies show how reverse flows, so called \"futile cycling\" play an important role for yeast in these transient conditions. Isotopomer analysis of labelling data show how in vivo pathway fluxes can be obtained from body fluids in ways capable of high throughput.\u003c\/p\u003e \u003cp\u003eIn contrast to unproven hopes of going from metabolites directly to organismic function, this book moves by in vivo NMR from the molecules of metabolism to the conditions set by systemic physiology. This book will appeal to all readers looking for information on the following topics:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eUp to date methodology and applications of in vivo NMR spectroscopy;\u003c\/li\u003e \u003cli\u003eBasic description of Metabolic Control Analysis, integrated with in vivo 13C and 31P NMR spectroscopy;\u003c\/li\u003e \u003cli\u003eModern usage of stable isotope labeling, detected by NMR; \u003cb\u003ein humans and animals\u003c\/b\u003e\n\u003c\/li\u003e \u003cli\u003eExperiments illustrating these new methods exploring the metabolism in muscle, liver and heart;\u003c\/li\u003e \u003cli\u003eYeast giving broad illustrations of alternate glucose pathways;\u003c\/li\u003e \u003cli\u003eStudies of yeast spores showing the energetic role of trehalose;\u003c\/li\u003e \u003cli\u003eIsotopomer analysis is presented clearly so as to \u003cb\u003edetermine fluxes from\u003c\/b\u003e \u003csup\u003e13\u003c\/sup\u003eC and \u003csup\u003e2\u003c\/sup\u003eH labeling.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThis book will appeal to the medical, biochemical and physiological communities, particularly those members who wish to understand the metabolic basis of human functions in modern quantitative terms, and the methods of \u003ci\u003ein vivo\u003c\/i\u003e NMR and Metabolic Control Analysis which have provided these insights.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989610578149,"sku":"NP9780470847190","price":218.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470847190.jpg?v=1761784799","url":"https:\/\/k12savings.com\/es\/products\/metabolomics-by-in-vivo-nmr-isbn-9780470847190","provider":"K12savings","version":"1.0","type":"link"}