{"product_id":"heart-failure-isbn-9780470015971","title":"Heart Failure","description":"Heart failure is the main cause of death and disability in the industrialized world. There is a major need for novel therapeutics for prevention and reversal of cardiac pathology associated with heart failure and cardiac enlargement. Over recent years, dramatic progress has been made in unravelling the cellular circuitry involved in cardiac failure, as well as in normal cardiac growth, development and apoptosis. This work has revealed new and unexpected therapeutic targets in the heart. In addition, advances in understanding the role of stem cells in cardiac physiology have suggested strategies for cardiac repair and regeneration once thought impossible.  \u003cp\u003eThis book describes the work of leading investigators studying the basic mechanisms of cardiac growth, function and dysfunction. There are also exciting contributions from researchers developing novel therapeutic strategies for cardiac disease. The unique feature is the discussions amongst the contributors, which always return to the same basic problem: how can new data from biological studies be used to design novel therapies for the treatment of cardiac dysfunction following myocardial infarction, hypertension and other disorders?\u003c\/p\u003e \u003cp\u003eWith its strong emphasis on translational research, this book will appeal to both scientists and clinicians interested in diminishing the impact of the current epidemic of cardiac diseases.\u003c\/p\u003e  Introduction \u003ci\u003e(Eric N. Olson)\u003c\/i\u003e.  \u003cp\u003eControl of cardiac hypertrophy and heart failure by histone acetylation\/deacetylation \u003ci\u003e(Eric N. Olson, Johannes Backs and Timothy A. McKinsey)\u003c\/i\u003e .\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eA novel mechanism of mechanical stress-induced hypertrophy \u003ci\u003e(Hiroshi Akazawa, Yunzeng Zou and Issei Komuro)\u003c\/i\u003e .\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eControlling cardiomyocyte survival \u003ci\u003e(N. de Jonge, M. J. Goumans, Daan Lips, Rutger Hassink, Eva J. Vlug, Roy van der Meel, Christopher Donald Emmerson, Joppe Nijman, Leon de Windt and Pieter A. Doevendans)\u003c\/i\u003e .\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eMechanisms of angiotensin II-dependent progression to heart failure \u003ci\u003e(Mona Nemer, Nassim Dali-Youcef, Hao Wang, Anne Aries and Pierre Paradis)\u003c\/i\u003e .\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eAlterations in myocardial gene expression as a basis for cardiomyopathies and heart failure \u003ci\u003e(Matthew R. Taylor and Michael R. Bristow)\u003c\/i\u003e .\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eRole of the insulin-like growth factor 1 (IGF1)\/phosphoinositide-3-kinase (PI3K) pathway mediating physiological cardiac hypertrophy \u003ci\u003e(Julie R. McMullen and Seigo Izumo)\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003eRole of Akt in cardiac growth and metabolism\u003ci\u003e(Anthony J. Muslin and Brian DeBosch)\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eNovel therapy for heart failure and exercise-induced ventricular tachycardia based on ‘fixing’ the leak in ryanodine receptors \u003ci\u003e(Andrew R. Marks)\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eGeneral discussion I.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003ePhospholamban as a therapeutic modality in heart failure \u003ci\u003e(Guoxiang Chu and Evangelia G. Kranias)\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eSarcomere protein gene mutations and inherited heart disease: a b-cardiac myosin heavy chain mutation causing endocardial fibroelastosis and heart failure \u003ci\u003e(Mitsuhiro Kamisago, Joachim P. Schmitt, Dennis McNamara, Christine Seidman and Jonathan G. Seidman)\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eThe cardiomyocyte cell cycle \u003ci\u003e(Pascal J. E. Lafontant and Loren J. Field)\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eRestoration of cardiac function with progenitor cells \u003ci\u003e(Carmen Urbich, Lothar Rössig and Stefanie Dimmeler)\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eSignalling pathways in cardiac regeneration \u003ci\u003e(Maria Paola Santini, Nadine Winn and Nadia Rosenthal)\u003c\/i\u003e\u003ci\u003e.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eBeyond small molecule drugs for heart failure: prospects for gene therapy \u003ci\u003e(Kenneth R. Chien)\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eDual roles of telomerase in cardiac protection and repair \u003ci\u003e(Michael D. Schneider).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDiscussion.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eFinal general discussion.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eClosing remarks: historical perspective \u003ci\u003e(Arnold M. Katz)\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003eIndex of contributors.\u003c\/p\u003e \u003cp\u003eSubject index.\u003c\/p\u003e  \"…most up-to-date analysis on ways that science might look to reduce the harsh impact of heart disease.\" (\u003ci\u003eElectric Review\u003c\/i\u003e, February\/March 2007)  \u003cp\u003e\"This book offers an update in the basic mechanism of heart failure from the premier investigators in the field.\" (\u003ci\u003eDoody's Health Services\u003c\/i\u003e)\u003c\/p\u003e The \u003cb\u003eNovartis Foundation\u003c\/b\u003e is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.  Heart failure is the main cause of death and disability in the industrialized world. There is a major need for novel therapeutics for prevention and reversal of cardiac pathology associated with heart failure and cardiac enlargement. Over recent years, dramatic progress has been made in unravelling the cellular circuitry involved in cardiac failure, as well as in normal cardiac growth, development and apoptosis. This work has revealed new and unexpected therapeutic targets in the heart. In addition, advances in understanding the role of stem cells in cardiac physiology have suggested strategies for cardiac repair and regeneration once thought impossible.   \u003cp\u003eThis book describes the work of leading investigators studying the basic mechanisms of cardiac growth, function and dysfunction.  There are also exciting contributions from researchers developing novel therapeutic strategies for cardiac disease. The unique feature is the discussions amongst the contributors, which always return to the same basic problem: how can new data from biological studies be used to design novel therapies for the treatment of cardiac dysfunction following myocardial infarction, hypertension and other disorders?\u003c\/p\u003e \u003cp\u003eWith its strong emphasis on translational research, this book will appeal to both scientists and clinicians interested in diminishing the impact of the current epidemic of cardiac diseases.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989353382117,"sku":"NP9780470015971","price":211.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470015971.jpg?v=1761783784","url":"https:\/\/k12savings.com\/es\/products\/heart-failure-isbn-9780470015971","provider":"K12savings","version":"1.0","type":"link"}