{"product_id":"general-and-molecular-pharmacology-isbn-9781118768570","title":"General and Molecular Pharmacology","description":"\u003cbr\u003e With a focus on functional relationships between drugs and their targets, this book covers basic and general pharmacology, from a cellular and molecular perspective, with particular attention  to the mechanisms of drug action – the fundamental basis for proper clinical use- without neglecting clinical application, toxicology and pharmacokinetics.\u003cbr\u003e \u003cbr\u003e •    Covers cell and molecular pharmacology, bringing together current research on regulation of drug targets, at a level appropriate for advanced undergrad and graduate students\u003cbr\u003e •    Discusses the relevance of pharmacokinetics and drug development for the clinical application of drugs\u003cbr\u003e •    Presents material from the perspective of drug targets and interaction, the theoretical basis of drug action analysis, and drug properties\u003cbr\u003e •    Focuses on structure-function relationships of drug targets – informing about their biochemical and physiologic functions and experimental and clinical pathways for drug discovery and development \u003cbr\u003e •    Has a companion website that offers a host of resources: short additional chapters about methodology, topics at the forefront of research, and all figures and tables from the book \u003cp\u003eLIST OF CONTRIBUTORS xlvi\u003cbr\u003e\u003cbr\u003ePreface xlix\u003cbr\u003e\u003cbr\u003e\u003cb\u003eSECTION 1 INTRODUCTION TO PHARMACOLOGY 1\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003e1 Essential Lexicon of Pharmacology 3\u003cbr\u003e\u003ci\u003eFrancesco Clementi and Guido Fumagalli\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e2 A Short History of Pharmacology 8\u003cbr\u003e\u003ci\u003eVittorio A. Sironi\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eSECTION 2 GETTING THE DRUG TO ITS SITE OF ACTION 19\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003e3 Cellular Basis of Pharmacokinetics 21\u003cbr\u003e\u003ci\u003eRiccardo Fesce and Guido Fumagalli\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e4 Drug Absorption and Administration Routes 31\u003cbr\u003e\u003ci\u003eRiccardo Fesce and Guido Fumagalli\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e5 Drug Distribution and Elimination 45\u003cbr\u003e\u003ci\u003eRiccardo Fesce and Guido Fumagalli\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e6 Drug Metabolism 61\u003cbr\u003e\u003ci\u003eEnzo Chiesara Laura Marabini and Sonia Radice Metabolic Modification of Drug Activity \u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e7 Control of Drug Plasma Concentration 73\u003cbr\u003e\u003ci\u003eRiccardo Fesce and Guido Fumagalli\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eSECTION 3 RECEPTORS AND SIGNAL TRANSDUCTION 91\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003e8 Drug–Receptor Interactions: Quantitative and Qualitative Aspects 93\u003cbr\u003e\u003ci\u003eGian Enrico Rovati and Valérie Capra\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e9 Receptors and Modulation of Their Response 109\u003cbr\u003e\u003ci\u003eFrancesco Clementi and Guido Fumagalli\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e10 A daptation to Drug Response and Drug Dependence 121\u003cbr\u003e\u003ci\u003eCristiano Chiamulera\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e11 Pharmacological Modulation of Posttranslational Modifications 130\u003cbr\u003e\u003ci\u003eMonica Di Luca Flavia Valtorta and Fabrizio Gardoni\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e12 Calcium Homeostasis Within the Cells 139\u003cbr\u003e\u003ci\u003eJacopo Meldolesi and Guido Fumagalli\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e13 Pharmacology of Map Kinases 147\u003cbr\u003e\u003ci\u003eLucia Vicentini and Maria Grazia Cattaneo\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e14 Small G Proteins 154\u003cbr\u003e\u003ci\u003eErzsébet Ligeti and Thomas Wieland\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e15 Integration in Intracellular Transduction of Receptor Signals 166\u003cbr\u003e\u003ci\u003eJacopo Meldolesi\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eSECTION 4 RECEPTOR CLASSES 173\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003e16 Ligand-Gated Ion Channels 175\u003cbr\u003e\u003ci\u003eCecilia Gotti and Francesco Clementi\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e17 G-Protein-Coupled Receptors 189\u003cbr\u003e\u003ci\u003eLucia Vallar Maria Pia Abbracchio and Lucia Vicentini\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e18 Growth Factor Receptors 202\u003cbr\u003e\u003ci\u003eSilvia Giordano Carla Boccaccio and Paolo M. Comoglio\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e19 Cytokine Receptors 217\u003cbr\u003e\u003ci\u003eMassimo Locati\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e20 A dhesion Molecule Receptors 225\u003cbr\u003e\u003ci\u003eGiorgio Berton and Carlo Laudanna\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e21 Soluble Cytokine Receptors and Monoclonal Antibodies in Pathophysiology and Therapy 235\u003cbr\u003e\u003ci\u003eAlberto Mantovani and Annunciata Vecchi\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eSECTION 5 MODULATION OF GENE ESPRESSION 241\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003e22 Pharmacology of Transcription 243\u003cbr\u003e\u003ci\u003eRoberta Benfante and Diego Fornasari\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e23 Pharmacogenetics and Personalized Therapy 256\u003cbr\u003e\u003ci\u003eDiego Fornasari\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e24 Intracellular Receptors 268\u003cbr\u003e\u003ci\u003eAdriana Maggi and Elisabetta Vegeto\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e25 Rna Molecule as a Drug: From Rna Interference to Aptamers 284\u003cbr\u003e\u003ci\u003eValerio Fulci and Giuseppe Macino\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eSECTION 6 REGENERATIVE MEDICINE 293\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003e26 Regenerative Medicine and Gene Therapy 295\u003cbr\u003e\u003ci\u003eLuciano Conti and Elena Cattaneo\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eSECTION 7 PHARMACOLOGICAL CONTROL OF MEMBRANE TRANSPORT 309\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003e27 Ion Channels 311\u003cbr\u003e\u003ci\u003eMaurizio Taglialatela and Enzo Wanke\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e28 Membrane Transporters 345\u003cbr\u003e\u003ci\u003eLucio Annunziato Giuseppe Pignataro and Gianfranco Di Renzo\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e29 Neurotransmitter Transporters 359\u003cbr\u003e\u003ci\u003eGaetano Di Chiara\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eSECTION 8 CONTROL OF PROTEOLYSIS 377\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003e30 Intracellular Proteolysis 379\u003cbr\u003e\u003ci\u003eFabio Di Lisa and Edon Melloni\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e31 Extracellular Proteolysis 395\u003cbr\u003e\u003ci\u003eFrancesco Blasi\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eSECTION 9 CONTROL OF CELL CYCLE AND CELLULAR PROLIFERATION 403\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003e32 Cell Cycle and Cell Death 405\u003cbr\u003e\u003ci\u003eMarco Corazzari and Mauro Piacentini\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e33 Mechanisms of Action of Antitumor Drugs 415\u003cbr\u003e\u003ci\u003eGiovanni Luca Beretta Laura Gatti and Paola Perego\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eSECTION 10 CONTROL OF CELLULAR METABOLISM 431\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003e34 Mitochondria Oxidative Stress and Cell Damage: Pharmacological Perspectives 433\u003cbr\u003e\u003ci\u003eClara De Palma Orazio Cantoni and Fabio Di Lisa\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e35 Pharmacological Control of Lipid Synthesis 439\u003cbr\u003e\u003ci\u003eLorenzo Arnaboldi Alberto Corsini and Nicola Ferri\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e36 Glucose Transport and Pharmacological Control of Glucose Metabolism 452\u003cbr\u003e\u003ci\u003ePaolo Moghetti and Giacomo Zoppini\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eSECTION 11 INTERCELLULAR COMMUNICATION 463\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003e37 Pharmacological Regulation of Synaptic Function 465\u003cbr\u003e\u003ci\u003eMichela Matteoli Elisabetta Menna Costanza Capuano and Claudia Verderio\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e38 Catecholaminergic Transmission 477\u003cbr\u003e\u003ci\u003ePier Franco Spano Maurizio Memo M. Cristina Missale Marina Pizzi and Sandra Sigala\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e39 Cholinergic Transmission 496\u003cbr\u003e\u003ci\u003eGiancarlo Pepeu\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e40 The Serotonergic Transmission 509\u003cbr\u003e\u003ci\u003eMaurizio Popoli Laura Musazzi and Giorgio Racagni\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e41 Histaminergic Transmission 520\u003cbr\u003e\u003ci\u003eEmanuela Masini and Laura Lucarini\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e42 Gabaergic Transmission 529\u003cbr\u003e\u003ci\u003eMariangela Serra Enrico Sanna and Giovanni Biggio\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e43 Glutamate-Mediated Neurotransmission 541\u003cbr\u003e\u003ci\u003eFlavio Moroni\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e44 Purinergic Transmission 553\u003cbr\u003e\u003ci\u003eStefania Ceruti Flaminio Cattabeni and Maria Pia Abbracchio\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e45 Neuropeptides 565\u003cbr\u003e\u003ci\u003eLucia Negri and Roberta Lattanzi\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e46 The Opioid System 572\u003cbr\u003e\u003ci\u003ePatrizia Romualdi and Sanzio Candeletti\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e47 The Endocannabinoid System 585\u003cbr\u003e\u003ci\u003eDaniela Parolaro and Tiziana Rubino\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e48 Pharmacology of Nitric Oxide 596\u003cbr\u003e\u003ci\u003eEmilio Clementi\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e49 A rachidonic Acid Metabolism 608\u003cbr\u003e\u003ci\u003eCarlo Patrono and Paola Patrignani\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eSECTION 12 PHARMACOLOGY OF DEFENCE PROCESSES 623\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003e50 Pharmacological Modulation of the Immune System 625\u003cbr\u003e\u003ci\u003eCarlo Riccardi and Graziella Migliorati\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e51 Mechanism of Action of Anti-Infective Drugs 641\u003cbr\u003e\u003ci\u003eFrancesco Scaglione\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eSECTION 13 TOXICOLOGY AND DRUG INTERACTIONS 663\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003e52 Introduction to Toxicology 665\u003cbr\u003e\u003ci\u003eHelmut Greim\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e53 Drug Interactions 678\u003cbr\u003e\u003ci\u003eAchille P. Caputi Giuseppina Fava and Angela De Sarro\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eSECTION 14 DRUG DEVELOPMENT 687\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003e54 Preclinical Research and Development of New Drugs 689\u003cbr\u003e\u003ci\u003eEnnio Ongini\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e55 Role of Drug Metabolism and Pharmacokinetics in Drug Development 700\u003cbr\u003e\u003ci\u003eSimone Braggio and Mario Pellegatti\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003e56 Clinical Development of a New Drug and Methodology of Drug Trials 708\u003cbr\u003e\u003ci\u003eCarlo Patrono\u003c\/i\u003e\u003cbr\u003e\u003cbr\u003eIndex 714\u003c\/p\u003e \u003cp\u003e\u003cb\u003eFrancesco Clementi\u003c\/b\u003e is a Professor Emeritus of Pharmacology at the University of Milan. He has been President of several national and international societies and is member of the Accademia dei Lincei, the prestigious Academy of Italian Sciences. He authored over 200 publications dealing with neurotransmitter receptors and co-edited several books on neuropharmacology and cell biology including all four editions of the Italian language version of this book, \u003ci\u003eFarmacologia Generale e Molecolare\u003c\/i\u003e.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eGuido Fumagalli\u003c\/b\u003e has been the Dean of Faculty Director of the PhD School of Translational Medicine, Vice-Provost for Research, and Vice-Provost for International Affairs at the University of Verona. He has over 80 publications in international journals to his credit along with numerous books on pharmacology and sports science\u003c\/p\u003e \u003cp\u003eDefined by ASPET as the study of the effects of chemical agents of therapeutic value or with the potential toxicity on biological systems, pharmacology is critical to understanding how drugs can correct the biochemical abnormalities responsible for human illness. It is one of the core disciplines students need to master in order to develop effective drugs and therapeutics.\u003cbr\u003e\u003cbr\u003eThis book, the updated and enhanced English translation of a successful and multi-edition Italian text, covers basic and general pharmacology, from a cellular and molecular perspective, with particular attention mechanisms of drug action – the fundamental basis for proper clinical use - without neglecting drug interactions, general physiological functions, and the toxicological effects of chemical compounds . As opposed to classical pharmacology textbooks, which spend more time detailing medical and therapeutic effects, the authors offer thorough discussion of drug action mechanisms at cell and molecular level and the rules governing drug pharmacokinetics and development.\u003cbr\u003e\u003cbr\u003eThe target-oriented approach within the text changes the common perception of drugs as chemical entities affecting organisms and highlights the interdisciplinary and dynamic nature of pharmacological research. As such, the book introduces pharmacologists to a more integrated view of their discipline and fosters a holistic approach to the analysis and treatment of diseases – one in which drugs are regarded as critical tools to discover new cell functions, mechanisms, and therapies.\u003cbr\u003e\u003cbr\u003eComplementary to the main text, the book has a companion website that builds on the content within the book itself by addressing more specific subjects and methodologies. The site is ideal for readers who have mastered the basic principles and are seeking more in-depth knowledge of detailed topics.\u003cbr\u003e\u003cbr\u003eMore than just a course text for pharmacology students, this book can also be a key reference and resource for researchers and professionals involved in any aspect of drug development\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989276344549,"sku":"NP9781118768570","price":128.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781118768570.jpg?v=1761783482","url":"https:\/\/k12savings.com\/es\/products\/general-and-molecular-pharmacology-isbn-9781118768570","provider":"K12savings","version":"1.0","type":"link"}