{"product_id":"inherited-bleeding-disorders-in-women-isbn-9781119426028","title":"Inherited Bleeding Disorders in Women","description":"\u003cp\u003e\u003cb\u003eThe essential guide for understanding and treating women with inherited bleeding disorders, revised and updated\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eNow in its second edition,\u003ci\u003e Inherited Bleeding Disorders in Women\u003c\/i\u003e includes the most recent developments and research in the field. This important guide offers the most current information available for the effective management of these complex and difficult to diagnose disorders. Treating women with inherited bleeding disorders can be challenging and requires close collaboration among practitioners in different specialties.\u003c\/p\u003e \u003cp\u003eThis important guide is written by a team of international experts who offer advice and practical suggestions for treating women with inherited bleeding disorders. \u003ci\u003eInherited Bleeding Disorders in Women\u003c\/i\u003e comprehensively covers obstetric and gynecological issues for carriers of hemophilia, women with von Willebrand disease, rare bleeding disorders and inherited platelet disorders. This important resource:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eOffers an updated guide for hematologists, obstetricans and gynecologists and other clinicians treating women with inherited bleeding disorders\u003c\/li\u003e \u003cli\u003eIncludes information for treating both common and rare bleeding disorders\u003c\/li\u003e \u003cli\u003eContains the most recent developments and advances in the field for the treatment and management of inherited bleeding disorders in women\u003c\/li\u003e \u003cli\u003ePresents information from noted experts in the field\u003c\/li\u003e \u003cli\u003eOffers a multidisciplinary approach to the topic\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eWritten for hematologists, obstetricians and gynecologists and other clinicians working with women, \u003ci\u003eInherited Bleeding Disorders in Women\u003c\/i\u003e has been fully revised and updated and continues to serve as a trusted guide for the management and treatment of women with inherited bleeding disorders. \u003c\/p\u003e \u003cp\u003ePreface to Second Edition ix\u003c\/p\u003e \u003cp\u003ePreface to First Edition xi\u003c\/p\u003e \u003cp\u003eList of Contributors xiii\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Hematological Assessment of a Patient with an Inherited Bleeding Disorder 1 \u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSue Pavord and Henna Wong\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.1 Introduction 1\u003c\/p\u003e \u003cp\u003e1.2 Normal Hemostasis 1\u003c\/p\u003e \u003cp\u003e1.3 Defects of Hemostasis 5\u003c\/p\u003e \u003cp\u003e1.4 Clinical Presentation of Bleeding 5\u003c\/p\u003e \u003cp\u003e1.5 Diagnosis 6\u003c\/p\u003e \u003cp\u003e1.6 Approach to a Female with a Bleeding History 6\u003c\/p\u003e \u003cp\u003e1.7 Summary 10\u003c\/p\u003e \u003cp\u003eReferences 11\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Bleeding Assessment Tools 13\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSarah H. O’Brien and Paula D. James\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introduction 13\u003c\/p\u003e \u003cp\u003e2.2 Evolution of Vicenza‐Based Bleeding Assessment Tools 13\u003c\/p\u003e \u003cp\u003e2.3 Women’s Studies Using Vincenza‐Based Bleeding Tools 22\u003c\/p\u003e \u003cp\u003e2.4 Tools to Evaluate Menstrual Blood Loss 23\u003c\/p\u003e \u003cp\u003e2.5 Young Women’s Hematology and Bleeding Assessment Tools 25\u003c\/p\u003e \u003cp\u003e2.6 Clinical Utility of Bleeding Assessment Tools 25\u003c\/p\u003e \u003cp\u003e2.7 Conclusion 26\u003c\/p\u003e \u003cp\u003eReferences 27\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Physiology of Menstruation 29\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eJane J. Reavey, Jacqueline A. Maybin, and Hilary O.D. Critchley\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1 Introduction 29\u003c\/p\u003e \u003cp\u003e3.2 Normal Menstruation 29\u003c\/p\u003e \u003cp\u003e3.3 Neuroendocrine Hormones 30\u003c\/p\u003e \u003cp\u003e3.4 Menarche 31\u003c\/p\u003e \u003cp\u003e3.5 Ovarian Follicle Development and Endocrine Function 31\u003c\/p\u003e \u003cp\u003e3.6 Endometrium 33\u003c\/p\u003e \u003cp\u003e3.7 Secretory Phase 34\u003c\/p\u003e \u003cp\u003e3.8 Menstruation 35\u003c\/p\u003e \u003cp\u003e3.9 Control of Bleeding 37\u003c\/p\u003e \u003cp\u003e3.10 Endometrial Repair 38\u003c\/p\u003e \u003cp\u003e3.11 Proliferative Phase 40\u003c\/p\u003e \u003cp\u003e3.12 Summary 40\u003c\/p\u003e \u003cp\u003eReferences 41\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Gynecology 45\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eJoanna S. Davies and Rezan A. Kadir\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction 45\u003c\/p\u003e \u003cp\u003e4.2 Heavy Menstrual Bleeding 48\u003c\/p\u003e \u003cp\u003e4.3 Management of Acute Episodes of Heavy Menstrual Bleeding 58\u003c\/p\u003e \u003cp\u003e4.4 Ovulation Bleeding 59\u003c\/p\u003e \u003cp\u003e4.5 Endometriosis 59\u003c\/p\u003e \u003cp\u003e4.6 Other Gynecological Conditions 60\u003c\/p\u003e \u003cp\u003e4.7 Conclusion 61\u003c\/p\u003e \u003cp\u003eReferences 61\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Carriers of Hemophilia A and Hemophilia B 65\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eRoseline d’Oiron\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.1 Inheritance 65\u003c\/p\u003e \u003cp\u003e5.2 Screening for the Genetic Status of Carriers of Hemophilia 65\u003c\/p\u003e \u003cp\u003e5.3 Confusion Between Genetic and Coagulation Testing 66\u003c\/p\u003e \u003cp\u003e5.4 When to Perform Genetic Testing 67\u003c\/p\u003e \u003cp\u003e5.5 What Reasons might Contribute to Delayed Genetic Diagnosis of Carriership? 68\u003c\/p\u003e \u003cp\u003e5.6 Bleeding Disorders in Carriers of Hemophilia 68\u003c\/p\u003e \u003cp\u003e5.7 Quality of Life of Carriers of Hemophilia 73\u003c\/p\u003e \u003cp\u003e5.8 Carriers of Hemophilia A and B and Pregnancy 73\u003c\/p\u003e \u003cp\u003e5.9 How to Improve Care for Carriers of Hemophilia 77\u003c\/p\u003e \u003cp\u003eReferences 79\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Von Willebrand Disease 83\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eCarolyn M. Millar\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.1 Introduction 83\u003c\/p\u003e \u003cp\u003e6.2 Structure and Function of Von Willebrand Factor 83\u003c\/p\u003e \u003cp\u003e6.3 Von Willebrand Factor Levels and Prevalence of Von Willebrand Disease 84\u003c\/p\u003e \u003cp\u003e6.4 VWF Levels, the Menstrual Cycle and Pregnancy 84\u003c\/p\u003e \u003cp\u003e6.5 Von Willebrand Disease Classification and Inheritance 85\u003c\/p\u003e \u003cp\u003e6.6 Clinical Presentation 87\u003c\/p\u003e \u003cp\u003e6.7 Menorrhagia and Postpartum Hemorrhage 87\u003c\/p\u003e \u003cp\u003e6.8 Diagnosis and Laboratory Testing 88\u003c\/p\u003e \u003cp\u003e6.9 Management of Von Willebrand Disease 90\u003c\/p\u003e \u003cp\u003e6.10 Management of Gynecological Bleeding 91\u003c\/p\u003e \u003cp\u003e6.11 Obstetric Management of Von Willebrand Disease 92\u003c\/p\u003e \u003cp\u003e6.12 Neonatal Management 94\u003c\/p\u003e \u003cp\u003e6.13 Cases 94\u003c\/p\u003e \u003cp\u003eReferences 96\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Factor XI Deficiency 101\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eBethan Myers and Rezan A. Kadir\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7.1 Factor XI Structure and Function in Coagulation 101\u003c\/p\u003e \u003cp\u003e7.2 Incidence and Inheritance of Factor XI Deficiency 101\u003c\/p\u003e \u003cp\u003e7.3 Bleeding Manifestations and Diagnosis of Factor XI Deficiency 103\u003c\/p\u003e \u003cp\u003e7.4 Factor XI Deficiency and Gynecological Issues 103\u003c\/p\u003e \u003cp\u003e7.5 Factor XI Deficiency and Pregnancy 105\u003c\/p\u003e \u003cp\u003e7.6 Neuroaxial Analgesia and Anesthesia 108\u003c\/p\u003e \u003cp\u003e7.7 Management of Postpartum Period 108\u003c\/p\u003e \u003cp\u003e7.8 Treatment Options 109\u003c\/p\u003e \u003cp\u003e7.9 Neonatal Bleeding 111\u003c\/p\u003e \u003cp\u003e7.10 Conclusions and Recommendations 111\u003c\/p\u003e \u003cp\u003eReferences 112\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Rare Bleeding Disorders 117\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eDanijela Mikovic, Marzia Menegatti, and Flora Peyvandi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.1 Introduction 117\u003c\/p\u003e \u003cp\u003e8.2 Clinical Symptoms 118\u003c\/p\u003e \u003cp\u003e8.3 Gynecological and Obstetrical Manifestations in Women with Rare Bleeding Disorders 119\u003c\/p\u003e \u003cp\u003e8.4 Laboratory Diagnosis 122\u003c\/p\u003e \u003cp\u003e8.5 Differential Diagnosis in Women with Menorrhagia 123\u003c\/p\u003e \u003cp\u003e8.6 Treatment 124\u003c\/p\u003e \u003cp\u003e8.7 Conclusion 128\u003c\/p\u003e \u003cp\u003eReferences 129\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Inherited Platelet Defects 133\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eMike Makris and Clare Samuelson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9.1 Introduction 133\u003c\/p\u003e \u003cp\u003e9.2 Normal Platelet Function 133\u003c\/p\u003e \u003cp\u003e9.3 Presentation 136\u003c\/p\u003e \u003cp\u003e9.4 Investigation 137\u003c\/p\u003e \u003cp\u003e9.5 Syndromic and Non‐Syndromic Inherited Platelet Disorders with Recognized Causative Genes 143\u003c\/p\u003e \u003cp\u003e9.6 Prenatal Diagnosis 143\u003c\/p\u003e \u003cp\u003e9.7 Management 144\u003c\/p\u003e \u003cp\u003e9.8 Future Directions 147\u003c\/p\u003e \u003cp\u003e9.9 Case Histories 147\u003c\/p\u003e \u003cp\u003e9.10 Conclusion 148\u003c\/p\u003e \u003cp\u003eReferences 149\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Genetic and Laboratory Diagnosis 153\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eAnne C. Goodeve\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10.1 Introduction 153\u003c\/p\u003e \u003cp\u003e10.2 Phenotypic Analysis of Hemophilia A 154\u003c\/p\u003e \u003cp\u003e10.3 Phenotypic Analysis of Hemophilia B 156\u003c\/p\u003e \u003cp\u003e10.4 Phenotypic Analysis of von Willebrand Disease 157\u003c\/p\u003e \u003cp\u003e10.5 Phenotypic Analysis of Inherited Bleeding Disorders 157\u003c\/p\u003e \u003cp\u003e10.6 Genetic Analysis of Hemophilia A 160\u003c\/p\u003e \u003cp\u003e10.7 Genetic Analysis of Hemophilia B 162\u003c\/p\u003e \u003cp\u003e10.8 Genetic Analysis of von Willebrand Disease 163\u003c\/p\u003e \u003cp\u003e10.9 Guidelines 164\u003c\/p\u003e \u003cp\u003e10.10 Summary 164\u003c\/p\u003e \u003cp\u003eReferences 164\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Antenatal Diagnosis 167\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eRezan A. Kadir, Irena Hudecova, and Claudia Chi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11.1 Introduction 167\u003c\/p\u003e \u003cp\u003e11.2 Genetic Counseling 167\u003c\/p\u003e \u003cp\u003e11.3 Prenatal Diagnosis 170\u003c\/p\u003e \u003cp\u003e11.4 Prenatal Diagnosis of Hemophilia 177\u003c\/p\u003e \u003cp\u003e11.5 Prenatal Diagnosis of von Willebrand Disease 180\u003c\/p\u003e \u003cp\u003e11.6 Prenatal Diagnosis of Rare Bleeding Disorders 180\u003c\/p\u003e \u003cp\u003e11.7 Preimplantation Genetic Diagnosis 181\u003c\/p\u003e \u003cp\u003e11.8 Views about and Experiences of Prenatal Diagnosis of Women in Families Affected with Inherited Bleeding Disorders 183\u003c\/p\u003e \u003cp\u003e11.9 Termination of Pregnancy 185\u003c\/p\u003e \u003cp\u003eReferences 186\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Analgesia and Anesthesia for Pregnant Women with Inherited Bleeding Disorders 191\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eAnne‐Sophie Bouthors, Adrian England, and Rezan A. Kadir\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12.1 Introduction 191\u003c\/p\u003e \u003cp\u003e12.2 Non‐Pharmacological Methods 192\u003c\/p\u003e \u003cp\u003e12.3 Pharmacological Methods 192\u003c\/p\u003e \u003cp\u003e12.4 Conclusion 201\u003c\/p\u003e \u003cp\u003eReferences 202\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 The Newborn 205\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eManuel Carcao and Vanessa Bouskill\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13.1 Introduction 205\u003c\/p\u003e \u003cp\u003e13.2 Developmental Hemostasis 205\u003c\/p\u003e \u003cp\u003e13.3 Laboratory Hemostatic Evaluation of the Neonate 208\u003c\/p\u003e \u003cp\u003e13.4 When to Suspect a Congenital Bleeding Disorder in a Newborn 209\u003c\/p\u003e \u003cp\u003e13.5 Congenital Bleeding Disorders and Their Presentation in Newborns 213\u003c\/p\u003e \u003cp\u003e13.6 Management of Bleeding in Neonates with Congenital Bleeding Disorders 218\u003c\/p\u003e \u003cp\u003e13.7 Conclusion 221\u003c\/p\u003e \u003cp\u003eReferences 222\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Women with Inherited Bleeding Disorders in Different Cultural Settings 225\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eTahira Zafar, Jameela Sathar, Ali T. Taher, Fadi G. Mirza, and Christine A. Lee\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14.1 Introduction 225\u003c\/p\u003e \u003cp\u003e14.2 Pakistan 225\u003c\/p\u003e \u003cp\u003e14.3 Malaysia 227\u003c\/p\u003e \u003cp\u003e14.4 Lebanon 229\u003c\/p\u003e \u003cp\u003e14.5 Discussion 231\u003c\/p\u003e \u003cp\u003eReferences 232\u003c\/p\u003e \u003cp\u003eIndex 235\u003c\/p\u003e \t \u003cp\u003e\u003cb\u003eRezan A. Kadir,\u003c\/b\u003e Professor in the Department of Obstetrics and Gynaecology and Katharine Dormandy Haemophilia and Thrombosis Centre, The Royal Free Foundation Hospital and Institute for Women's Health, University College London, London, UK. \u003c\/p\u003e\u003cp\u003e\u003cb\u003ePaula D. James,\u003c\/b\u003e Professor in the Department of Medicine, Queen's University, Kingston, Canada. \u003c\/p\u003e\u003cp\u003e\u003cb\u003eChristine A. Lee,\u003c\/b\u003e Emeritus Professor of Hemophilia, University College London, London, UK.  \u003c\/p\u003e\u003cp\u003e\u003cb\u003eThe Essential Guide for Understanding and Treating Women with Inherited Bleeding Disorders, Revised and Updated\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eTreating women with inherited bleeding disorders can be challenging and requires close collaboration among practitioners in different specialties. Now in its second edition, \u003ci\u003eInherited Bleeding Disorders in Women\u003c\/i\u003e includes the most recent developments and research in the field, and offers the most current information available for the effective management of these complex and difficult-to-diagnose disorders.\u003c\/p\u003e \u003cp\u003eWritten by a team of international experts who offer advice and practical suggestions for treating women with inherited bleeding disorders. \u003ci\u003eInherited Bleeding Disorders in Women \u003c\/i\u003ecomprehensively covers obstetric and gynecological issues for carriers of hemophilia, women with von Willebrand disease, rare bleeding disorders, and inherited platelet disorders. This important resource:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eOffers an updated guide for hematologists, obstetricans and gynecologists, and other clinicians treating women with inherited bleeding disorders,\u003c\/li\u003e \u003cli\u003eIncludes information for treating both common and rare bleeding disorders,\u003c\/li\u003e \u003cli\u003eContains the most recent developments and advances in the field for the management of inherited bleeding disorders in women,\u003c\/li\u003e \u003cli\u003ePresents information from noted experts in the field, and\u003c\/li\u003e \u003cli\u003eOffers a multidisciplinary approach to the topic.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eEssential reading for hematologists, obstetricians and gynecologists, and other clinicians working with women, \u003ci\u003eInherited Bleeding Disorders in Women\u003c\/i\u003e has been fully revised and updated and continues to serve as a trusted guide for the management of women with inherited bleeding disorders.\u003c\/p\u003e","brand":"Wiley-Blackwell","offers":[{"title":"Default Title","offer_id":47989424750821,"sku":"NP9781119426028","price":215.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781119426028.jpg?v=1761784052","url":"https:\/\/k12savings.com\/es\/products\/inherited-bleeding-disorders-in-women-isbn-9781119426028","provider":"K12savings","version":"1.0","type":"link"}