{"product_id":"leukodystrophies-isbn-9781907655098","title":"Leukodystrophies","description":"\u003cp\u003eThe leukodystrophies are serious, progressive disorders of demyelination, manifesting themselves in infancy or early childhood and progressing rapidly, leading to loss of sight, hearing, speech, and ambulation, and early death. A comprehensive guide to the genetics and pathogenesis of these disorders, as well as their clinical features, diagnosis and therapy, is needed, particularly as their early identification can allow more effective treatment.\u003c\/p\u003e \u003cp\u003eThis book is the only up-to-date, comprehensive text on leukodystrophies. Its purpose is to summarize for the reader all aspects of the inherited disorders of myelin in children and adults. After a comprehensive overview of myelin and the role of oligodendrocytes, astrocytes and microglia in white matter disease, chapters are then devoted to individual disorders, covering their biochemical and molecular basis, genetics, pathophysiology, clinical features, diagnosis, treatment and screening. The final chapters address therapeutic approaches in leukodystrophies and present a clinical approach to diagnosing leukoencephalopathies in children and adults.\u003c\/p\u003e \u003cp\u003eThe book was conceived by Hugo Moser, whose research led to major developments in the treatment of adrenoleukodystrophy, and is dedicated to him by his colleagues.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eReadership:\u003c\/b\u003e Paediatric and adult neurologists, paediatricians, geneticists.\u003c\/p\u003e  AUTHORS' APPOINTMENTS vii  \u003cp\u003eDEDICATION AND ACKNOWLEDGMENT x\u003c\/p\u003e \u003cp\u003eFOREWORD xi\u003cbr\u003e \u003ci\u003eAnn Moser\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1 LEUKODYSTROPHY AND MYELIN 1\u003cbr\u003e \u003ci\u003eHugo Moser and Gerald V. Raymond\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 MYELINATION IN HEALTH AND DISEASE 5\u003cbr\u003e \u003ci\u003eGrahame Kidd and Bruce D. Trapp\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 THE ROLE OF ASTROCYTES IN WHITE MATTER DISEASE 37\u003cbr\u003e \u003ci\u003eJörg Dietrich and Chris Pröschel\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 MICROGLIA AND LEUKODYSTROPHIES 60\u003cbr\u003e \u003ci\u003ePatricia Musolino and Florian Eichler\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 X-LINKED ADRENOLEUKODYSTROPHY 75\u003cbr\u003e \u003ci\u003eGerald V. Raymond\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 KRABBE DISEASE (GLOBOID CELL LEUKODYSTROPHY) 90\u003cbr\u003e \u003ci\u003eDavid A. Wenger\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 ALEXANDER DISEASE 106\u003cbr\u003e \u003ci\u003eDaniel Flint and Michael Brenner\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 METACHROMATIC LEUKODYSTROPHY 130\u003cbr\u003e \u003ci\u003eVolkmar Gieselmann and Ingeborg Krägeloh-Mann\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 CANAVAN DISEASE 156\u003cbr\u003e \u003ci\u003eKimberlee Michals and Reuben Matalon\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 PELIZAEUS–MERZBACHER DISEASE: GENETIC MODELS AND MECHANISMS 170\u003cbr\u003e \u003ci\u003eKlaus-Armin Nave and Ajit Singh Dhaunchak\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 THERAPEUTIC APPROACHES IN LEUKODYSTROPHIES 188\u003cbr\u003e \u003ci\u003eAli Fatemi and Charles Peters\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 CLINICAL APPROACH TO IDENTIFICATION OF LEUKOENCEPHALOPATHIES 209\u003cbr\u003e \u003ci\u003eSakkubai Naidu, Genila Bibat and Doris Lin\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eINDEX 229\u003c\/p\u003e \u003cp\u003eCOLOUR PLATES\u003c\/p\u003e  \u003cb\u003eGerald Raymond\u003c\/b\u003e is a pediatric neurologist and research scientist at Kennedy Krieger Institute, Associate Professor of Neurology at Johns Hopkins University and on the medical staff in the Department of Pediatrics and Neurology at Johns Hopkins Hospital. He has been involved in the study of adrenoleukodystrophy and other peroxisomal disorders for over 15 years.\u003cbr\u003e \u003cbr\u003e \u003cb\u003eFlorian Eichler\u003c\/b\u003e is Director of the Leukodystrophy Service at Massachusetts General Hospital and Assistant Professor of Neurology at Harvard Medical School. His research focus is on the genetics of peroxisomal disorders, lipid metabolism, and spatial aspects of nuclear magnetic resonance spectroscopy.\u003cbr\u003e \u003cbr\u003e \u003cb\u003eAli Fatemi\u003c\/b\u003e is a pediatric neurologist in the Division of Neurology and Developmental Medicine and an investigator at the Hugo W. Moser Research Institute at Kennedy Krieger. He is also Assistant Professor of Neurology and Pediatrics at Johns Hopkins University. His research interest is in genetic and acquired conditions that affect the brain’s white matter in newborns and infants.\u003cbr\u003e \u003cbr\u003e \u003cb\u003eSakkubai Naidu\u003c\/b\u003e is a research scientist at the Kennedy Krieger Institute and a Professor in the Departments of Neurology and Pediatrics at the Johns Hopkins University School of Medicine. She has a special interest in developmental and neurogenetic disorders affecting children and adults.","brand":"Mac Keith Press","offers":[{"title":"Default Title","offer_id":47989525610725,"sku":"NP9781907655098","price":123.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781907655098.jpg?v=1761784461","url":"https:\/\/k12savings.com\/es\/products\/leukodystrophies-isbn-9781907655098","provider":"K12savings","version":"1.0","type":"link"}