{"product_id":"hepatotoxicity-isbn-9780470057162","title":"Hepatotoxicity","description":"This book addresses all the current, up-to-date developments in this scientific discipline. Liver is the chief metabolizing site in the body, and thus, it is a major target organ for drug and chemical toxicity. Therefore, hepatotoxicity is an important endpoint in the safety evaluation of drugs and chemicals.  \u003cp\u003eContributions from leading investigators in hepatotoxicity research address current developments in this scientific discipline and discuss use of current cutting edge technology such as microarrays in hepatotoxicity thus providing a better understanding of hepatotoxins, their interactions and mechanisms of action.\u003c\/p\u003e \u003cp\u003eThis valuable authoritative source of information is the first book to address this topic for nearly ten years, making it an essential resource for readers from a wide range of disciplines such as toxicology, pharmacology, hepatology, drug toxicity and food science.\u003c\/p\u003e  Contributors.  \u003cp\u003ePreface.\u003c\/p\u003e \u003cp\u003eAcknowledgements.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSECTION 1: MODELS FOR HEPATOTOXICITY TESTING.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Current \u003ci\u003ein vitro\u003c\/i\u003e Models to Study Drug-Induced Liver Injury (\u003ci\u003eJulio C. Davila, Jinghai J. Xu, Keith A. Hoffmaster, Peter J. O’Brien and Stephen C. Storm\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e2 Utilization of an \u003ci\u003ein vitro\u003c\/i\u003e Hepatotoxicity Test in the Early Stage of Drug Discovery (\u003ci\u003eIkuo Horii, Hiroshi Yamada, Rie Kikkawa, Toshinori Yamamoto, Tamio Fukushima and Kaori Tomizawa\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e3 Use of Hepatocytes for Characterizing a Candidate Drug’s Metabolism and Drug Interaction Potential (\u003ci\u003eSrikanth C. Nallani, John M. Strong and Shiew Mei Huang\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e4 Human-Based \u003ci\u003ein vitro\u003c\/i\u003e Experimental Systems for the Evaluation of Human Drug Safety (\u003ci\u003eAlbert P. Li\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e5 Hepatocytes as a Model for Screening Food-Related Hepatotoxins and Studying Mechanisms of their Toxicity (\u003ci\u003eSaura C. Sahu\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e6 Some Experimental Models of Liver Damage (\u003ci\u003ePablo Muriel\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSECTION 2: HEPATOCYTE CULTURES.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e7 Application of Short- and Long-Term Hepatocyte Cultures to Predict Toxicities (\u003ci\u003eGregor Tuschl, Jens Hrach, Philip G. Hewitt and Stefan O. Mueller\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSECTION 3: BIOMARKERS OF HEPATOTOXICITY.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8 Biomarkers of Mycotoxin Exposure in Liver Toxicity (\u003ci\u003eAngela J. Harris\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSECTION 4: MECHANISMS OF HEPATOTOXICITY.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e9 Mechanisms of Toxic Liver Injury (\u003ci\u003eNora Anderson and J¨urgen Borlak\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e10 A Role of Cytochrome P450 in Quinone-Induced Hepatotoxicity (\u003ci\u003eYasuhiro Ishihara and Norio Shimamoto\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e11 A Mechanistic View of Troglitazone Hepatotoxicity (\u003ci\u003eRawiwan Maniratanachote and Tsuyoshi Yokoi\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e12 Role of the Kupffer Cell in Hepatotoxicity and Hepatocarcinogenesis (\u003ci\u003eJames E. Klaunig, Stacy M. Corthals, Lisa M. Kamendulis and Binu K. Philip\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e13 Sinusoidal Cells in Liver Injury and Repair (\u003ci\u003eCarol R. Gardner and Debra L. Laskin\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e14 Cytokines in Liver Diseases (\u003ci\u003ePablo Muriel\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e15 Bile Acids as Modulators of Apoptosis (\u003ci\u003eRui E. Castro, Susana Sol´a, Clifford J. Steer and Cec´ılia M.P. Rodrigues\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e16 Drug-Induced Intrahepatic Cholestasis by Interaction with the Hepatic Bile Salt Export Pump (BSEP) (\u003ci\u003eChristoph Funk, Johannes No´e, Ren´ee Portmann, Ruben Alvarez-S´anchez, Florian Klammers, Christiane Lamy, Axel Paehler and Michael Pantze\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSECTION 5: GENOMICS OF HEPATOTOXICITY.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e17 Application of Toxicogenomics in Predicting Hepatotoxicity – Potentials and Challenges (\u003ci\u003eWen Lin, Guoxiang Shen, Tin Oo Khor and Ah-Ng Tony Kong\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e18 Genomic Profiling of Liver Injury (\u003ci\u003eKevin Gerrish and David E. Malarkey\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e19 Use of DNA Arrays in Understanding Hepatic Test Systems (\u003ci\u003eAngela J. Harris and Daniel A. Casciano\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e20 Prediction of Hepatotoxicity Based on the Toxicogenomics Database (\u003ci\u003eTetsuro Urushidani\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e21 Relationship between \u003ci\u003eN\u003c\/i\u003e-acetyltransferase-2 Gene Polymorphism and Isoniazid-Induced Hepatotoxicity (\u003ci\u003eYasuo Shimizu, Kunio Dobashi and Masatomo Mori\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSECTION 6: GENDER DIFFERENCES IN HEPATOTOXICITY.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e22 Human and Animal-Based Differences in Hepatic Xenobiotic Metabolism and Toxicity (\u003ci\u003ePeter J. O’Brien, Katie Chan and Raymond J. Poon\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSECTION 7: HEPATOTOXICITY AND HEPATOCARCINOGENICITY.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e23 Hepatotoxicity in Oncology Drug Development (\u003ci\u003eWei Chen, Kenneth Hastings and John K. Leighton\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e24 The Potent Rat Hepatocarcinogen Methapyrilene: An Hypothesis Regarding its Hepatotoxicology (\u003ci\u003eDaniel A. Casciano\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSECTION 8: HEPATOTOXICITY AND BOTANICAL SUPPLEMENTS.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e25 Botanical Supplements and Hepatotoxicity (\u003ci\u003eShabana Khan, Ikhlas Khan and Larry Walker\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSECTION 9: RISK ANALYSIS OF HEPATOTOXINS.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e26 Physiologically Based Pharmokinetic Modeling and Risk Assessment of Hepatotoxicants (\u003ci\u003eKannan Krishnan\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eIndex.\u003c\/p\u003e \"This provides valuable insight into the current and future directions of research in this field and wil be a valuable resource of up-to-date information for toxicologists, risk assessors, and regulators in academia, industry and government.\" (\u003ci\u003eDoody's\u003c\/i\u003e, August 2008) \u003cb\u003eDr. Sahu\u003c\/b\u003e is the US Editor for the Journal of Applied Toxicology.  Liver, the primary organ involved in xenobiotic metabolism, is a major target organ for many drugs, chemicals and microbial pathogens. Therefore, hepatotoxicity is one of the most serious safety concerns in their safety evaluation.  \u003cp\u003e\u003ci\u003eHepatotoxicity\u003c\/i\u003e is an authoritative compilation of recent advances in this discipline, presented by leading international investigators, and demonstrating the multidisciplinary nature of this research field. The book addresses newer methodologies and emerging new technologies including toxicogenomics.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eTopics covered include:\u003c\/b\u003e\u003c\/p\u003e \u003cul\u003e \u003cli\u003emodels that are currently used for hepatotoxicity testing and screening\u003c\/li\u003e \u003cli\u003ehepatocyte cultures\u003c\/li\u003e \u003cli\u003ebiomarkers of hepatotoxicity\u003c\/li\u003e \u003cli\u003evarious mechanisms involved in hepatotoxicity\u003c\/li\u003e \u003cli\u003egenomics of hepatotoxicity\u003c\/li\u003e \u003cli\u003egender difference in hepatotoxicity\u003c\/li\u003e \u003cli\u003erelationship between hepatotoxicity and hepatocarcinogenicity\u003c\/li\u003e \u003cli\u003ehepatotoxicity of botanical supplements\u003c\/li\u003e \u003cli\u003erisk assessment of hepatotoxins.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eHepatotoxicity\u003c\/i\u003e gives an essential insight into the current trends and future directions of research in this field, and will be a valuable and excellent source of up-to-date information for toxicologists, investigators, risk assessors and regulators in academia, industry and government.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989357904101,"sku":"NP9780470057162","price":298.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470057162.jpg?v=1761783802","url":"https:\/\/k12savings.com\/es\/products\/hepatotoxicity-isbn-9780470057162","provider":"K12savings","version":"1.0","type":"link"}