{"product_id":"impact-of-engineered-nanomaterials-in-genomics-and-epigenomics-isbn-9781119896227","title":"Impact of Engineered Nanomaterials in Genomics and Epigenomics","description":"\u003cb\u003eImpact of Engineered Nanomaterials in Genomics and Epigenomics\u003c\/b\u003e \u003cp\u003e\u003cb\u003eOverview of current research and technologies in nanomaterial science as applied to omics science at the single cell level\u003c\/b\u003e \u003c\/p\u003e\u003cp\u003e\u003ci\u003eImpact of Engineered Nanomaterials in Genomics and Epigenomics\u003c\/i\u003e is a comprehensive and authoritative compilation of the genetic processes and instructions that specifically direct individual genes to turn on or off, focusing on the developing technologies of engineering nanomaterials and their role in cell engineering which have become important research tools for pharmaceutical, biological, medical, and toxicological studies. \u003c\/p\u003e\u003cp\u003eCombining state-of-the art information on the impact of engineered nanomaterials in genomics and epigenomics, from a range of internationally recognized investigators from around the world, this edited volume offers unique insights into the current trends and future directions of research in this scientific field.  \u003c\/p\u003e\u003cp\u003e\u003ci\u003eImpact of Engineered Nanomaterials in Genomics and Epigenomics\u003c\/i\u003e includes detailed information on sample topics such as: \u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eImpact of engineered nanomaterials in genomics and epigenomics, including adverse impact on glucose energy metabolism\u003c\/li\u003e \u003cli\u003eToxicogenomics, toxicoepigenomics, genotoxicity and epigenotoxicity, and mechanisms of toxicogenomics and toxicoepigenomics\u003c\/li\u003e \u003cli\u003eAdverse effects of engineered nanomaterials on human environment and metabolomics pathways leading to ecological toxicity\u003c\/li\u003e \u003cli\u003eMeta-analysis methods to identify genomic toxicity mechanisms of engineered nanomaterials and biological effects of engineered nanomaterial exposure\u003c\/li\u003e \u003cli\u003eArtificial intelligence and machine learning of single-cell transcriptomics of engineered nanoparticles and trends in plant nano-interaction to mitigate abiotic stresses\u003c\/li\u003e\n\u003c\/ul\u003e \u003cp\u003eThis comprehensive work is a valuable and excellent source of authoritative and up-to-date information for advanced students and researchers, toxicologists, the drug industry, risk assessors and regulators in academia, industry, and government, as well as for clinical scientists working in hospital and clinical environments. \u003c\/p\u003e\u003cp\u003eContents\u003c\/p\u003e \u003cp\u003eList of Contributors xv\u003c\/p\u003e \u003cp\u003ePreface xix\u003c\/p\u003e \u003cp\u003eAcknowledgments xxi\u003c\/p\u003e \u003cp\u003e1 Impact of Engineered Nanomaterials in Genomics and Epigenomics 1\u003c\/p\u003e \u003cp\u003eSaura C. Sahu Contents\u003c\/p\u003e \u003cp\u003eNanotechnology: A Technological Advancement of the Twenty-First Century 1\u003c\/p\u003e \u003cp\u003eGenomics and Epigenomics 1\u003c\/p\u003e \u003cp\u003eBeneficial Impacts of Engineered Nanomaterials on Human Life 2\u003c\/p\u003e \u003cp\u003ePotential Adverse Health Effects of Engineered Nanomaterials 2\u003c\/p\u003e \u003cp\u003eConclusions 3\u003c\/p\u003e \u003cp\u003eReferences 3\u003c\/p\u003e \u003cp\u003e2 Molecular Impacts of Advanced Nanomaterials at Genomic and Epigenomic Levels 5\u003c\/p\u003e \u003cp\u003eKamran Shekh, Rais A Ansari, Yadollah Omidi, and Saghir A. Shakil\u003c\/p\u003e \u003cp\u003eIntroduction 5\u003c\/p\u003e \u003cp\u003eClassification of NMs 6\u003c\/p\u003e \u003cp\u003eAbsorption and Distribution of NMs 6\u003c\/p\u003e \u003cp\u003eMajor Adverse Effects of NMs 8\u003c\/p\u003e \u003cp\u003eKnown Cellular and Nuclear Uptake Mechanisms for Nanoparticles 10\u003c\/p\u003e \u003cp\u003eEpigenetic Mechanisms and the Effect of NMs 11\u003c\/p\u003e \u003cp\u003eDNA Methylation 12\u003c\/p\u003e \u003cp\u003eGenetic and Genomic Effects of NMs 20\u003c\/p\u003e \u003cp\u003eConclusion 25\u003c\/p\u003e \u003cp\u003eReferences 26\u003c\/p\u003e \u003cp\u003e3 Endocrine Disruptors: Genetic, Epigenetic, and Related Pathways 41\u003c\/p\u003e \u003cp\u003eRais A. Ansari, Saleh Alfuraih, Kamran Shekh, Yadollah Omidi, Saleem Javed, and Saghir A. Shakil\u003c\/p\u003e \u003cp\u003eIntroduction 41\u003c\/p\u003e \u003cp\u003eToxic Effects of EDCs on Wildlife and Humans 47\u003c\/p\u003e \u003cp\u003eEffects During Development 48\u003c\/p\u003e \u003cp\u003eDelayed Effects 48\u003c\/p\u003e \u003cp\u003eTransgenerational Effects 49\u003c\/p\u003e \u003cp\u003eIdentification of EDC: Methods 49\u003c\/p\u003e \u003cp\u003eGenetic Pathways 50\u003c\/p\u003e \u003cp\u003ePhosphorylation-Mediated Signaling Pathways of Nuclear Receptors and Other Transcription Factors: Link to EDC 53\u003c\/p\u003e \u003cp\u003eER-Signaling Pathways 53\u003c\/p\u003e \u003cp\u003eXenoandrogens and Metabolic Syndrome 54\u003c\/p\u003e \u003cp\u003eAR Signaling Pathways 54\u003c\/p\u003e \u003cp\u003eMechanism of ED 55\u003c\/p\u003e \u003cp\u003eMethylation and Gene Regulation 55\u003c\/p\u003e \u003cp\u003eRole of Noncoding RNAs 59\u003c\/p\u003e \u003cp\u003eTransgenerational Inheritance of Epigenetics Induced by EDCs 59\u003c\/p\u003e \u003cp\u003eAnti-Thyroids 60\u003c\/p\u003e \u003cp\u003eOrganotin 62\u003c\/p\u003e \u003cp\u003eEpigenetic Effects of Organotin 63\u003c\/p\u003e \u003cp\u003eTCDD and Related Compounds 63\u003c\/p\u003e \u003cp\u003eTCDD and Genetic Response 64\u003c\/p\u003e \u003cp\u003eTCDD-Mediated Epigenetic Response 65\u003c\/p\u003e \u003cp\u003eConclusions 65\u003c\/p\u003e \u003cp\u003eReferences 66\u003c\/p\u003e \u003cp\u003e4 Nanoplastics in Agroecosystem and Phytotoxicity: An Evaluation of Cytogenotoxicity and Epigenetic Regulation 83\u003c\/p\u003e \u003cp\u003ePiyoosh Kumar Babele and Ravi Kant Bhatia\u003c\/p\u003e \u003cp\u003eIntroduction 83\u003c\/p\u003e \u003cp\u003eFate and Behavior of NPs in Agroecosystem and Soil Environment 85\u003c\/p\u003e \u003cp\u003eUptake and Accumulation of NPs in Plants 87\u003c\/p\u003e \u003cp\u003eNPs and Phytotoxicity 88\u003c\/p\u003e \u003cp\u003eCan NPs Cause Cytogenotoxicity and Dysregulate Epigenetic Markers in Plants? 89\u003c\/p\u003e \u003cp\u003eNPs and Epigenetic Regulation 91\u003c\/p\u003e \u003cp\u003eConclusion and Perspectives 92\u003c\/p\u003e \u003cp\u003eReferences 93\u003c\/p\u003e \u003cp\u003e5 Metal Oxide Nanoparticles and Graphene-Based Nanomaterials: Genotoxic, Oxidative, and Epigenetic Effects 99\u003c\/p\u003e \u003cp\u003eDelia Cavallo, Pieranna Chiarella, Anna Maria Fresegna, Aureliano Ciervo, Valentina Del Frate, and Cinzia Lucia Ursini\u003c\/p\u003e \u003cp\u003eIntroduction 99\u003c\/p\u003e \u003cp\u003ePhysicochemical Properties of NMs and Toxicity 100\u003c\/p\u003e \u003cp\u003eMechanism of NM Genotoxicity 101\u003c\/p\u003e \u003cp\u003eEpigenetic Effects of Nanomaterials 102\u003c\/p\u003e \u003cp\u003eStudies on Genotoxic and Oxidative Effects of Metal Oxides and Graphene-Based Nanomaterials 104\u003c\/p\u003e \u003cp\u003eGraphene-Based NMs 120\u003c\/p\u003e \u003cp\u003eStudies on Epigenetic Effects of Metal Oxides and Graphene-Based Nanomaterials 123\u003c\/p\u003e \u003cp\u003eStudies on Workers – Genotoxic and Oxidative Effects of Occupational Exposure to Metal Oxides Nanoparticles, SiO2 NPs, and Graphene-Based Nanomaterials 127\u003c\/p\u003e \u003cp\u003eConclusions 132\u003c\/p\u003e \u003cp\u003eReferences 132\u003c\/p\u003e \u003cp\u003e6 Epigenotoxicity of Titanium Dioxide Nanoparticles 145\u003c\/p\u003e \u003cp\u003eCarlos Wells, Marta Pogribna, Beverly Lyn-Cook, and George Hammons\u003c\/p\u003e \u003cp\u003eIntroduction 145\u003c\/p\u003e \u003cp\u003eCellular Uptake and Biodistribution 147\u003c\/p\u003e \u003cp\u003eDNA Methylation and TiO2 Nanoparticles 151\u003c\/p\u003e \u003cp\u003eHistone Modifications and TiO2 Nanoparticles 157\u003c\/p\u003e \u003cp\u003eMicroRNAs and TiO2 Nanoparticles 161\u003c\/p\u003e \u003cp\u003eRisk Assessment 167\u003c\/p\u003e \u003cp\u003eConclusion 173\u003c\/p\u003e \u003cp\u003eDisclaimer 174\u003c\/p\u003e \u003cp\u003eReferences 174\u003c\/p\u003e \u003cp\u003e7 Toxicogenomics of Multi-Walled Carbon Nanotubes 187\u003c\/p\u003e \u003cp\u003ePius Joseph\u003c\/p\u003e \u003cp\u003eIntroduction 187\u003c\/p\u003e \u003cp\u003eMWCNTs 188\u003c\/p\u003e \u003cp\u003eLung Injury 190\u003c\/p\u003e \u003cp\u003eInflammation 190\u003c\/p\u003e \u003cp\u003eOxidative Stress 192\u003c\/p\u003e \u003cp\u003eFibrosis 193\u003c\/p\u003e \u003cp\u003eMesothelioma 195\u003c\/p\u003e \u003cp\u003eLung Cancer 196\u003c\/p\u003e \u003cp\u003eGenotoxicity 197\u003c\/p\u003e \u003cp\u003eToxicogenomics of ENMs 198\u003c\/p\u003e \u003cp\u003eTranscriptomics – Technical Aspects 199\u003c\/p\u003e \u003cp\u003eToxicogenomics of MWCNTs – Animal Studies 201\u003c\/p\u003e \u003cp\u003eToxicogenomics of MWCNT – Human Studies 206\u003c\/p\u003e \u003cp\u003eDisclaimer 207\u003c\/p\u003e \u003cp\u003eReferences 207\u003c\/p\u003e \u003cp\u003e8 Nano-Engineering in Traumatic Brain Injury 217\u003c\/p\u003e \u003cp\u003eNajlaa Al-Thani, Mohammad Z. Haider , Maryam Al-Mansoob, Stuti Patel, Salma M.S. Ahmad, Firas Kobeissy, and Abdullah Shaito\u003c\/p\u003e \u003cp\u003eIntroduction 217\u003c\/p\u003e \u003cp\u003eNanoparticles in the Treatment of TBI 218\u003c\/p\u003e \u003cp\u003eConclusion 222\u003c\/p\u003e \u003cp\u003eReferences 223\u003c\/p\u003e \u003cp\u003e9 Application of Nanoemulsions in Food Industries: Recent Progress, Challenges, and Opportunities 229\u003c\/p\u003e \u003cp\u003eRamesh Chaudhari, Vishva Patel, and Ashutosh Kumar\u003c\/p\u003e \u003cp\u003eIntroduction 229\u003c\/p\u003e \u003cp\u003eComponents of Nanoemulsions 231\u003c\/p\u003e \u003cp\u003eApproaches for Nanoemulsion Production 232\u003c\/p\u003e \u003cp\u003eApplications of Food-Grade Nanoemulsions 235\u003c\/p\u003e \u003cp\u003eComparison of Nanoemulsion from Conventional Methods 241\u003c\/p\u003e \u003cp\u003eProblems and Probable Solutions of Nanoemulsions 242\u003c\/p\u003e \u003cp\u003eFuture Trends and Challenges 243\u003c\/p\u003e \u003cp\u003eRegulations and Safety Aspects 243\u003c\/p\u003e \u003cp\u003eConclusion 244\u003c\/p\u003e \u003cp\u003eConflict of Interest 245\u003c\/p\u003e \u003cp\u003eAcknowledgments 245\u003c\/p\u003e \u003cp\u003eReferences 245\u003c\/p\u003e \u003cp\u003e10 Adverse Epigenetic Effects of Environmental Engineered Nanoparticles as Drug Carriers 251\u003c\/p\u003e \u003cp\u003eYingxue Zhang, Eid Alshammari, Nouran Yonis, and Zhe Yang\u003c\/p\u003e \u003cp\u003eIntroduction 251\u003c\/p\u003e \u003cp\u003eENP-Based Drug-Delivery Systems 252\u003c\/p\u003e \u003cp\u003eAdverse Epigenetic Effects of ENPs 257\u003c\/p\u003e \u003cp\u003eENP-Induced Epigenetic Toxicity Likely Mediated by ROS 269\u003c\/p\u003e \u003cp\u003eConclusion 271\u003c\/p\u003e \u003cp\u003eReferences 271\u003c\/p\u003e \u003cp\u003e11 Engineered Nanoparticles Adversely Impact Glucose Energy Metabolism 283\u003c\/p\u003e \u003cp\u003eYingxue Zhang, Alexander Yang, and Zhe Yang\u003c\/p\u003e \u003cp\u003eIntroduction 283\u003c\/p\u003e \u003cp\u003eBiological Toxicity of Engineered Nanoparticles 284\u003c\/p\u003e \u003cp\u003eEngineered Nanoparticles Alter Glucose Metabolism 285\u003c\/p\u003e \u003cp\u003eEngineered Nanoparticles Alter TCA Cycle 288\u003c\/p\u003e \u003cp\u003eEngineered Nanoparticles Alter Oxidative Phosphorylation 289\u003c\/p\u003e \u003cp\u003eConclusion 291\u003c\/p\u003e \u003cp\u003eReferences 291\u003c\/p\u003e \u003cp\u003e12 Artificial Intelligence and Machine Learning of Single-Cell Transcriptomics of Engineered Nanoparticles 295\u003c\/p\u003e \u003cp\u003eAlexander Yang, Yingxue Zhang, and Zhe Yang\u003c\/p\u003e \u003cp\u003eIntroduction 295\u003c\/p\u003e \u003cp\u003eImpact of Nanoparticles on Single-Cell Transcriptomics and Response Heterogeneity 297\u003c\/p\u003e \u003cp\u003eAI and ML in scRNA-Seq Data Analysis 301\u003c\/p\u003e \u003cp\u003eDetermining Cell Differentiation and Lineage Based on Single-Cell Entropy 303\u003c\/p\u003e \u003cp\u003eConclusion 304\u003c\/p\u003e \u003cp\u003eReferences 305\u003c\/p\u003e \u003cp\u003e13 Toxicogenomics and Toxicological Mechanisms of Engineered Nanomaterials 309\u003c\/p\u003e \u003cp\u003eEid Alshammari, Yingxue Zhang, Alexander Yang, and Zhe Yang\u003c\/p\u003e \u003cp\u003eIntroduction 309\u003c\/p\u003e \u003cp\u003eGenomic Responses to ENMs 310\u003c\/p\u003e \u003cp\u003eTranscriptomic Responses to ENMs 313\u003c\/p\u003e \u003cp\u003eConclusion 314\u003c\/p\u003e \u003cp\u003eReferences 315\u003c\/p\u003e \u003cp\u003e14 Carbon Nanotubes Alter Metabolomics Pathways Leading to Broad Ecological Toxicity 319\u003c\/p\u003e \u003cp\u003eNouran Yonis, Eid Alshammari, and Zhe Yang\u003c\/p\u003e \u003cp\u003eIntroduction 319\u003c\/p\u003e \u003cp\u003eBiomedical Application and Toxicity of Carbon Nanotubes 321\u003c\/p\u003e \u003cp\u003eMetabolomics Toxicity of Carbon Nanotubes 323\u003c\/p\u003e \u003cp\u003eConclusion 326\u003c\/p\u003e \u003cp\u003eReferences 326\u003c\/p\u003e \u003cp\u003e15 Assessment of the Biological Impact of Engineered Nanomaterials Using Mass Spectrometry-Based MultiOmics Approaches 331\u003c\/p\u003e \u003cp\u003eNicholas Day, Tong Zhang, Matthew J. Gaffrey, Brian D. Thrall, and Wei-Jun Qian\u003c\/p\u003e \u003cp\u003eIntroduction 331\u003c\/p\u003e \u003cp\u003eApplications of MS for the Measurements of Proteins, PTMs, Lipids, and Metabolites 332\u003c\/p\u003e \u003cp\u003eMultiomics Investigation of ENM Exposure to Microorganisms 335\u003c\/p\u003e \u003cp\u003eMultiomics Investigation of ENM Exposure Using In Vitro Cell Culture Models 337\u003c\/p\u003e \u003cp\u003eMultiomics Studies Reveal Organ-Specific Toxicity at the Organismal Level 340\u003c\/p\u003e \u003cp\u003eConclusions and Perspectives 344\u003c\/p\u003e \u003cp\u003eAcknowledgments 347\u003c\/p\u003e \u003cp\u003eCompliance with Ethical Standards 347\u003c\/p\u003e \u003cp\u003eReferences 347\u003c\/p\u003e \u003cp\u003e16 Current Scenario and Future Trends of Plant Nano-Interaction to Mitigate Abiotic Stresses: A Review 355\u003c\/p\u003e \u003cp\u003eFarhat Yasmeen, Ghazala Mustafa, Hafiz Muhammad Jhanzab, and Setsuko Komatsu\u003c\/p\u003e \u003cp\u003eAbbreviations 355\u003c\/p\u003e \u003cp\u003eIntroduction 355\u003c\/p\u003e \u003cp\u003eSynthesis of Nanoparticles 356\u003c\/p\u003e \u003cp\u003eMorphophysiological Effects of Nanoparticles on Plant 364\u003c\/p\u003e \u003cp\u003eMolecular Mechanism Altered by Nanoparticles 370\u003c\/p\u003e \u003cp\u003eNanoparticles Interaction with Plants 374\u003c\/p\u003e \u003cp\u003eConclusion and Future Prospects 375\u003c\/p\u003e \u003cp\u003eReferences 376\u003c\/p\u003e \u003cp\u003e17 Latest Insights on Genomic and Epigenomic Mechanisms of Nanotoxicity 397\u003c\/p\u003e \u003cp\u003eVratko Himič, Nikolaos Syrmos, Gianfranco K.I. Ligarotti, and Mario Ganau\u003c\/p\u003e \u003cp\u003eIntroduction 397\u003c\/p\u003e \u003cp\u003eMechanisms of Genotoxicity 397\u003c\/p\u003e \u003cp\u003eGenomic Consequences of ENM Exposure 400\u003c\/p\u003e \u003cp\u003eA Primer on Epigenetic Processes 403\u003c\/p\u003e \u003cp\u003eEpigenomic Consequences of ENM Exposure 404\u003c\/p\u003e \u003cp\u003eImportance of Properties of ENMs 409\u003c\/p\u003e \u003cp\u003eFuture Perspectives 411\u003c\/p\u003e \u003cp\u003eReferences 411\u003c\/p\u003e \u003cp\u003eIndex 419\u003c\/p\u003e  \u003cp\u003e\u003cb\u003eSaura C. Sahu, PhD,\u003c\/b\u003e is a former Research Chemist with the Division of Toxicology at the Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition at the United States Food and Drug Administration.   \u003c\/p\u003e\u003cp\u003e\u003cb\u003eOverview of current research and technologies in nanomaterial science as applied to omics science at the single cell level\u003c\/b\u003e \u003c\/p\u003e\u003cp\u003e\u003ci\u003eImpact of Engineered Nanomaterials in Genomics and Epigenomics\u003c\/i\u003e is a comprehensive and authoritative compilation of the genetic processes and instructions that specifically direct individual genes to turn on or off, focusing on the developing technologies of engineering nanomaterials and their role in cell engineering which have become important research tools for pharmaceutical, biological, medical, and toxicological studies. \u003c\/p\u003e\u003cp\u003eCombining state-of-the art information on the impact of engineered nanomaterials in genomics and epigenomics, from a range of internationally recognized investigators from around the world, this edited volume offers unique insights into the current trends and future directions of research in this scientific field.  \u003c\/p\u003e\u003cp\u003e\u003ci\u003eImpact of Engineered Nanomaterials in Genomics and Epigenomics\u003c\/i\u003e includes detailed information on sample topics such as: \u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eImpact of engineered nanomaterials in genomics and epigenomics, including adverse impact on glucose energy metabolism\u003c\/li\u003e \u003cli\u003eToxicogenomics, toxicoepigenomics, genotoxicity and epigenotoxicity, and mechanisms of toxicogenomics and toxicoepigenomics\u003c\/li\u003e \u003cli\u003eAdverse effects of engineered nanomaterials on human environment and metabolomics pathways leading to ecological toxicity\u003c\/li\u003e \u003cli\u003eMeta-analysis methods to identify genomic toxicity mechanisms of engineered nanomaterials and biological effects of engineered nanomaterial exposure\u003c\/li\u003e \u003cli\u003eArtificial intelligence and machine learning of single-cell transcriptomics of engineered nanoparticles and trends in plant nano-interaction to mitigate abiotic stresses\u003c\/li\u003e\n\u003c\/ul\u003e \u003cp\u003eThis comprehensive work is a valuable and excellent source of authoritative and up-to-date information for advanced students and researchers, toxicologists, the drug industry, risk assessors and regulators in academia, industry, and government, as well as for clinical scientists working in hospital and clinical environments.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989404500197,"sku":"NP9781119896227","price":220.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781119896227.jpg?v=1761783981","url":"https:\/\/k12savings.com\/es\/products\/impact-of-engineered-nanomaterials-in-genomics-and-epigenomics-isbn-9781119896227","provider":"K12savings","version":"1.0","type":"link"}