{"product_id":"introduction-to-heterocyclic-chemistry-isbn-9781119417590","title":"Introduction to Heterocyclic Chemistry","description":"\u003cb\u003eA unique approach to a core topic in organic chemistry presented by an experienced teacher to students and professionals\u003c\/b\u003e \u003cbr\u003e\u003cbr\u003eHeterocyclic rings are present in the majority of known natural products, contributing to enormous structural diversity. In addition, they often possess significant biological activity. Medicinal chemists have embraced this last property in designing most of the small molecule drugs in use today. This book offers readers a fundamental understanding of the basics of heterocyclic chemistry and their occurrence in natural products such as amino acids, DNA, vitamins, and antibiotics. Based on class lectures that the author has developed over more than 40 years of teaching, it focuses on the chemistry of such heterocyclic substances and how they differ from carbocyclic systems. \u003cbr\u003e\u003cbr\u003e\u003ci\u003eIntroductory Heterocyclic Chemistry\u003c\/i\u003e offers in-depth chapters covering naturally occurring heterocycles; properties of aromatic heterocycles; π-deficient heterocycles; π-excessive heterocycles; and ring transformations of heterocycles. It then offers an overview of 1,3-dipolar cycloadditions before finishing up with a back-to-basics section on nitriles and amidines. \u003cbr\u003e\u003cbr\u003e \u003cul\u003e \u003cli\u003ePresents a conversational approach to a fundamental topic in organic chemistry teaching \u003c\/li\u003e \u003cli\u003eOffers a unique look at this core organic chemistry topic via important naturally occurring and\/or biologically active heterocycles \u003c\/li\u003e \u003cli\u003eBased on the author's many years of class lectures for teaching at the undergraduate and graduate level as well as pharmaceutical-industry courses \u003c\/li\u003e \u003cli\u003eClear, concise, and accessible for advanced students of chemistry to gain a fundamental understanding of the basics of heterocyclic chemistry \u003c\/li\u003e \u003c\/ul\u003e \u003cbr\u003e\u003ci\u003eIntroductory Heterocyclic Chemistry\u003c\/i\u003e is an excellent text for undergraduate and graduate students as well as chemists in industrial environments in chemistry, pharmacy, medicinal chemistry, and biology. \u003cp\u003ePreface ix\u003c\/p\u003e \u003cp\u003eAcknowledgments xi\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Some Biologically Important Heterocycles of Nature 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1.1 Vitamins 3\u003c\/p\u003e \u003cp\u003e1.2 Antibiotics and Tetrapyrroles 8\u003c\/p\u003e \u003cp\u003eReferences 10\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Orbitals and Aromaticity; Chemical Reactivity 11\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eReferences 15\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 A Prelude to Synthesis 17\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eReferences 21\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 π‐Deficient Heterocycles: Some Physical Properties 23\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eReferences 25\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 π‐Deficient Heterocycles: De Novo Syntheses 27\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 De Novo Syntheses, Pyrimidines 32\u003c\/p\u003e \u003cp\u003e5.2 Fused‐Ring Systems, Quinolines 33\u003c\/p\u003e \u003cp\u003e5.2.1 Isoquinolines 34\u003c\/p\u003e \u003cp\u003eReferences 37\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 π‐Deficient Heterocycles: Introduction of New Substituents: Nucleophilic Substitution 39\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eReferences 48\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 π‐Deficient Heterocycles: Introduction of New Substituents: Heterocyclic N‐Oxides 49\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e7.1 Further Reactions of N‐Oxides 61\u003c\/p\u003e \u003cp\u003eReferences 73\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 π‐Deficient Heterocycles: Introduction of New Substituents: Quinolines and Isoquinolines 75\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eReferences 86\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 π‐Deficient Heterocycles: Manipulation of Existing Substituents 89\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e9.1 Summary 103\u003c\/p\u003e \u003cp\u003eReferences 105\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 π‐Excessive Heterocycles: General Properties 107\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eReferences 114\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 π‐Excessive Heterocycles: De Novo Syntheses 115\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e11.1 Synthesis of 1,3‐Azoles 127\u003c\/p\u003e \u003cp\u003e11.2 Synthesis of 1,2‐Azoles 131\u003c\/p\u003e \u003cp\u003e11.3 Fischer Indole Synthesis 133\u003c\/p\u003e \u003cp\u003eReferences 136\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 π‐Excessive Heterocycles: Introduction of New Substituents 139\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eReferences 153\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Ring Transformations of π‐Excessive Heterocycles: Diels‐Alder Reactions 157\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eReferences 175\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Heterocycles as Synthons 177\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eReferences 205\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 1,3‐Dipolar Cycloadditions—An Overview 207\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eReferences 234\u003c\/p\u003e \u003cp\u003e\u003cb\u003e16 Back to Basics 239\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eReferences 245\u003c\/p\u003e \u003cp\u003e\u003cb\u003e17 A Brief Synopsis 247\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eIndex 251\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePETER A. JACOBI, PhD\u003c\/b\u003e, received his B.S. degree in Chemistry from the University of New Hampshire (1967), and his Ph.D. in Organic Chemistry from Princeton University (1973). After two years at Harvard as a postdoctoral fellow, he joined the faculty of Wesleyan University (1975). In the fall of 1997 he moved from Wesleyan to Dartmouth, where in 2004 he was appointed the New Hampshire Professor of Chemistry, a position he held until 2013. Dr. Jacobi is the recipient of numerous awards including the American Cyanamid Company Award for \"Advancement of the Art and Science of Synthesis\" (1985); the Connecticut Valley ACS Award for \"Outstanding Contributions to Chemistry\" (1988); and the Caleb T. Winchester Award for \"Excellence as a Scholar-Teacher\" (1996). In 2010 he was elected as a Fellow of the American Chemical Society. He is the author of nearly 100 publications in the general area of heterocyclic chemistry, in particular as applied to natural product synthesis.\u003c\/p\u003e   \u003cp\u003e\u003cb\u003eA UNIQUE APPROACH TO A CORE TOPIC IN ORGANIC CHEMISTRY PRESENTED BY AN EXPERIENCED TEACHER TO STUDENTS AND PROFESSIONALS\u003c\/b\u003e \u003c\/p\u003e\u003cp\u003eHeterocyclic rings are present in the majority of known natural products, contributing to enormous structural diversity. In addition, they often possess significant biological activity. Medicinal chemists have embraced this last property in designing most of the small molecule drugs in use today. This book offers readers a fundamental understanding of the basics of heterocyclic chemistry and their occurrence in natural products such as amino acids, DNA, vitamins, and antibiotics. Based on class lectures that the author has developed over more than 40 years of teaching, it focuses on the chemistry of such heterocyclic substances and how they differ from carbocyclic systems. \u003c\/p\u003e\u003cp\u003e\u003ci\u003eIntroductory Heterocyclic Chemistry\u003c\/i\u003e offers in-depth chapters covering naturally occurring heterocycles; properties of aromatic heterocycles; -deficient heterocycles; -excessive heterocycles; and ring transformations of heterocycles. It then offers an overview of 1,3-dipolar cycloadditions before finishing up with a back-to-basics section on nitriles and amidines. \u003c\/p\u003e\u003cul\u003e \u003cli\u003ePresents a conversational approach to a fundamental topic in organic chemistry teaching\u003c\/li\u003e \u003cli\u003eOffers a unique look at this core organic chemistry topic via important naturally occurring and\/or biologically active heterocycles\u003c\/li\u003e \u003cli\u003eBased on the author's many years of class lectures for teaching at the undergraduate and graduate level as well as pharmaceutical-industry courses\u003c\/li\u003e \u003cli\u003eClear, concise, and accessible for advanced students of chemistry to gain a fundamental understanding of the basics of heterocyclic chemistry\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eIntroductory Heterocyclic Chemistry\u003c\/i\u003e is an excellent text for undergraduate and graduate students as well as chemists in industrial environments in chemistry, pharmacy, medicinal chemistry, and biology.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989460926693,"sku":"NP9781119417590","price":67.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781119417590.jpg?v=1761784190","url":"https:\/\/k12savings.com\/es\/products\/introduction-to-heterocyclic-chemistry-isbn-9781119417590","provider":"K12savings","version":"1.0","type":"link"}