Histocompatibility and Immunogenetics

The EFI-, ASHI-, and APHIA-endorsed professional guide for laboratory diagnostics in transplantation medicine

In Histocompatibility and Immunogenetics: A Guide for Practitioners, expert authors from across the globe deliver an authoritative introduction to the concepts, methods, and clinical applications of matching donors with acceptors of transplanted cells and organs. Fundamental concepts and limitations of current immunogenetic as well as histocompatibility diagnostic approaches are explained, and best practices to improving the outcomes of transplantation therapies are discussed. Readers will also find:

• A holistic view of transplantation diagnostics, including drug and disease associations with histocompatibility markers
• Options for the medical treatment of organ rejection
• Practical discussions of specific methods in immunogenetics and histocompatibility, such as crossmatching in transplantation and KIR genotyping
• A thorough introduction to the regulatory aspects of histocompatibility and immunogenetics

Perfect for clinical geneticists and immunologists, Histocompatibility and Immunogenetics will also benefit medical and research professionals working in medical laboratories and hospitals. Part 1: BIOLOGICAL BASICS
(1) Innate Immune Defence
(2) Specific Immune Defence
(3) The HLA/MHC System
(4) The HNA System
(5) Natural Killer Cell Receptors
(6) The HPA System
(7) Other Polymorphic Systems

Part 2: CLINICAL APPLICATIONS
(8) Basic Concepts of Organ Transplantation
(9) Basic Concepts of Organ Rejection
(10) Treatment of Organ Rejection
(11) Stem Cell Transplantation
(12) Stem Cell Transplantation from Unrelated Donors
(13) Chimerism Testing in Stem Cell Transplantation
(14) Disease Associations with HLA Alleles
(15) Drug Associations with HLA Alleles
(16) Diseases in the Field of Transfusion Medicine

Part 3: METHODS IN IMMUNOGENETICS AND HISTOCOMPATIBILITY
(17) Isolation and Purification of Test Material
(18) HLA-Antibody Determination
(19) Low/ medium-resolution HLA typing
(20) High-resolution HLA Typing
(21) Crossmatching in Transplantation
(22) Determination of Antibodies and Typing in the HPA System
(23) KIR Genotyping
(24) Determination of Antibodies and Typing in the HNA System
(25) Determination and Typing of Other Polymorphic Systems

Part 4: REGULATORY ASPECTS
(26) Regulations in Histocompatibility and Immunogenetics: Accreditation, External Proficiency Testing, Quality Management
Glossary and Index

Volker Oberle, PhD, is the EFI-Director of the Laboratory for Transplantation Immunology at Jena University Hospital. He studied chemistry and biochemistry at the Universities of Freiburg and Halle-Wittenberg, is a DGI-certified Fachimmungenetiker and holds an ESHI diploma.

The EFI-, ASHI-, and APHIA-endorsed professional guide for laboratory diagnostics in transplantation medicine

In Histocompatibility and Immunogenetics: A Guide for Practitioners, expert authors from across the globe deliver an authoritative introduction to the concepts, methods, and clinical applications of matching donors with acceptors of transplanted cells and organs. Fundamental concepts and limitations of current immunogenetic as well as histocompatibility diagnostic approaches are explained, and best practices to improving the outcomes of transplantation therapies are discussed. Readers will also find:

• A holistic view of transplantation diagnostics, including drug and disease associations with histocompatibility markers
• Options for the medical treatment of organ rejection
• Practical discussions of specific methods in immunogenetics and histocompatibility, such as crossmatching in transplantation and KIR genotyping
• A thorough introduction to the regulatory aspects of histocompatibility and immunogenetics

Perfect for clinical geneticists and immunologists, Histocompatibility and Immunogenetics will also benefit medical and research professionals working in medical laboratories and hospitals.