{"product_id":"medicinal-chemistry-of-nucleic-acids-isbn-9780470596685","title":"Medicinal Chemistry of Nucleic Acids","description":"\u003cb\u003eComplete, up-to-date coverage of the broad area of nucleic acid chemistry and biology\u003c\/b\u003e  \u003cp\u003eAssembling contributions from a collection of authors with expertise in all areas of nucleic acids, medicinal chemistry, and therapeutic applications, \u003ci\u003eMedicinal Chemistry of Nucleic Acids\u003c\/i\u003e presents a thorough overview of nucleic acid chemistry—a rapidly evolving and highly challenging discipline directly responsible for the development of antiviral and antitumor drugs. This reliable resource delves into a multitude of subject areas involving the study of nucleic acids—such as the new advances in genome sequencing, and the processes for creating RNA interference (RNAi) based drugs—to assist pharmaceutical researchers in removing roadblocks that hinder their ability to predict drug efficacy. Offering the latest cutting-edge science in this growing field, Medicinal Chemistry of Nucleic Acids includes:\u003c\/p\u003e \u003cul\u003e \u003cli\u003e \u003cp\u003eIn-depth coverage of the development and application of modified nucleosides and nucleotides in medicinal chemistry\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eA close look at a large range of current topics on nucleic acid chemistry and biology\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eEssential information on the use of nucleic acid drugs to treat diseases like cancer\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eA thorough exploration of siRNA for RNAi and the regulation of microRNA, non-coding RNA (ncRNA), a newly developing and exciting research area\u003c\/p\u003e \u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThorough in its approach and promising in its message, \u003ci\u003eMedicinal Chemistry of Nucleic Acids\u003c\/i\u003e probes the new domains of pharmaceutical research—and exposes readers to a wealth of new drug discovery opportunities emerging in the dynamic field of nucleic acid chemistry.\u003c\/p\u003e  FOREWORD vii  \u003cp\u003eCONTRIBUTORS xi\u003c\/p\u003e \u003cp\u003eINTRODUCTION xv\u003c\/p\u003e \u003cp\u003e1 RECENT ADVANCES IN CARBOCYCLIC NUCLEOSIDES: SYNTHESIS AND BIOLOGICAL ACTIVITY 1\u003cbr\u003e \u003ci\u003eJianing Wang, Ravindra K. Rawal, and Chung K. Chu\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 STRUCTURES AND FUNCTIONS OF NUCLEIC ACIDS MODIFIED WITH S, Se, AND Te AND COMPLEXED WITH SMALL MOLECULES 101\u003cbr\u003e \u003ci\u003eWen Zhang, Jia Sheng, and Zhen Huang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 UNRAVELING OF THE NAD CYCLIZING AND CALCIUM SIGNALING FUNCTIONS OF HUMAN CD38 142\u003cbr\u003e \u003ci\u003eHon Cheung Lee\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 DNA AND RNA BINDING SMALL MOLECULES 164\u003cbr\u003e \u003ci\u003eShibo Li and Zhen Xi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 G-QUADRUPLEX DNA AND ITS LIGANDS IN ANTICANCER THERAPY 206\u003cbr\u003e \u003ci\u003eZhi-Shu Huang, Jia-Heng Tan, Tian-Miao Ou, Ding Li, and Lian-Quan Gu\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 MOLECULAR MODELING IN NUCLEIC ACID-TARGETED DRUG DESIGN 258\u003cbr\u003e \u003ci\u003eLidan Sun, Hongwei Jin, Liangren Zhang, and Lihe Zhang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 STRUCTURE OF 10–23 DNAzyme IN COMPLEX WITH THE TARGET RNA \u003ci\u003eIN SILICO\u003c\/i\u003e—A PROGRESS REPORT ON THE MECHANISM OF RNA CLEAVAGE BY DNA ENZYME 272\u003cbr\u003e \u003ci\u003eOleksandr Plashkevych and Jyoti Chattopadhyaya\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 LABELING OLIGONUCLEOTIDES TOWARD THE BIOMEDICAL PROBE 292\u003cbr\u003e \u003ci\u003eIl Joon Lee and Byeang Hyean Kim\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 LOCKED NUCLEIC ACID OLIGONUCLEOTIDES TOWARD CLINICAL APPLICATIONS 335\u003cbr\u003e \u003ci\u003eRakesh N. Veedu and Jesper Wengel\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 THE PHARMACOKINETICS RESEARCH OF NUCLEIC ACID DRUGS 349\u003cbr\u003e \u003ci\u003eShengqi Wang, Dandan Lu, Qingqing Wang, Haifeng Song, Chan Gao, Caihong Liu, and Ying Wang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 INDUCIBLE RNAi AND DRUG TARGET VALIDATION 390\u003cbr\u003e \u003ci\u003eWei Xiong, Jing Zhao, Yufan Zhang, Jinxi Wang, Yong-Xiang Zheng, Qiu-Chen He, Li-He Zhang, and De-Min Zhou\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 siRNA: THE SPECIFICITY AND OFF-TARGET EFFECTS 405\u003cbr\u003e \u003ci\u003eQuan Du, Huang Huang, and Zicai Liang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eINDEX 423\u003c\/p\u003e  \u003cp\u003e“The book gives a good overview on some aspects of current research in the field. ... For those in the field seeking inspiration, it is a good book.”  (\u003ci\u003eChemMedChem,\u003c\/i\u003e 2012)\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e  \u003cb\u003eLI-HE ZHANG\u003c\/b\u003e is President of the academic committee of State Key Laboratory of Natural and Biomimetic Drugs, as well as Professor of Medicinal Chemistry at Peking University. He is also a member of the Chinese Academy of Sciences, Fellow of the Royal Society of Chemistry, former vice president of the Chinese Pharmaceutical Association, and past president of the Asian Federation of Medicinal Chemistry.  \u003cp\u003e\u003cb\u003eZHEN XI\u003c\/b\u003e, PhD, is Deputy Director of the State Key Laboratory of Elemento-organic Chemistry, as well as Professor of Pesticide Science and Chemical Biology, and Vice Dean of the College of Chemistry at Nankai University. He holds seven patents and has written a number of reviews and book chapters and sixty-four original research articles.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eJYOTI CHATTOPADHYAYA\u003c\/b\u003e, PhD, DSc, is the University Chair of Bioorganic Chemistry and the chair of the Chemical Biology Program at Uppsala University. He is a guest professor of chemistry at both Jilin University and Nankai University. He has written over 410 peer-reviewed original research articles and is also on the editorial boards of several international journals.\u003c\/p\u003e  \u003cb\u003eComplete, up-to-date coverage of the broad area of nucleic acid chemistry and biology\u003c\/b\u003e  \u003cp\u003eAssembling contributions from a collection of authors with expertise in all areas of nucleic acids, medicinal chemistry, and therapeutic applications, \u003ci\u003eMedicinal Chemistry of Nucleic Acids\u003c\/i\u003e presents a thorough overview of nucleic acid chemistry—a rapidly evolving and highly challenging discipline directly responsible for the development of antiviral and antitumor drugs. This reliable resource delves into a multitude of subject areas involving the study of nucleic acids—such as the new advances in genome sequencing, and the processes for creating RNA interference (RNAi) based drugs—to assist pharmaceutical researchers in removing roadblocks that hinder their ability to predict drug efficacy. Offering the latest cutting-edge science in this growing field, Medicinal Chemistry of Nucleic Acids includes:\u003c\/p\u003e \u003cul\u003e \u003cli\u003e \u003cp\u003eIn-depth coverage of the development and application of modified nucleosides and nucleotides in medicinal chemistry\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eA close look at a large range of current topics on nucleic acid chemistry and biology\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eEssential information on the use of nucleic acid drugs to treat diseases like cancer\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eA thorough exploration of siRNA for RNAi and the regulation of microRNA, non-coding RNA (ncRNA), a newly developing and exciting research area\u003c\/p\u003e \u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThorough in its approach and promising in its message, \u003ci\u003eMedicinal Chemistry of Nucleic Acids\u003c\/i\u003e probes the new domains of pharmaceutical research—and exposes readers to a wealth of new drug discovery opportunities emerging in the dynamic field of nucleic acid chemistry.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989603467493,"sku":"NP9780470596685","price":191.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470596685.jpg?v=1761784772","url":"https:\/\/k12savings.com\/es\/products\/medicinal-chemistry-of-nucleic-acids-isbn-9780470596685","provider":"K12savings","version":"1.0","type":"link"}