{"product_id":"growth-factors-and-psychiatric-disorders-isbn-9780470516041","title":"Growth Factors and Psychiatric Disorders","description":"The recent identification of susceptibility genes for schizophrenia, depression and learning and memory dysfunction suggest that psychiatric disorders may be influenced by a small number of genes with multiple actions. This is the first book to investigate the role of growth factors in these disorders, which should provide clues to the underlying biochemical mechanisms. For example, recent studies have substantiated the provocative finding that \u003ci\u003eneuregulin 1 (NRG1)\u003c\/i\u003eis a candidate gene for schizophrenia. Neuregulin and its receptors, the ErbB tyrosine kinases, are essential for development of the cardiovascular and nervous systems. Lack of NRG1 function may be involved in dysregulation of synaptogenesis and synaptic plasticity in the adult mediated through glutamate receptor function. Polymorphisms for BDNF (brain-derived neurotrophic factor) have also been implicated in the pathogenesis of schizophrenia. BDNF is a prevalent neurotrophic factor that plays an important role in the pathophysiology of depression, bipolar disease and other psychiatric disorders. Other topics addressed in this book include neuroplasticity and neurotrophic factors, signal transduction by neurotrophins, intracellular trafficking of growth factors, trophic factors and cognitive functions, neurotrophins and depression, and pharmacological treatments of schizophrenia.  \u003ci\u003eSymposium on Growth factors and psychiatric disorders, held at the Novartis Foundation,\u003c\/i\u003e \u003ci\u003eLondon, 20–22 March 2007.\u003c\/i\u003e  \u003cp\u003e\u003ci\u003eEditors: Derek J. Chadwick (Organizer) and Jamie Goode.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eThis symposium is based on a proposal made by Moses Chao.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eMoses Chao\u003c\/b\u003e Chair’s introduction.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eDaniel C. Javitt\u003c\/b\u003e Phenomenology, aetiology and treatment of  schizophrenia.\u003c\/p\u003e \u003cp\u003eDiscussion.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eJonathan Flint, Sagiv Shifman, Marcus Munafo\u003c\/b\u003e and \u003cb\u003eRichard Mott\u003c\/b\u003e Genetic variants in major depression.\u003c\/p\u003e \u003cp\u003eDiscussion.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eEero Castrén\u003c\/b\u003e and \u003cb\u003eTomi Rantamäki\u003c\/b\u003e Neurotrophins in depression and antidepressant effects.\u003c\/p\u003e \u003cp\u003eDiscussion.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eJinbo Fan\u003c\/b\u003e and \u003cb\u003ePamela Sklar\u003c\/b\u003e Genetics of bipolar disorder: focus on BDNF Val66Met polymorphism.\u003c\/p\u003e \u003cp\u003eDiscussion.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eDavid A. Talmage\u003c\/b\u003e Mechanisms of neuregulin action.\u003c\/p\u003e \u003cp\u003eDiscussion.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eGeneral discussion I.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eH. Akil, S. J. Evans, C. A. Turner, J. Perez, R. M. Myers, W. E. Bunney,\u003c\/b\u003e \u003cb\u003eE. G. Jones, S. J. Watson\u003c\/b\u003e and \u003cb\u003eother members of the Pritzker Consortium\u003c\/b\u003e The fibroblast growth factor family and mood disorders.\u003c\/p\u003e \u003cp\u003eDiscussion.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eJay N. Giedd, Rhoshel K. Lenroot, Philip Shaw, Francois Lalonde,\u003c\/b\u003e \u003cb\u003eMark Celano, Samantha White, Julia Tossell, Anjene Addington\u003c\/b\u003e and \u003cb\u003eNitin Gogtay\u003c\/b\u003e Trajectories of anatomic brain development as a phenotype.\u003c\/p\u003e \u003cp\u003eDiscussion.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eBai Lu\u003c\/b\u003e and \u003cb\u003eKeri Martinowich\u003c\/b\u003e Cell biology of BDNF and its relevance to schizophrenia.\u003c\/p\u003e \u003cp\u003eDiscussion.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eEnrico Tongiorgi\u003c\/b\u003e and \u003cb\u003eGabriele Baj\u003c\/b\u003e Functions and mechanisms of BDNF mRNA trafficking.\u003c\/p\u003e \u003cp\u003eDiscussion.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAmar Sahay\u003c\/b\u003e and \u003cb\u003eRené Hen\u003c\/b\u003e Hippocampal neurogenesis and depression.\u003c\/p\u003e \u003cp\u003eDiscussion.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAndrés Buonanno, Oh-Bin Kwon, Leqin Yan, Carmen Gonzalez,\u003c\/b\u003e \u003cb\u003eMarines Longart, Dax Hoffman\u003c\/b\u003e and \u003cb\u003eDetlef Vullhorst\u003c\/b\u003e Neuregulins and neuronal plasticity: possible relevance in schizophrenia.\u003c\/p\u003e \u003cp\u003eDiscussion.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eZhe-Yu Chen, Kevin Bath, Bruce McEwen, Barbara Hempstead\u003c\/b\u003e and \u003cb\u003eFrancis Lee\u003c\/b\u003e Impact of genetic variant BDNF (Val66Met) on brain structure and function.\u003c\/p\u003e \u003cp\u003eDiscussion.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eGeneral discussion II.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eD. Malaspina, M. Perrin, K. R. Kleinhaus, M. Opler\u003c\/b\u003e and \u003cb\u003eS. Harlap\u003c\/b\u003e Growth and schizophrenia: aetiology, epidemiology and epigenetics.\u003c\/p\u003e \u003cp\u003eDiscussion.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eLuiz M. Camargo, Qi Wang\u003c\/b\u003e and \u003cb\u003eNicholas J. Brandon\u003c\/b\u003e What can we learn from the disrupted in schizophrenia 1 interactome: lessons for target identification and disease biology?\u003c\/p\u003e \u003cp\u003eDiscussion.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eMichael Spedding\u003c\/b\u003e and \u003cb\u003ePierre Gressens\u003c\/b\u003e Neurotrophins and cytokines in neuronal plasticity.\u003c\/p\u003e \u003cp\u003eDiscussion.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eMoses Chao\u003c\/b\u003e Closing remarks.\u003c\/p\u003e \u003cp\u003eIndex of contributors.\u003c\/p\u003e \u003cp\u003eSubject index.\u003c\/p\u003e  The \u003cb\u003eNovartis Foundation\u003c\/b\u003e is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.\u003cbr\u003e \u003cb\u003eChair:\u003c\/b\u003e MOSES V CHAO, Skirball Institute of Biomolecular Medicine, New York, USA  \u003cb\u003eNovartis Foundation Symposium 289\u003c\/b\u003e  \u003cp\u003e\u003cb\u003e\u003ci\u003eGrowth factors and psychiatric disorders\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eChair: Moses V. Chao\u003c\/p\u003e \u003cp\u003ePsychiatric disorders such as depression, bipolar disease and schizophrenia are debilitating illnesses that are influenced by many genetic and environmental factors. While little is known about the neural circuits that underlie such disorders, the convergence of psychiatric, genetic and basic neuroscience research is providing new and exciting insights.\u003c\/p\u003e \u003cp\u003eIn recent years genetic studies have identified several growth factors as susceptibility genes for depression, schizophrenia, and learning and memory. This suggests that psychiatric disorders may be influenced by a small number of genes with multiple actions. These genes will provide clues to the biochemical mechanisms and pathways that underlie these complex disorders.\u003c\/p\u003e \u003cp\u003eThis is the first book to undertake a comprehensive investigation of this research. International leading experts are brought together to discuss the latest findings and look at future directions.\u003c\/p\u003e \u003cp\u003eTopics addressed include\u003c\/p\u003e \u003cul type=\"disc\"\u003e \u003cli\u003eNeuroplasticity and neurotrophic factors.\u003c\/li\u003e \u003cli\u003eMechanisms of intracellular trafficking of growth factors.\u003c\/li\u003e \u003cli\u003eBDNF gene variants in affective disorders.\u003c\/li\u003e \u003cli\u003eTrophic factors and cognitive functions.\u003c\/li\u003e \u003cli\u003eNeurotrophins and depression.\u003c\/li\u003e \u003cli\u003eSchizophrenia genes and neuropathology.\u003c\/li\u003e \u003cli\u003ePharmacological treatments of schizophrenia.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003cb\u003e\u003ci\u003eGrowth factors and psychiatric disorders\u003c\/i\u003e will be of particular interest to psychiatrists, neurologists and geneticists, as well as cell and molecular biologists, and neuroscientists.\u003c\/b\u003e\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989316911333,"sku":"NP9780470516041","price":253.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470516041.jpg?v=1761783644","url":"https:\/\/k12savings.com\/es\/products\/growth-factors-and-psychiatric-disorders-isbn-9780470516041","provider":"K12savings","version":"1.0","type":"link"}