{"product_id":"maldi-tof-and-tandem-ms-for-clinical-microbiology-isbn-9781118960257","title":"MALDI-TOF and Tandem MS for Clinical Microbiology","description":"\u003cp\u003eThis book highlights the triumph of MALDI-TOF mass spectrometry over the past decade and provides insight into new and expanding technologies through a comprehensive range of short chapters that enable the reader to gauge their current status and how they may progress over the next decade.  This book serves as a platform to consolidate current strengths of the technology and highlight new frontiers in tandem MS\/MS that are likely to eventually supersede MALDI-TOF MS. Chapters discuss:\u003cbr\u003eChallenges of Identifying Mycobacterium to the Species level \u003cbr\u003eIdentification of \u003ci\u003eBacteroides\u003c\/i\u003e and Other Clinically Relevant Anaerobes\u003cbr\u003eIdentification of Species in Mixed Microbial Populations\u003cbr\u003eDetection of Resistance Mechanisms\u003cbr\u003eProteomics as a biomarker discovery and validation platform\u003cbr\u003eDetermination of Antimicrobial Resistance using Tandem Mass Spectrometry\u003c\/p\u003e \u003cp\u003eList of Contributors xxi\u003c\/p\u003e \u003cp\u003ePreface xxix\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart I MALDI-TOF Mass Spectrometry 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 A Paradigm Shift from Research to Front]Line Microbial Diagnostics in MALDI]TOF and LC]MS\/MS: A Laboratory’s Vision and Relentless Resolve to Help Develop and Implement This New Technology amidst Formidable Obstacles 3\u003cbr\u003e\u003ci\u003eHaroun N. Shah and Saheer E. Gharbia\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 Criteria for Development of MALDI]TOF Mass Spectral Database 39\u003cbr\u003e\u003ci\u003eMarkus Kostrzewa and Thomas Maier\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 Applications of MALDI]TOF Mass Spectrometry in Clinical Diagnostic Microbiology 55\u003cbr\u003e\u003ci\u003eOnya Opota, Guy Prod’hom and Gilbert Greub\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 The Challenges of Identifying Mycobacterium to the Species Level using MALDI]TOF MS 93\u003c\/p\u003e \u003cp\u003e5 Transformation of Anaerobic Microbiology since the Arrival of MALDI]TOF Mass Spectrometry 123\u003cbr\u003e\u003ci\u003eElisabeth Nagy, Mariann Abrok, Edith Urban, A.C.M. Veloo, Arie Jan van Winkelhoff, Itaru Dekio, Saheer E. Gharbia and Haroun N. Shah\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 Differentiation of Closely Related Organisms using MALDI]TOF MS 147\u003cbr\u003e\u003ci\u003eMark A. Fisher\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 Identification of Species in Mixed Microbial Populations using MALDI]TOF MS 167\u003cbr\u003e\u003ci\u003ePierre Mahe, Maud Arsac, Nadine Perrot, Marie]Helene Charles, Patrick Broyer, Jay Hyman, John Walsh, Sonia Chatellier, Victoria Girard, Alex van Belkum, and Jean]Baptiste Veyrieras\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 Microbial DNA Analysis by MALDI]TOF Mass Spectrometry 187\u003c\/p\u003e \u003cp\u003e9 Impact of MALDI]TOF MS in Clinical Mycology; Progress and Barriers in Diagnostics 211\u003cbr\u003e\u003ci\u003eCledir R. Santos, Elaine Francisco, Mariana Mazza, Ana Carolina B. Padovan, Arnaldo Colombo and Nelson Lima\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 Development and Application of MALDI]TOF for Detection of Resistance Mechanisms 231\u003cbr\u003e\u003ci\u003eStefan Zimmermann and Irene Burckhardt\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 Discrimination of Burkholderia Species, Brucella Biovars, Francisella tularensis and Other Taxa at the Subspecies Level by MALDI]TOF Mass Spectrometry 249\u003cbr\u003e\u003ci\u003eAxel Karger\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 MALDI]TOF]MS Based on Ribosomal Protein Coding in S10]spc]alpha Operons for Proteotyping 269\u003cbr\u003e\u003ci\u003eHiroto Tamura\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart II Tandem MS\/MS-Based Approaches to Microbial Characterization 311\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e13 Tandem Mass Spectrometry Analysis as an Approach to Delineate Genetically Related Taxa 313\u003cbr\u003e\u003ci\u003eRaju V. Misra, Tom Gaulton, Nadia Ahmod, Min Fang, Martin Hornshaw, Jenny Ho, Saheer E. Gharbia and Haroun N. Shah\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14 Mapping of the Proteogenome of Clostridium difficile Isolates of Varying Virulence 379\u003cbr\u003e\u003ci\u003eCaroline H. Chilton, Saheer E. Gharbia, Raju V. Misra, Min Fang, Ian R. Poxton, Peter S. Borriello and Haroun N. Shah\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15 Determination of Antimicrobial Resistance using Tandem Mass\u003cbr\u003eSpectrometry 399\u003cbr\u003e\u003ci\u003eAjit J. Shah, Vlad Serafim, Zhen Xu, Hermine Mkrtchyan and Haroun N. Shah\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16 Proteotyping: Tandem Mass Spectrometry Shotgun Proteomic Characterization and Typing of Pathogenic Microorganisms 419\u003cbr\u003e\u003ci\u003eRoger Karlsson, Lucia Gonzales]Siles, Fredrik Boulund, Asa Lindgren, Liselott Svensson]Stadler, Anders Karlsson, Erik Kristiansson and Edward R.B. Moore\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17 Proteogenomics of Pseudomonas aeruginosa in Cystic Fibrosis Infections 451\u003cbr\u003e\u003ci\u003eLiang Yang and Song Lin Chua\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18 Top]Down Proteomics in the Study of Microbial Pathogenicity 493\u003cbr\u003e\u003ci\u003eJoseph Gault, Egor Vorontsov, Mathieu Dupre, Valeria Calvaresi, Magalie Duchateau, Diogo B. Lima, Christian Malosse and Julia Chamot]Rooke\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e19 Tandem Mass Spectrometry in Resolving Complex Gut Microbiota Functions 505\u003cbr\u003e\u003ci\u003eCarolin Kolmeder, Kaarina Lahteenmaki, Pirjo Wacklin, Annika Kotovuori, Ilja Ritamo, Jaana Matto, Willem M. de Vos, and Leena Valmu\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e20 Proteogenomics of Non]model Microorganisms 529\u003cbr\u003e\u003ci\u003eJean Armengaud\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e21A Analysis of MALDI]TOF MS Spectra using the BioNumerics Software 539\u003cbr\u003e\u003ci\u003eKatleen Vranckx, Katrien De Bruyne and Bruno Pot\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e21B Subtyping of Staphylococcus spp. Based upon MALDI]TOF MS Data Analysis 563\u003cbr\u003e\u003ci\u003eZhen Xu, Ali Olkun, Katleen Vranckx, Hermine V. Mkrtchyan, Ajit J. Shah, Bruno Pot, Ronald R. Cutler and Haroun N. Shah\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e21C Elucidating the Intra]Species Proteotypes of Pseudomonas aeruginosa from Cystic Fibrosis 579\u003cbr\u003e\u003ci\u003eAli Olkun, Ajit J. Shah and Haroun N. Shah\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eReferences 588\u003c\/p\u003e \u003cp\u003eIndex 593\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e   \u003cp\u003e\u003cb\u003e EDITORS\u003cbr\u003e Haroun N. Shah,\u003c\/b\u003e Department of Natural Sciences, Middlesex University, London, UK   \u003c\/p\u003e\u003cp\u003e\u003cb\u003e Saheer E. Gharbia,\u003c\/b\u003e Genomic Research, Public Health England, London, UK    \u003c\/p\u003e\u003cp\u003eThis comprehensive handbook highlights the triumph and developments of MALDI-TOF mass spectrometry in diagnostic approaches to clinical microbiology over the past decade, and provides insight into new technologies including tandem MS\/MS. Presenting the reader with detailed coverage of current research and future opportunities, this volume, divided into two parts, with 21 chapters, includes such topics as:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eApplications of MALDI-TOF Mass Spectrometry in Clinical Diagnostic Microbiology\u003c\/li\u003e \u003cli\u003eThe Potential of MALDI-TOF MS to Distinguish between Taxonomically Similar Species that Manifest Different Infections\u003c\/li\u003e \u003cli\u003eMicrobial DNA Analysis by MALDI-TOF Mass Spectrometry\u003c\/li\u003e \u003cli\u003eDevelopment and Application of MALDI-TOF MS for Detection of Resistance Mechanisms\u003c\/li\u003e \u003cli\u003eDetermination of Antimicrobial Resistance using Tandem Mass Spectrometry\u003c\/li\u003e \u003cli\u003eTop-Down Proteomics in the Study of Microbial Pathogenicity\u003c\/li\u003e \u003cli\u003eProteogenomics of Non-Model Microorganisms\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003ePrimarily aimed at clinical microbiologists, diagnostic technologists, biomedical scientists, researchers, clinicians, academics and scientists in bio-resource centres, this book is also relevant to researchers, post-graduate scientists, technologists in the food industry, pharmaceuticals and agriculture.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989558280421,"sku":"NP9781118960257","price":179.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781118960257.jpg?v=1761784590","url":"https:\/\/k12savings.com\/es\/products\/maldi-tof-and-tandem-ms-for-clinical-microbiology-isbn-9781118960257","provider":"K12savings","version":"1.0","type":"link"}