{"product_id":"inflammation-and-allergy-drug-design-isbn-9781444330144","title":"Inflammation and Allergy Drug Design","description":"Our knowledge and understanding of allergic diseases of the respiratory tract has improved to a point where new therapies are being developed for patient benefit.\u003cbr\u003e \u003cbr\u003e   \u003cp\u003e\u003cb\u003e\u003ci\u003eInflammation and Allergy Drug Design\u003c\/i\u003e\u003c\/b\u003e explains the biologic science that underpins the pathophysiology of asthma and related disorders, as well as their mechanisms. This authoritative guide consists of 25 chapters, each detailing the cutting-edge developments in a particular field. It is divided into three parts, covering cytokines, chemokines, grow factors and mediators.\u003c\/p\u003e \u003cp\u003eThis book allows immunologists, allergologists and researchers in the pharmaceutical industry to learn and appreciate the target biology in drug development. It also provides medical and pharmaceutical postgraduate\u003cbr\u003e students and clinicians with a basic understanding of allergic diseases in the respiratory tract.\u003c\/p\u003e  Contributors, vii  \u003cp\u003ePreface, xiii\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart I: Cells contributing to the pathogenesis of allergic diseases in the respiratory tract\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Novel anti-infl ammatory drugs based on targeting lung dendritic cells and airway epithelial cells, 3\u003cbr\u003e \u003ci\u003eBart N. Lambrecht, Maud Plantinga, Monique Willart, and Hamida Hammad\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 Role of Th2 cells in the allergic diathesis, 15\u003cbr\u003e \u003ci\u003eMarsha Wills-Karp\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 Importance of Th17- and Th1-associated responses for the development of asthma, 27\u003cbr\u003e \u003ci\u003eTomohiro Yoshimoto, Hiroko Tsutsui, and Kenji Nakanishi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 Regulatory T cells, 39\u003cbr\u003e \u003ci\u003eChris Corrigan and Kimuli Ryanna\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 A role for natural killer T-cell subsets in the pathogenesis of various allergic disorders, 59\u003cbr\u003e \u003ci\u003eHiroshi Watarai, Michishige Harada, Mayumi Tamari, and Masaru Taniguchi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 Regulatory roles of B cells in allergy and infl ammation, 67\u003cbr\u003e \u003ci\u003eKiyoshi Takatsu, Masashi Ikutani and Yoshinori Nagai\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 Mast cells, 79\u003cbr\u003e \u003ci\u003eMindy Tsai and Stephen J. Galli\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 Eosinophils, 107\u003cbr\u003e \u003ci\u003eNancy A. Lee, Mark V. Dahl, Elizabeth A. Jacobsen, and Sergei I. Ochkur\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 Basophils in infl ammation and allergy drug design, 123\u003cbr\u003e \u003ci\u003eDonald MacGlashan, Jr.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 Epithelial cells, 139\u003cbr\u003e \u003ci\u003eTillie-Louise Hackett, Stephanie Warner, Dorota Stefanowicz, and Darryl Knight\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 Fibroblasts, 149\u003cbr\u003e \u003ci\u003eAlastair G. Stewart, Lilian Soon, and Michael Schuliga\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 Airway smooth muscle cells, 163\u003cbr\u003e \u003ci\u003eAndrew J. Halayko and Pawan Sharma\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart II: Cytokines contributing to the pathogenesis of allergic diseases in the respiratory tract\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e13 Interleukin 4, interleukin 13, and interleukin 9, 175\u003cbr\u003e \u003ci\u003eKenji Izuhara, Shoichiro Ohta, Hiroshi Shiraishi, and Shoichi Suzuki\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14 Interleukin 3, interleukin 5, and granulocyte–macrophage colony-stimulating factor, 187\u003cbr\u003e \u003ci\u003eAlba Llop-Guevara, Josip Marcinko, Ramzi Fattouh, and Manel Jordana\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15 Interleukin 15, interleukin 17, and interleukin 25, 197\u003cbr\u003e \u003ci\u003eHiroshi Nakajima and Itsuo Iwamoto\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16 Thymic stromal lymphopoietin, 205\u003cbr\u003e \u003ci\u003eKazuhiko Arima and Yong-Jun Liu\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17 Interleukin 10, 215\u003cbr\u003e \u003ci\u003eWhitney W. Stevens, Larry Borish, and John W. Steinke\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18 Tumor necrosis factor alpha, 225\u003cbr\u003e \u003ci\u003eChristopher Brightling, Latifa Chachi, Dhan Desai, and Yassine Amrani\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e19 Profi brotic and angiogenic factors in asthma, 237\u003cbr\u003e \u003ci\u003eNeville Berkman and Francesca Levi-Schaffer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e20 Chemokines, 253\u003cbr\u003e \u003ci\u003eLuis M. Teran and Juan R. Velazquez\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e21 Epithelial growth factors, 263\u003cbr\u003e \u003ci\u003eYasuhiro Gon and Shu Hashimoto\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart III: Other mediators contributing to the pathogenesis of allergic diseases in the respiratory tract\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e22 Prostanoids, 273\u003cbr\u003e \u003ci\u003eSarah A. Maher, Deborah L. Clarke, and Maria G. Belvisi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e23 Leukotrienes, 285\u003cbr\u003e \u003ci\u003eKatsuhide Okunishi and Marc Peters-Golden\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e24 Proteases in allergy, 297\u003cbr\u003e \u003ci\u003eKeisuke Oboki and Hirohisa Saito\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e25 Toll-like receptors, 307\u003cbr\u003e \u003ci\u003eJessica L. Allen, Aurelien Trompette, and Christopher L. Karp\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex, 317\u003c\/p\u003e  Edited by\u003cbr\u003e K. Izuhara, MD, PhD, Saga Medical School, Nabeshima, Japan\u003cbr\u003e Stephen T. Holgate, MD, DSc, FRCP, Southampton General Hospital, UK\u003cbr\u003e Marsha Wills-Karp, PhD, Children’s Hospital Medical Center, Cincinnati, USA  Our knowledge and understanding of allergic diseases of the respiratory tract has improved to a point where new therapies are being developed for patient benefit.\u003cbr\u003e \u003cbr\u003e   \u003cp\u003e\u003cb\u003e\u003ci\u003eInflammation and Allergy Drug Design\u003c\/i\u003e\u003c\/b\u003e explains the biologic science that underpins the pathophysiology of asthma and related disorders, as well as their mechanisms. This authoritative guide consists of 25 chapters, each detailing the cutting-edge developments in a particular field. It is divided into three parts, covering cytokines, chemokines, grow factors and mediators.\u003c\/p\u003e \u003cp\u003eThis book allows immunologists, allergologists and researchers in the pharmaceutical industry to learn and appreciate the target biology in drug development. It also provides medical and pharmaceutical postgraduate\u003cbr\u003e students and clinicians with a basic understanding of allergic diseases in the respiratory tract.\u003c\/p\u003e","brand":"Wiley-Blackwell","offers":[{"title":"Default Title","offer_id":47989420327141,"sku":"NP9781444330144","price":153.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781444330144.jpg?v=1761784035","url":"https:\/\/k12savings.com\/es\/products\/inflammation-and-allergy-drug-design-isbn-9781444330144","provider":"K12savings","version":"1.0","type":"link"}