{"product_id":"heterocyclic-chemistry-isbn-9781405133005","title":"Heterocyclic Chemistry","description":"\u003cb\u003eThis book has so closely matched the requirements of its readership over the years that it has become the first choice for chemists worldwide.\u003c\/b\u003e  \u003cp\u003eHeterocyclic chemistry comprises at least half of all organic chemistry research worldwide. In particular, the vast majority of organic work done in the pharmaceutical and agrochemical industries is heterocyclic chemistry.\u003c\/p\u003e \u003cp\u003eThe fifth edition of \u003ci\u003eHeterocyclic Chemistry\u003c\/i\u003e maintains the principal objective of earlier editions – to teach the fundamentals of heterocyclic reactivity and synthesis in a way that is understandable to second- and third-year undergraduate chemistry students. The inclusion of more advanced and current material also makes the book a valuable reference text for postgraduate taught courses, postgraduate researchers, and chemists at all levels working with heterocyclic compounds in industry.\u003c\/p\u003e \u003cp\u003eFully updated and expanded to reflect important 21\u003csup\u003est\u003c\/sup\u003e century advances, the fifth edition of this classic text includes the following innovations:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eExtensive use of colour to highlight changes in structure and bonding during reactions\u003c\/li\u003e \u003cli\u003eEntirely new chapters on organometallic heterocyclic chemistry, heterocyclic natural products, especially in biochemical processes, and heterocycles in medicine\u003c\/li\u003e \u003cli\u003eNew sections focusing on heterocyclic fluorine compounds, isotopically labeled heterocycles, and solid-phase chemistry, microwave heating and flow reactors in the heterocyclic context\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eEssential teaching material in the early chapters is followed by short chapters throughout the text which capture the essence of heterocyclic reactivity in concise resumés suitable as introductions or summaries, for example for examination preparation. Detailed, systematic discussions cover the reactivity and synthesis of all the important heterocyclic systems. Original references and references to reviews are given throughout the text, vital for postgraduate teaching and for research scientists. Problems, divided into straightforward revision exercises, and more challenging questions (with solutions available online), help the reader to understand and apply the principles of heterocyclic reactivity and synthesis.\u003c\/p\u003e \u003cp\u003ePreface to the Fifth Edition xix\u003c\/p\u003e \u003cp\u003eP.1 Hazards xxi\u003c\/p\u003e \u003cp\u003eP.2 How to Use This Textbook xxi\u003c\/p\u003e \u003cp\u003eAcknowledgements xxii\u003c\/p\u003e \u003cp\u003eReferences xxii\u003c\/p\u003e \u003cp\u003eWeb Site xxii     \u003c\/p\u003e \u003cp\u003eBiography xxiii\u003c\/p\u003e \u003cp\u003eDefinitions of Abbreviations xxv\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Heterocyclic Nomenclature 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Structures and Spectroscopic Properties of Aromatic Heterocycles 5\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Substitutions of Aromatic Heterocycles 19\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Organometallic Heterocyclic Chemistry 37\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Methods in Heterocyclic Chemistry 97\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Ring Synthesis of Aromatic Heterocycles 107\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Typical Reactivity of Pyridines, Quinolines and Isoquinolines 115\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Pyridines: Reactions and Synthesis 125\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Quinolines and Isoquinolines: Reactions and Synthesis 177\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Typical Reactivity of Pyrylium and Benzopyrylium Ions, Pyrones and Benzopyrones 205\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Pyryliums, 2- and 4-Pyrones: Reactions and Synthesis 209\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Benzopyryliums and Benzopyrones: Reactions and Synthesis 229\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Typical Reactivity of the Diazine: Pyridazine, Pyrimidine and Pyrazine 249\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 The Diazines: Pyridazine, Pyrimidine, and Pyrazine: Reactions and Synthesis 253\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 Typical Reactivity of Pyrroles, Furans and Thiophenes 289\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e16 Pyrroles: Reactions and Synthesis 295\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e17 Thiophenes: Reactions and Synthesis 325\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e18 Furans: Reactions and Synthesis 347\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e19 Typical Reactivity of Indoles, Benzo[b]thiophenes, Benzo[b]furans, Isoindoles, Benzo[c]thiophenes and Isobenzofurans 369\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e20 Indoles: Reactions and Synthesis 373\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e21 Benzo[b]thiophenes and Benzo[b]furans: Reactions and Synthesis 433\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e22 Isoindoles, Benzo[c]thiophenes and Isobenzofurans: Reactions and Synthesis 447\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e23 Typical Reactivity of 1,3- and 1,2-Azoles and Benzo-1,3- and -1,2-Azoles 455\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e24 1,3-Azoles: Imidazoles, Thiazoles and Oxazoles: Reactions and Synthesis 461\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e25 1,2-Azoles: Pyrazoles, Isothiazoles, Isoxazoles: Reactions and Synthesis 485\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e26 Benzanellated Azoles: Reactions and Synthesis 503\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e27 Purines: Reactions and Synthesis 515\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e28 Heterocycles Containing a Ring-Junction Nitrogen (Bridgehead Compounds) 539\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e29 Heterocycles Containing More Than Two Heteroatoms 557\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e30 Saturated and Partially Unsaturated Heterocyclic Compounds: Reactions and Synthesis 587\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e31 Special Topics 609\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e32 Heterocycles in Biochemistry; Heterocyclic Natural Products 629\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e33 Heterocycles in Medicine 645\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eIndex 665\u003c\/p\u003e  \u003cp\u003e“Overall, this book is recommended as a text for undergraduate and more advanced students on this pervasive, important, and underappreciated topic in chemistry.”  (\u003ci\u003eJournal of Chemical Education\u003c\/i\u003e, 1 October 2012)\u003c\/p\u003e \u003cp\u003e\"This excellent book is well written, heavily referenced, and thoroughly indexed. Accordingly, it serves as both an instructional heterocyclic chemistry textbook and a portal to the primary synthetic chemistry literature.\" (Journal of Medicinal Chemistry, 2011)\u003c\/p\u003e \u003cp\u003e\"My favourite chapter is the organometallic chemistry that presents an up-to-date treatment of the topic and helps confirms a colleague's observation that ‘With today's techniques one can be convinced that a modern organic chemist can make any small molecule he or she desires.' I particularly like the treatment of the concatenation of five-membered ring systems, an increasingly important area in medicinal chemistry. This chapter proves a real ‘coup de grace'.\" (\u003ci\u003eReviews\u003c\/i\u003e, December 2010)\u003c\/p\u003e \u003cp\u003e\"In summary, Heterocyclic Chemistry by Joule and Mills is in a class of its own and can be thoroughly recommended as supplementary reading for undergraduate courses and as a first port of call for researchers seeking a quick entry to the extensive heterocyclic literature.\" (Applied Organometallic Chemistry, 2010)\u003c\/p\u003e \u003cp\u003e\"My recommendation is, even if you already have the 4th edition, to buy the latest version. At only £39.95 for the paperback version this is outstanding value for money.\" (\u003ci\u003eOrganic Process Research \u0026amp; Development Journal\u003c\/i\u003e, 2010)\u003c\/p\u003e  \u003cb\u003eJohn Joule\u003c\/b\u003e is Emeritus Professor in the School of Chemistry, The University of Manchester, UK  \u003cp\u003e\u003cb\u003eKeith Mills\u003c\/b\u003e spent 25 years in the Medicinal Chemistry and Development Chemistry departments at GlaxoSmithKline, Stevenage, UK, and is now an independent consultant.\u003c\/p\u003e  Heterocyclic chemistry is a central part of organic chemistry and biochemistry. The term refers to a particular set of chemical structure characteristics, with many drugs and specialty chemicals, and most agrochemicals, containing these characteristics. Heterocyclic Chemistry by Joule \u0026amp; Mills has established itself as the premier textbook of heterocyclic chemistry, used by high level undergraduates, postgraduates and industrial researchers all over the world. \u003cbr\u003e \u003cp\u003e\u003cbr\u003e \u003c\/p\u003e \u003cp\u003eHeterocyclic Chemistry covers the fundamentals of heterocyclic reactivity and synthesis in a way that is understandable to second- and third-year undergraduate chemistry students. It also includes more advanced material, making the book appropriate for postgraduate taught courses and to researchers, either at postgraduate degree level or those working with heterocyclic compounds in industry. Essential teaching material is collected in specific introductory chapters, explaining the principles of heterocyclic reactivity in the simplest terms, suitable either as introductions or as summaries for examination preparation. These chapters are augmented by detailed, systematic discussions of the chemical reactivity of particular heterocyclic systems. References to both primary literature and reviews are given throughout the text, and whilst these are essential for postgraduate teaching and to research workers, they do not interfere with the readability of the text for undergraduate students.\u003c\/p\u003e","brand":"Wiley-Blackwell","offers":[{"title":"Default Title","offer_id":47989359083749,"sku":"NP9781405133005","price":56.5,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781405133005.jpg?v=1761783805","url":"https:\/\/k12savings.com\/es\/products\/heterocyclic-chemistry-isbn-9781405133005","provider":"K12savings","version":"1.0","type":"link"}