{"product_id":"handbook-of-magnetic-resonance-spectroscopy-in-vivo-isbn-9781118997666","title":"Handbook of Magnetic Resonance Spectroscopy In Vivo","description":"\u003cp\u003eThis handbook covers the entire field of magnetic resonance spectroscopy (MRS), a unique method that allows the non-invasive identification, quantification and spatial mapping of metabolites in living organisms–including animal models and patients.\u003c\/p\u003e \u003cp\u003eComprised of three parts:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eMethodology covers basic MRS theory, methodology for acquiring, quantifying spectra, and spatially localizing spectra, and equipment essentials, as well as vital ancillary issues such as motion suppression and physiological monitoring.\u003c\/li\u003e \u003cli\u003eApplications focuses on MRS applications, both in animal models of disease and in human studies of normal physiology and disease, including cancer, neurological disease, cardiac and muscle metabolism, and obesity.\u003c\/li\u003e \u003cli\u003eReference includes useful appendices and look up tables of relative MRS signal-to-noise ratios, typical tissue concentrations, structures of common metabolites, and useful formulae.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003cb\u003eAbout eMagRes Handbooks\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eeMagRes\u003c\/i\u003e (formerly the \u003ci\u003eEncyclopedia of Magnetic Resonance\u003c\/i\u003e) publishes a wide range of online articles on all aspects of magnetic resonance in physics, chemistry, biology and medicine. The existence of this large number of articles, written by experts in various fields, is enabling the publication of a series of \u003ci\u003eeMagRes Handbooks\u003c\/i\u003e on specific areas of NMR and MRI. The chapters of each of these handbooks will comprise a carefully chosen selection of \u003ci\u003eeMagRes\u003c\/i\u003e articles. In consultation with the \u003ci\u003eeMagRes\u003c\/i\u003e Editorial Board, the \u003ci\u003eeMagRes Handbooks\u003c\/i\u003e are coherently planned in advance by specially-selected Editors, and new articles are written to give appropriate complete coverage. The handbooks are intended to be of value and interest to research students, postdoctoral fellows and other researchers learning about the scientific area in question and undertaking relevant experiments, whether in academia or industry.\u003c\/p\u003e \u003cp\u003eHave the content of this handbook and the complete content of \u003ci\u003eeMagRes\u003c\/i\u003e at your fingertips!\u003cbr\u003eVisit the \u003ca href=\"http:\/\/www.wileyonlinelibrary.com\/ref\/eMagRes\" target=\"_blank\"\u003eeMagRes Homepage\u003c\/a\u003e \u003cbr\u003e \u003c\/p\u003e \u003cp\u003e1 Basics of NMR\u003c\/p\u003e \u003cp\u003e2 Magnetic Resonance Spectroscopy Instrumentation\u003c\/p\u003e \u003cp\u003e3 Detection coils for MRS\u003c\/p\u003e \u003cp\u003e4 A Practical Guide to in-vivo MRS\u003c\/p\u003e \u003cp\u003e5 Adiabatic Excitation Pulses for MRS\u003c\/p\u003e \u003cp\u003e6 Localized MRS employing radiofrequency field (B1) gradients\u003c\/p\u003e \u003cp\u003e7 Single Voxel MRS\u003c\/p\u003e \u003cp\u003e8 Chemical shift imaging with phase- and sensitivity-encoding\u003c\/p\u003e \u003cp\u003e9 Spatial Encoding and Decoding with Prior Knowledge from MRI and Spatio-Spectral Correlation\u003c\/p\u003e \u003cp\u003e10 Accurate Localized Spectroscopy from Anatomically Matched Regions with Optimal Spatial Response Function\u003c\/p\u003e \u003cp\u003e11 Accelerated Spatially-Encoded MRS of Arbitrarily-Shaped Compartments Using Linear Algebraic Modeling\u003c\/p\u003e \u003cp\u003e12 High-Speed Spatial-Spectral Encoding with Echo-Planar and Spiral Spectroscopic Imaging\u003c\/p\u003e \u003cp\u003e13 Direct Water--Fat Imaging Methods: Chemical Shift-Selective and Chemical Shift-Encoded MRI\u003c\/p\u003e \u003cp\u003e14 Physiological maintenance in animal experiments\u003c\/p\u003e \u003cp\u003e15 Physiological maintenance in MRI and MRS of large animals\u003c\/p\u003e \u003cp\u003e16 Physiological Monitoring in human MRS\u003c\/p\u003e \u003cp\u003e17 Physiologic Motion: Dealing with Cardiac, Respiratory and Other Sporadic Motion in MRS\u003c\/p\u003e \u003cp\u003e18 Quantifying Spectra in the Frequency Domain\u003c\/p\u003e \u003cp\u003e19 Quantifying Spectra in the Time Domain\u003c\/p\u003e \u003cp\u003e20 Advanced spectral quantification: parameter handling, non-parametric pattern modeling and multi-dimensional fitting\u003c\/p\u003e \u003cp\u003e21 1H-NMR Chemical Shifts and Coupling Constants for Brain Metabolites\u003c\/p\u003e \u003cp\u003e22 Pattern Recognition Analysis of MR Spectra\u003c\/p\u003e \u003cp\u003e23 Quantifying Metabolite Ratios and Concentrations by 1H MRS\u003c\/p\u003e \u003cp\u003e24 Quantifying Metabolite Ratios and Concentrations by Non-1H MRS\u003c\/p\u003e \u003cp\u003e25 Measuring intra- and extra-cellular pH by MRS\u003c\/p\u003e \u003cp\u003e26 Temperature Monitoring Using Chemical Shift\u003c\/p\u003e \u003cp\u003e27 Diffusion-Weighted MRS\u003c\/p\u003e \u003cp\u003e28 Measuring biochemical reaction rates in vivo with magnetization transfer\u003c\/p\u003e \u003cp\u003e29 Proton Chemical Exchange Saturation Transfer MRS and MRI\u003c\/p\u003e \u003cp\u003e30 Two-Dimensional NMR Spectroscopy Plus Spatial Encoding\u003c\/p\u003e \u003cp\u003e31 Spectral editing\u003c\/p\u003e \u003cp\u003e32 Multiple quantum MRS\u003c\/p\u003e \u003cp\u003e33 Hyperpolarization Methods for MRS\u003c\/p\u003e \u003cp\u003e34 Pulse sequences for hyperpolarized MRS\u003c\/p\u003e \u003cp\u003e35 MRS of Perfused Cells, Tissues and Organs\u003c\/p\u003e \u003cp\u003e36 Metabolism and Metabolomics by MRS\u003c\/p\u003e \u003cp\u003e37 In Vivo 19F MRS\u003c\/p\u003e \u003cp\u003e38 13C MRS in Human Tissue\u003c\/p\u003e \u003cp\u003e39 Hyperpolarized 13C MRI and MRS Studies\u003c\/p\u003e \u003cp\u003e40 Integrating 13C Isotopomer Methods with Hyperpolarization for a Comprehensive Picture of Metabolism\u003c\/p\u003e \u003cp\u003e41 Muscle studies by 1H MRS\u003c\/p\u003e \u003cp\u003e42 Muscle Studies by 31P MRS\u003c\/p\u003e \u003cp\u003e43 Measuring Intracellular Oxygenation with Myoglobin 1H MRS\u003c\/p\u003e \u003cp\u003e44 Body Fat MRS\u003c\/p\u003e \u003cp\u003e45 In Vivo MRS of Lipids in Adipose Tissue, Bone Marrow, and Liver\u003c\/p\u003e \u003cp\u003e46 Assessing Fatty Liver with MRS\u003c\/p\u003e \u003cp\u003e47 MRS Studies of Muscle and Heart in Obesity and Diabetes\u003c\/p\u003e \u003cp\u003e48 Studying Cardiac Lipids in Obese and Diabetic patients by 1H MRS\u003c\/p\u003e \u003cp\u003e49 Cardiac MRS Studies in Rodents and Other Animals\u003c\/p\u003e \u003cp\u003e50 Assessing Cardiac Transplant Viability with MRS\u003c\/p\u003e \u003cp\u003e51 MRS in the Failing Heart: from Mice to Humans\u003c\/p\u003e \u003cp\u003e52 MRS studies of Creatine Kinase metabolism in human heart\u003c\/p\u003e \u003cp\u003e53 Studying Aging, Dementia, Trauma, Infection, and Developmental Disorders of the Brain with 1H MRS\u003c\/p\u003e \u003cp\u003e54 Studying Stroke and Cerebral Ischemia by 1H MRS\u003c\/p\u003e \u003cp\u003e55 31P MRS in Psychiatric Disorders\u003c\/p\u003e \u003cp\u003e56 The significance of N-Acetyl Aspartate in Human Brain MRS\u003c\/p\u003e \u003cp\u003e57 MRS in Brain Cancer\u003c\/p\u003e \u003cp\u003e58 MRS in Breast Cancer\u003c\/p\u003e \u003cp\u003e59 MRS in Prostate Cancer\u003c\/p\u003e \u003cp\u003e60 Clinical Trials of MRS Methods\u003c\/p\u003e \u003cp\u003e61 Clinical Trials that Utilize MRS as a Biomarker\u003c\/p\u003e \u003cp\u003e62 Properties of NMR-visible isotopes and their biological content in human tissue\u003c\/p\u003e \u003cp\u003e63 Concentration ranges of common metabolites detected by MRS in healthy human tissue\u003c\/p\u003e \u003cp\u003e64 Peak Assignments for Some Common Metabolites\u003c\/p\u003e \u003cp\u003e65 Biochemical reactions and molecular structures of common MRS metabolites\u003c\/p\u003e \u003cp\u003e66 Some standard formulae used in MRS\u003c\/p\u003e \u003cp\u003e67 Common MRS Artefacts\u003c\/p\u003e \u003cp\u003e68 In Vivo Spectra with Peak Assignments\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePaul A. Bottomley\u003c\/b\u003e, BSc (Hon.), 1975, PhD, 1978, Physics, University of Nottingham, UK. Research Associate, Johns Hopkins University, Baltimore, 1978–1980. Physicist, G. E. Research and Development Center, 1980–1994. Currently Russell H Morgan Professor and Director of the Division of MR Research, of the Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University. Fellow and Gold Medal recipient of the Society of Magnetic Resonance in Medicine, 1989; Coolidge Fellowship and medal, G.E. Company, 1990; Gold, Silver, and Bronze patent medals, G.E. Company; Gold Medal, American Roentgen Ray Society 2015; over 40 issued patents, about 180 peer-reviewed papers, 24 book chapters, 13 editorials, and over 225 published abstracts. Research specialties: in vivo NMR, MRI, tissue relaxation times, localized NMR spectroscopy, human cardiac NMR spectroscopy, interventional MRI, and MRI safety.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eJohn Griffiths,\u003c\/b\u003e Qualified in medicine and biochemistry. In the early 1980s, his research group pioneered the use of MRS for studies on living tumors, and he has worked since then on MRI and MRS of cancer, both in vivo and ex vivo. He has published more than 300 peer-reviewed articles to date. His recent interests include the metabolomics of cancer.\u003c\/p\u003e \u003cp\u003eIn vivo magnetic resonance spectroscopy (MRS) has generated a vast cloud of scientific papers spanning numerous topics in a large diversity of journals, ranging from the physical sciences to the clinical ‘-ology’ literature. In addition, there is a vast amount of accumulated but unpublished inside knowledge on what makes a successful in vivo MRS study that is known only to its present and past practitioners. The goal of this comprehensive text, written by an outstanding group of world experts on MRS in vivo, is to steer a pathway through all of the technologies needed to perform MRS in vivo today and tomorrow, showing how to apply in vivo MRS today, what can and might be done with it, why it is useful, and how the results might be interpreted.\u003c\/p\u003e \u003cp\u003eThe book begins with a first half on methodology that spans the basics of NMR, localization methods and MRS parametric measurements. The reader will find numerous spatial localization and signal processing techniques as well as methods for measuring metabolite diffusion, pH, chemical reaction rates and chemical exchange magnetization transfer, metabolite and fat concentrations, spin coupling, and multiple quantum transitions among non-proton (1H) nuclei. There are “how to” chapters on performing MRS on non-1H nuclei in vivo, and the latest methods for studying hyperpolarizing nuclei and the sequences needed to realize the enormous sensitivity gains now available therefrom.\u003c\/p\u003e \u003cp\u003eThe second half of the book is comprised of applications to healthy and diseased tissues, from animal models to humans, which cover the entire body from head to limb. It starts with cells and tissue extracts, then studies of animals and organs for transplantation. This is followed by a series of critical reviews of the state-of-the-art of clinical and research applications of MRS in obesity, diabetes, heart, brain disorders and cancer. There are two reviews on the current state of clinical trials that employ MRS. The book ends with comprehensive appendices that include tabulations of tissue concentrations of NMR nuclei, common metabolites, spectral assignments, frequently-used equations, typical spectra, and common artefacts appearing in MRS in vivo, which should be of practical value.\u003c\/p\u003e \u003cp\u003eThe audience for this reference book is multi-faceted, ranging from researchers involved in MRS methodology and its applications, to clinicians and biomedical scientists wishing to comprehend the types of clinical information that MRS can deliver, and how MRS can augment our understanding of healthy and disease states.  Undergraduate and postgraduate students, clinical radiological technicians and MRI scanner operators who are learning about MRS or training in magnetic resonance in medicine, as well as those just wishing to update their knowledge of current MRS methods, will find the book a useful compendium of the current state of the art of the field.\u003c\/p\u003e \u003cp\u003eAbout eMagRes Handbooks\u003c\/p\u003e \u003cp\u003eeMagRes publishes a wide range of online articles on all aspects of magnetic resonance in physics, chemistry, biology and medicine. The existence of this large number of articles, written by experts in various fields, is enabling the publication of a series of eMagRes Handbooks on specific areas of NMR and MRI. The chapters of each of these handbooks will comprise a carefully chosen selection of eMagRes articles. In consultation with the eMagRes Editorial Board, the eMagRes Handbooks are coherently planned in advance by specially-selected Editors, and new articles are written to give appropriate complete coverage. The handbooks are intended to be of value and interest to research students, postdoctoral fellows and other researchers learning about the scientific area in question and undertaking relevant experiments, whether in academia or industry.\u003c\/p\u003e \u003cp\u003eHave the content of this Handbook and the complete content of eMagRes at your fingertips! Visit: \u003ca href=\"http:\/\/www.wileyonlinelibrary.com\/ref\/eMagRes\"\u003ewww.wileyonlinelibrary.com\/ref\/eMagRes\u003c\/a\u003e\u003c\/p\u003e \u003cp\u003e[E-book logo] Also available as an e-book\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989335654629,"sku":"NP9781118997666","price":250.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781118997666.jpg?v=1761783713","url":"https:\/\/k12savings.com\/es\/products\/handbook-of-magnetic-resonance-spectroscopy-in-vivo-isbn-9781118997666","provider":"K12savings","version":"1.0","type":"link"}