{"product_id":"mammalian-trp-channels-as-molecular-targets-isbn-9780470862544","title":"Mammalian TRP Channels as Molecular Targets","description":"This book brings together contributions from key investigators in the area of Transient Receptor Potential (TRP) channel structure and function. It covers the structure, function and regulation of mammalian TRP channels and mechanisms of signal transduction. The discussions indicate research that would improve understanding of the role of TRP channels in normal cellular physiology, the involvement of TRP channels in disease states and their potential use as molecular targets for novel therapeutic agents.  Chair's Introduction (J. Putney).  \u003cp\u003eMolecular genetics of \u003ci\u003eDrosophila\u003c\/i\u003e TRP channels (C. Montell).\u003c\/p\u003e \u003cp\u003eMammalian TRPC channnel subunit assembly (W. Schilling and M. Goel).\u003c\/p\u003e \u003cp\u003eTRPC channel interactions with calmodulin and IP\u003csub\u003e3\u003c\/sub\u003e receptors (M. Zhu \u0026amp; J. Tang).\u003c\/p\u003e \u003cp\u003ePlasma membrane localizations of TRPC channels: role of caveolar lipid rafts (I. Ambudkar, \u003ci\u003eet al\u003c\/i\u003e.).\u003c\/p\u003e \u003cp\u003eAssembly and gating of TRPC channels in signalling microdomains (P. Delmas).\u003c\/p\u003e \u003cp\u003eGeneral discussion I.\u003c\/p\u003e \u003cp\u003eActivation, subunit composition and physiological relevance of DAG-sensitive TRPC  proteins (T. Gudermann, \u003ci\u003eet al\u003c\/i\u003e.).\u003c\/p\u003e \u003cp\u003eSignalling mechanisms for TRPC3 channels (J. Putney, \u003ci\u003eet al\u003c\/i\u003e.).\u003c\/p\u003e \u003cp\u003eDiversity of TRP channel activation (B. Nilius and T. Voets).\u003c\/p\u003e \u003cp\u003eGeneral discussion II.\u003c\/p\u003e \u003cp\u003eRegulation of \u003ci\u003eDrosophila\u003c\/i\u003e TRP channels by lipid messengers (R. Hardie).\u003c\/p\u003e \u003cp\u003eControl of TRPC and store-operated channels by protein kinase C (K. Venkatachalam, \u003ci\u003eet al\u003c\/i\u003e.).\u003c\/p\u003e \u003cp\u003eTRPC4 and TRPC4 deficient mice (M. Freichel, \u003ci\u003eet al\u003c\/i\u003e.).\u003c\/p\u003e \u003cp\u003eTRP channels as drug targets (S. Li, \u003ci\u003eet al\u003c\/i\u003e.).\u003c\/p\u003e \u003cp\u003eRole of TRP channels in oxidative stress (K. Groschner, \u003ci\u003eet al\u003c\/i\u003e.).\u003c\/p\u003e \u003cp\u003eDistribution of TRPC channels in a visceral sensory pathway (M. Buniel, \u003ci\u003eet al\u003c\/i\u003e.).\u003c\/p\u003e \u003cp\u003eEmerging roles of TRPM channels (A. Fleig and R. Penner).\u003c\/p\u003e \u003cp\u003eFinal discussion.\u003c\/p\u003e \u003cp\u003eIndex of contributors.\u003c\/p\u003e \u003cp\u003eSubject index.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eDerek J. Chadwick\u003c\/b\u003e and \u003cb\u003eJamie A. Goode\u003c\/b\u003e are editors for \u003ci\u003eMammalian TRP Channels as Molecular Targets\u003c\/i\u003e and other scientific titles.\u003c\/p\u003e \u003cp\u003eTransient receptor potential (TRP) genes were originally identified as encoding critical components of phototransduction in \u003ci\u003eDrosophila\u003c\/i\u003e. Since the discovery of the first mammalian transient receptor potential channel (TRPC), more than 20 mammalian homologues have been reported. These ion channel proteins are widely distributed in tissues and appear to play a fundamental role in cell signalling, growth and death.\u003c\/p\u003e \u003cp\u003eThere are two major subfamilies of TRP channels. The TRPV channels include the VR1 vanilloid receptor, epithelial Ca2+ channels and OTRPC4, a channel that appears to be regulated by changes in osmolarity. Their functions may range from sensory transduction in nerves to Ca2+ transport in the gastrointestinal tract and renal tubule. The TRPM channels, which are the largest proteins in the TRP family, include the founding member, melastatin, and a novel bifunctional channel enzyme, TRP-PLIK.\u003c\/p\u003e \u003cp\u003eThis book brings together contributions from key investigators in the area of TRP channels. It covers the structure, function and regulation of mammalian TRP channels and of mechanisms of signal transduction. The discussions highlight future studies towards a better understanding of the role of TRP channels in normal cellular physiology, the involvement of TRP channels in disease states, and their potential use as molecular targets for novel therapeutic agents.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e\u003ci\u003eRelated Novartis Foundation symposia:\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e245 Ion channels: from atomic resolution physiology to functional genomics\u003c\/p\u003e \u003cp\u003eChair: Frances Ashcroft\u003c\/p\u003e \u003cp\u003e241 Sodium channels and neuronal hyperexcitability\u003c\/p\u003e \u003cp\u003eChair: Stephen G. Waxman\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989558444261,"sku":"NP9780470862544","price":211.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470862544.jpg?v=1761784591","url":"https:\/\/k12savings.com\/es\/products\/mammalian-trp-channels-as-molecular-targets-isbn-9780470862544","provider":"K12savings","version":"1.0","type":"link"}